19 results on '"Rosenblad A"'
Search Results
2. Virtual clinic for young people with type 1 diabetes: a randomised wait-list controlled study
- Author
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Leksell, Janeth, Toft, Eva, Rosman, Jessica, Eriksson, Jan W., Fischier, Johan, Lindholm-Olinder, Anna, Rosenblad, Andreas, and Nerpin, Elisabet
- Published
- 2023
- Full Text
- View/download PDF
3. Self-efficacy in breastfeeding predicts how mothers perceive their preterm infant’s state-regulation
- Author
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Rosenblad, Andreas Karlsson and Funkquist, Eva-Lotta
- Published
- 2022
- Full Text
- View/download PDF
4. The relationship between attitudes to homelessness and perceptions of caring behaviours: a cross-sectional study among women experiencing homelessness, nurses and nursing students
- Author
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Gaber, Sophie Nadia, Rosenblad, Andreas Karlsson, Mattsson, Elisabet, and Klarare, Anna
- Published
- 2022
- Full Text
- View/download PDF
5. Caring Behaviors Inventory-24: translation, cross-cultural adaptation and psychometric testing for use in a Swedish context
- Author
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Klarare, Anna, Söderlund, Mona, Wikman, Anna, McGreevy, Jenny, Mattsson, Elisabet, and Rosenblad, Andreas
- Published
- 2021
- Full Text
- View/download PDF
6. Risk factors for poor health-related quality of life in patients with colon cancer include stoma and smoking habits
- Author
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Tiselius, Catarina, Rosenblad, Andreas, Strand, Eva, and Smedh, Kenneth
- Published
- 2021
- Full Text
- View/download PDF
7. Quality of life after gastric bypass surgery in patients with type 2 diabetes: patients’ experiences during 2 years of follow-up
- Author
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Katsogiannos, Petros, Randell, Eva, Sundbom, Magnus, Rosenblad, Andreas, Eriksson, Jan W., and Leksell, Janeth
- Published
- 2020
- Full Text
- View/download PDF
8. The round goby genome provides insights into mechanisms that may facilitate biological invasions
- Author
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Adrian-Kalchhauser, Irene, Blomberg, Anders, Larsson, Tomas, Musilova, Zuzana, Peart, Claire R., Pippel, Martin, Solbakken, Monica Hongroe, Suurväli, Jaanus, Walser, Jean-Claude, Wilson, Joanna Yvonne, Alm Rosenblad, Magnus, Burguera, Demian, Gutnik, Silvia, Michiels, Nico, Töpel, Mats, Pankov, Kirill, Schloissnig, Siegfried, and Winkler, Sylke
- Published
- 2020
- Full Text
- View/download PDF
9. The mitochondrial genome sequences of the round goby and the sand goby reveal patterns of recent evolution in gobiid fish.
- Author
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Adrian-Kalchhauser, Irene, Svensson, Ola, Kutschera, Verena E., Rosenblad, Magnus Alm, Pippel, Martin, Winkler, Sylke, Schloissnig, Siegfried, Blomberg, Anders, and Burkhardt-Holm, Patricia
- Subjects
FISH genomes ,GOBIIDAE ,NUCLEOTIDE sequencing ,MITOCHONDRIAL DNA ,NEOGOBIUS fluviatilis ,NUCLEOTIDE sequence - Abstract
Background: Vertebrate mitochondrial genomes are optimized for fast replication and low cost of RNA expression. Accordingly, they are devoid of introns, are transcribed as polycistrons and contain very little intergenic sequences. Usually, vertebrate mitochondrial genomes measure between 16.5 and 17 kilobases (kb). Results: During genome sequencing projects for two novel vertebrate models, the invasive round goby and the sand goby, we found that the sand goby genome is exceptionally small (16.4 kb), while the mitochondrial genome of the round goby is much larger than expected for a vertebrate. It is 19 kb in size and is thus one of the largest fish and even vertebrate mitochondrial genomes known to date. The expansion is attributable to a sequence insertion downstream of the putative transcriptional start site. This insertion carries traces of repeats from the control region, but is mostly novel. To get more information about this phenomenon, we gathered all available mitochondrial genomes of Gobiidae and of nine gobioid species, performed phylogenetic analyses, analysed gene arrangements, and compared gobiid mitochondrial genome sizes, ecological information and other species characteristics with respect to the mitochondrial phylogeny. This allowed us amongst others to identify a unique arrangement of tRNAs among Ponto-Caspian gobies. Conclusions: Our results indicate that the round goby mitochondrial genome may contain novel features. Since mitochondrial genome organisation is tightly linked to energy metabolism, these features may be linked to its invasion success. Also, the unique tRNA arrangement among Ponto-Caspian gobies may be helpful in studying the evolution of this highly adaptive and invasive species group. Finally, we find that the phylogeny of gobiids can be further refined by the use of longer stretches of linked DNA sequence. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
10. Identification and comparative analysis of components from the signal recognition particle in protozoa and fungi
- Author
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Tore Samuelsson, Christian W Zwieb, and Magnus Alm Rosenblad
