6 results on '"Ming Qiao"'
Search Results
2. Effects of intensity of electroacupuncture on chronic pain in patients with knee osteoarthritis: a randomized controlled trial
- Author
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Lv, Zheng-tao, Shen, Lin-lin, Zhu, Bing, Zhang, Zhao-qing, Ma, Chao-yang, Huang, Guo-fu, Yin, Jing, Yu, Ling-ling, Yu, Si-yi, Ding, Ming-qiao, Li, Jing, Yuan, Xiao-cui, He, Wei, Jing, Xiang-hong, and Li, Man
- Published
- 2019
- Full Text
- View/download PDF
3. Bone marrow derived mesenchymal stem cells pretreated with erythropoietin accelerate the repair of acute kidney injury
- Author
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Ding Liu, Jianmin Hu, Liuyang Li, Min Li, Yu-ming Qiao, Ming Zhao, Ying Guo, Li-pei Fan, Jun Liao, Yong-guang Liu, and Song Zhou
- Subjects
lcsh:Biotechnology ,Bone marrow derived mesenchymal stem cells ,Pharmacology ,General Biochemistry, Genetics and Molecular Biology ,lcsh:Biochemistry ,SIRT1 ,stomatognathic system ,lcsh:TP248.13-248.65 ,Medicine ,lcsh:QD415-436 ,lcsh:QH301-705.5 ,Blood urea nitrogen ,Erythropoietin ,Kidney ,business.industry ,Research ,Mesenchymal stem cell ,Acute kidney injury ,Lung entrapment ,hemic and immune systems ,medicine.disease ,medicine.anatomical_structure ,lcsh:Biology (General) ,Apoptosis ,Bone marrow ,Stem cell ,business ,medicine.drug - Abstract
Background Mesenchymal stem cells (MSCs) represent a promising treatment option for acute kidney injury (AKI). The main drawbacks of MSCs therapy, including the lack of specific homing after systemic infusion and early cell death in the inflammatory microenvironment, directly affect the therapeutic efficacy of MSCs. Erythropoietin (EPO)-preconditioning of MSCs promotes their therapeutic effect, however, the underlying mechanism remains unknown. In this study, we sought to investigate the efficacy and mechanism of EPO in bone marrow derived mesenchymal stem cells (BMSCs) for AKI treatment. Results We found that incubation of BMSCs with ischemia/reperfusion(I/R)-induced AKI kidney homogenate supernatant (KHS) caused apoptosis in BMSCs, which was decreased by EPO pretreatment, indicating that EPO protected the cells from apoptosis. Further, we showed that EPO up-regulated silent information regulator 1 (SIRT1) and Bcl-2 expression and down-regulated p53 expression. This effect was partially reversed by SIRT1 siRNA intervention. The anti-apoptotic effect of EPO in pretreated BMSCs may be mediated through the SIRT1 pathway. In a rat AKI model, 24 h after intravenous infusion, GFP-BMSCs were predominantly located in the lungs. However, EPO pretreatment reduced the lung entrapment of BMSCs and increased their distribution in the target organs. AKI rats infused with EPO-BMSCs had significantly lower levels of serum IL-1β and TNF-α, and a significantly higher level of IL-10 as compared to rats infused with untreated BMSCs. The administration of EPO-BMSCs after reperfusion reduced serum creatinine, blood urea nitrogen, and pathological scores in I/R-AKI rats more effectively than BMSCs treatment did. Conclusions Our data suggest that EPO pretreatment enhances the efficacy of BMSCs to improve the renal function and pathological presentation of I/R-AKI rats.
- Published
- 2020
4. Effects of intensity of electroacupuncture on chronic pain in patients with knee osteoarthritis: a randomized controlled trial
- Author
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Chao-yang Ma, Ming-qiao Ding, Xiao-Cui Yuan, Man Li, Ling-ling Yu, Zhao-qing Zhang, Lin lin Shen, Xiang-Hong Jing, Zheng-tao Lv, Guo-fu Huang, Wei He, Jing Yin, Bing Zhu, Siyi Yu, and Jing Li
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,WOMAC ,lcsh:Diseases of the musculoskeletal system ,Visual analogue scale ,Electroacupuncture ,medicine.medical_treatment ,Pain ,Osteoarthritis ,Diffuse noxious inhibitory control ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Humans ,Aged ,030203 arthritis & rheumatology ,business.industry ,Chronic pain ,Middle Aged ,Osteoarthritis, Knee ,medicine.disease ,Rheumatology ,Clinical trial ,030104 developmental biology ,Treatment Outcome ,Anesthesia ,Female ,Knee osteoarthritis ,lcsh:RC925-935 ,Chronic Pain ,business ,human activities ,Research Article - Abstract
Background Conditioned pain modulation (CPM) is impaired in people with chronic pain such as knee osteoarthritis (KOA). The purpose of this randomized, controlled clinical trial was to investigate whether strong electroacupuncture (EA) was more effective on chronic pain by strengthening the CPM function than weak EA or sham EA in patients with KOA. Methods In this multicenter, three-arm parallel, single-blind randomized controlled trial, 301 patients with KOA were randomly assigned. Patients were randomized into three groups based on EA current intensity: strong EA (> 2 mA), weak EA (
- Published
- 2019
5. Electroacupuncture inhibits chronification of the acute pain of knee osteoarthritis: study protocol for a randomized controlled trial.
