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Your search keyword '"Philippens, Marielle"' showing total 11 results
Start Over Author "Philippens, Marielle" Publisher biomed central
11 results on '"Philippens, Marielle"'

3. Association of histological features with laryngeal squamous cell carcinoma recurrences: a population-based study of 1502 patients in the Netherlands

Author

Fysica Radiotherapie Research, Cancer, MS Radiotherapie, Klinische Fysica RT, MS Hoofd-Hals Chirurgische Oncologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Pathologie Pathologen staf, Ruiter, Lilian N, van Dijk, Boukje A C, Bruggink, Annette H, Doornaert, Patricia A H, Philippens, Marielle E P, de Bree, Remco, van Gils, Carla H, Willems, Stefan M, Fysica Radiotherapie Research, Cancer, MS Radiotherapie, Klinische Fysica RT, MS Hoofd-Hals Chirurgische Oncologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Pathologie Pathologen staf, Ruiter, Lilian N, van Dijk, Boukje A C, Bruggink, Annette H, Doornaert, Patricia A H, Philippens, Marielle E P, de Bree, Remco, van Gils, Carla H, and Willems, Stefan M

Published
2022

4. Does setup on rectal wall improve rectal cancer boost radiotherapy?

Author

Kleijnen, Jean-Paul J E, van Asselen, Bram, Intven, Martijn, Burbach, Johannes P M, Philippens, Marielle E P, Lagendijk, Jan J W, Raaymakers, Bas W, Kleijnen, Jean-Paul J E, van Asselen, Bram, Intven, Martijn, Burbach, Johannes P M, Philippens, Marielle E P, Lagendijk, Jan J W, and Raaymakers, Bas W

Published
2018

5. Does setup on rectal wall improve rectal cancer boost radiotherapy?

Author

Experimentele klinische fysica, Cancer, Klinische Fysica RT, MS Radiotherapie, Onderzoek Radiotherapie, Kleijnen, Jean-Paul J E, van Asselen, Bram, Intven, Martijn, Burbach, Johannes P M, Philippens, Marielle E P, Lagendijk, Jan J W, Raaymakers, Bas W, Experimentele klinische fysica, Cancer, Klinische Fysica RT, MS Radiotherapie, Onderzoek Radiotherapie, Kleijnen, Jean-Paul J E, van Asselen, Bram, Intven, Martijn, Burbach, Johannes P M, Philippens, Marielle E P, Lagendijk, Jan J W, and Raaymakers, Bas W

Published
2018

7. GTV delineation in supraglottic laryngeal carcinoma: interobserver agreement of CT versus CT-MR delineation

Author

MS Radiotherapie, Fysica Radiotherapie Research, Klinische Fysica RT, Cancer, MS Radiologie, Jager, Elise Anne, Kasperts, Nicolien, Caldas Magalhaes, Joana, Philippens, Marielle E. P., Pameijer, Frank A., Terhaard, Chris H. J., Raaijmakers, Cornelis P. J., MS Radiotherapie, Fysica Radiotherapie Research, Klinische Fysica RT, Cancer, MS Radiologie, Jager, Elise Anne, Kasperts, Nicolien, Caldas Magalhaes, Joana, Philippens, Marielle E. P., Pameijer, Frank A., Terhaard, Chris H. J., and Raaijmakers, Cornelis P. J.

Published
2015

8. MRI and CT imaging for preoperative target volume delineation in breast-conserving therapy

Author

den Hartogh, Mariska D, Philippens, Marielle E P, van Dam, Iris E, Kleynen, Catharina E, Tersteeg, Robbert J H A, Pijnappel, Ruud M, Kotte, Alexis N T J, Verkooijen, Helena M, van den Bosch, Maurice A A J, van Vulpen, Marco, van Asselen, Bram, van den Bongard, Hjg Desirée, den Hartogh, Mariska D, Philippens, Marielle E P, van Dam, Iris E, Kleynen, Catharina E, Tersteeg, Robbert J H A, Pijnappel, Ruud M, Kotte, Alexis N T J, Verkooijen, Helena M, van den Bosch, Maurice A A J, van Vulpen, Marco, van Asselen, Bram, and van den Bongard, Hjg Desirée

Published
2014

9. MRI and CT imaging for preoperative target volume delineation in breast-conserving therapy

Author

Arts-assistenten Radiotherapie, Cancer, MS Radiotherapie, Other research (not in main researchprogram), MS Radiologie, Klinische Fysica RT, Trialbureau Beeld, Circulatory Health, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Divisie Beeld & Oncologie, Radiotherapie, den Hartogh, Mariska D, Philippens, Marielle E P, van Dam, Iris E, Kleynen, Catharina E, Tersteeg, Robbert J H A, Pijnappel, Ruud M, Kotte, Alexis N T J, Verkooijen, Helena M, van den Bosch, Maurice A A J, van Vulpen, Marco, van Asselen, Bram, van den Bongard, Hjg Desirée, Arts-assistenten Radiotherapie, Cancer, MS Radiotherapie, Other research (not in main researchprogram), MS Radiologie, Klinische Fysica RT, Trialbureau Beeld, Circulatory Health, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Divisie Beeld & Oncologie, Radiotherapie, den Hartogh, Mariska D, Philippens, Marielle E P, van Dam, Iris E, Kleynen, Catharina E, Tersteeg, Robbert J H A, Pijnappel, Ruud M, Kotte, Alexis N T J, Verkooijen, Helena M, van den Bosch, Maurice A A J, van Vulpen, Marco, van Asselen, Bram, and van den Bongard, Hjg Desirée