- Subjects
lcsh:QH426-470 ,lcsh:Biotechnology ,Molecular Sequence Data ,Protozoan Proteins ,Sequence alignment ,Biology ,environment and public health ,Fungal Proteins ,03 medical and health sciences ,lcsh:TP248.13-248.65 ,Databases, Genetic ,Genetics ,Animals ,Signal recognition particle RNA ,Amino Acid Sequence ,Protein secondary structure ,Gene ,Phylogeny ,030304 developmental biology ,0303 health sciences ,Signal recognition particle ,Fungal protein ,SRP protozoa fungi RNA ,Base Sequence ,Sequence Homology, Amino Acid ,030302 biochemistry & molecular biology ,Fungal genetics ,Fungi ,RNA ,Eukaryota ,RNA, Fungal ,lcsh:Genetics ,Nucleic Acid Conformation ,Genome, Fungal ,Genome, Protozoan ,Sequence Alignment ,Signal Recognition Particle ,RNA, Protozoan ,Biotechnology ,Research Article - Abstract
Background The signal recognition particle (SRP) is a ribonucleoprotein complex responsible for targeting proteins to the ER membrane. The SRP of metazoans is well characterized and composed of an RNA molecule and six polypeptides. The particle is organized into the S and Alu domains. The Alu domain has a translational arrest function and consists of the SRP9 and SRP14 proteins bound to the terminal regions of the SRP RNA. So far, our understanding of the SRP and its evolution in lower eukaryotes such as protozoa and yeasts has been limited. However, genome sequences of such organisms have recently become available, and we have now analyzed this information with respect to genes encoding SRP components. Results A number of SRP RNA and SRP protein genes were identified by an analysis of genomes of protozoa and fungi. The sequences and secondary structures of the Alu portion of the RNA were found to be highly variable. Furthermore, proteins SRP9/14 appeared to be absent in certain species. Comparative analysis of the SRP RNAs from different Saccharomyces species resulted in models which contain features shared between all SRP RNAs, but also a new secondary structure element in SRP RNA helix 5. Protein SRP21, previously thought to be present only in Saccharomyces, was shown to be a constituent of additional fungal genomes. Furthermore, SRP21 was found to be related to metazoan and plant SRP9, suggesting that the two proteins are functionally related. Conclusions Analysis of a number of not previously annotated SRP components show that the SRP Alu domain is subject to a more rapid evolution than the other parts of the molecule. For instance, the RNA portion is highly variable and the protein SRP9 seems to have evolved into the SRP21 protein in fungi. In addition, we identified a secondary structure element in the Sacccharomyces RNA that has been inserted close to the Alu region. Together, these results provide important clues as to the structure, function and evolution of SRP.
- Published
- 2004
11. Metagenomics reveals that detoxification systems are underrepresented in marine bacterial communities.
- Author
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Bengtsson-Palme, Johan, Rosenblad, Magnus Alm, Molin, Mikael, and Blomberg, Anders
- Abstract
Background: Environmental shotgun sequencing (metagenomics) provides a new way to study communities in microbial ecology. We here use sequence data from the Global Ocean Sampling (GOS) expedition to investigate toxicant selection pressures revealed by the presence of detoxification genes in marine bacteria. To capture a broad range of potential toxicants we selected detoxification protein families representing systems protecting microorganisms from a variety of stressors, such as metals, organic compounds, antibiotics and oxygen radicals. Results: Using a bioinformatics procedure based on comparative analysis to finished bacterial genomes we found that the amount of detoxification genes present in marine microorganisms seems surprisingly small. The underrepresentation is particularly evident for toxicant transporters and proteins involved in detoxifying metals. Exceptions are enzymes involved in oxidative stress defense where peroxidase enzymes are more abundant in marine bacteria compared to bacteria in general. In contrast, catalases are almost completely absent from the open ocean environment, suggesting that peroxidases and peroxiredoxins constitute a core line of defense against reactive oxygen species (ROS) in the marine milieu. Conclusions: We found no indication that detoxification systems would be generally more abundant close to the coast compared to the open ocean. On the contrary, for several of the protein families that displayed a significant geographical distribution, like peroxidase, penicillin binding transpeptidase and divalent ion transport protein, the open ocean samples showed the highest abundance. Along the same lines, the abundance of most detoxification proteins did not increase with estimated pollution. The low level of detoxification systems in marine bacteria indicate that the majority of marine bacteria have a low capacity to adapt to increased pollution. Our study exemplifies the use of metagenomics data in ecotoxicology, and in particular how anthropogenic consequences on life in the sea can be examined. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
