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Your search keyword '"Jan Roar Mellembakken"' showing total 3 results
Start Over Author "Jan Roar Mellembakken" Publisher bioscientifica
3 results on '"Jan Roar Mellembakken"'

1. Higher blood pressure in normal weight women with PCOS compared to controls

Author

Jan Roar Mellembakken, Azita Mahmoudan, Lars Mørkrid, Inger Sundström-Poromaa, Laure Morin-Papunen, Juha S Tapanainen, Terhi T Piltonen, Angelica Lindén Hirschberg, Elisabet Stener-Victorin, Eszter Vanky, Pernille Ravn, Richard Christian Jensen, Marianne Skovsager Andersen, and Dorte Glintborg

Subjects
polycystic ovary syndrome, blood pressure, hypertension, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Objective: Obesity is considered to be the strongest predictive factor for cardio-metabolic risk in women with polycystic ovary syndrome (PCOS). The aim of the study was to compare blood pressure (BP) in normal weight women with PCOS and controls matched for age and BMI. Methods: From a Nordic cross-sectional base of 2615 individuals of Nordic ethnicity, we studied a sub cohort of 793 normal weight women with BMI < 25 k g/m2 (512 women with PCOS according to Rotterdam criteria and 281 age and BMI-matched controls). Participants underwent measurement of BP and body composition (BMI, waist-hip ratio), lipid status, and fasting BG. Data were presented as median (quartiles). Results: The median age for women with PCOS were 28 (25, 32) years and median BMI was 22.2 (20.7, 23.4) kg/m2. Systolic BP was 118 (109, 128) mmHg in women with PCOS compared to 110 (105, 120) mmHg in controls and diastolic BP was 74 (67, 81) vs 70 (64, 75) mmHg, both P < 0.001. The prevalence of women with BP ≥ 140/90 mmHg was 11.1% (57/512) in women with PCOS vs 1.8% (5/281) in controls, P < 0.001. In women ≥ 35 years the prevalence of BP ≥ 140/90 mmHg was comparable in women with PCOS and controls (12.7% vs 9.8%, P = 0.6). Using multiple regression analyses, the strongest association with BP was found for age, waist circumference, and total cholesterol in women with PCOS. Conclusions: Normal weight women with PCOS have higher BP than controls. BP and metabolic screening are relevant also in young normal weight women with PCOS.

Published
2021
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2. Higher blood pressure in normal weight women with pcos compared to controls

Author

Inger Sundström-Poromaa, Pernille Ravn, Dorte Glintborg, Angelica Lindén Hirschberg, Marianne Andersen, Laure Morin-Papunen, Jan Roar Mellembakken, Elisabet Stener-Victorin, Richard Christian Jensen, Lars Mørkrid, Terhi Piltonen, Azita Mahmoudan, Eszter Vanky, Juha S. Tapanainen, HUS Gynecology and Obstetrics, Reproductive Disease Modeling, Department of Obstetrics and Gynecology, Clinicum, University of Helsinki, and Helsinki University Hospital Area

Subjects
medicine.medical_specialty, Waist, hypertension, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Diastole, 030209 endocrinology & metabolism, lcsh:Diseases of the endocrine glands. Clinical endocrinology, MORBIDITY, 03 medical and health sciences, AGE, 0302 clinical medicine, Endocrinology, 3123 Gynaecology and paediatrics, MANAGEMENT, Internal Medicine, Medicine, METABOLIC RISK, lcsh:RC648-665, 030219 obstetrics & reproductive medicine, business.industry, Obstetrics, Research, nutritional and metabolic diseases, blood pressure, ASSOCIATION, POLYCYSTIC-OVARY-SYNDROME, medicine.disease, Obesity, Polycystic ovary, EUROPEAN-SOCIETY, NATIONWIDE POPULATION, Blood pressure, Quartile, Normal weight, CARDIOVASCULAR-DISEASE, polycystic ovary syndrome, 3121 General medicine, internal medicine and other clinical medicine, Cohort, business
Abstract

Objective Obesity is considered to be the strongest predictive factor for cardio-metabolic risk in women with polycystic ovary syndrome (PCOS). The aim of the study was to compare blood pressure (BP) in normal weight women with PCOS and controls matched for age and BMI. Methods From a Nordic cross-sectional base of 2615 individuals of Nordic ethnicity, we studied a sub cohort of 793 normal weight women with BMI 2 (512 women with PCOS according to Rotterdam criteria and 281 age and BMI-matched controls). Participants underwent measurement of BP and body composition (BMI, waist-hip ratio), lipid status, and fasting BG. Data were presented as median (quartiles). Results The median age for women with PCOS were 28 (25, 32) years and median BMI was 22.2 (20.7, 23.4) kg/m2. Systolic BP was 118 (109, 128) mmHg in women with PCOS compared to 110 (105, 120) mmHg in controls and diastolic BP was 74 (67, 81) vs 70 (64, 75) mmHg, both P < 0.001. The prevalence of women with BP ≥ 140/90 mmHg was 11.1% (57/512) in women with PCOS vs 1.8% (5/281) in controls, P < 0.001. In women ≥ 35 years the prevalence of BP ≥ 140/90 mmHg was comparable in women with PCOS and controls (12.7% vs 9.8%, P = 0.6). Using multiple regression analyses, the strongest association with BP was found for age, waist circumference, and total cholesterol in women with PCOS. Conclusions Normal weight women with PCOS have higher BP than controls. BP and metabolic screening are relevant also in young normal weight women with PCOS.

Published
2021

3. Fructose content of low calorie diets: effect on cardiometabolic risk factors in obese women with polycystic ovarian syndrome: a randomized controlled trial

Author

Line K Johnson, Jan Roar Mellembakken, Jøran Hjelmesæth, Kirsten B. Holven, Njord Nordstrand, and Tom Tanbo

Subjects
obesity, medicine.medical_specialty, Waist, Endocrinology, Diabetes and Metabolism, Carbohydrate metabolism, fructose, law.invention, chemistry.chemical_compound, Endocrinology, cardiometabolic risk-factors, Randomized controlled trial, law, Weight loss, Internal medicine, PCOS, Internal Medicine, medicine, low calorie diets, business.industry, Research, Fructose, medicine.disease, Obesity, Blood pressure, chemistry, Uric acid, weight loss, medicine.symptom, business
Abstract

We aimed to examine whether a whole-grain crispbread (CB) low-fructose, low-calorie diet (LCD) might be superior to a traditional LCD based on fructose-rich liquid meal replacements (LMRs) with respect to improvement of various cardiometabolic risk factors and reproductive hormones. Parallel-group randomised controlled clinical trial. Morbidly obese women with polycystic ovarian syndrome (PCOS) were randomised to either an 8-week CB-LCD or LMR-LCD (900–1100 kcal/day, fructose 17 g/day or 85 g/day). A total of 51 women completed the study. Body weight, fat mass and waist circumference reduced by mean (s.d.) 10.0 (4.8) kg, 7.4 (4.2) kg and 8.5 (4.4) cm, with no significant differences between groups. Total-cholesterol, HDL-cholesterol and Apo-A1 were significantly reduced within both groups (all P values ClinicalTrials.gov: NCT00779571.

Published
2015

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