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4 results on '"Takahiro Oike"'

1. Stereotactic body radiotherapy for adenoid cystic carcinoma metastatic to the lung: a case report

Author

Tsuneo Shimizu, Takahiro Oike, Tatsuji Mizukami, Atsushi Musha, Jun-ichi Saitoh, Tatsuya Ohno, Takashi Nakano, Hiro Sato, Takanori Abe, and Daijiro Kobayashi

Subjects
Male, medicine.medical_specialty, Lung Neoplasms, Adenoid cystic carcinoma, Stereotactic body radiotherapy, lcsh:Medicine, Case Report, Radiosurgery, Effective dose (radiation), 03 medical and health sciences, 0302 clinical medicine, Cyberknife, Surgical oncology, Radioresistance, medicine, Humans, Lung volumes, Lung, Aged, business.industry, lcsh:R, General Medicine, respiratory system, medicine.disease, Primary tumor, Carcinoma, Adenoid Cystic, medicine.anatomical_structure, 030228 respiratory system, 030220 oncology & carcinogenesis, Radiology, Radiation pneumonitis, Neoplasm Recurrence, Local, business, Lung metastases
Abstract

Background Adenoid cystic carcinoma (ACC) is a rare malignant tumor involving mostly the head and neck region, and frequently the salivary glands. The development of lung metastasis after treatment of the primary tumor is a common occurrence in ACC. Although lung metastases show a slow rate of growth, approximately 10% of patients die from distant metastases. The radioresistance of ACC limits the efficacy of conventional radiotherapy for lung metastases, and the optimal dose remains to be determined. Stereotactic body radiotherapy (SBRT) using CyberKnife can deliver a high dose to the lung tumor, while sparing the surrounding normal lung tissues, leading to favorable local control in non-squamous cell lung cancer and metastatic lung tumors. We report a case of lung metastases from ACC treated successfully with SBRT using CyberKnife. Case presentation A 76-year-old Japanese man with ACC who was treated with carbon ion radiotherapy for a primary oropharynx tumor presented with three metastatic lesions in the lung. The tumor masses were located in the right upper, right lower, and left lower lobes of the lungs. Surgical resection was not indicated because of the presence of multiple tumors. The patient underwent SBRT at 60 Gy in 10 sequential fractions for each tumor. The biologically effective dose based on an alpha/beta ratio of 2 Gy was 240 Gy per tumor. The percentage of the total lung volume irradiated with >20 Gy was 4.9%, 3.2%, and 2.6% for each tumor. The patient developed acute radiation pneumonitis during the initial therapy, which resolved at 6 months after the CyberKnife treatment. At 21 months after the first CyberKnife treatment, three tumors showed no signs of recurrence. No late toxicity was observed. Conclusions SBRT using CyberKnife is an effective and feasible approach to the management of multiple lung metastases of ACC.

Published
2021

2. Predictive factors of acute skin reactions to carbon ion radiotherapy for the treatment of malignant bone and soft tissue tumors

Author

Takahiro Oike, Shin-ei Noda, Tatsuya Ohno, Jun-ichi Saitoh, Hiroki Kiyohara, Takashi Nakano, and Yosuke Takakusagi

Subjects
Male, medicine.medical_treatment, Dermatitis, Soft Tissue Neoplasms, 030218 nuclear medicine & medical imaging, Malignant bone and soft tissue tumors, 0302 clinical medicine, Relative biological effectiveness, Medicine, Neoplasm Metastasis, Skin, integumentary system, Soft tissue, Liposarcoma, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Oncology, 030220 oncology & carcinogenesis, Total dose, Acute skin reactions, Female, Carbon ions, Predictive factors, lcsh:Medical physics. Medical radiology. Nuclear medicine, Adult, medicine.medical_specialty, lcsh:R895-920, Chondrosarcoma, Bone Neoplasms, Heavy Ion Radiotherapy, lcsh:RC254-282, Sensitivity and Specificity, 03 medical and health sciences, Young Adult, Chordoma, Humans, Radiology, Nuclear Medicine and imaging, Aged, business.industry, Research, medicine.disease, Carbon, Surgery, Radiation therapy, Skin reaction, ROC Curve, Carbon Ion Radiotherapy, business, Nuclear medicine, Relative Biological Effectiveness
Abstract

Background The skin is considered a critical organ at risk in carbon ion radiotherapy (CIRT) for locally advanced malignant bone and soft tissue tumors (MBSTs). The predictive factors for acute skin reactions after CIRT have not been investigated. The present study aimed to identify these factors and evaluate the correlation between the severity of acute skin reactions and skin dose parameters. Methods CIRT with total doses of 64.0–70.4 Gy (relative biological effectiveness [RBE]) was administered to 22 patients with MBSTs. The skin-tumor distance (STD), maximum skin total dose (Dmax), and area of the skin receiving a total dose of X Gy (RBE) were evaluated. Results All patients developed acute skin reactions after CIRT, including Grades 1 and 2 dermatitis in 15 (71%) and 6 (29%) patients, respectively. There was a significant difference in the STD between the two groups (P = 0.007), and the cut-off value of STD for predicting Grade 2 acute skin reactions was 11 mm. There was a significant difference in Dmax between the groups (P

Published
2017

3. Predictive factors of acute skin reactions to carbon ion radiotherapy for the treatment of malignant bone and soft tissue tumors.