12. Species and gene divergence in Littorina snails detected by array comparative genomic hybridization.
- Author
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Panova, Marina, Johansson, Tomas, Canbäck, Björn, Bentzer, Johan, Rosenblad, Magnus Alm, Johannesson, Kerstin, Tunlid, Anders, and André, Carl
- Abstract
Background: Array comparative genomic hybridization (aCGH) is commonly used to screen different types of genetic variation in humans and model species. Here, we performed aCGH using an oligonucleotide gene-expression array for a non-model species, the intertidal snail Littorina saxatilis. First, we tested what types of genetic variation can be detected by this method using direct re-sequencing and comparison to the Littorina genome draft. Secondly, we performed a genome-wide comparison of four closely related Littorina species: L. fabalis, L. compressa, L. arcana and L. saxatilis and of populations of L. saxatilis found in Spain, Britain and Sweden. Finally, we tested whether we could identify genetic variation underlying “Crab” and “Wave” ecotypes of L. saxatilis. Results: We could reliably detect copy number variations, deletions and high sequence divergence (i.e. above 3%), but not single nucleotide polymorphisms. The overall hybridization pattern and number of significantly diverged genes were in close agreement with earlier phylogenetic reconstructions based on single genes. The trichotomy of L. arcana, L. compressa and L. saxatilis could not be resolved and we argue that these divergence events have occurred recently and very close in time. We found evidence for high levels of segmental duplication in the Littorina genome (10% of the transcripts represented on the array and up to 23% of the analyzed genomic fragments); duplicated genes and regions were mostly the same in all analyzed species. Finally, this method discriminated geographically distant populations of L. saxatilis, but we did not detect any significant genome divergence associated with ecotypes of L. saxatilis. Conclusions: The present study provides new information on the sensitivity and the potential use of oligonucleotide arrays for genotyping of non-model organisms. Applying this method to Littorina species yields insights into genome evolution following the recent species radiation and supports earlier single-gene based phylogenies. Genetic differentiation of L. saxatilis ecotypes was not detected in this study, despite pronounced innate phenotypic differences. The reason may be that these differences are due to single-nucleotide polymorphisms. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
13. School nurses' attitudes and experiences regarding the human papillomavirus vaccination programme in Sweden: a population-based survey.
- Author
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Grandahl, Maria, Tydén, Tanja, Rosenblad, Andreas, Oscarsson, Marie, Nevéus, Tryggve, and Stenhammar, Christina
- Subjects
SCHOOL nursing ,HUMAN papillomavirus vaccines ,EDUCATION ,CONFIDENCE intervals ,SCHOOL health services ,PUBLIC health - Abstract
Background Sweden introduced a school-based human papillomavirus (HPV) vaccination programme in 2012, and school nurses are responsible for managing the vaccinations. The aim of the present study was to investigate the attitudes and experiences of school nurses regarding the school-based HPV vaccination programme 1 year after its implementation. Methods Data were collected using a web-based questionnaire in the spring of 2013, and 83.1% (851/1024) of nurses responded. Results There were strong associations between the nurses' education about the HPV vaccine and their perceived knowledge about the vaccine and a favourable attitude towards vaccination (both p < 0.001). School nurses who received a high level of education were more likely to have a positive attitude to HPV vaccination compared with nurses with little education about HPV vaccination (adjusted odds ratio [OR] = 9.8; 95% confidence interval [CI]:3.797- 25.132). Nurses with high perceived knowledge were more likely to have a positive attitude compared with those with a low level of perceived knowledge (OR = 2.5; 95% CI: 1.299- 4.955). If financial support from the government was used to fund an additional school nurse, nurses were more likely to have a positive attitude than if the financial support was not used to cover the extra expenses incurred by the HPV vaccination (OR = 2.1; 95% CI:1.051- 4.010). The majority, 648 (76.1%), had been contacted by parents with questions about the vaccine, mostly related to adverse effects. In addition, 570 (66.9%) stated that they had experienced difficulties with the vaccinations, and 337 (59.1%) of these considered the task to be time-consuming. Conclusions A high level of education and perceived good knowledge about HPV are associated with a positive attitude of school nurses to the HPV vaccination programme. Thus, nurses require adequate knowledge, education, skills and time to address the questions and concerns of parents, as well as providing information about HPV. Strategic financial support is required because HPV vaccination is a complex and time-consuming task. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