- Author
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Lin-lin Shen, Guo-fu Huang, Wen Tian, Ling-ling Yu, Xiao-cui Yuan, Zhao-qing Zhang, Jing Yin, Chao-yang Ma, Guo-wei Cai, Jian-wu Li, Ming-qiao Ding, Wei He, Xin-yan Gao, Bing Zhu, Xiang-hong Jing, and Man Li
- Subjects
ELECTROACUPUNCTURE ,PAIN ,OSTEOARTHRITIS ,RESEARCH protocols ,CLINICAL trials - Abstract
Background: Previous studies have shown that electroacupuncture (EA) has a significant effect on acute pain, but it has not solved the clinical problem of the chronification of acute pain. Diffuse noxious inhibitory controls (DNIC) function as a reliable indicator to predict the risk of chronic pain events. DNIC function in knee osteoarthritis (KOA) patients has been demonstrated to gradually decrease during the development of chronic pain. The purpose of this study is to conduct a randomized, controlled clinical trial to determine if EA can repair impaired DNIC function and thus prevent chronification of the acute pain of KOA. Methods/Design: This is a multicenter, single blind, randomized, controlled, three-arm, large-scale clinical trial. A total of 450 KOA patients will be randomly assigned to three groups. The strong EA group will receive EA with high-intensity current (2 mA < current < 5 mA) at the ipsilateral 'Neixiyan' (EX-LE5), 'Dubi'(ST35), 'Liangqiu'(ST34) and 'Xuehai' (SP10). The weak EA group will receive EA with low-intensity current (0 mA < current < 0.5 mA) on the same acupoints. The sham EA group will receive EA with low-intensity current (0 mA < current < 0.5 mA) with fine needles inserted superficially into the sites 2 cm lateral to the above acupoints. The patients will be treated with EA once a day, 30 minutes per session, in 5 sessions per week, for 2 weeks. In order to determine the best stage of KOA for effective EA intervention, patients within the treatment groups also will be divided into four stages. The primary outcomes are Visual Analog Scale (VAS), DNIC function and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Clinical assessments will be evaluated at baseline (before treatment) and after 5 to 10 sessions of treatment. Discussion: This trial will be helpful in identifying whether strong EA is more effective than weak EA in reversing chronification of acute pain through repairing the impaired DNIC function and in screening for the best stage of KOA for effective EA intervention. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
6. Electroacupuncture inhibits chronification of the acute pain of knee osteoarthritis: study protocol for a randomized controlled trial.
- Author
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Shen, Lin-Lin, Huang, Guo-Fu, Tian, Wen, Yu, Ling-Ling, Yuan, Xiao-Cui, Zhang, Zhao-Qing, Yin, Jing, Ma, Chao-Yang, Cai, Guo-Wei, Li, Jian-Wu, Ding, Ming-Qiao, He, Wei, Gao, Xin-Yan, Zhu, Bing, Jing, Xiang-Hong, and Li, Man
- Abstract
Background: Previous studies have shown that electroacupuncture (EA) has a significant effect on acute pain, but it has not solved the clinical problem of the chronification of acute pain. Diffuse noxious inhibitory controls (DNIC) function as a reliable indicator to predict the risk of chronic pain events. DNIC function in knee osteoarthritis (KOA) patients has been demonstrated to gradually decrease during the development of chronic pain. The purpose of this study is to conduct a randomized, controlled clinical trial to determine if EA can repair impaired DNIC function and thus prevent chronification of the acute pain of KOA.Methods/design: This is a multicenter, single blind, randomized, controlled, three-arm, large-scale clinical trial. A total of 450 KOA patients will be randomly assigned to three groups. The strong EA group will receive EA with high-intensity current (2 mA < current < 5 mA) at the ipsilateral 'Neixiyan' (EX-LE5), 'Dubi'(ST35), 'Liangqiu'(ST34) and 'Xuehai' (SP10). The weak EA group will receive EA with low-intensity current (0 mA < current < 0.5 mA) on the same acupoints. The sham EA group will receive EA with low-intensity current (0 mA < current < 0.5 mA) with fine needles inserted superficially into the sites 2 cm lateral to the above acupoints. The patients will be treated with EA once a day, 30 minutes per session, in 5 sessions per week, for 2 weeks. In order to determine the best stage of KOA for effective EA intervention, patients within the treatment groups also will be divided into four stages. The primary outcomes are Visual Analog Scale (VAS), DNIC function and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Clinical assessments will be evaluated at baseline (before treatment) and after 5 to 10 sessions of treatment.Discussion: This trial will be helpful in identifying whether strong EA is more effective than weak EA in reversing chronification of acute pain through repairing the impaired DNIC function and in screening for the best stage of KOA for effective EA intervention.Trial Registration: Chinese Clinical Trial Registry Number: ChiCTR-ICR-14005411. The date of registration is 31 October 2014. [ABSTRACT FROM AUTHOR]- Published
- 2015
- Full Text
- View/download PDF
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