Author

Yosuke Takakusagi, Jun-ichi Saitoh, Hiroki Kiyohara, Takahiro Oike, Shin-ei Noda, Tatsuya Ohno, Takashi Nakano, Takakusagi, Yosuke, Saitoh, Jun-Ichi, Kiyohara, Hiroki, Oike, Takahiro, Noda, Shin-Ei, Ohno, Tatsuya, and Nakano, Takashi

Subjects
RADIOTHERAPY complications, BONE cancer treatment, SOFT tissue tumors, SKIN inflammation, CANCER relapse, TUMOR treatment, BONE tumors, CARBON, GERM cell tumors, LIPOSARCOMA, METASTASIS, RADIATION doses, RADIOTHERAPY, SKIN, RECEIVER operating characteristic curves, CHONDROSARCOMA
Abstract

Background: The skin is considered a critical organ at risk in carbon ion radiotherapy (CIRT) for locally advanced malignant bone and soft tissue tumors (MBSTs). The predictive factors for acute skin reactions after CIRT have not been investigated. The present study aimed to identify these factors and evaluate the correlation between the severity of acute skin reactions and skin dose parameters.Methods: CIRT with total doses of 64.0-70.4 Gy (relative biological effectiveness [RBE]) was administered to 22 patients with MBSTs. The skin-tumor distance (STD), maximum skin total dose (Dmax), and area of the skin receiving a total dose of X Gy (RBE) were evaluated.Results: All patients developed acute skin reactions after CIRT, including Grades 1 and 2 dermatitis in 15 (71%) and 6 (29%) patients, respectively. There was a significant difference in the STD between the two groups (P = 0.007), and the cut-off value of STD for predicting Grade 2 acute skin reactions was 11 mm. There was a significant difference in Dmax between the groups (P < 0.001), and the cut-off value of Dmax for predicting Grade 2 acute skin reactions was 52 Gy (RBE). Significant differences between the two groups were observed in terms of the area irradiated with 40 Gy (RBE) (S40), and the cut-off value of S40 for predicting Grade 2 acute skin reactions was 25 cm2.Conclusions: In acute skin reactions after CIRT for MBSTs, STD, Dmax, and S40 were found to be significant predictive factors for acute skin reactions. [ABSTRACT FROM AUTHOR]

Published
2017
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4. Can combined intracavitary/interstitial approach be an alternative to interstitial brachytherapy with the Martinez Universal Perineal Interstitial Template (MUPIT) in computed tomography-guided adaptive brachytherapy for bulky and/or irregularly shaped gynecological tumors?

Author

Takahiro Oike, Tatsuya Ohno, Shin-ei Noda, Hiroki Kiyohara, Ken Ando, Kei Shibuya, Tomoaki Tamaki, Yosuke Takakusagi, Hiro Sato, and Takashi Nakano

Subjects
*GYNECOLOGIC cancer, *INTERSTITIAL brachytherapy, *COMPUTED tomography, *RADIATION doses, *TUMORS
Abstract

Background Interstitial brachytherapy (ISBT) is an optional treatment for locally advanced gynecological tumours for which conventional intracavitary brachytherapy (ICBT) would result in suboptimal dose coverage. However, ISBT with Martinez Universal Perineal Interstitial Template (MUPIT), in which ~10-20 needles are usually applied, is more time-consuming and labor-intensive than ICBT alone, making it a burden on both practitioners and patients. Therefore, here we investigated the applicability of a combined intracavitary/interstitial (IC/IS) approach in image-guided adaptive brachytherapy for bulky and/or irregularly shaped gynecological tumours for which interstitial brachytherapy (ISBT) was performed. Methods Twenty-one consecutive patients with gynecological malignancies treated with computed tomography-guided ISBT using MUPIT were analyzed as cases for this dosimetric study. For each patient, the IC/IS plan using a tandem and 1 or 2 interstitial needles, which was modeled after the combined IC/IS approach, was generated and compared with the IS plan based on the clinical ISBT plan, while the IC plan using only the tandem was applied as a simplified control. Maximal dose was prescribed to the high-risk clinical target volume (HR-CTV) while keeping the dose constraints of D2cc bladder < 7.0 Gy and D2cc rectum < 6.0 Gy. The plan with D90 HR-CTV exceeding 6.0 Gy was considered acceptable. Results The average D90 HR-CTV was 77%, 118% and 140% in the IC, IC/IS and IS plans, respectively, where 6 Gy corresponds to 100%. The average of the ratio of D90 HR-CTV to D2cc rectum (gain factor (GF) rectum) in the IC, IC/IS and IS plans was 0.8, 1.3 and 1.5 respectively, while GFbladder was 0.9, 1.4 and 1.6, respectively. In the IC/IS plan, D90 HRCTV, GFrectum and GFbladder exceeded 100%, 1.0 and 1.0, respectively, in all patients. Conclusions These data demonstrated that the combined IC/IS approach could be a viable alternative to ISBT for gynecological malignancies with bulky and/or irregularly shaped tumours. [ABSTRACT FROM AUTHOR]

Published
2014
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