158 results on '"Severi, Gianluca"'
Search Results
2. Trajectories of long-term exposure to PCB153 and Benzo[a]pyrene (BaP) air pollution and risk of breast cancer
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Desnavailles, Pauline, Praud, Delphine, Le Provost, Blandine, Kobayashi, Hidetaka, Deygas, Floriane, Amadou, Amina, Coudon, Thomas, Grassot, Lény, Faure, Elodie, Couvidat, Florian, Severi, Gianluca, Mancini, Francesca Romana, Fervers, Béatrice, Proust-Lima, Cécile, and Leffondré, Karen
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- 2024
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3. Correction: Antibody response, associated symptoms and profile of patients presumably infected by SARS-CoV-2 with taste or smell disorders in the SAPRIS multicohort study
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Ramillon, Julien, de Lamballerie, Xavier, Robineau, Olivier, Blanché, Hélène, Severi, Gianluca, Touvier, Mathilde, Zins, Marie, Carrat, Fabrice, and Lapidus, Nathanaël
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- 2023
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4. Antibody response, associated symptoms and profile of patients presumably infected by SARS-CoV-2 with taste or smell disorders in the SAPRIS multicohort study
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Ramillon, Julien, de Lamballerie, Xavier, Robineau, Olivier, Blanché, Hélène, Severi, Gianluca, Touvier, Mathilde, Zins, Marie, Carrat, Fabrice, and Lapidus, Nathanaël
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- 2023
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5. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts
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Rothwell, Joseph A., Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K., Eichelmann, Fabian, Schulze, Matthias B., van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W. G., Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, and Gunter, Marc J.
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- 2023
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6. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition
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Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., and Viallon, Vivian
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- 2022
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7. Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
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Cairat, Manon, Rinaldi, Sabina, Navionis, Anne-Sophie, Romieu, Isabelle, Biessy, Carine, Viallon, Vivian, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Severi, Gianluca, Kvaskoff, Marina, Fortner, Renée T., Kaaks, Rudolf, Aleksandrova, Krasimira, Schulze, Matthias B., Masala, Giovanna, Tumino, Rosario, Sieri, Sabina, Grasso, Chiara, Mattiello, Amalia, Gram, Inger T., Olsen, Karina Standahl, Agudo, Antonio, Etxezarreta, Pilar Amiano, Sánchez, Maria-Jose, Santiuste, Carmen, Barricarte, Aurelio, Monninkhof, Evelyn, Hiensch, Anouk E., Muller, David, Merritt, Melissa A., Travis, Ruth C., Weiderpass, Elisabete, Gunter, Marc J., and Dossus, Laure
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- 2022
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8. Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies
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Dugué, Pierre-Antoine, Bodelon, Clara, Chung, Felicia F., Brewer, Hannah R., Ambatipudi, Srikant, Sampson, Joshua N., Cuenin, Cyrille, Chajès, Veronique, Romieu, Isabelle, Fiorito, Giovanni, Sacerdote, Carlotta, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Polidoro, Silvia, Baglietto, Laura, English, Dallas, Severi, Gianluca, Giles, Graham G., Milne, Roger L., Herceg, Zdenko, Garcia-Closas, Montserrat, Flanagan, James M., and Southey, Melissa C.
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- 2022
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9. Application of two statistical approaches (Bayesian Kernel Machine Regression and Principal Component Regression) to assess breast cancer risk in association to exposure to mixtures of brominated flame retardants and per- and polyfluorinated alkylated substances in the E3N cohort
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Frenoy, Pauline, Perduca, Vittorio, Cano-Sancho, German, Antignac, Jean-Philippe, Severi, Gianluca, and Mancini, Francesca Romana
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- 2022
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10. Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations
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Nimptsch, Katharina, Aleksandrova, Krasimira, Fedirko, Veronika, Jenab, Mazda, Gunter, Marc J., Siersema, Peter D., Wu, Kana, Katzke, Verena, Kaaks, Rudolf, Panico, Salvatore, Palli, Domenico, May, Anne M, Sieri, Sabina, Bueno-de-Mesquita, Bas, Standahl, Karina, Sánchez, Maria-Jose, Perez-Cornago, Aurora, Olsen, Anja, Tjønneland, Anne, Bonet, Catalina Bonet, Dahm, Christina C., Chirlaque, María-Dolores, Fiano, Valentina, Tumino, Rosario, Gurrea, Aurelio Barricarte, Boutron-Ruault, Marie-Christine, Menegaux, Florence, Severi, Gianluca, van Guelpen, Bethany, Lee, Young-Ae, and Pischon, Tobias
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- 2022
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11. Changes in household use of disinfectant and cleaning products during the first lockdown period in France.
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Pacheco Da Silva, Emilie, Varraso, Raphaëlle, Orsi, Laurent, Wiernik, Emmanuel, Goldberg, Marcel, Paris, Christophe, Fezeu, Léopold K., Ribet, Céline, Nadif, Rachel, Carrat, Fabrice, Bajos, Nathalie, Ancel, Pierre-Yves, Charles, Marie-Aline, Jusot, Florence, Martin, Claude, Meyer, Laurence, Pailhé, Ariane, Severi, Gianluca, Spire, Alexis, and Deschasaux, Mélanie
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COVID-19 pandemic ,HOUSEHOLD employees ,CLEANING compounds ,STAY-at-home orders ,DISINFECTION & disinfectants - Abstract
Background: Few studies evaluated the use of Household Disinfectant and Cleaning Products (HDCPs) during the COVID-19 pandemic, but no population-based cohorts used longitudinal data. We studied changes in HDCPs during the first lockdown, based on longitudinal data from the French population-based NutriNet-Santé and CONSTANCES cohorts. Methods: Based on standardized questionnaires on household cleaning tasks in 2018–2019 and around the first lockdown in France (March17-May3 2020), we compared the duration of weekly use of HDCPs (< 1 day/week, < 10 min/week; 10-30 min/week; > 30 min/week) and the household cleaning help (yes/no) before and during the lockdown period by Bhapkar and McNemar's tests. Moreover, we assessed self-reported changes in the frequency of HDCPs during the lockdown from before (unchanged/increased). Results: Analyses were carried on 31,105 participants of NutriNet-Santé (48 years, 75% women, 81% ≥ high school diploma) and 49,491 of CONSTANCES (47 years, 51% women, 87% ≥ high school diploma). During the lockdown, compared with 2018–2019, duration of HDCPs use increased (> 30 min; NutriNet-Santé: 44% versus 18%; CONSTANCES: 63% versus 16%) and household help decreased (NutriNet-Santé: 5% versus 40%; CONSTANCES: 3% versus 56%). Regarding the frequency of HDCPs use, 55% of participants of NutriNet-Santé (57% women/49% men) and 83% of CONSTANCES (86% women/81% men) reported an increased use since the beginning of the lockdown, significantly higher among women (p < 0.0001). Conclusions: The frequency and duration of weekly use of HDCPs has significantly increased since the pandemic. As the use of HDCPs is associated with health issues, further studies are now needed to evaluate the potential health impacts of these changes. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Use of systemic glucocorticoids and risk of breast cancer in a prospective cohort of postmenopausal women
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Cairat, Manon, Al Rahmoun, Marie, Gunter, Marc J., Heudel, Pierre-Etienne, Severi, Gianluca, Dossus, Laure, and Fournier, Agnès
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- 2021
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13. Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort
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His, Mathilde, Viallon, Vivian, Dossus, Laure, Schmidt, Julie A., Travis, Ruth C., Gunter, Marc J., Overvad, Kim, Kyrø, Cecilie, Tjønneland, Anne, Lécuyer, Lucie, Rothwell, Joseph A., Severi, Gianluca, Johnson, Theron, Katzke, Verena, Schulze, Matthias B., Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Tumino, Rosario, Macciotta, Alessandra, Boer, Jolanda M. A., Monninkhof, Evelyn M., Olsen, Karina Standahl, Nøst, Therese H., Sandanger, Torkjel M., Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Ardanaz, Eva, Vidman, Linda, Winkvist, Anna, Heath, Alicia K., Weiderpass, Elisabete, Huybrechts, Inge, and Rinaldi, Sabina
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- 2021
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14. Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score
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Aleksandrova, Krasimira, Reichmann, Robin, Kaaks, Rudolf, Jenab, Mazda, Bueno-de-Mesquita, H. Bas, Dahm, Christina C., Eriksen, Anne Kirstine, Tjønneland, Anne, Artaud, Fanny, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Hüsing, Anika, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Panico, Salvatore, Masala, Giovanna, Grioni, Sara, Sacerdote, Carlotta, Tumino, Rosario, Elias, Sjoerd G., May, Anne M., Borch, Kristin B., Sandanger, Torkjel M., Skeie, Guri, Sánchez, Maria-Jose, Huerta, José María, Sala, Núria, Gurrea, Aurelio Barricarte, Quirós, José Ramón, Amiano, Pilar, Berntsson, Jonna, Drake, Isabel, van Guelpen, Bethany, Harlid, Sophia, Key, Tim, Weiderpass, Elisabete, Aglago, Elom K., Cross, Amanda J., Tsilidis, Konstantinos K., Riboli, Elio, and Gunter, Marc J.
