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Your search keyword '"Tsankova, Nadejda"' showing total 8 results
Start Over Author "Tsankova, Nadejda" Publisher biomed central
8 results on '"Tsankova, Nadejda"'

5. Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19

Author

Fullard, John F., Lee, Hao-Chih, Voloudakis, Georgios, Suo, Shengbao, Javidfar, Behnam, Shao, Zhiping, Peter, Cyril, Zhang, Wen, Jiang, Shan, Corvelo, André, Wargnier, Heather, Woodoff-Leith, Emma, Purohit, Dushyant P., Ahuja, Sadhna, Tsankova, Nadejda M., Jette, Nathalie, Hoffman, Gabriel E., Akbarian, Schahram, Fowkes, Mary, Crary, John F., Yuan, Guo-Cheng, and Roussos, Panos

Published
2021
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6. A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons

Author

Espeso-Gil, Sergio, Halene, Tobias, Bendl, Jaroslav, Kassim, Bibi, Ben Hutta, Gabriella, Iskhakova, Marina, Shokrian, Neda, Auluck, Pavan, Javidfar, Behnam, Rajarajan, Prashanth, Chandrasekaran, Sandhya, Peter, Cyril J., Cote, Alanna, Birnbaum, Rebecca, Liao, Will, Borrman, Tyler, Wiseman, Jennifer, Bell, Aaron, Bannon, Michael J., Roussos, Panagiotis, Crary, John F., Weng, Zhiping, Marenco, Stefano, Lipska, Barbara, Tsankova, Nadejda M., Huckins, Laura, Jiang, Yan, and Akbarian, Schahram

Published
2020
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8. BK virus encephalopathy and sclerosing vasculopathy in a patient with hypohidrotic ectodermal dysplasia and immunodeficiency.

Author

Darbinyan, Armine, Major, Eugene O., Morgello, Susan, Holland, Steven, Ryschkewitsch, Caroline, Monaco, Maria Chiara, Naidich, Thomas P., Bederson, Joshua, Malaczynska, Joanna, Ye, Fei, Gordon, Ronald, Cunningham-Rundles, Charlotte, Fowkes, Mary, and Tsankova, Nadejda M.

Subjects
BK virus, IMMUNOSUPPRESSION, ECTODERMAL dysplasia
Abstract

Human BK polyomavirus (BKV) is reactivated under conditions of immunosuppression leading most commonly to nephropathy or cystitis; its tropism for the brain is rare and poorly understood. We present a unique case of BKV-associated encephalopathy in a man with hypohidrotic ectodermal dysplasia and immunodeficiency (HED-ID) due to IKK-gamma (NEMO) mutation, who developed progressive neurological symptoms. Brain biopsy demonstrated polyomavirus infection of gray and white matter, with predominant involvement of cortex and distinct neuronal tropism, in addition to limited demyelination and oligodendroglial inclusions. Immunohistochemistry demonstrated polyoma T-antigen in neurons and glia, but expression of VP1 capsid protein only in glia. PCR analysis on both brain biopsy tissue and cerebrospinal fluid detected high levels of BKV DNA. Sequencing studies further identified novel BKV variant and disclosed unique rearrangements in the noncoding control region of the viral DNA (BKVN NCCR). Neuropathological analysis also demonstrated an unusual form of obliterative fibrosing vasculopathy in the subcortical white matter with abnormal lysosomal accumulations, possibly related to the patient's underlying ectodermal dysplasia. Our report provides the first neuropathological description of HED-ID due to NEMO mutation, and expands the diversity of neurological presentations of BKV infection in brain, underscoring the importance of its consideration in immunodeficient patients with unexplained encephalopathy. We also document novel BKVN NCCR rearrangements that may be associated with the unique neuronal tropism in this patient. [ABSTRACT FROM AUTHOR]

Published
2016
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