14. Combined analysis of circulating ß-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects.
- Author
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Rhodin, Annica, Grönbladh, Alfhild, Ginya, Harumi, Nilsson, Kent W., Rosenblad, Andreas, Qin Zhou, Enlund, Mats, Hallberg, Mathias, Gordh, Torsten, and Nyberg, Fred
- Subjects
ENDORPHINS ,GENETIC polymorphisms ,OPIOIDS ,DRUG side effects ,ANALGESICS ,SINGLE nucleotide polymorphisms ,MOLECULAR biology ,DRUG metabolism - Abstract
Background: Opioids are associated with wide inter-individual variability in the analgesic response and a narrow therapeutic index. This may be partly explained by the presence of single nucleotide polymorphisms (SNPs) in genes encoding molecular entities involved in opioid metabolism and receptor activation. This paper describes the investigation of SNPs in three genes that have a functional impact on the opioid response: OPRM1, which codes for the µ-opioid receptor; ABCB1 for the ATP-binding cassette B1 transporter enzyme; and the calcium channel complex subunit CACNA2D2. The genotyping was combined with an analysis of plasma levels of the opioid peptide ß-endorphin in 80 well-defined patients with chronic low back pain scheduled for spinal fusion surgery, and with differential sensitivity to the opioid analgesic remifentanil. This patient group was compared with 56 healthy controls. Results: The plasma ß-endorphin levels were significantly higher in controls than in pain patients. A higher incidence of opioid-related side effects and sex differences was found in patients with the minor allele of the ABCB1 gene. Further, a correlation between increased opioid sensitivity and the major CACNA2D2 allele was confirmed. A tendency of a relationship between opioid sensitivity and the minor allele of OPRM1 was also found. Conclusions: Although the sample cohort in this study was limited to 80 patients it appears that it was possible to observe significant correlations between polymorphism in relevant genes and various items related to pain sensitivity and opioid response. Of particular interest is the new finding of a correlation between increased opioid sensitivity and the major CACNA2D2 allele. These observations may open for improved strategies in the clinical treatment of chronic pain with opioids. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
15. Comparison of a high and a low intensity smoking cessation intervention in a dentistry setting in Sweden - a randomized trial.
- Author
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Nohlert, Eva, Tegelberg, Åke, Tillgren, Per, Johansson, Pia, Rosenblad, Andreas, and Helgason, Ásgeir R.
- Subjects
SMOKING cessation ,LIFESTYLES ,EARLY death ,PUBLIC health - Abstract
Background: Tobacco is still the number one life style risk factor for ill health and premature death and also one of the major contributors to oral problems and diseases. Dentistry may be a potential setting for several aspects of clinical public health interventions and there is a growing interest in several countries to develop tobacco cessation support in dentistry setting. The aim of the present study was to assess the relative effectiveness of a high intensity intervention compared with a low intensity intervention for smoking cessation support in a dental clinic setting. Methods: 300 smokers attending dental or general health care were randomly assigned to two arms and referred to the local dental clinic for smoking cessation support. One arm received support with low intensity treatment (LIT), whereas the other group was assigned to high intensity treatment (HIT) support. The main outcome measures included self-reported point prevalence and continuous abstinence (≥ 183 days) at the 12-month follow-up. Results: Follow-up questionnaires were returned from 86% of the participants. People in the HIT-arm were twice as likely to report continuous abstinence compared with the LIT-arm (18% vs. 9%, p = 0.02). There was a difference (not significant) between the arms in point prevalence abstinence in favour of the HIT-protocol (23% vs. 16%). However, point prevalence cessation rates in the LIT-arm reporting additional support were relatively high (23%) compared with available data assessing abstinence in smokers trying to quit without professional support. Conclusion: Screening for willingness to quit smoking within the health care system and offering smoking cessation support within dentistry may be an effective model for smoking cessation support in Sweden. The LIT approach is less expensive and time consuming and may be appropriate as a first treatment option, but should be integrated with other forms of available support in the community. The more extensive and expensive HIT-protocol should be offered to those who are unable to quit with the LIT approach in combination with other support. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