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- 2021
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15. The impact of lifecourse socio-economic position and individual social mobility on breast cancer risk
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Berger, Eloïse, Maitre, Noële, Romana Mancini, Francesca, Baglietto, Laura, Perduca, Vittorio, Colineaux, Hélène, Sieri, Sabina, Panico, Salvatore, Sacerdote, Carlotta, Tumino, Rosario, Vineis, Paolo, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Castagné, Raphaële, and Delpierre, Cyrille
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- 2020
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16. Use of nonsteroidal anti-inflammatory drugs and breast cancer risk in a prospective cohort of postmenopausal women
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Cairat, Manon, Al Rahmoun, Marie, Gunter, Marc J., Severi, Gianluca, Dossus, Laure, and Fournier, Agnès
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- 2020
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17. Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses
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Seyed Khoei, Nazlisadat, Jenab, Mazda, Murphy, Neil, Banbury, Barbara L., Carreras-Torres, Robert, Viallon, Vivian, Kühn, Tilman, Bueno-de-Mesquita, Bas, Aleksandrova, Krasimira, Cross, Amanda J., Weiderpass, Elisabete, Stepien, Magdalena, Bulmer, Andrew, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Carbonnel, Franck, Katzke, Verena, Boeing, Heiner, Bergmann, Manuela M., Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Palli, Domenico, Tagliabue, Giovanna, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Skeie, Guri, Merino, Susana, Bonet, Catalina, Rodríguez-Barranco, Miguel, Gil, Leire, Chirlaque, Maria-Dolores, Ardanaz, Eva, Myte, Robin, Hultdin, Johan, Perez-Cornago, Aurora, Aune, Dagfinn, Tsilidis, Konstantinos K., Albanes, Demetrius, Baron, John A., Berndt, Sonja I., Bézieau, Stéphane, Brenner, Hermann, Campbell, Peter T., Casey, Graham, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Cotterchio, Michelle, Gallinger, Steven, Gruber, Stephen B., Haile, Robert W., Hampe, Jochen, Hoffmeister, Michael, Hopper, John L., Hsu, Li, Huyghe, Jeroen R., Jenkins, Mark A., Joshi, Amit D., Kampman, Ellen, Larsson, Susanna C., Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Lindor, Noralane M., Martín, Vicente, Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Parfrey, Patrick S., Pharoah, Paul D. P., Rennert, Gad, Sakoda, Lori C., Schafmayer, Clemens, Schmit, Stephanie L., Schoen, Robert E., Slattery, Martha L., Thibodeau, Stephen N., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., Weigl, Korbinian, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Zhang, Xuehong, Ferrari, Pietro, Anton, Gabriele, Peters, Annette, Peters, Ulrike, Gunter, Marc J., Wagner, Karl-Heinz, and Freisling, Heinz
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- 2020
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18. Plasma concentration of brominated flame retardants and postmenopausal breast cancer risk: a nested case-control study in the French E3N cohort
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Mancini, Francesca Romana, Cano-Sancho, German, Mohamed, Oceane, Cervenka, Iris, Omichessan, Hanane, Marchand, Philippe, Boutron-Ruault, Marie-Christine, Arveux, Patrick, Severi, Gianluca, Antignac, Jean-Philippe, and Kvaskoff, Marina
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- 2020
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19. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
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Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam S., Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kühn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C., Menéndez, Virginia, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio Barricarte, Tong, Tammy Y. N., Schmidt, Julie A., Tzoulaki, Ioanna, Tsilidis, Konstantinos K., Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Picavet, H. Susan J., Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Jenab, Mazda, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick J., Gunter, Marc J., and Ferrari, Pietro
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- 2020
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20. Development and performance evaluation of a GIS-based metric to assess exposure to airborne pollutant emissions from industrial sources
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Coudon, Thomas, Danjou, Aurélie Marcelle Nicole, Faure, Elodie, Praud, Delphine, Severi, Gianluca, Mancini, Francesca Romana, Salizzoni, Pietro, and Fervers, Béatrice
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- 2019
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21. Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts
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Epi Kanker Team B, Cancer, MS MDL 1, Rothwell, Joseph A, Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J, Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C, Nøst, Therese Haugdahl, Sandanger, Torkjel M, Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K, Eichelmann, Fabian, Schulze, Matthias B, van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W G, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, Gunter, Marc J, Epi Kanker Team B, Cancer, MS MDL 1, Rothwell, Joseph A, Bešević, Jelena, Dimou, Niki, Breeur, Marie, Murphy, Neil, Jenab, Mazda, Wedekind, Roland, Viallon, Vivian, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Scalbert, Augustin, Huybrechts, Inge, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J, Keun, Hector, Chadeau-Hyam, Marc, Boutron-Ruault, Marie-Christine, Overvad, Kim, Dahm, Christina C, Nøst, Therese Haugdahl, Sandanger, Torkjel M, Skeie, Guri, Zamora-Ros, Raul, Tsilidis, Kostas K, Eichelmann, Fabian, Schulze, Matthias B, van Guelpen, Bethany, Vidman, Linda, Sánchez, Maria-José, Amiano, Pilar, Ardanaz, Eva, Smith-Byrne, Karl, Travis, Ruth, Katzke, Verena, Kaaks, Rudolf, Derksen, Jeroen W G, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Palli, Domenico, Pasanisi, Fabrizio, Eriksen, Anne Kirstine, Tjønneland, Anne, Severi, Gianluca, and Gunter, Marc J
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- 2023
22. Prospective analysis of circulating metabolites and breast cancer in EPIC
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His, Mathilde, Viallon, Vivian, Dossus, Laure, Gicquiau, Audrey, Achaintre, David, Scalbert, Augustin, Ferrari, Pietro, Romieu, Isabelle, Onland-Moret, N. Charlotte, Weiderpass, Elisabete, Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Rothwell, Joseph A., Severi, Gianluca, Kühn, Tilman, Fortner, Renée T., Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, van Gils, Carla H., Nøst, Therese H., Sandanger, Torkjel M., Skeie, Guri, Quirós, J. Ramón, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Huerta, José María, Ardanaz, Eva, Schmidt, Julie A., Travis, Ruth C., Riboli, Elio, Tsilidis, Konstantinos K., Christakoudi, Sofia, Gunter, Marc J., and Rinaldi, Sabina
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- 2019
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23. Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies
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Bodelon, Clara, Ambatipudi, Srikant, Dugué, Pierre-Antoine, Johansson, Annelie, Sampson, Joshua N., Hicks, Belynda, Karlins, Eric, Hutchinson, Amy, Cuenin, Cyrille, Chajès, Veronique, Southey, Melissa C., Romieu, Isabelle, Giles, Graham G., English, Dallas, Polidoro, Silvia, Assumma, Manuela, Baglietto, Laura, Vineis, Paolo, Severi, Gianluca, Herceg, Zdenko, Flanagan, James M., Milne, Roger L., and Garcia-Closas, Montserrat
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- 2019
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24. Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk
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Johansson, Annelie, Palli, Domenico, Masala, Giovanna, Grioni, Sara, Agnoli, Claudia, Tumino, Rosario, Giurdanella, Maria Concetta, Fasanelli, Francesca, Sacerdote, Carlotta, Panico, Salvatore, Mattiello, Amalia, Polidoro, Silvia, Jones, Michael E., Schoemaker, Minouk J., Orr, Nick, Tomczyk, Katarzyna, Johnson, Nichola, Fletcher, Olivia, Perduca, Vittorio, Baglietto, Laura, Dugué, Pierre-Antoine, Southey, Melissa C., Giles, Graham G., English, Dallas R., Milne, Roger L., Severi, Gianluca, Ambatipudi, Srikant, Cuenin, Cyrille, Chajès, Veronique, Romieu, Isabelle, Herceg, Zdenko, Swerdlow, Anthony J., Vineis, Paolo, and Flanagan, James M.
