1. PW01-001 – Pyrin-PSTPIP1 relation during cell migration
- Author
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ZY Akkaya, Engin Yilmaz, Nuhan Purali, Banu Balci-Peynircioglu, and Arda Cetinkaya
- Subjects
business.industry ,Familial Mediterranean fever ,Cell migration ,macromolecular substances ,Gene mutation ,MEFV ,Bioinformatics ,medicine.disease ,Pyrin domain ,Cell biology ,Rheumatology ,Pediatrics, Perinatology and Child Health ,Meeting Abstract ,medicine ,Immunology and Allergy ,Pediatrics, Perinatology, and Child Health ,NEUTROPHIL MIGRATION ,business ,Gene ,Actin - Abstract
MEFV (MEditerranien FeVer) gene mutations cause Familial Mediterranean Fever (FMF). This gene encodes a protein termed as Pyrin, which appears to play an important role in the inflammatory pathways. It is far characterized that Pyrin, which is expressed in neutrophils, interacts with PSTPIP1 and actin proteins. In previous studies PSTPIP1 has been shown to interact with cell migration proteins and actin polymerization is a main force driving neutrophil migration. Therefore, we hypothesized that Pyrin can play role in cell migration through the interaction with actin and PSTPIP1.
- Published
- 2013