Search

Your search keyword '"Andrew Lansdown"' showing total 21 results
Start Over Author "Andrew Lansdown" Publisher bioscientifica
21 results on '"Andrew Lansdown"'

1. Spinal epidural lipomatosis: a rare association of Cushing’s disease

Author

Sajjad Ahmad, Thomas Best, Andrew Lansdown, Caroline Hayhurst, Fiona Smeeton, Steve Davies, and Aled Rees

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Excess cortisol is associated with hypertrophy and redistribution of adipose tissue leading to central obesity which is classically seen in Cushing’s syndrome. Abnormal accumulation of fatty tissue in the spinal canal is most commonly associated with chronic steroid therapy and rarely reported with endogenous Cushing’s syndrome. Herein, we describe a case of spinal epidural lipomatosis (SEL) associated with Cushing’s disease. A 17-year-old man was referred with lower limb weakness, weight gain, multiple stretch marks, back pain and loss of height. He had clinical and biochemical features of Cushing’s syndrome. MRI and Inferior Petrosal Sinus Sampling (IPSS) confirmed a pituitary adenoma as the source. On day 1 post trans-sphenoidal adenectomy he developed spastic paraparesis with a sensory deficit to the level of T5. MRI spine showed increased fat deposition in the spinal canal from T2 to T9 consistent with a diagnosis of SEL. He was managed conservatively and made a good recovery following restoration of eucortisolism and a period of rehabilitation.

Published
2020
Full Text
View/download PDF

2. Acromegaly and the information gap: patient perceptions of the journey from primary to tertiary care

Author

Hei Yi Vivian Pak, Andrew Lansdown, Peter Taylor, Dafydd Aled Rees, John Stephen Davies, and Caroline Hayhurst

Subjects
acromegaly, long-term impact, qualitative, patient perspective, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Objective: Acromegaly is a rare condition and there is often a long path to diagnosis for many patients. We sought to explore patient’s perceptions a nd understanding of acromegaly, to examine the quality of communication and find gap s in the information provided at diagnosis. Design: A prospective study using qualitative research methodology and grounded theory. A semi-structured interview was conducted with 18 patie nts treated for acromegaly in a single tertiary centre and verbatim transcripts were thematically analysed for overarching themes. Results: Eighteen patients with acromegaly were interviewed. The mean a ge of participants was 52 (range 30–72). Four overarching themes emerged; (1) Patients rely on online resources to understand acromegaly in the time between d iagnosis and tertiary care clinic; (2) There is not enough support available for pati ents; (3) Patients have a basic understanding of acromegaly and associated conditions, bu t the long-term impact is underestimated; and (4) Patients initially felt intimidated by the multidisciplinary team panel, but overall found it useful. Conclusion: Acromegalic patients have a strong need for information at the point of initial diagnosis, in particular online resources and interaction with other experienced patients. Wider dissemination of patient educational resources into prima ry and secondary care settings may improve overall patient satisfaction, treatment ad herence and subsequent health care provider–patient relationships.

Published
2020
Full Text
View/download PDF

8. Natural history of non-functioning pituitary microadenomas - results from the UK NFA consortium

Author

Ross Hamblin, Athanasios Fountas, Kirstie Lithgow, Paul Benjamin Loughrey, Efstathios Bonanos, Shinwari Shah Khalid, Kirsten Mitchell, Syed Shah, Lydia Grixti, Mike Matheou, Kristina Isand, David McLaren, Ashutosh Surya, Ullah Hafiz Zubair, Katarina Klaucane, Anuradha Jayasuriya, Sumbal Bhatti, Akash Mavilakandy, Masato Ahsan, Susan Mathew, Ziad Hussein, Thijs Jansz, Wunna Wunna, John Ayuk, Prakash Abraham, William Drake, Antonia Brooke, Stephanie E. Baldeweg, Amir H. Sam, Niamh Martin, Claire Higham, Narendra Reddy, Rupa Ahluwalia, John Newell-Price, Joannis Vamvakopoulos, Amutha Krishnan, Andrew Lansdown, Robert D Murray, Aparna Pal, Karin Bradley, Yaasir Mamoojee, Tejpal Purewal, Janki Panicker, Freel E Marie, Faisal Hasan, Mohit Kumar, Biju Jose, Steven Hunter, and Niki Karavitaki

Published
2022

9. Spinal epidural lipomatosis: a rare association of Cushing’s disease

Author

Caroline Hayhurst, Thomas Best, Sajjad Ahmad, Andrew Lansdown, Aled Rees, Fiona Smeeton, and Steve Davies