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- 2019
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25. Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
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Campa, Daniele, Barrdahl, Myrto, Santoro, Aurelia, Severi, Gianluca, Baglietto, Laura, Omichessan, Hanane, Tumino, Rosario, Bueno-de-Mesquita, H. B(as)., Peeters, Petra H., Weiderpass, Elisabete, Chirlaque, Maria-Dolores, Rodríguez-Barranco, Miguel, Agudo, Antonio, Gunter, Marc, Dossus, Laure, Krogh, Vittorio, Matullo, Giuseppe, Trichopoulou, Antonia, Travis, Ruth C., Canzian, Federico, and Kaaks, Rudolf
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- 2018
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26. Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations
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MS MDL 1, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Nimptsch, Katharina, Aleksandrova, Krasimira, Fedirko, Veronika, Jenab, Mazda, Gunter, Marc J, Siersema, Peter D, Wu, Kana, Katzke, Verena, Kaaks, Rudolf, Panico, Salvatore, Palli, Domenico, May, Anne M, Sieri, Sabina, Bueno-de-Mesquita, Bas, Standahl, Karina, Sánchez, Maria-Jose, Perez-Cornago, Aurora, Olsen, Anja, Tjønneland, Anne, Bonet, Catalina Bonet, Dahm, Christina C, Chirlaque, María-Dolores, Fiano, Valentina, Tumino, Rosario, Gurrea, Aurelio Barricarte, Boutron-Ruault, Marie-Christine, Menegaux, Florence, Severi, Gianluca, van Guelpen, Bethany, Lee, Young-Ae, Pischon, Tobias, MS MDL 1, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Nimptsch, Katharina, Aleksandrova, Krasimira, Fedirko, Veronika, Jenab, Mazda, Gunter, Marc J, Siersema, Peter D, Wu, Kana, Katzke, Verena, Kaaks, Rudolf, Panico, Salvatore, Palli, Domenico, May, Anne M, Sieri, Sabina, Bueno-de-Mesquita, Bas, Standahl, Karina, Sánchez, Maria-Jose, Perez-Cornago, Aurora, Olsen, Anja, Tjønneland, Anne, Bonet, Catalina Bonet, Dahm, Christina C, Chirlaque, María-Dolores, Fiano, Valentina, Tumino, Rosario, Gurrea, Aurelio Barricarte, Boutron-Ruault, Marie-Christine, Menegaux, Florence, Severi, Gianluca, van Guelpen, Bethany, Lee, Young-Ae, and Pischon, Tobias
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- 2022
27. Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score
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Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Aleksandrova, Krasimira, Reichmann, Robin, Kaaks, Rudolf, Jenab, Mazda, Bueno-de-Mesquita, H Bas, Dahm, Christina C, Eriksen, Anne Kirstine, Tjønneland, Anne, Artaud, Fanny, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Hüsing, Anika, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Panico, Salvatore, Masala, Giovanna, Grioni, Sara, Sacerdote, Carlotta, Tumino, Rosario, Elias, Sjoerd G, May, Anne M, Borch, Kristin B, Sandanger, Torkjel M, Skeie, Guri, Sánchez, Maria-Jose, Huerta, José María, Sala, Núria, Gurrea, Aurelio Barricarte, Quirós, José Ramón, Amiano, Pilar, Berntsson, Jonna, Drake, Isabel, van Guelpen, Bethany, Harlid, Sophia, Key, Tim, Weiderpass, Elisabete, Aglago, Elom K, Cross, Amanda J, Tsilidis, Konstantinos K, Riboli, Elio, Gunter, Marc J, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Aleksandrova, Krasimira, Reichmann, Robin, Kaaks, Rudolf, Jenab, Mazda, Bueno-de-Mesquita, H Bas, Dahm, Christina C, Eriksen, Anne Kirstine, Tjønneland, Anne, Artaud, Fanny, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Hüsing, Anika, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Panico, Salvatore, Masala, Giovanna, Grioni, Sara, Sacerdote, Carlotta, Tumino, Rosario, Elias, Sjoerd G, May, Anne M, Borch, Kristin B, Sandanger, Torkjel M, Skeie, Guri, Sánchez, Maria-Jose, Huerta, José María, Sala, Núria, Gurrea, Aurelio Barricarte, Quirós, José Ramón, Amiano, Pilar, Berntsson, Jonna, Drake, Isabel, van Guelpen, Bethany, Harlid, Sophia, Key, Tim, Weiderpass, Elisabete, Aglago, Elom K, Cross, Amanda J, Tsilidis, Konstantinos K, Riboli, Elio, and Gunter, Marc J
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- 2021
28. Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses
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Khoei, Nazlisadat Seyed, Jenab, Mazda, Murphy, Neil, Banbury, Barbara L., Carreras Torres, Robert, Viallon, Vivian, Kühn, Tilman, Bueno de Mesquita, H. Bas, Aleksandrova, Krasimira, Cross, Amanda J., Weiderpass, Elisabete, Stepien, Magdalena, Bulmer, Andrew, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Carbonnel, Franck, Katzke, Verena, Boeing, Heiner, Bergmann, Manuela M., Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Palli, Domenico, Tagliabue, Giovanna, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Skeie, Guri, Merino, Susana, Bonet Bonet, Catalina, Rodríguez Barranco, Miguel, Gil, Leire, Chirlaque, María Dolores, Ardanaz, Eva, Myte, Robin, Hultdin, Johan, Pérez Cornago, Aurora, Aune, Dagfinn, Tsilidis, Konstantinos K., Albanes, Demetrius, Baron, John A., Berndt, Sonja I., Bézieau, Stéphane, Brenner, Hermann, Campbell, Peter T., Casey, Graham, Chan, Andrew T., Chang Claude, Jenny, Chanock, Stephen J., Cotterchio, Michelle, Gallinger, Steven, Gruber, Stephen B., Haile, Robert W., Hampe, Jochen, Hoffmeister, Michael, Hopper, John L., Hsu, Li, Huyghe, Jeroen R., Jenkins, Mark A., Joshi, Amit D., Kampman, Ellen, Larsson, Susanna C., Marchand, Loïc Le, Li, Christopher I., Li, Li, Lindblom, Annika, Lindor, Noralane M., Martín Sánchez, Vicente, Moreno Aguado, Víctor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Parfrey, Patrick S., Pharoah, Paul D. P., Rennert, Gad, Sakoda, Lori C., Schafmayer, Clemens, Schmit, Stephanie L., Schoen, Robert E., Slattery, Martha L., Thibodeau, Stephen N., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., Weigl, Korbinian, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Zhang, Xuehong, Ferrari, Pietro, Anton, Gabriele, Peters, Annette, Peters, Ulrike, Gunter, Marc J., Wagner, Karl-Heinz, Freisling, Heinz, Apollo - University of Cambridge Repository, and Pharoah, Paul [0000-0001-8494-732X]
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Adult ,Male ,Nutrition and Disease ,Mendelian randomization analysis ,lcsh:Medicine ,Polymorphism, Single Nucleotide ,Antioxidants ,Càncer colorectal ,Risk Factors ,Voeding en Ziekte ,Humans ,Prospective Studies ,VLAG ,Cancer ,Aged ,lcsh:R ,Bilirubin ,Middle Aged ,Colorectal cancer ,Europe ,Case-Control Studies ,Anti-oxidants ,Female ,Colorectal Neoplasms ,Research Article - Abstract
Background: Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate whether alterations in circulating levels of bilirubin are associated with risk of colorectal cancer (CRC). We decided a priori to perform analyses separately in men and women based on suggestive evidence that associations may differ by sex. Methods: In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC), pre-diagnostic unconjugated bilirubin (UCB, the main component of total bilirubin) concentrations were measured by high-performance liquid chromatography in plasma samples of 1386 CRC cases and their individually matched controls. Additionally, 115 single-nucleotide polymorphisms (SNPs) robustly associated (P < 5 × 10−8) with circulating total bilirubin were instrumented in a 2-sample MR to test for a potential causal effect of bilirubin on CRC risk in 52,775 CRC cases and 45,940 matched controls in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colon Cancer Family Registry (CCFR), and the Colorectal Transdisciplinary (CORECT) study. Results: The associations between circulating UCB levels and CRC risk differed by sex (Pheterogeneity = 0.008). Among men, higher levels of UCB were positively associated with CRC risk (odds ratio [OR] = 1.19, 95% confidence interval [CI] = 1.04–1.36; per 1-SD increment of log-UCB). In women, an inverse association was observed (OR = 0.86 (0.76–0.97)). In the MR analysis of the main UGT1A1 SNP (rs6431625), genetically predicted higher levels of total bilirubin were associated with a 7% increase in CRC risk in men (OR = 1.07 (1.02–1.12); P = 0.006; per 1-SD increment of total bilirubin), while there was no association in women (OR = 1.01 (0.96–1.06); P = 0.73). Raised bilirubin levels, predicted by instrumental variables excluding rs6431625, were suggestive of an inverse association with CRC in men, but not in women. These differences by sex did not reach formal statistical significance (Pheterogeneity ≥ 0.2). Conclusions: Additional insight into the relationship between circulating bilirubin and CRC is needed in order to conclude on a potential causal role of bilirubin in CRC development.
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- 2020
29. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
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Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam S, Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kühn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C, Menéndez, Virginia, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio Barricarte, Tong, Tammy Y N, Schmidt, Julie A, Tzoulaki, Ioanna, Tsilidis, Konstantinos K, Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Picavet, H Susan J, Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Jenab, Mazda, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick J, Gunter, Marc J, Ferrari, Pietro, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam S, Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kühn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C, Menéndez, Virginia, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio Barricarte, Tong, Tammy Y N, Schmidt, Julie A, Tzoulaki, Ioanna, Tsilidis, Konstantinos K, Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Picavet, H Susan J, Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Jenab, Mazda, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick J, Gunter, Marc J, and Ferrari, Pietro
