1. Molecular mechanisms involved in HIV latency and implications for HIV treatment and eradication
- Author
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Mayte Coiras, Mayte Pérez-Olmeda, José Alcamí, and María Rosa López-Huertas
- Subjects
business.industry ,Latent Reservoir ,Human immunodeficiency virus (HIV) ,Invited Speaker Presentation ,Cellular Element ,Computational biology ,Bioinformatics ,medicine.disease_cause ,Viral miRNAs ,Chromatin ,Infectious Diseases ,Virology ,Medicine ,Current Treatment Strategy ,Viral integration ,Gene Expression Program ,Latency (engineering) ,Hiv treatment ,business - Abstract
Methods For years, the molecular mechanisms leading to HIV-1 reactivation have been characterised in detail but the study of latency has remained elusive due to the technical limitations that arise when a negative phenomenon, like the absence of replication, is studied. Development of new techniques for studying HIV-1 latency, the identification of factors that restrict retroviral infections, the characterisation of chromatin structure in the setting of viral integration, and the discovery of new systems regulating gene expression
- Published
- 2010