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Your search keyword '"Spinelli, Elena"' showing total 21 results
Start Over Author "Spinelli, Elena" Publisher biomed central
21 results on '"Spinelli, Elena"'

1. Electrical impedance tomography monitoring in adult ICU patients: state-of-the-art, recommendations for standardized acquisition, processing, and clinical use, and future directions

Author

Scaramuzzo, Gaetano, Pavlovsky, Bertrand, Adler, Andy, Baccinelli, Walter, Bodor, Dani L., Damiani, L. Felipe, Franchineau, Guillaume, Francovich, Juliette, Frerichs, Inéz, Giralt, Juan A. Sánchez, Grychtol, Bartłomiej, He, Huaiwu, Katira, Bhushan H., Koopman, Alette A., Leonhardt, Steffen, Menga, Luca S., Mousa, Amne, Pellegrini, Mariangela, Piraino, Thomas, Priani, Paolo, Somhorst, Peter, Spinelli, Elena, Händel, Claas, Suárez-Sipmann, Fernando, Wisse, Jantine J., Becher, Tobias, and Jonkman, Annemijn H.

Published
2024
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5. Individualized positive end-expiratory pressure guided by end-expiratory lung volume in early acute respiratory distress syndrome: study protocol for the multicenter, randomized IPERPEEP trial

Author

Grieco, Domenico Luca, Maggiore, Salvatore Maurizio, Bellani, Giacomo, Spadaro, Savino, Spinelli, Elena, Tonetti, Tommaso, Menga, Luca S., Pozzi, Marco, Battaglini, Denise, Di Mussi, Rosa, Bruni, Andrea, De Gaetano, Andrea, Iovino, Carmine Giovanni, Brioni, Matteo, Mojoli, Francesco, Foti, Giuseppe, Volta, Carlo Aberto, Pelosi, Paolo, Navalesi, Paolo, Grasso, Salvatore, Ranieri, V. Marco, and Antonelli, Massimo

Published
2022
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20. Automated detection and quantification of reverse triggering effort under mechanical ventilation.

Author

Pham, Tài, Montanya, Jaume, Telias, Irene, Piraino, Thomas, Magrans, Rudys, Coudroy, Rémi, Damiani, L. Felipe, Mellado Artigas, Ricard, Madorno, Matías, Blanch, Lluis, Brochard, Laurent, the BEARDS study investigators, Mellado Artigas, Ricard, Santis, Cesar, Mauri, Tommaso, Spinelli, Elena, Grasselli, Giacomo, Spadaro, Savino, Volta, Carlo Alberto, and Mojoli, Francesco

Abstract

Background: Reverse triggering (RT) is a dyssynchrony defined by a respiratory muscle contraction following a passive mechanical insufflation. It is potentially harmful for the lung and the diaphragm, but its detection is challenging. Magnitude of effort generated by RT is currently unknown. Our objective was to validate supervised methods for automatic detection of RT using only airway pressure (Paw) and flow. A secondary objective was to describe the magnitude of the efforts generated during RT.Methods: We developed algorithms for detection of RT using Paw and flow waveforms. Experts having Paw, flow and esophageal pressure (Pes) assessed automatic detection accuracy by comparison against visual assessment. Muscular pressure (Pmus) was measured from Pes during RT, triggered breaths and ineffective efforts.Results: Tracings from 20 hypoxemic patients were used (mean age 65 ± 12 years, 65% male, ICU survival 75%). RT was present in 24% of the breaths ranging from 0 (patients paralyzed or in pressure support ventilation) to 93.3%. Automatic detection accuracy was 95.5%: sensitivity 83.1%, specificity 99.4%, positive predictive value 97.6%, negative predictive value 95.0% and kappa index of 0.87. Pmus of RT ranged from 1.3 to 36.8 cmH20, with a median of 8.7 cmH20. RT with breath stacking had the highest levels of Pmus, and RTs with no breath stacking were of similar magnitude than pressure support breaths.Conclusion: An automated detection tool using airway pressure and flow can diagnose reverse triggering with excellent accuracy. RT generates a median Pmus of 9 cmH2O with important variability between and within patients.Trial Registration: BEARDS, NCT03447288. [ABSTRACT FROM AUTHOR]

Published
2021
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21. Type I interferon-dependent gene MxA in perinatal HIV-infected patients under antiretroviral therapy as marker for therapy failure and blood plasmacytoid dendritic cells depletion.

Author

Badolato, Raffaele, Ghidini, Claudia, Facchetti, Fabio, Serana, Federico, Sottini, Alessandra, Chiarini, Marco, Spinelli, Elena, Lonardi, Silvia, Plebani, Alessandro, Caimi, Luigi, and Imberti, Luisa

Subjects
INTERFERONS, HIV-positive persons, HIGHLY active antiretroviral therapy, ANTIRETROVIRAL agents, DENDRITIC cells
Abstract

Background: To determine the role of interferon-alpha in controlling HIV infection we phenotypically and functionally analyzed circulating plasmacytoid dendritic cells (pDC), which are known to be the highest interferon-alpha producing cells, in 33 perinatally infected HIV+ patients undergoing standard antiretroviral therapy. Methods: Circulating pDC were identified by flow cytometry using anti-BDCA-2 monoclonal antibody and by measuring BDCA-2 mRNA by real-time PCR, while tissue-resident pDC were identified by immunohistochemistry. mRNA for interferon-alpha and MxA, a gene that is specifically induced by interferon-alpha, was quantified in peripheral blood cells by real-time PCR, while serum interferon-alpha protein was measured by ELISA. Results: While median values of pDC, both in terms of percentage and absolute number, were not statistically different from age-matched controls, interferon-alpha mRNA was increased in HIVinfected patients. However, in a group of patients with long disease duration, having a low number of both pDC and CD4+ lymphocytes and a significant increase of serum interferon-alpha, MxA mRNA was produced at high level and its expression directly correlated with HIV RNA copy numbers. Furthermore in patients displaying a low CD4+ blood cell count, a severe depletion of pDC in the tonsils could be documented. Conclusion: HIV replication unresponsive to antiretroviral treatment in perinatal-infected patients with advanced disease and pDC depletion may lead to interferon-alpha expression and subsequent induction of MxA mRNA. Thus, the latter measurement may represent a valuable marker to monitor the clinical response to therapy in HIV patients. [ABSTRACT FROM AUTHOR]

Published
2008
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