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- 2020
30. Nutritional risk factors for SARS-CoV-2 infection: a prospective study within the NutriNet-Santé cohort.
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Deschasaux-Tanguy, Mélanie, Srour, Bernard, Bourhis, Laurent, Arnault, Nathalie, Druesne-Pecollo, Nathalie, Esseddik, Younes, de Edelenyi, Fabien Szabo, Allègre, Julien, Allès, Benjamin, Andreeva, Valentina A., Baudry, Julia, Fezeu, Leopold K., Galan, Pilar, Julia, Chantal, Kesse-Guyot, Emmanuelle, Péneau, Sandrine, Hercberg, Serge, Bajos, Nathalie, Severi, Gianluca, and Zins, Marie
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SARS-CoV-2 ,DIETARY calcium ,FOOD consumption ,FOOD diaries ,COVID-19 ,NON-communicable diseases - Abstract
Background: Nutritional factors are essential for the functioning of the immune system and could therefore play a role in COVID-19 but evidence is needed. Our objective was to study the associations between diet and the risk of SARS-CoV-2 infection in a large population-based sample. Methods: Our analyses were conducted in the French prospective NutriNet-Santé cohort study (2009--2020). Seroprevalence of anti-SARS-CoV-2 antibodies was assessed by ELISA on dried blood spots. Dietary intakes were derived from repeated 24 h dietary records (at least 6) in the two years preceding the start of the COVID-19 pandemic in France (February 2020). Multi-adjusted logistic regression models were computed. Results: A total of 7766 adults (70.3% women, mean age: 60.3 years) were included, among which 311 were positive for anti-SARS-CoV-2 antibodies. Dietary intakes of vitamin C (OR for 1 SD=0.86 (0.75--0.98), P=0.02), vitamin B9 (OR=0.84 (0.72--0.98), P=0.02), vitamin K (OR=0.86 (0.74--0.99), P=0.04), fibers (OR=0.84 (0.72--0.98), P=0.02), and fruit and vegetables (OR=0.85 (0.74--0.97), P=0.02) were associated to a decreased probability of SARS-CoV-2 infection while dietary intakes of calcium (OR=1.16 (1.01--1.35), P=0.04) and dairy products (OR=1.19 (1.06--1.33), P=0.002) associated to increased odds. No association was detected with other food groups or nutrients or with the overall diet quality. Conclusions: Higher dietary intakes of fruit and vegetables and, consistently, of vitamin C, folate, vitamin K and fibers were associated with a lower susceptibility to SARS-CoV-2 infection. Beyond its established role in the prevention of non-communicable diseases, diet could therefore also contribute to prevent some infectious diseases such as COVID-19. [ABSTRACT FROM AUTHOR]
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- 2021
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31. When lockdown policies amplify social inequalities in COVID-19 infections: evidence from a cross-sectional population-based survey in France.
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Bajos, Nathalie, Jusot, Florence, Pailhé, Ariane, Spire, Alexis, Martin, Claude, Meyer, Laurence, Lydié, Nathalie, Franck, Jeanna-Eve, Zins, Marie, Carrat, Fabrice, for the SAPRIS study group, Ancel, Pierre-Yves, Charles, Marie-Aline, Rouquette, Alexandra, Severi, Gianluca, Touvier, Mathilde, and SAPRIS study group
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COVID-19 ,STAY-at-home orders ,COMMUNICABLE disease control ,EQUALITY ,HEALTH equity ,SOCIAL classes - Abstract
Background: Significant differences in COVID-19 incidence by gender, class and race/ethnicity are recorded in many countries in the world. Lockdown measures, shown to be effective in reducing the number of new cases, may not have been effective in the same way for all, failing to protect the most vulnerable populations. This survey aims to assess social inequalities in the trends in COVID-19 infections following lockdown.Methods: A cross-sectional survey conducted among the general population in France in April 2020, during COVID-19 lockdown. Ten thousand one hundred one participants aged 18-64, from a national cohort who lived in the three metropolitan French regions most affected by the first wave of COVID-19. The main outcome was occurrence of possible COVID-19 symptoms, defined as the occurrence of sudden onset of cough, fever, dyspnea, ageusia and/or anosmia, that lasted more than 3 days in the 15 days before the survey. We used multinomial regression models to identify social and health factors related to possible COVID-19 before and during the lockdown.Results: In all, 1304 (13.0%; 95% CI: 12.0-14.0%) reported cases of possible COVID-19. The effect of lockdown on the occurrence of possible COVID-19 was different across social hierarchies. The most privileged class individuals saw a significant decline in possible COVID-19 infections between the period prior to lockdown and during the lockdown (from 8.8 to 4.3%, P = 0.0001) while the decline was less pronounced among working class individuals (6.9% before lockdown and 5.5% during lockdown, P = 0.03). This differential effect of lockdown remained significant after adjusting for other factors including history of chronic disease. The odds of being infected during lockdown as opposed to the prior period increased by 57% among working class individuals (OR = 1.57; 95% CI: 1.00-2.48). The same was true for those engaged in in-person professional activities during lockdown (OR = 1.53; 95% CI: 1.03-2.29).Conclusions: Lockdown was associated with social inequalities in the decline in COVID-19 infections, calling for the adoption of preventive policies to account for living and working conditions. Such adoptions are critical to reduce social inequalities related to COVID-19, as working-class individuals also have the highest COVID-19 related mortality, due to higher prevalence of comorbidities. [ABSTRACT FROM AUTHOR]- Published
- 2021
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32. Incidence and risk factors of COVID-19-like symptoms in the French general population during the lockdown period: a multi-cohort study.
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Carrat, Fabrice, Touvier, Mathilde, Severi, Gianluca, Meyer, Laurence, Jusot, Florence, Lapidus, Nathanael, Rahib, Delphine, Lydié, Nathalie, Charles, Marie-Aline, Ancel, Pierre-Yves, Rouquette, Alexandra, de Lamballerie, Xavier, Zins, Marie, Bajos, Nathalie, for the SAPRIS study group, Martin, Claude, Pailhé, Ariane, Spire, Alexis, and SAPRIS study group
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NON-communicable diseases ,SYMPTOMS ,STAY-at-home orders ,RESPIRATORY diseases ,COVID-19 ,AGE groups - Abstract
Background: Our main objectives were to estimate the incidence of illnesses presumably caused by SARS-CoV-2 infection during the lockdown period and to identify the associated risk factors.Methods: Participants from 3 adult cohorts in the general population in France were invited to participate in a survey on COVID-19. The main outcome was COVID-19-Like Symptoms (CLS), defined as a sudden onset of cough, fever, dyspnea, ageusia and/or anosmia, that lasted more than 3 days and occurred during the 17 days before the survey. We used delayed-entry Cox models to identify associated factors.Results: Between April 2, 2020 and May 12, 2020, 279,478 participants were invited, 116,903 validated the questionnaire and 106,848 were included in the analysis. Three thousand thirty-five cases of CLS were reported during 62,099 person-months of follow-up. The cumulative incidences of CLS were 6.2% (95% Confidence Interval (95%CI): 5.7%; 6.6%) on day 15 and 8.8% (95%CI 8.3%; 9.2%) on day 45 of lockdown. The risk of CLS was lower in older age groups and higher in French regions with a high prevalence of SARS-CoV-2 infection, in participants living in cities > 100,000 inhabitants (vs rural areas), when at least one child or adolescent was living in the same household, in overweight or obese people, and in people with chronic respiratory diseases, anxiety or depression or chronic diseases other than diabetes, cancer, hypertension or cardiovascular diseases.Conclusion: The incidence of CLS in the general population remained high during the first 2 weeks of lockdown, and decreased significantly thereafter. Modifiable and non-modifiable risk factors were identified. [ABSTRACT FROM AUTHOR]- Published
- 2021
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33. Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
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Epi Methoden Team 2, Cancer, JC onderzoeksprogramma Kanker, Campa, Daniele, Barrdahl, Myrto, Santoro, Aurelia, Severi, Gianluca, Baglietto, Laura, Omichessan, Hanane, Tumino, Rosario, Bueno-de-Mesquita, H. B(as), Peeters, Petra H., Weiderpass, Elisabete, Chirlaque, Maria Dolores, Rodríguez-Barranco, Miguel, Agudo, Antonio, Gunter, Marc, Dossus, Laure, Krogh, Vittorio, Matullo, Giuseppe, Trichopoulou, Antonia, Travis, Ruth C., Canzian, Federico, Kaaks, Rudolf, Epi Methoden Team 2, Cancer, JC onderzoeksprogramma Kanker, Campa, Daniele, Barrdahl, Myrto, Santoro, Aurelia, Severi, Gianluca, Baglietto, Laura, Omichessan, Hanane, Tumino, Rosario, Bueno-de-Mesquita, H. B(as), Peeters, Petra H., Weiderpass, Elisabete, Chirlaque, Maria Dolores, Rodríguez-Barranco, Miguel, Agudo, Antonio, Gunter, Marc, Dossus, Laure, Krogh, Vittorio, Matullo, Giuseppe, Trichopoulou, Antonia, Travis, Ruth C., Canzian, Federico, and Kaaks, Rudolf
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- 2018
34. Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma : A nested case-control study
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Fedirko, Veronika, Tran, Hao Quang, Gewirtz, Andrew T., Stepien, Magdalena, Trichopoulou, Antonia, Aleksandrova, Krasimira, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Carbonnel, Franck, Boutron-Ruault, Marie Christine, Severi, Gianluca, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Bamia, Christina, Lagiou, Pagona, Grioni, Sara, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Naccarati, Alessio, Peeters, Petra H., Bueno-de-Mesquita, H. B., Weiderpass, Elisabete, Castaño, José María Huerta, Barricarte, Aurelio, Sánchez, María José, Dorronsoro, Miren, Quirós, J. Ramón, Agudo, Antonio, Sjöberg, Klas, Ohlsson, Bodil, Hemmingsson, Oskar, Werner, Mårten, Bradbury, Kathryn E., Khaw, Kay Tee, Wareham, Nick, Tsilidis, Konstantinos K., Aune, Dagfinn, Scalbert, Augustin, Romieu, Isabelle, Riboli, Elio, Jenab, Mazda, Fedirko, Veronika, Tran, Hao Quang, Gewirtz, Andrew T., Stepien, Magdalena, Trichopoulou, Antonia, Aleksandrova, Krasimira, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Carbonnel, Franck, Boutron-Ruault, Marie Christine, Severi, Gianluca, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Bamia, Christina, Lagiou, Pagona, Grioni, Sara, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Naccarati, Alessio, Peeters, Petra H., Bueno-de-Mesquita, H. B., Weiderpass, Elisabete, Castaño, José María Huerta, Barricarte, Aurelio, Sánchez, María José, Dorronsoro, Miren, Quirós, J. Ramón, Agudo, Antonio, Sjöberg, Klas, Ohlsson, Bodil, Hemmingsson, Oskar, Werner, Mårten, Bradbury, Kathryn E., Khaw, Kay Tee, Wareham, Nick, Tsilidis, Konstantinos K., Aune, Dagfinn, Scalbert, Augustin, Romieu, Isabelle, Riboli, Elio, and Jenab, Mazda
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- 2017
35. Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models : results from the EPIC cohort
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Fortner, Renée T., Vitonis, Allison F., Schock, Helena, Hüsing, Anika, Johnson, Theron, Fichorova, Raina N., Fashemi, Titilayo, Yamamoto, Hidemi S., Tjønneland, Anne, Hansen, Louise, Overvad, Kim, Boutron-Ruault, Marie Christine, Kvaskoff, Marina, Severi, Gianluca, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vassiliki, La Vecchia, Carlo, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Matullo, Giuseppe, Mattiello, Amalia, Onland-Moret, N. Charlotte, Peeters, Petra H., Weiderpass, Elisabete, Gram, Inger Torhild, Jareid, Mie, Quirós, J. Ramón, Duell, Eric J., Sánchez, Maria Jose, Chirlaque, María Dolores, Ardanaz, Eva, Larrañaga, Nerea, Nodin, Björn, Brändstedt, Jenny, Idahl, Annika, Khaw, Kay Tee, Allen, Naomi, Gunter, Marc, Johansson, Mattias, Dossus, Laure, Merritt, Melissa A., Riboli, Elio, Cramer, Daniel W., Kaaks, Rudolf, Terry, Kathryn L., Fortner, Renée T., Vitonis, Allison F., Schock, Helena, Hüsing, Anika, Johnson, Theron, Fichorova, Raina N., Fashemi, Titilayo, Yamamoto, Hidemi S., Tjønneland, Anne, Hansen, Louise, Overvad, Kim, Boutron-Ruault, Marie Christine, Kvaskoff, Marina, Severi, Gianluca, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vassiliki, La Vecchia, Carlo, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Matullo, Giuseppe, Mattiello, Amalia, Onland-Moret, N. Charlotte, Peeters, Petra H., Weiderpass, Elisabete, Gram, Inger Torhild, Jareid, Mie, Quirós, J. Ramón, Duell, Eric J., Sánchez, Maria Jose, Chirlaque, María Dolores, Ardanaz, Eva, Larrañaga, Nerea, Nodin, Björn, Brändstedt, Jenny, Idahl, Annika, Khaw, Kay Tee, Allen, Naomi, Gunter, Marc, Johansson, Mattias, Dossus, Laure, Merritt, Melissa A., Riboli, Elio, Cramer, Daniel W., Kaaks, Rudolf, and Terry, Kathryn L.
