1. Implications of post-translational modifications of IRF7 on pDC IFN-alpha response
- Author
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Sylvie LeGall, EH Doyle, RJ Lindsay, Julie Boucau, Marcus Altfeld, M Griesbeck, and J. Judy Chang
- Subjects
lcsh:Immunologic diseases. Allergy ,biology ,business.industry ,Type I IFN production ,hemic and immune systems ,TLR7 ,Bioinformatics ,Ifn alpha ,Infectious Diseases ,Virology ,Immunology ,Poster Presentation ,biology.protein ,Posttranslational modification ,Medicine ,IRF7 ,Antibody ,business ,lcsh:RC581-607 ,CD8 ,Interferon regulatory factors - Abstract
Background We previously showed that plasmacytoid dendritic cells (pDCs) derived from females can produce significantly more IFN-alpha in response to HIV-1 and HIV-1-encoded TLR7/8 ligands than pDCs derived from males, resulting in stronger secondary activation of CD8+ T cells (Meier et al., Nat Med 2009). Given the crucial role of interferon regulatory factor 7 (IRF7) in the regulation of type I IFN production by pDCs, the goal of the current study was to investigate its impact on the observed differences.
- Published
- 2012