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Your search keyword '"Michelle Connole"' showing total 1 results
Start Over Author "Michelle Connole" Publisher biomed central
1 results on '"Michelle Connole"'

1. Maturation of protective immunity induced by SIVΔnef correlates with differential expression of transcription factors in SIV-specific CD8+ T cells

Author

James M. Billingsley, Wenjun Li, Nadine C. Salisch, Henoch S. Hong, R P Johnson, Premeela A. Rajakumar, Yury V. Kuzmichev, Roger Keith Reeves, Michelle Connole, and H Kang

Subjects
lcsh:Immunologic diseases. Allergy, biology, business.industry, animal diseases, T cell, virus diseases, chemical and pharmacologic phenomena, C-C chemokine receptor type 7, Bioinformatics, medicine.anatomical_structure, Infectious Diseases, Downregulation and upregulation, Virology, Immunology, Poster Presentation, biology.protein, Medicine, Cytotoxic T cell, Antibody, business, Interleukin-7 receptor, lcsh:RC581-607, Transcription factor, CD8
Abstract

Background Protective immunity against vaginal challenge in SIVΔnef-vaccinated macaques develops at 20 weeks after vaccination, whereas the magnitude of SIV-specific CD8+ T cell responses peaks at 5 weeks. SIV-specific CD8+ T cells phenotypically mature from week 5 to 20, as characterized by upregulation of CCR7 and CD127, suggesting that the quality of the CD8+ T cell response may correlate with protection.

Published
2012

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