1. Second trimester maternal serum D-dimer combined with alpha-fetoprotein and free β-subunit of human chorionic gonadotropin predict hypertensive disorders of pregnancy: a systematic review and retrospective case–control study
- Author
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Gu Linyuan, Caihe Wen, Xie Zhen, Yijie Chen, Wenwen Ning, Yiming Chen, Xue Wang, Li Liyao, and Chu Xuelian
- Subjects
Gestational hypertension ,medicine.medical_specialty ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Likelihood ratios in diagnostic testing ,Gastroenterology ,Chorionic Gonadotropin ,General Biochemistry, Genetics and Molecular Biology ,Preeclampsia ,Human chorionic gonadotropin ,Fibrin Fibrinogen Degradation Products ,03 medical and health sciences ,0302 clinical medicine ,Pre-Eclampsia ,Pregnancy ,Internal medicine ,Prenatal Diagnosis ,D-dimer ,medicine ,Humans ,Retrospective Studies ,030219 obstetrics & reproductive medicine ,Receiver operating characteristic ,business.industry ,Research ,lcsh:R ,General Medicine ,Hypertension, Pregnancy-Induced ,medicine.disease ,Hypertensive disorders of pregnancy ,Case-Control Studies ,Pregnancy Trimester, Second ,Alpha-fetoprotein ,Female ,Free β subunit of human chorionic gonadotropin ,alpha-Fetoproteins ,business ,Biomarkers - Abstract
Background This study investigated whether maternal serum D-dimer (DD) alone or DD combined with alpha-fetoprotein (AFP) and free β-subunit of human chorionic gonadotropin (free β-hCG) in the second trimester could be used to predict hypertensive disorders of pregnancy (HDP). Materials and methods In this retrospective case–control study, the data of gravidas patients who delivered at hospital were divided into the following groups: control (n = 136), gestational hypertension (GH, n = 126), preeclampsia (PE, n = 53), and severe preeclampsia (SPE, n = 41). Receiver operator characteristic (ROC) curves were used to evaluate the diagnostic value of maternal serum DD, AFP, and free β-hCG levels for HDP. Results DD levels of the GH, PE, and SPE groups were significantly higher than that of the control group (P DD > DD + AFP > DD + free β-hCG > AFP + free β-hCG > AFP > free β-hCG. For predicting different types of HDP, DD alone had the best diagnostic value for SPE, followed by PE and GH. DD alone had a sensitivity of 100% with a 0% false negative rate and had the highest positive likelihood ratio (+ LR) for SPE. DD alone in combination with AFP alone, free β-hCG alone and AFP + free β-hCG could reduce false positive rate and improve + LR. Conclusion DD is possible the best individual predictive marker for predicting HDP. Levels of DD alone in the second trimester were positively correlated with the progression of elevated blood pressure in the third trimester, demonstrating the predicting the occurrence of HDP. The risk calculation model constructed with DD + free β-hCG + AFP had the greatest diagnostic value for SPE.
- Published
- 2021