Subjects
Male, medicine.medical_specialty, Neurology, Endocrinology, Diabetes and Metabolism, Lipomatosis, 030209 endocrinology & metabolism, Physical examination, White, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Adolescent/young adult, 03 medical and health sciences, 0302 clinical medicine, Pituitary adenoma, Internal Medicine, medicine, Back pain, Spinal canal, lcsh:RC648-665, medicine.diagnostic_test, business.industry, Cushing's disease, medicine.disease, United Kingdom, Inferior petrosal sinus sampling, medicine.anatomical_structure, Pituitary, October, Unique/unexpected symptoms or presentations of a disease, 030220 oncology & carcinogenesis, Radiology, medicine.symptom, business
Abstract

Summary Excess cortisol is associated with hypertrophy and redistribution of adipose tissue leading to central obesity which is classically seen in Cushing’s syndrome. Abnormal accumulation of fatty tissue in the spinal canal is most commonly associated with chronic steroid therapy and rarely reported with endogenous Cushing’s syndrome. Herein, we describe a case of spinal epidural lipomatosis (SEL) associated with Cushing’s disease. A 17-year-old man was referred with lower limb weakness, weight gain, multiple stretch marks, back pain and loss of height. He had clinical and biochemical features of Cushing’s syndrome. MRI and Inferior Petrosal Sinus Sampling (IPSS) confirmed a pituitary adenoma as the source. On day 1 post trans-sphenoidal adenectomy he developed spastic paraparesis with a sensory deficit to the level of T5. MRI spine showed increased fat deposition in the spinal canal from T2 to T9 consistent with a diagnosis of SEL. He was managed conservatively and made a good recovery following restoration of eucortisolism and a period of rehabilitation. Learning points: SEL is a serious complication of glucocorticoid excess and should be considered in any patient presenting with new lower limb neurological symptoms associated with hypercortisolism. It is important to distinguish symptomatic SEL from cortisol-induced proximal myopathy by good history and clinical examination. MRI of the spine is the gold standard investigation for making a diagnosis of SEL. Restoration of eucortisolism can lead to resolution of fat accumulation and good neurological outcome.

Published
2020

13. How do I set up a new service?

Author

Andrew Lansdown

Subjects
Service (business), Set (abstract data type), Operations research, Computer science
Published
2019

14. Hypercalcaemia: hypervitaminosis D or not ?

Author

Stamatios Zouras, Aled Rees, Preethi Nalla, Carol Evans, and Andrew Lansdown

Subjects
medicine.medical_specialty, Endocrinology, Hypercalcaemia, business.industry, Internal medicine, medicine, medicine.disease, business, Hypervitaminosis D
Published
2019

15. Paraganglioma of the seminal vesicle

Author

Justyna Witczak, Ldke Premawardhana, Andrew Lansdown, and Ravikumar Ravindran

Subjects
Pathology, medicine.medical_specialty, Seminal vesicle, medicine.anatomical_structure, Paraganglioma, medicine, Biology, medicine.disease
Published
2019

17. Addressing adrenal incidentalomas (AIs): a snapshot of the investigation of AIs in a tertiary endocrine centre and the effect of implementing a local management pathway

Author

Mohammed Rahman, Jennifer Brooke, Janet Lewis, Gala Gutierrez Buey, Anna Scholz, Carolyn Tang, Eleanor Gait-Carr, Andrew Lansdown, Ruth Ellis-Owen, and Aled Rees

Subjects
medicine.medical_specialty, business.industry, medicine, Snapshot (computer storage), Endocrine system, Intensive care medicine, business
Published
2018

18. Management of 'Anomalous' thyroid results

Author

D. Aled Rees, Carol Evans, Lakdasa Premawardhana, Andrew Lansdown, and Lezia D Souza

Subjects
Pathology, medicine.medical_specialty, medicine.anatomical_structure, business.industry, Thyroid, medicine, business
Published
2018

21. Effectiveness of metyrapone in 195 patients with Cushing's syndrome

Author

Tara Kearney, Andrew Lansdown, Kelly Cheer, Surya Panicker Rajeev, Omar G Mustafa, John Newell-Price, Atif Munir, Isabel Huquet, Anna-Elisabeth H Minder, Kirun Gunganah, Kristien Boelaert, William Drake, Niki Karavitaki, Vasileios Chortis, Christina Daousi, Julian R. E. Davis, Neil E. Hill, Ashley B. Grossman, Daniel J. Cuthbertson, Simon Aylwin, Aled Rees, Andrew S Powlson, Karim Meeran, Eleni Daniel, Steve Ball, Kumar Mohit, Peter J Trainer, and Mark Gurnell

Subjects
medicine.medical_specialty, Endocrinology, S syndrome, Metyrapone, business.industry, Internal medicine, medicine, business, medicine.drug
Published
2014

Catalog

Books, media, physical & digital resources
See catalog results