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- 2017
36. Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort
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Epidemiology & Health Economics, Cardiovasculaire Epi Team 3, Brain, Circulatory Health, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Epi Kanker Team 1, Fortner, Renée T., Vitonis, Allison F., Schock, Helena, Hüsing, Anika, Johnson, Theron, Fichorova, Raina N., Fashemi, Titilayo, Yamamoto, Hidemi S., Tjønneland, Anne, Hansen, Louise, Overvad, Kim, Boutron-Ruault, Marie Christine, Kvaskoff, Marina, Severi, Gianluca, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vassiliki, La Vecchia, Carlo, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Matullo, Giuseppe, Mattiello, Amalia, Onland-Moret, N. Charlotte, Peeters, Petra H., Weiderpass, Elisabete, Gram, Inger Torhild, Jareid, Mie, Quirós, J. Ramón, Duell, Eric J., Sánchez, Maria Jose, Chirlaque, María Dolores, Ardanaz, Eva, Larrañaga, Nerea, Nodin, Björn, Brändstedt, Jenny, Idahl, Annika, Khaw, Kay Tee, Allen, Naomi, Gunter, Marc, Johansson, Mattias, Dossus, Laure, Merritt, Melissa A., Riboli, Elio, Cramer, Daniel W., Kaaks, Rudolf, Terry, Kathryn L., Epidemiology & Health Economics, Cardiovasculaire Epi Team 3, Brain, Circulatory Health, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Epi Kanker Team 1, Fortner, Renée T., Vitonis, Allison F., Schock, Helena, Hüsing, Anika, Johnson, Theron, Fichorova, Raina N., Fashemi, Titilayo, Yamamoto, Hidemi S., Tjønneland, Anne, Hansen, Louise, Overvad, Kim, Boutron-Ruault, Marie Christine, Kvaskoff, Marina, Severi, Gianluca, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vassiliki, La Vecchia, Carlo, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Matullo, Giuseppe, Mattiello, Amalia, Onland-Moret, N. Charlotte, Peeters, Petra H., Weiderpass, Elisabete, Gram, Inger Torhild, Jareid, Mie, Quirós, J. Ramón, Duell, Eric J., Sánchez, Maria Jose, Chirlaque, María Dolores, Ardanaz, Eva, Larrañaga, Nerea, Nodin, Björn, Brändstedt, Jenny, Idahl, Annika, Khaw, Kay Tee, Allen, Naomi, Gunter, Marc, Johansson, Mattias, Dossus, Laure, Merritt, Melissa A., Riboli, Elio, Cramer, Daniel W., Kaaks, Rudolf, and Terry, Kathryn L.
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- 2017
37. Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: A nested case-control study
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Epidemiology & Health Economics, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Fedirko, Veronika, Tran, Hao Quang, Gewirtz, Andrew T., Stepien, Magdalena, Trichopoulou, Antonia, Aleksandrova, Krasimira, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Carbonnel, Franck, Boutron-Ruault, Marie Christine, Severi, Gianluca, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Bamia, Christina, Lagiou, Pagona, Grioni, Sara, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Naccarati, Alessio, Peeters, Petra H., Bueno-de-Mesquita, H. B., Weiderpass, Elisabete, Castaño, José María Huerta, Barricarte, Aurelio, Sánchez, María José, Dorronsoro, Miren, Quirós, J. Ramón, Agudo, Antonio, Sjöberg, Klas, Ohlsson, Bodil, Hemmingsson, Oskar, Werner, Mårten, Bradbury, Kathryn E., Khaw, Kay Tee, Wareham, Nick, Tsilidis, Konstantinos K., Aune, Dagfinn, Scalbert, Augustin, Romieu, Isabelle, Riboli, Elio, Jenab, Mazda, Epidemiology & Health Economics, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Fedirko, Veronika, Tran, Hao Quang, Gewirtz, Andrew T., Stepien, Magdalena, Trichopoulou, Antonia, Aleksandrova, Krasimira, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Carbonnel, Franck, Boutron-Ruault, Marie Christine, Severi, Gianluca, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Bamia, Christina, Lagiou, Pagona, Grioni, Sara, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Naccarati, Alessio, Peeters, Petra H., Bueno-de-Mesquita, H. B., Weiderpass, Elisabete, Castaño, José María Huerta, Barricarte, Aurelio, Sánchez, María José, Dorronsoro, Miren, Quirós, J. Ramón, Agudo, Antonio, Sjöberg, Klas, Ohlsson, Bodil, Hemmingsson, Oskar, Werner, Mårten, Bradbury, Kathryn E., Khaw, Kay Tee, Wareham, Nick, Tsilidis, Konstantinos K., Aune, Dagfinn, Scalbert, Augustin, Romieu, Isabelle, Riboli, Elio, and Jenab, Mazda
- Published
- 2017
38. Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort
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Fages, Anne, Duarte-Salles, Talita, Stepien, Magdalena, Ferrari, Pietro, Fedirko, Veronika, Pontoizeau, Clement, Trichopoulou, Antonia, Aleksandrova, Krasimira, Tjonneland, Anne, Olsen, Anja, Clavel-Chapelon, Franoise, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Kaaks, Rudolf, Kuhn, Tilman, Floegel, Anna, Boeing, Heiner, Lagiou, Pagona, Bamia, Christina, Trichopoulos, Dimitrios, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Weiderpass, Elisabete, Agudo, Antonio, Molina-Montes, Esther, Maria Huerta, Jose, Ardanaz, Eva, Dorronsoro, Miren, Sjoberg, Klas, Ohlsson, Bodil, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Schmidt, Julie A., Cross, Amanda, Gunter, Marc, Riboli, Elio, Scalbert, Augustin, Romieu, Isabelle, Elena-Herrmann, Benedicte, Jenab, Mazda, Fages, Anne, Duarte-Salles, Talita, Stepien, Magdalena, Ferrari, Pietro, Fedirko, Veronika, Pontoizeau, Clement, Trichopoulou, Antonia, Aleksandrova, Krasimira, Tjonneland, Anne, Olsen, Anja, Clavel-Chapelon, Franoise, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Kaaks, Rudolf, Kuhn, Tilman, Floegel, Anna, Boeing, Heiner, Lagiou, Pagona, Bamia, Christina, Trichopoulos, Dimitrios, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Weiderpass, Elisabete, Agudo, Antonio, Molina-Montes, Esther, Maria Huerta, Jose, Ardanaz, Eva, Dorronsoro, Miren, Sjoberg, Klas, Ohlsson, Bodil, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Schmidt, Julie A., Cross, Amanda, Gunter, Marc, Riboli, Elio, Scalbert, Augustin, Romieu, Isabelle, Elena-Herrmann, Benedicte, and Jenab, Mazda
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- 2015
39. Epigenetic supersimilarity of monozygotic twin pairs.
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Van Baak, Timothy E., Coarfa, Cristian, Dugué, Pierre-Antoine, Fiorito, Giovanni, Laritsky, Eleonora, Baker, Maria S., Kessler, Noah J., Dong, Jianrong, Duryea, Jack D., Silver, Matt J., Saffari, Ayden, Prentice, Andrew M., Moore, Sophie E., Ghantous, Akram, Routledge, Michael N., Gong, Yun Yun, Herceg, Zdenko, Vineis, Paolo, Severi, Gianluca, and Hopper, John L.