Published
2014

10. Consequences of tumor planning target volume reduction in treatment of T2-T4 laryngeal cancer.

Author

Vugts, Cornelia A. J. M., Terhaard, Chris H. J., Philippens, Marielle E. P., Pameijer, Frank A., Kasperts, Nicolien, and Raaijmakers, Cornelis P. J.

Abstract

Background and purpose: Since lymph nodes volumes are generally four times the volume of the primary PTV, the advantage of using tight margins around the primary PTV is not clear. Therefore treatment margins of T2-T4 laryngeal carcinoma for IMRT are generally chosen in such a way that the PTV is comparable to that in conventional radiotherapy. The aim of this study is to quantify the effect of volume reduction of the primary PTV of T2-T4 laryngeal carcinoma with regard to late toxicity despite elective irradiation of lymph node levels II to IV. Methods: Two treatment plans based on conservative (GTV-PTV = 15 mm and 20 mm cranial), and on evidence-based tight margins (GTV-PTV = 8 mm) were calculated for 16 patients. Toxicity effects were estimated based on the dose distributions. Results: Compared to conservative margins, using tight margins resulted in: 1) significant reduction of the normal tissue complication probability (NTCP) for swallowing muscles and submandibular glands, 2) significant reduction of the mean dose in all organs at risk (OAR), 3) a mean dose smaller than 60 Gy for all OARs except for the laryngeal cartilages. When the lymph node levels II to IV were prescribed with an elective dose, an NTCP reduction of 53% for the swallowing muscles and of 23% for the submandibular glands was found by using tight instead of conservative margins. When positive nodes were present, NTCP reduction amounted to 29% and 15%, respectively. Conclusions: There is a potential benefit in realizing evidence-based tight margins for laryngeal cancer patients despite elective irradiation of lymph node levels II to IV. [ABSTRACT FROM AUTHOR]

Published
2014
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11. MRI and CT imaging for preoperative target volume delineation in breast-conserving therapy.

Author

den Hartogh, Mariska D., Philippens, Marielle E. P., van Dam, Iris E., Kleynen, Catharina E., Tersteeg, Robbert J. H. A., Pijnappel, Ruud M., Kotte, Alexis N. T. J., Verkooijen, Helena M., van den Bosch, Maurice A. A. J., van Vulpen, Marco, van Asselen, Bram, and van den Bongard, H. J. G. Desirée

Subjects
*MAGNETIC resonance imaging, *LUMPECTOMY, *RADIOTHERAPY treatment planning, *COMPUTED tomography, *ONCOLOGISTS, *TUMORS, *PHYSIOLOGY
Abstract

Background Accurate tumor bed delineation after breast-conserving surgery is important. However, consistency among observers on standard postoperative radiotherapy planning CT is low and volumes can be large due to seroma formation. A preoperative delineation of the tumor might be more consistent. Therefore, the purpose of this study was to determine the consistency of preoperative target volume delineation on CT and MRI for breast-conserving radiotherapy. Methods Tumors were delineated on preoperative contrast-enhanced (CE) CT and newly developed 3D CE-MR images, by four breast radiation oncologists. Clinical target volumes (CTVs) were created by addition of a 1.5 cm margin around the tumor, excluding skin and chest wall. Consistency in target volume delineation was expressed by the interobserver variability. Therefore, the conformity index (CI), centre of mass distance (dCOM) and volumes were calculated. Tumor characteristics on CT and MRI were scored by an experienced breast radiologist. Results Preoperative tumor delineation resulted in a high interobserver agreement with a high median CI for the CTV, for both CT (0.80) and MRI (0.84). The tumor was missed on CT in 2/14 patients (14%). Leaving these 2 patients out of the analysis, CI was higher on MRI compared to CT for the GTV (p < 0.001) while not for the CTV (CT (0.82) versus MRI (0.84), p = 0.123). The dCOM did not differ between CT and MRI. The median CTV was 48 cm³ (range 28-137 cm³) on CT and 59 cm³ (range 30-153 cm³) on MRI (p < 0.001). Tumor shapes and margins were rated as more irregular and spiculated on CE-MRI. Conclusions This study showed that preoperative target volume delineation resulted in small target volumes with a high consistency among observers. MRI appeared to be necessary for tumor detection and the visualization of irregularities and spiculations. Regarding the tumor delineation itself, no clinically relevant differences in interobserver variability were observed. These results will be used to study the potential for future MRI-guided and neoadjuvant radiotherapy. Trial registration International Clinical Trials Registry Platform NTR3198 [ABSTRACT FROM AUTHOR]

Published
2014
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