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Your search keyword '"Alexander D Miras"' showing total 12 results
Start Over Author "Alexander D Miras" Publisher bioscientifica
12 results on '"Alexander D Miras"'

2. Liraglutide 3.0 mg within a NHS Tier-3/4 weight management service results in similar weight loss compared to regulatory trials - The LIPOSAX first UK real-world evidence study

Author

Georgios K. Dimitriadis, Lewis Spencer, Aparna Duggirala, Roux C le, Danielle Bate, Royce P Vincent, Allan Davasgaium, Bianca M. Leca, Gyanendra Tripathi, Simon Aylwin, Mark Christian, Alexander D. Miras, Federica Dimitri, and Harpal Randeva

Subjects
Service (business), business.industry, Weight loss, Liraglutide, General Chemical Engineering, Weight management, Medicine, Operations management, medicine.symptom, Real world evidence, business, medicine.drug
Published
2021
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3. Investigation of the mechanism of action of duodenal mucosal resurfacing in insulin resistant women with polycystic ovarian syndrome. the DOMINO multicentre randomised controlled trial

Author

Channa N. Jayasena, Yun Miao, Belén Pérez-Pevida, Nicola Jackson, Vasha Kaur, Davinder Bansi, Georgios K. Dimitriadis, Alexander D. Miras, Barbara A. Fielding, Frederick Mears, Lisa Webber, Margot Umpleby, Danielle Bate, Danai Balfoussia, Lucy Coppin, Brett Johnson, and Harpal Randeva

Subjects
medicine.medical_specialty, Mechanism of action, Randomized controlled trial, law, business.industry, Internal medicine, medicine, Insulin resistant, medicine.symptom, business, Gastroenterology, Domino, law.invention
Published
2020
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4. Liraglutide downregulates the expression of miRNA-424 in patients with obesity

Author

Mark Christian, Georgios Dimitriadis, Allan Davasgaium, Gyanendra Tripathi, Harpal S. Randeva, Francesco Rubino, Bianca M. Leca, Danielle Bate, Alexander D. Miras, and Federica Dimitri

Subjects
business.industry, Liraglutide, General Chemical Engineering, microRNA, Medicine, In patient, business, Bioinformatics, medicine.disease, Obesity, medicine.drug
Published
2020
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5. The differential effects of weight loss by RYGB versus very-low calorie diet (VLCD) on gut hormone levels and appetite: potential contribution to sustained weight loss

Author

Sirazum Choudhury, Stephen R. Bloom, Krishna Moorthy, Kleopatra Alexiadou, Preeshila Behary, Ahmed, Alexander D. Miras, David Hope, Sanjay Purkayastha, Tricia Tan, Haya Alessimii, Chedie Doyle, George Tharakan, Oluwaseun Anyiam, and Harvinder Chahal

Subjects
medicine.medical_specialty, business.industry, media_common.quotation_subject, food.diet, Appetite, Differential effects, Very low calorie diet, Endocrinology, food, Weight loss, Internal medicine, Medicine, medicine.symptom, business, media_common, Hormone
Published
2019
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6. Effects of visfatin on brown adipose tissue energy regulation

Author

Raghu Adya, Vinod Menon, Georgios Dimitriadis, Terence A. Jones, Harpal S. Randeva, Gregory Kaltsas, Bee K. Tan, Alexander D. Miras, and Manjunath Ramanjaneya

Subjects
medicine.medical_specialty, Endocrinology, medicine.anatomical_structure, Chemistry, Internal medicine, Brown adipose tissue, medicine, Energy regulation
Published
2018
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7. Poor responsiveness after bariatric surgery: clinical and eating behaviour characteristics

Author

Tricia Tan, Barbara McGowan, Veronica Greener, Belén Pérez-Pevida, Rachel J. Gibson, Emma Rose McGlone, Samantha Scholtz, Francesco Rubino, Omar A. Khan, Anna Kamocka, Alexander D. Miras, Madhawi Aldhwayanand, and S.R. Bloom

Subjects
medicine.medical_specialty, business.industry, Physical therapy, Medicine, Poor responsiveness, business, Eating behaviour
Published
2018
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8. Eating behaviour and psychological relationship to food following Roux-en-Y Gastric bypass surgery or VLCD intervention: insights into mechanisms of sustained weight loss

Author

Haya Alessimii, Ahmed, Julia Kenkre, Sanjay Purkayastha, Belén Pérez-Pevida, Alexander D. Miras, Chedie Doyle, Harvinder Chahal, Tricia Tan, and Samantha Scholtz

Subjects
Gastric bypass surgery, Weight loss, business.industry, Intervention (counseling), Anesthesia, medicine, medicine.symptom, Eating behaviour, medicine.disease_cause, business, Roux-en-Y anastomosis
Published
2018
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9. Nuclear factor-kappa beta activation and monocyte-endothelial adhesion lead to chemerin induced endothelial cell inflammation