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- 2018
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40. Characterisation of microbial communities within aggressive prostate cancer tissues.
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Yow, Melissa A., Tabrizi, Sepehr N., Severi, Gianluca, Bolton, Damien M., Pedersen, John, Giles, Graham G., and Southey, Melissa C.
- Abstract
Background: An infectious aetiology for prostate cancer has been conjectured for decades but the evidence gained from questionnaire-based and sero-epidemiological studies is weak and inconsistent, and a causal association with any infectious agent is not established. We describe and evaluate the application of new technology to detect bacterial and viral agents in high-grade prostate cancer tissues. The potential of targeted 16S rRNA gene sequencing and total RNA sequencing was evaluated in terms of its utility to characterise microbial communities within high-grade prostate tumours. Methods: Two different Massively Parallel Sequencing (MPS) approaches were applied. First, to capture and enrich for possible bacterial species, targeted-MPS of the V2-V3 hypervariable regions of the 16S rRNA gene was performed on DNA extracted from 20 snap-frozen prostate tissue cores from ten "aggressive" prostate cancer cases. Second, total RNA extracted from the same prostate tissue samples was also sequenced to capture the sequence profile of both bacterial and viral transcripts present. Results: Overall, 16S rRNA sequencing identified Enterobacteriaceae species common to all samples and P. acnes in 95% of analyzed samples. Total RNA sequencing detected endogenous retroviruses providing proof of concept but there was no evidence of bacterial or viral transcripts suggesting active infection, although it does not rule out a previous 'hit and run' scenario. Conclusions: As these new investigative methods and protocols become more refined, MPS approaches may be found to have significant utility in identifying potential pathogens involved in disease aetiology. Further studies, specifically designed to detect associations between the disease phenotype and aetiological agents, are required. [ABSTRACT FROM AUTHOR]
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- 2017
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41. Tools for translational epigenetic studies involving formalin-fixed paraffin-embedded human tissue: applying the Infinium HumanMethyation450 Beadchip assay to large population-based studies.
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Ee Ming Wong, Joo, JiHoon E., McLean, Catriona A., Baglietto, Laura, English, Dallas R., Severi, Gianluca, Hopper, John L., Milne, Roger L., FitzGerald, Liesel M., Giles, Graham G., and Southey, Melissa C.
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EPIGENETICS ,TISSUE physiology ,METHYLATION ,IMMUNOASSAY ,IMMUNOENZYME technique - Abstract
Background: Large population-based translational epigenetic studies are emerging due to recent technological advances that have made molecular analyses possible. For example, the Infinium HumanMethylation450 Beadchip (HM450K) has enabled studies of genome-wide methylation on a scale not previously possible. However, application of the HM450K to DNA extracted from formalin-fixed paraffin-embedded (FFPE) tumour material has been more challenging than application to high quality DNA extracted from blood. To facilitate the application of this assay consistently across a large number of FFPE tumour-enriched DNA samples we have devised a modification to the HM450K protocol for FFPE that includes an additional quality control (QC) checkpoint. Results: QC checkpoint 3 was designed to assess the presence of DNA after bisulfite conversion and restoration, just prior to application of the HM450K assay. DNA was extracted from 474 archival FFPE breast tumour material. Five samples did not have a detectable amount of DNA with an additional 42 failing to progress past QC checkpoint 3. Genome-wide methylation was measured for the remaining 428 tumour-enriched DNA. Of these, only 4 samples failed our stringent HM450K data criteria thus representing a 99 % success rate. Using prior knowledge about methylation marks associated with breast cancer we further explored the quality of the data. Twenty probes in the BRCA1 promoter region showed increased methylation in triple-negative breast cancers compared to Luminal A, Luminal B and HER2-positive breast cancer subtypes. Validation of this observation in published data from The Cancer Genome Atlas (TCGA) Network (obtained from DNA extracted from fresh frozen tumour samples) confirms the quality of the data obtained from the improved protocol. Conclusions: The modified protocol is suitable for the analysis of FFPE tumour-enriched DNA and can be systematically applied to hundreds of samples. This protocol will have utility in population-based translational epigenetic studies and is applicable to a wide variety of translated studies interested in analysis of methylation and its role in the predisposition to disease and disease progression. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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42. Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis.
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van Veldhoven, Karin, Polidoro, Silvia, Baglietto, Laura, Severi, Gianluca, Sacerdote, Carlotta, Panico, Salvatore, Mattiello, Amalia, Palli, Domenico, Masala, Giovanna, Krogh, Vittorio, Agnoli, Claudia, Tumino, Rosario, Frasca, Graziella, Flower, Kirsty, Curry, Ed, Orr, Nicholas, Tomczyk, Katarzyna, Jones, Michael E., Ashworth, Alan, and Swerdlow, Anthony
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- 2015
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43. Detection of infectious organisms in archival prostate cancer tissues.
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Yow, Melissa A., Tabrizi, Sepehr N., Severi, Gianluca, Bolton, Damien M., Pedersen, John, Longano, Anthony, Garland, Suzanne M., Southey, Melissa C., and Giles, Graham G.
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DIAGNOSIS ,PROSTATE cancer ,EPIDEMIOLOGY ,DNA analysis ,HISTOPATHOLOGY ,SEXUALLY transmitted diseases - Abstract
Background: Seroepidemiological studies have reported associations between exposure to sexually transmitted organisms and prostate cancer risk. This study sought DNA evidence of candidate organisms in archival prostate cancer tissues with the aim of assessing if a subset of these cancers show any association with common genital infections. Methods: 221 archival paraffin-embedded tissue blocks representing 128 histopathologically confirmed prostate cancers comprising 52 "aggressive" (Gleason score ≥ 7) and 76 "non-aggressive" (Gleason score ≤ 6) TURP or radical prostatectomy specimens were examined, as well as unaffected adjacent tissue when available. Representative tissue sections were subjected to DNA extraction, quality tested and screened by PCR for HSV-1, HSV-2, XMRV, BKV, HPV, Chlamydia trachomatis, Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma genitalium, and Trichomonas vaginalis. Results: 195 of 221 DNA samples representing 49 "aggressive" and 66 "non-aggressive" prostate cancer cases were suitable for analysis after DNA quality assessment. Overall, 12.2% (6/49) aggressive and 7.6% (5/66) non-aggressive cases were positive for any of the candidate organisms. Mycoplasma genitalium DNA was detected in 4/66 non-aggressive, 5/49 aggressive cancers and in one cancer-unaffected adjacent tissue block of an aggressive case. Ureaplasma urealyticum DNA was detected in 0/66 non-aggressive and 1/49 aggressive cancers and HSV DNA in 1/66 non-aggressive and 0/49 aggressive cancers. This study did not detect BKV, XMRV, T. vaginalis, U. parvum, C. trachomatis or HPV DNA. Conclusions: The low prevalence of detectable microbial DNA makes it unlikely that persistent infection by the selected candidate microorganisms contribute to prostate cancer risk, regardless of tumour phenotype. [ABSTRACT FROM AUTHOR]
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- 2014
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44. The use of DNA from archival dried blood spots with the Infinium HumanMethylation450 array.
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Joo, JiHoon E., Wong, Ee Ming, Baglietto, Laura, Jung, Chol-Hee, Tsimiklis, Helen, Park, Daniel J., Wong, Nicholas C., English, Dallas R., Hopper, John L., Severi, Gianluca, Giles, Graham G., and Southey, Melissa C.
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DNA methylation ,BLOOD collection ,DNA analysis ,BUFFY coat ,MOLECULAR genetics ,EPIGENETICS ,FEASIBILITY studies - Abstract
Background: Dried blood (Guthrie card) spots provide an efficient way to collect and store blood specimens. DNA from this source has been utilised for a number of molecular analyses including genome-wide association studies, but only few studies have tested the feasibility of using it for epigenetic applications, particularly at a genome-wide level. Results: In this study, we demonstrate the successful use of DNA isolated from archived dried blood spots for the Infinium HumanMethylation450 Beadchip, along with DNA from matched frozen buffy coats. We obtained high quality and reproducible genome-wide DNA methylation profiles using both sample types. We also report high correlations (r > 0.9907) between DNA obtained from matched dried blood spots and frozen buffy coats, sufficient to distinguish between unrelated individuals. Conclusions: We, thus, demonstrate that DNA from archived dried blood spots is suitable for genome-wide DNA methylation profiling. [ABSTRACT FROM AUTHOR]
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- 2013
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45. Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families.
