9 results on '"Wagner Ulrich"'
Search Results
2. Integrative hospital treatment in older patients to benchmark and improve outcome and length of stay – the In-HospiTOOL study
- Author
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Kutz, Alexander, Koch, Daniel, Conca, Antoinette, Baechli, Ciril, Haubitz, Sebastian, Regez, Katharina, Schild, Ursula, Caldara, Zeljka, Ebrahimi, Fahim, Bassetti, Stefano, Eckstein, Jens, Beer, Juerg, Egloff, Michael, Kaplan, Vladimir, Ehmann, Tobias, Hoess, Claus, Schaad, Heinz, Wagner, Ulrich, de Geest, Sabina, Schuetz, Philipp, and Mueller, Beat
- Published
- 2019
- Full Text
- View/download PDF
3. Using country of origin to inform targeted tuberculosis screening in asylum seekers: a modelling study of screening data in a German federal state, 2002–2015
- Author
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Bozorgmehr, Kayvan, Preussler, Stella, Wagner, Ulrich, Joggerst, Brigitte, Szecsenyi, Joachim, Razum, Oliver, and Stock, Christian
- Published
- 2019
- Full Text
- View/download PDF
4. Mobil Air Quality Studies (MAQS)-an international project.
- Author
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Groneberg, David A, Scutaru, Cristian, Lauks, Mathias, Takemura, Masaya, Fischer, Tanja C., Kölzow, Silvana, van Mark, Anke, Uibel, Stefanie, Wagner, Ulrich, Vitzthum, Karin, Beck, Fabian, Mache, Stefanie, Kreiter, Carolin, Kusma, Bianca, Friedebold, Annika, Zell, Hanna, Gerber, Alexander, Bock, Johanna, Al-Mutawakl, Khaled, and Donat, Johannes
- Subjects
EMISSION standards ,CHEMICALS ,GOVERNMENT policy ,TECHNOLOGY & children ,AIR quality - Abstract
Due to an increasing awareness of the potential hazardousness of air pollutants, new laws, rules and guidelines have recently been implemented globally. In this respect, numerous studies have addressed traffic-related exposure to particulate matter using stationary technology so far. By contrast, only few studies used the advanced technology of mobile exposure analysis. The Mobile Air Quality Study (MAQS) addresses the issue of air pollutant exposure by combining advanced high-granularity spatial-temporal analysis with vehicle-mounted, person-mounted and roadside sensors. The MAQS-platform will be used by international collaborators in order 1) to assess air pollutant exposure in relation to road structure, 2) to assess air pollutant exposure in relation to traffic density, 3) to assess air pollutant exposure in relation to weather conditions, 4) to compare exposure within vehicles between front and back seat (children) positions, and 5) to evaluate "traffic zone"-exposure in relation to non-"traffic zone"-exposure. Primarily, the MAQS-platform will focus on particulate matter. With the establishment of advanced mobile analysis tools, it is planed to extend the analysis to other pollutants including NO2, SO2, nanoparticles and ozone. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
5. Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat.
- Author
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Schmidt, Rene, Staats, Petra, Groneberg, David A., and Wagner, Ulrich
- Subjects
LEUKOTRIENE antagonists ,DRUG antagonism ,PLATELET activating factor ,TACHYKININS ,PHARMACODYNAMICS - Abstract
Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic asthma. Leukotriene receptor antagonists are recommended as add-on therapy for this disease. The cys-leukotriene-1 receptor antagonist montelukast has been used in clinical asthma therapy during the last years. Besides its inhibitory action on bronchoconstriction, only little is known about its effects on airway secretions. Therefore, the aim of this study was to evaluate the effects of montelukast on platelet activating factor- and tachykinin induced tracheal secretory activity. Methods: The effects of montelukast on platelet activating factor- and tachykinin induced tracheal secretory activity in the rat were assessed by quantification of secreted
35 SO4 labelled mucus macromolecules using the modified Ussing chamber technique. Results: Platelet activating factor potently stimulated airway secretion, which was completely inhibited by the platelet activating factor receptor antagonist WEB 2086 and montelukast. In contrast, montelukast had no effect on tachykinin induced tracheal secretory activity. Conclusion: Cys-leukotriene-1 receptor antagonism by montelukast reverses the secretagogue properties of platelet activating factor to the same degree as the specific platelet activating factor antagonist WEB 2086 but has no influence on treacheal secretion elicited by tachykinins. These results suggest a role of montelukast in the signal transduction pathway of platelet activating factor induced secretory activity of the airways and may further explain the beneficial properties of cysleukotriene-1 receptor antagonists. [ABSTRACT FROM AUTHOR]- Published
- 2008
- Full Text
- View/download PDF
6. Analysis of airway secretions in a model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD).
- Author
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Wagner, Ulrich, Staats, Petra, Fehmann, Hans-Christoph, Fischer, Axel, Welte, Tobias, and Groneberg, David A.