16. Identification and comparative analysis of components from the signal recognition particle in protozoa and fungi.
- Author
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Rosenblad, Magnus Alm, Zwieb, Christian, and Samuelsson, Tore
- Subjects
- *
RIBOSOMES , *PROTOZOA , *FUNGI , *MICROBIAL genetics , *NUCLEOTIDE sequence , *RNA , *CHROMOSOMAL proteins - Abstract
Background: The signal recognition particle (SRP) is a ribonucleoprotein complex responsible for targeting proteins to the ER membrane. The SRP of metazoans is well characterized and composed of an RNA molecule and six polypeptides. The particle is organized into the S and Alu domains. The Alu domain has a translational arrest function and consists of the SRP9 and SRP14 proteins bound to the terminal regions of the SRP RNA. So far, our understanding of the SRP and its evolution in lower eukaryotes such as protozoa and yeasts has been limited. However, genome sequences of such organisms have recently become available, and we have now analyzed this information with respect to genes encoding SRP components. Results: A number of SRP RNA and SRP protein genes were identified by an analysis of genomes of protozoa and fungi. The sequences and secondary structures of the Alu portion of the RNA were found to be highly variable. Furthermore, proteins SRP9/14 appeared to be absent in certain species. Comparative analysis of the SRP RNAs from different Saccharomyces species resulted in models which contain features shared between all SRP RNAs, but also a new secondary structure element in SRP RNA helix 5. Protein SRP21, previously thought to be present only in Saccharomyces, was shown to be a constituent of additional fungal genomes. Furthermore, SRP21 was found to be related to metazoan and plant SRP9, suggesting that the two proteins are functionally related. Conclusions: Analysis of a number of not previously annotated SRP components show that the SRP Alu domain is subject to a more rapid evolution than the other parts of the molecule. For instance, the RNA portion is highly variable and the protein SRP9 seems to have evolved into the SRP21 protein in fungi. In addition, we identified a secondary structure element in the Sacccharomyces RNA that has been inserted close to the Alu region. Together, these results provide important clues as to the structure, function and evolution of SRP. [ABSTRACT FROM AUTHOR]
- Published
- 2004
- Full Text
- View/download PDF
17. The round goby genome provides insights into mechanisms that may facilitate biological invasions
- Author
-
Adrian-Kalchhauser, Irene, Blomberg, Anders, Larsson, Tomas, Musilova, Zuzana, Peart, Claire R, Pippel, Martin, Solbakken, Monica Hongroe, Suurväli, Jaanus, Walser, Jean-Claude, Wilson, Joanna Yvonne, Alm Rosenblad, Magnus, Burguera, Demian, Gutnik, Silvia, Michiels, Nico, Töpel, Mats, Pankov, Kirill, Schloissnig, Siegfried, and Winkler, Sylke
- Subjects
570 Life sciences ,biology ,14. Life underwater ,500 Science - Abstract
BACKGROUND The invasive benthic round goby (Neogobius melanostomus) is the most successful temperate invasive fish and has spread in aquatic ecosystems on both sides of the Atlantic. Invasive species constitute powerful in situ experimental systems to study fast adaptation and directional selection on short ecological timescales and present promising case studies to understand factors involved the impressive ability of some species to colonize novel environments. We seize the unique opportunity presented by the round goby invasion to study genomic substrates potentially involved in colonization success. RESULTS We report a highly contiguous long-read-based genome and analyze gene families that we hypothesize to relate to the ability of these fish to deal with novel environments. The analyses provide novel insights from the large evolutionary scale to the small species-specific scale. We describe expansions in specific cytochrome P450 enzymes, a remarkably diverse innate immune system, an ancient duplication in red light vision accompanied by red skin fluorescence, evolutionary patterns of epigenetic regulators, and the presence of osmoregulatory genes that may have contributed to the round goby's capacity to invade cold and salty waters. A recurring theme across all analyzed gene families is gene expansions. CONCLUSIONS The expanded innate immune system of round goby may potentially contribute to its ability to colonize novel areas. Since other gene families also feature copy number expansions in the round goby, and since other Gobiidae also feature fascinating environmental adaptations and are excellent colonizers, further long-read genome approaches across the goby family may reveal whether gene copy number expansions are more generally related to the ability to conquer new habitats in Gobiidae or in fish.
18. Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects.
- Author
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Rhodin A, Grönbladh A, Ginya H, Nilsson KW, Rosenblad A, Zhou Q, Enlund M, Hallberg M, Gordh T, and Nyberg F
- Subjects
- ATP Binding Cassette Transporter, Subfamily B, Adult, Aged, Analgesics, Opioid therapeutic use, Female, Gene Frequency genetics, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Pain drug therapy, Quality of Life, ATP Binding Cassette Transporter, Subfamily B, Member 1 genetics, Analgesics, Opioid adverse effects, Calcium Channels genetics, Pain genetics, Polymorphism, Single Nucleotide genetics, Receptors, Opioid, mu genetics, beta-Endorphin blood
- Abstract
Background: Opioids are associated with wide inter-individual variability in the analgesic response and a narrow therapeutic index. This may be partly explained by the presence of single nucleotide polymorphisms (SNPs) in genes encoding molecular entities involved in opioid metabolism and receptor activation. This paper describes the investigation of SNPs in three genes that have a functional impact on the opioid response: OPRM1, which codes for the μ-opioid receptor; ABCB1 for the ATP-binding cassette B1 transporter enzyme; and the calcium channel complex subunit CACNA2D2. The genotyping was combined with an analysis of plasma levels of the opioid peptide β-endorphin in 80 well-defined patients with chronic low back pain scheduled for spinal fusion surgery, and with differential sensitivity to the opioid analgesic remifentanil. This patient group was compared with 56 healthy controls., Results: The plasma β-endorphin levels were significantly higher in controls than in pain patients.A higher incidence of opioid-related side effects and sex differences was found in patients with the minor allele of the ABCB1 gene. Further, a correlation between increased opioid sensitivity and the major CACNA2D2 allele was confirmed. A tendency of a relationship between opioid sensitivity and the minor allele of OPRM1 was also found., Conclusions: Although the sample cohort in this study was limited to 80 patients it appears that it was possible to observe significant correlations between polymorphism in relevant genes and various items related to pain sensitivity and opioid response. Of particular interest is the new finding of a correlation between increased opioid sensitivity and the major CACNA2D2 allele. These observations may open for improved strategies in the clinical treatment of chronic pain with opioids.
- Published
- 2013
- Full Text
- View/download PDF
19. Hospital employees' theoretical knowledge on what to do in an in-hospital cardiac arrest.
- Author
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Källestedt ML, Rosenblad A, Leppert J, Herlitz J, and Enlund M
- Subjects
- Adolescent, Adult, Aged, Cardiopulmonary Resuscitation standards, Female, Humans, Inservice Training, Male, Middle Aged, Surveys and Questionnaires, Young Adult, Health Knowledge, Attitudes, Practice, Heart Arrest therapy, Models, Theoretical, Personnel, Hospital
- Abstract
Background: Guidelines recommend that all health care professionals should be able to perform cardiopulmonary resuscitation (CPR), including the use of an automated external defibrillator. Theoretical knowledge of CPR is then necessary.The aim of this study was to investigate how much theoretical knowledge in CPR would increase among all categories of health care professionals lacking training in CPR, in an intervention hospital, after a systematic standardised training. Their results were compared with the staff at a control hospital with an ongoing annual CPR training programme., Methods: Health care professionals at two hospitals, with a total of 3144 employees, answered a multiple-choice questionnaire before and after training in CPR. Bootstrapped chi-square tests and Fisher's exact test were used for the statistical analyses., Results: In the intervention hospital, physicians had the highest knowledge pre-test, but other health care professionals including nurses and assistant nurses reached a relatively high level post-test. Improvement was inversely related to the level of previous knowledge and was thus most marked among other health care professionals and least marked among physicians.The staff at the control hospital had a significantly higher level of knowledge pre-test than the intervention hospital, whereas the opposite was found post-test., Conclusions: Overall theoretical knowledge increased after systematic standardised training in CPR. The increase was more pronounced for those without previous training and for those staff categories with the least medical education.
- Published
- 2010
- Full Text
- View/download PDF
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