Author

Georgios Dimitriadis, Claire Hewins, Nilisha Nalawade, Maria Mytilinaiou, Harpal S. Randeva, Alexander D. Miras, Diane Sambrook, Jaspreet Kaur, and Allan Davasgaium

Subjects
biology, Chemistry, Monocyte, Inflammation, Adhesion, Endothelial stem cell, medicine.anatomical_structure, medicine, biology.protein, Cancer research, Chemerin, medicine.symptom, Beta (finance), Kappa
Published
2017
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10. Using kisspeptin to assess GnRH function in an unusual case of primary amenorrhoea

Author

Julia K Prague, Adam Buckley, Karim Meeran, Lisa Yang, Stephen Franks, Alexander D. Miras, Shakunthala Narayanaswamy, Sunitha Vimalesvaran, and Waljit S. Dhillo

Subjects
0301 basic medicine, endocrine system, medicine.medical_specialty, endocrine system diseases, medicine.drug_class, media_common.quotation_subject, Endocrinology, Diabetes and Metabolism, Physiology, Fertility, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Menstruation, 03 medical and health sciences, 0302 clinical medicine, Sex hormone-binding globulin, Kisspeptin, Novel Diagnostic Procedure, Internal medicine, Internal Medicine, medicine, Medroxyprogesterone acetate, Testosterone, media_common, lcsh:RC648-665, 030219 obstetrics & reproductive medicine, biology, Surrogate endpoint, business.industry, Hyperandrogenism, medicine.disease, Polycystic ovary, female genital diseases and pregnancy complications, 030104 developmental biology, Endocrinology, biology.protein, Gonadotropin, business, hormones, hormone substitutes, and hormone antagonists, Hormone, medicine.drug
Abstract

Summary Primary amenorrhoea is defined as the failure to commence menstruation by the age of 15 years, in the presence of normal secondary sexual development. The potential causes of primary amenorrhoea extend from structural to chromosomal abnormalities. Polycystic ovarian syndrome (PCOS) is a common cause of secondary amenorrhoea but an uncommon cause of primary amenorrhoea. An early and prompt diagnosis of PCOS is important, as up to 30% of these women are predisposed to glucose intolerance and obesity, with the subgroup of women presenting with primary amenorrhoea and PCOS displaying a higher incidence of metabolic dysfunction. We describe a case of an 18-year-old female presenting with primary amenorrhoea of unknown aetiology. Although initial investigations did not demonstrate clinical or biochemical hyperandrogenism or any radiological evidence of polycystic ovaries, a raised luteinising hormone (LH) suggested a diagnosis of PCOS. If PCOS was the correct diagnosis, then one would expect intact hypothalamic GnRH and pituitary gonadotropin release. We used the novel hormone kisspeptin to confirm intact hypothalamic GnRH release and a GnRH stimulation test to confirm intact pituitary gonadotroph function. This case highlights that kisspeptin is a potential unique tool to test GnRH function in patients presenting with reproductive disorders. Learning points: Polycystic ovarian syndrome (PCOS) can present with primary amenorrhoea, and therefore, should be considered in the differential diagnosis. PCOS is a heterogeneous condition that may present in lean women with few or absent signs of hyperandrogenism. GnRH stimulation tests are useful in evaluating pituitary function; however, to date, we do not have a viable test of GnRH function. Kisspeptin has the potential to form a novel diagnostic tool for assessing hypothalamic GnRH function by monitoring gonadotropin response as a surrogate marker of GnRH release. Confirmation of intact GnRH function helps consolidate a diagnosis in primary amenorrhoea and gives an indication of future fertility.

Published
2017
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11. The early improvement of glycaemia following RYGB can be mimicked by a Very Low Calorie Diet in obese volunteers with diabetes

Author

George Tharakan, Werd Al-Najim, Alexander D. Miras, Harvinder Chahal, S.R. Bloom, Ahmed, Kostadin Stoenchev, Krishna Moorthy, Adrian Brown, Preeshila Behary, Sanjay Purkayastha, and Tricia Tan

Subjects
Very low calorie diet, medicine.medical_specialty, Endocrinology, food, business.industry, Internal medicine, Diabetes mellitus, food.diet, medicine, business, medicine.disease
Published
2017
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12. A pathway to investigate and manage patients complaining of symptoms suggestive of hypoglycaemia post Roux-en-Y gastric bypass surgery

Author

Candace Bovril-Taylor, Asta Julnaite, Ahmed, Jonathan Cousins, Krishna Moorthy, Preeshila Behary, Jo Boyle, Sarah Allen, George Tharakan, Alexander D. Miras, Tricia Tan, Harvinder Chahal, Sherif Hakky, and Sanjay Purkayastha

Subjects
medicine.medical_specialty, business.industry, Gastric bypass surgery, Medicine, business, medicine.disease_cause, Roux-en-Y anastomosis, Surgery
Published
2014
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