- Subjects
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OBSTRUCTIVE lung diseases , *INFLAMMATION , *ETIOLOGY of diseases , *FIBROSIS , *HISTOLOGY , *EDEMA - Abstract
Hypersecretion and chronic phlegm are major symptoms of chronic obstructive pulmonary disease (COPD) but animal models of COPD with a defined functional hypersecretion have not been established so far. To identify an animal model of combined morphological signs of airway inflammation and functional hypersecretion, rats were continuously exposed to different levels of sulfur dioxide (SO2, 5 ppm, 10 ppm, 20 ppm, 40 ppm, 80 ppm) for 3 (short-term) or 20-25 (longterm) days. Histology revealed a dose-dependent increase in edema formation and inflammatory cell infiltration in short-term-exposed animals. The submucosal edema was replaced by fibrosis after long-term-exposure. The basal secretory activity was only significantly increased in the 20 ppm group. Also, stimulated secretion was significantly increased only after exposure to 20 ppm. BrdU-assays and AgNOR-analysis demonstrated cellular metaplasia and glandular hypertrophy rather than hyperplasia as the underlying morphological correlate of the hypersecretion. In summary, SO2-exposure can lead to characteristic airway remodeling and changes in mucus secretion in rats. As only long-term exposure to 20 ppm leads to a combination of hypersecretion and airway inflammation, only this mode of exposure should be used to mimic human COPD. Concentrations less or higher than 20 ppm or short term exposure do not induce the respiratory symptom of hypersecretion. The present model may be used to characterize the effects of new compounds on mucus secretion in the background of experimental COPD. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
7. MIAME/Plant -- adding value to plant microarrray experiments.
- Author
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Zimmerman, Philip, Schildknecht, Beatrice, Craigon, David, Garcia-Hernandez, Margarita, Gruissem, Wilhelm, May, Sean, Mukherjee, Gaurab, Parkinson, Helen, Rhee, Seung, Wagner, Ulrich, and Hennig, Lars
- Subjects
DNA microarrays ,EXPERIMENTS ,TECHNICAL specifications ,DATA warehousing ,MANAGEMENT information systems ,PROCEDURE manuals ,PLANTS ,BIOLOGY ,ANNOTATIONS - Abstract
Appropriate biological interpretation of microarray data calls for relevant experimental annotation. The widely accepted MIAME guidelines provide a generic, organism-independant standard for minimal information about microarray experiments. In its overall structure, MIAME is very general and specifications cover mostly technical aspects, while relevant organism-specific information useful to understand the underlying experiments is largely missing. If plant biologists want to use results from published microarray experiments, they need detailed information about biological aspects, such as growth conditions, harvesting time or harvested organ(s). Here, we propose MIAME/Plant, a standard describing which biological details to be captured for describing microarray experiments involving plants. We expect that a more detailed and more systematic annotation of microarray experiments will greatly increase the use of transcriptome data sets for the scientific community. The power and value of systematic annotation of microarray data is convincingly demonstrated by data warehouses such as Genevestigator® or NASCArrays, and better experimental annotation will make these applications even more powerful. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
8. Analysing the causes of chronic cough: relation to diesel exhaust, ozone, nitrogen oxides, sulphur oxides and other environmental factors.
- Author
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Groneberg-Kloft B, Kraus T, Mark Av, Wagner U, and Fischer A
- Abstract
Air pollution remains a leading cause of many respiratory diseases including chronic cough. Although episodes of incidental, dramatic air pollution are relatively rare, current levels of exposure of pollutants in industrialized and developing countries such as total articles, diesel exhaust particles and common cigarette smoke may be responsible for the development of chronic cough both in children and adults. The present study analyses the effects of common environmental factors as potential causes of chronic cough. Different PubMed-based researches were performed that related the term cough to various environmental factors. There is some evidence that chronic inhalation of diesel can lead to the development of cough. For long-term exposure to nitrogen dioxide (NO2), children were found to exhibit increased incidences of chronic cough and decreased lung function parameters. Although a number of studies did not show that outdoor pollution directly causes the development of asthma, they have demonstrated that high levels pollutants and their interaction with sunlight produce ozone (O3) and that repeated exposure to it can lead to chronic cough. In summary, next to the well-known air pollutants which also include particulate matter and sulphur dioxide, a number of other indoor and outdoor pollutants have been demonstrated to cause chronic cough and therefore, environmental factors have to be taken into account as potential initiators of both adult and pediatric chronic cough.
- Published
- 2006
- Full Text
- View/download PDF
9. MIAME/Plant - adding value to plant microarrray experiments.
- Author
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Zimmermann P, Schildknecht B, Craigon D, Garcia-Hernandez M, Gruissem W, May S, Mukherjee G, Parkinson H, Rhee S, Wagner U, and Hennig L
- Abstract
Appropriate biological interpretation of microarray data calls for relevant experimental annotation. The widely accepted MIAME guidelines provide a generic, organism-independant standard for minimal information about microarray experiments. In its overall structure, MIAME is very general and specifications cover mostly technical aspects, while relevant organism-specific information useful to understand the underlying experiments is largely missing. If plant biologists want to use results from published microarray experiments, they need detailed information about biological aspects, such as growth conditions, harvesting time or harvested organ(s). Here, we propose MIAME/Plant, a standard describing which biological details to be captured for describing microarray experiments involving plants. We expect that a more detailed and more systematic annotation of microarray experiments will greatly increase the use of transcriptome data sets for the scientific community. The power and value of systematic annotation of microarray data is convincingly demonstrated by data warehouses such as Genevestigator(R) or NASCArrays, and better experimental annotation will make these applications even more powerful.
- Published
- 2006
- Full Text
- View/download PDF
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