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Bailey-Wilson, Joan E., Childs, Erica J., Cropp, Cheryl D., Schaid, Daniel J., Jianfeng Xu, Camp, Nicola J., Cannon-Albright, Lisa A., Farnham, James M., George, Asha, Powell, Isaac, Carpten, John D., Giles, Graham G., Hopper, John L., Severi, Gianluca, English, Dallas R., Foulkes, William D., M‘hle, Lovise, M›ller, P†l, Eeles, Rosalind, and Easton, Douglas
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PROSTATE cancer ,CANCER susceptibility ,CANCER genetics ,ETIOLOGY of diseases ,LOCUS (Genetics) - Abstract
Background: Genetic variants are likely to contribute to a portion of prostate cancer risk. Full elucidation of the genetic etiology of prostate cancer is difficult because of incomplete penetrance and genetic and phenotypic heterogeneity. Current evidence suggests that genetic linkage to prostate cancer has been found on several chromosomes including the X; however, identification of causative genes has been elusive. Methods: Parametric and non-parametric linkage analyses were performed using 26 microsatellite markers in each of 11 groups of multiple-case prostate cancer families from the International Consortium for Prostate Cancer Genetics (ICPCG). Meta-analyses of the resultant family-specific linkage statistics across the entire 1,323 families and in several predefined subsets were then performed. Results: Meta-analyses of linkage statistics resulted in a maximum parametric heterogeneity lod score (HLOD) of 1.28, and an allele-sharing lod score (LOD) of 2.0 in favor of linkage to Xq27-q28 at 138 cM. In subset analyses, families with average age at onset less than 65 years exhibited a maximum HLOD of 1.8 (at 138 cM) versus a maximum regional HLOD of only 0.32 in families with average age at onset of 65 years or older. Surprisingly, the subset of families with only 2-3 affected men and some evidence of male-to-male transmission of prostate cancer gave the strongest evidence of linkage to the region (HLOD = 3.24, 134 cM). For this subset, the HLOD was slightly increased (HLOD = 3.47 at 134 cM) when families used in the original published report of linkage to Xq27-28 were excluded. Conclusions: Although there was not strong support for linkage to the Xq27-28 region in the complete set of families, the subset of families with earlier age at onset exhibited more evidence of linkage than families with later onset of disease. A subset of families with 2-3 affected individuals and with some evidence of male to male disease transmission showed stronger linkage signals. Our results suggest that the genetic basis for prostate cancer in our families is much more complex than a single susceptibility locus on the X chromosome, and that future explorations of the Xq27-28 region should focus on the subset of families identified here with the strongest evidence of linkage to this region. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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46. Second to fourth digit ratio (2D:4D) and concentrations of circulating sex hormones in adulthood.
- Author
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Muller, David C., Giles, Graham G., Bassett, Julie, Morris, Howard A, Manning, John T., Hopper, John L., English, Dallas R., and Severi, Gianluca
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STEROID hormones ,TESTOSTERONE ,DEHYDROEPIANDROSTERONE ,ENDOCRINOLOGY ,SEX hormones - Abstract
Background: The second to fourth digit ratio (2D:4D) is used as a marker of prenatal sex hormone exposure. The objective of this study was to examine whether circulating concentrations of sex hormones and SHBG measured in adulthood was associated with 2D:4D. Methods: This analysis was based on a random sample from the Melbourne Collaborative Cohort Study. The sample consisted of of 1036 men and 620 post-menopausal women aged between 39 and 70 at the time of blood draw. Concentrations of circulating sex hormones were measured from plasma collected at baseline (1990- 1994), while digit length was measured from hand photocopies taken during a recent follow-up (2003-2009). The outcome measures were circulating concentrations of testosterone, oestradiol, dehydroepiandrosterone sulphate, androstenedione, Sex Hormone Binding Globulin, androstenediol glucoronide for men only and oestrone sulphate for women only. Free testosterone and oestradiol were estimated using standard formulae derived empirically. Predicted geometric mean hormone concentrations (for tertiles of 2D:4D) and conditional correlation coefficients (for continuous 2D:4D) were obtained using mixed effects linear regression models. Results: No strong associations were observed between 2D:4D measures and circulating concentrations of hormones for men or women. For males, right 2D:4D was weakly inversely associated with circulating testosterone (predicted geometric mean testosterone was 15.9 and 15.0 nmol/L for the lowest and highest tertiles of male right 2D:4D respectively (P-trend = 0.04). There was a similar weak association between male right 2D:4D and the ratio of testosterone to oestradiol. These associations were not evident in analyses of continuous 2D:4D. Conclusions: There were no strong associations between any adult circulating concentration of sex hormone or SHGB and 2D:4D. These results contribute to the growing body of evidence indicating that 2D:4D is unrelated to adult sex hormone concentrations. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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47. The 4q27 locus and prostate cancer risk.
- Author
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Tindall, Elizabeth A., Hoang, Hoa N., Southey, Melissa C., English, Dallas R., Hopper, John L., Giles, Graham G., Severi, Gianluca, and Hayes, Vanessa M.
- Subjects
PROSTATE cancer ,CANCER patients ,CANCER risk factors ,CELLULAR immunity ,AUTOIMMUNE diseases - Abstract
Background: Chronic inflammation is considered to be implicated in the development of prostate cancer. In this study we are the first to investigate a potential association between variants in an autoimmune related region on chromosome 4q27 and prostate cancer risk. This region harbors two cytokine genes IL-2 and the recently described IL-21. Methods: We genotyped six variants previously associated with autoimmune disease (namely rs13151961, rs13119723, rs17388568, rs3136534, rs6822844 and rs6840978) and one functional IL-2 promoter variant (rs2069762) for possible association with prostate cancer risk using the Australian Risk Factors for Prostate Cancer case-control Study. Results: Overall, our results do not support an association between the seven variants at position 4q27 and prostate cancer risk. Per allele odds ratios (ORs) were not significantly different from 1 (all P-values = 0.06). However, we found suggestive evidence for a significant association between the presence of the rs13119723 variant (located in a protein of unknown function) and men with a family history of prostate cancer in first-degree relatives (P-value for interaction 0.02). The per allele OR associated with this variant was significantly higher than 1 (2.37; 95% C.I. = 1.01-5.57). Conclusions: We suggest that genetic variation within the chromosome 4q27 locus might be associated with prostate cancer susceptibility in men with a family history of the disease. Furthermore, our study alludes to a potential role of unknown protein KIAA1109 in conferring this risk. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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48. Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
- Author
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Johnson, Nichola, Dudbridge, Frank, Orr, Nick, Gibson, Lorna, Jones, Michael E, Schoemaker, Minouk J, Folkerd, Elizabeth J, Haynes, Ben P, Hopper, John L, Southey, Melissa C, Dite, Gillian S, Apicella, Carmel, Schmidt, Marjanka K, Broeks, Annegien, Van’t Veer, Laura J, Atsma, Femke, Muir, Kenneth, Lophatananon, Artitaya, Fasching, Peter A, Beckmann, Matthias W, Ekici, Arif B, Renner, Stefan P, Sawyer, Elinor, Tomlinson, Ian, Kerin, Michael, Miller, Nicola, Burwinkel, Barbara, Marme, Frederik, Schneeweiss, Andreas, Sohn, Christof, Guénel, Pascal, Truong, Therese, Cordina, Emilie, Menegaux, Florence, Bojesen, Stig E, Nordestgaard, Børge G, Flyger, Henrik, Milne, Roger, Zamora, M Pilar, Arias Perez, Jose Ignacio, Benitez, Javier, Bernstein, Leslie, Anton-Culver, Hoda, Ziogas, Argyrios, Clarke Dur, Christina, Brenner, Hermann, Müller, Heiko, Arndt, Volker, Dieffenbach, Aida Karina, Meindl, Alfons, Heil, Joerg, Bartram, Claus R, Schmutzler, Rita K, Brauch, Hiltrud, Justenhoven, Christina, Ko, Yon-Dschun, Nevanlinna, Heli, Muranen, Taru A, Aittomäki, Kristiina, Blomqvist, Carl, Matsuo, Keitaro, Dörk, Thilo, Bogdanova, Natalia V, Antonenkova, Natalia N, Lindblom, Annika, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Chenevix-Trench, Georgia, Beesley, Jonathan, Wu, Anna H, Van den Berg, David, Tseng, Chiu-Chen, Lambrechts, Diether, Smeets, Dominiek, Neven, Patrick, Wildiers, Hans, Chang-Claude, Jenny, Rudolph, Anja, Nickels, Stefan, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Bonanni, Bernardo, Pensotti, Valeria, Couch, Fergus J, Olson, Janet E, Wang, Xianshu, Fredericksen, Zachary, Pankratz, Vernon S, Giles, Graham G, Severi, Gianluca, Baglietto, Laura, Haiman, Chris, Simard, Jacques, Goldberg, Mark S, Labrèche, France, Dumont, Martine, Soucy, Penny, Teo, Soo, Yip, Cheng Har, Phuah, Sze Yee, Cornes, Belinda K, Kristensen, Vessela N, Grenaker Alnæs, Grethe, Børresen-Dale, Anne-Lise, Zheng, Wei, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Andrulis, Irene L, Knight, Julia A, Glendon, Gord, Mulligan, Anna Marie, Devillee, Peter, Figueroa, Jonine, Chanock, Stephen J, Lissowska, Jolanta, Sherman, Mark E, Hall, Per, Schoof, Nils, Hooning, Maartje, Hollestelle, Antoinette, Oldenburg, Rogier A, Tilanus-Linthorst, Madeleine, Liu, Jianjun, Cox, Angie, Brock, Ian W, Reed, Malcolm WR, Cross, Simon S, Blot, William, Signorello, Lisa B, Pharoah, Paul DP, Dunning, Alison M, Shah, Mitul, Kang, Daehee, Noh, Dong-Young, Park, Sue K, Choi, Ji-Yeob, Hartman, Mikael, Miao, Hui, Lim, Wei Yen, Tang, Anthony, Hamann, Ute, Försti, Asta, Rüdiger, Thomas, Ulmer, Hans Ulrich, Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, McKay, James, Slager, Susan, Toland, Amanda E, Vachon, Celine, Yannoukakos, Drakoulis, Shen, Chen-Yang, Yu, Jyh-Cherng, Huang, Chiun-Sheng, Hou, Ming-Feng, González-Neira, Anna, Tessier, Daniel C, Vincent, Daniel, Bacot, Francois, Luccarini, Craig, Dennis, Joe, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Jean, Easton, Douglas F, García-Closas, Montserrat, Dowsett, Mitch, Ashworth, Alan, Swerdlow, Anthony J, Peto, Julian, dos Santos Silva, Isabel, and Fletcher, Olivia
- Abstract
Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years. Methods: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics. Results: We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (Ptrend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (Ptrend = 0.005) but not cases (Ptrend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (Phet = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; Ptrend = 0.002) but not for those who had their menarche age ≤11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; Ptrend = 0.29). Conclusions: To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.
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- 2014
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49. A case control study investigating the effects of levels of physical activity at work as a risk factor for prostate cancer.
- Author
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Doolan, Glenn W, Benke, Geza, Giles, Graham G, Severi, Gianluca, and Kauppinen, Timo
- Abstract
Background: A potential risk factor for prostate cancer is occupational physical activity. The occupational aetiology of prostate cancer remains unclear. The purpose of this research was to examine associations between the level of exposure to various measures of physical activity at work and the risk of Prostate Cancer.Methods: Using the Finnish Job Exposure Matrix and the occupational history of 1,436 cases and 1,349 matched controls from an Australian case control study; we investigated five related exposure variables considered to be risk factors by comparing odds ratios.Results: Modestly increasing odds ratios were detected with increasing levels of workload but there was no difference in this trend between moderate and high grade tumours. In regard to occupational physical workload no statistically significant association was observed overall but an increasing trend with level of exposure was observed for high grade compared with moderate grade tumours.Conclusion: Both workload and physical workload merit further investigation, particularly for the latter in relation to grade of tumour. [ABSTRACT FROM AUTHOR]- Published
- 2014
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50. Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study
- Author
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Augustin Scalbert, Dagfinn Aune, Andrew T. Gewirtz, Mazda Jenab, Veronika Fedirko, Christina Bamia, Nicholas J. Wareham, Elio Riboli, J. Ramón Quirós, Rudolf Kaaks, Aurelio Barricarte, Rosario Tumino, Salvatore Panico, María José Sánchez, Gianluca Severi, Kim Overvad, Antonia Trichopoulou, Sara Grioni, Domenico Palli, H. B. Bueno-De-Mesquita, Antonio Agudo, Isabelle Romieu, Mårten Werner, Tilman Kühn, Elisabete Weiderpass, Oskar Hemmingsson, Kathryn E. Bradbury, Pagona Lagiou, Hao Quang Tran, Marie-Christine Boutron-Ruault, Anne Tjønneland, Alessio Naccarati, José María Huerta Castaño, Franck Carbonnel, Magdalena Stepien, Kay-Tee Khaw, Krasimira Aleksandrova, Bodil Ohlsson, Petra H.M. Peeters, Heiner Boeing, Anja Olsen, Konstantinos K. Tsilidis, Miren Dorronsoro, Klas Sjöberg, Khaw, Kay-Tee [0000-0002-8802-2903], Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository, Fedirko, Veronika, Tran, Hao Quang, Gewirtz, Andrew T, Stepien, Magdalena, Trichopoulou, Antonia, Aleksandrova, Krasimira, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Carbonnel, Franck, Boutron Ruault, Marie Christine, Severi, Gianluca, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Bamia, Christina, Lagiou, Pagona, Grioni, Sara, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Naccarati, Alessio, Peeters, Petra H, Bueno de Mesquita, H. B, Weiderpass, Elisabete, Castaño, José María Huerta, Barricarte, Aurelio, Sánchez, María José, Dorronsoro, Miren, Quirós, J. Ramón, Agudo, Antonio, Sjöberg, Kla, Ohlsson, Bodil, Hemmingsson, Oskar, Werner, Mårten, Bradbury, Kathryn E, Khaw, Kay Tee, Wareham, Nick, Tsilidis, Konstantinos K, Aune, Dagfinn, Scalbert, Augustin, Romieu, Isabelle, Riboli, Elio, and Jenab, Mazda
- Subjects
Lipopolysaccharides ,Male ,0301 basic medicine ,Immunoglobulin A ,Hepatocellular carcinoma ,lcsh:Medicine ,Cohort Studies ,0302 clinical medicine ,Endotoxin ,Risk Factors ,Prospective cohort study ,RISK ,Medicine(all) ,biology ,NONALCOHOLIC STEATOHEPATITIS ,GUT MICROBIOTA ,Liver Neoplasms ,Confounding ,11 Medical And Health Sciences ,General Medicine ,VDP::Medical disciplines: 700::Health sciences: 800 ,Middle Aged ,Hepatitis B ,CANCER ,CROHNS-DISEASE ,Multicenter Study ,VDP::Medisinske Fag: 700::Helsefag: 800 ,030220 oncology & carcinogenesis ,NUTRITION ,Female ,Liver cancer ,Life Sciences & Biomedicine ,Research Article ,Adult ,DIET-INDUCED OBESITY ,Carcinoma, Hepatocellular ,Lipopolysaccharide ,Càncer de fetge ,03 medical and health sciences ,Medicine, General & Internal ,SDG 3 - Good Health and Well-being ,General & Internal Medicine ,Journal Article ,medicine ,Humans ,FATTY LIVER-DISEASE ,Aged ,Science & Technology ,business.industry ,lcsh:R ,Klinisk medicin ,medicine.disease ,Endotoxins ,030104 developmental biology ,PROSPECTIVE COHORT ,Case-Control Studies ,Immunoglobulin G ,Nested case-control study ,Immunology ,biology.protein ,Clinical Medicine ,business ,Prospective studies ,Flagellin - Abstract
All Author: Veronika Fedirko, Hao Quang Tran, Andrew T. Gewirtz, Magdalena Stepien, Antonia Trichopoulou, Krasimira Aleksandrova, Anja Olsen, Anne Tjønneland, Kim Overvad, Franck Carbonnel, Marie-Christine Boutron-Ruault, Gianluca Severi, Tilman Kühn, Rudolf Kaaks, Heiner Boeing, Christina Bamia, Pagona Lagiou, Sara Grioni, Salvatore Panico, Domenico Palli, Rosario Tumino, Alessio Naccarati, Petra H. Peeters, H. B. Bueno-de-Mesquita, Elisabete Weiderpass, José María Huerta Castaño, Aurelio Barricarte, María-José Sánchez, Miren Dorronsoro, J. Ramón Quirós, Antonio Agudo, Klas Sjöberg, Bodil Ohlsson, Oskar Hemmingsson, Mårten Werner, Kathryn E. Bradbury, Kay-Tee Khaw, Nick Wareham, Konstantinos K. Tsilidis, Dagfinn Aune, Augustin Scalbert, Isabelle Romieu, Elio Riboli and Mazda Jenab., Background: Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking. Methods: We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma. A total of 139 men and women diagnosed with hepatocellular carcinoma between 1992 and 2010 were matched to 139 control subjects. Multivariable rate ratios (RRs), including adjustment for potential confounders, hepatitis B/C positivity, and degree of liver dysfunction, were calculated with conditional logistic regression. Results: Antibody response to LPS and flagellin was associated with a statistically significant increase in the risk of hepatocellular carcinoma (highest vs. lowest quartile: RR = 11.76, 95% confidence interval = 1.70–81.40; Ptrend = 0.021). This finding did not vary substantially by time from enrollment to diagnosis, and did not change after adjustment for chronic infection with hepatitis B and C viruses. Conclusions: These novel findings, based on exposures up to several years prior to diagnosis, support a role for gut-derived bacterial products in hepatocellular carcinoma development. Further study into the role of gut barrier failure and exposure to bacterial products in liver diseases is warranted., This work was supported by the French National Cancer Institute (L’Institut National du Cancer; INCA) (grant number 2009-139; Principal Investigator: M. Jenab). The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by the Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, and Institut National de la Santé et de la Recherche Médicale (INSERM) (France); Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); the Sicilian Government, AIRE ONLUS Ragusa, AVIS Ragusa, Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), and Statistics Netherlands (the Netherlands); Nordic Centre of Excellence programme on Food, Nutrition and Health. (Norway); Health Research Fund (FIS), PI13/00061 to Granada), Regional Governments of Andalucía, Asturias, Basque Country, Murcia (no. 6236) and Navarra, Regional Government of Asturias (Asturias, Spain), and ISCIII RETIC (RD06/0020) (Spain); Swedish Cancer Society, Swedish Scientific Council, and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 to EPIC-Oxford) and Medical Research Council (1000143 to EPIC-Norfolk) (United Kingdom); and a Girdlers’ New Zealand Health Research Council Fellowship (to Dr. K.E. Bradbury). The funding sources had no influence on the design of the study; the collection, analysis, and interpretation of data; the writing of the report; or the decision to submit the paper for publication.
- Published
- 2017
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