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Your search keyword '"Marco Salmoiraghi"' showing total 3 results
Start Over Author "Marco Salmoiraghi" Publisher biomed central
3 results on '"Marco Salmoiraghi"'

1. Risk factors associated with severe hospital burden of COVID-19 disease in Regione Lombardia: a cohort study

Author

Anne M. Presanis, Giacomo Grasselli, Christopher Jackson, Maria Gramegna, Kevin Kunzmann, Alice Corbella, Marco Salmoiraghi, Daniela De Angelis, Francesca Maria Grosso, Danilo Cereda, Apollo - University of Cambridge Repository, Presanis, Anne [0000-0003-3078-4427], Jackson, Christopher [0000-0002-6656-8913], and De Angelis, Daniela [0000-0001-6619-6112]

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Population, Hospital-fatality risk, Infectious and parasitic diseases, RC109-216, Disease, Cohort Studies, Public health surveillance, Risk Factors, Health care, Medicine, Humans, education, Mixture model, education.field_of_study, business.industry, SARS-CoV-2, Research, COVID-19, Odds ratio, Multi-state model, Length of Stay, Hospitals, Intensive Care Units, Critical care, Infectious Diseases, Tropical medicine, Emergency medicine, Communicable Disease Control, business, RA, Cohort study
Abstract

BackgroundUnderstanding the risk factors associated with hospital burden of COVID-19 is crucial for healthcare planning for any future waves of infection.MethodsAn observational cohort study is performed, using data on all PCR-confirmed cases of COVID-19 in Regione Lombardia, Italy, during the first wave of infection from February-June 2020. A multi-state modelling approach is used to simultaneously estimate risks of progression through hospital to final outcomes of either death or discharge, by pathway (via critical care or not) and the times to final events (lengths of stay). Logistic and time-to-event regressions are used to quantify the association of patient and population characteristics with the risks of hospital outcomes and lengths of stay respectively.ResultsRisks of severe outcomes such as ICU admission and mortality have decreased with month of admission (for example, the odds ratio of ICU admission in June vs March is 0.247 [0.120–0.508]) and increased with age (odds ratio of ICU admission in 45–65 vs 65 + age group is 0.286 [0.201–0.406]). Care home residents aged 65 + are associated with increased risk of hospital mortality and decreased risk of ICU admission. Being a healthcare worker appears to have a protective association with mortality risk (odds ratio of ICU mortality is 0.254 [0.143–0.453] relative to non-healthcare workers) and length of stay. Lengths of stay decrease with month of admission for survivors, but do not appear to vary with month for non-survivors.ConclusionsImprovements in clinical knowledge, treatment, patient and hospital management and public health surveillance, together with the waning of the first wave after the first lockdown, are hypothesised to have contributed to the reduced risks and lengths of stay over time.

Published
2021

2. Decreasing hospital burden of COVID-19 during the first wave in Regione Lombardia: an emergency measures context.

Author

Grosso, Francesca Maria, Presanis, Anne Margaret, Kunzmann, Kevin, Jackson, Chris, Corbella, Alice, Grasselli, Giacomo, Andreassi, Aida, Bodina, Annalisa, Gramegna, Maria, Castaldi, Silvana, Cereda, Danilo, Angelis, Daniela De, Covid-19 Lombardy Working Group, Ambra, Castrofino, Gabriele, Del Castillo, Lucia, Crottogini, Marcello, Tirani, Alberto, Zanella, and Marco, Salmoiraghi

Subjects
CORONAVIRUS diseases, HOSPITAL patients, LENGTH of stay in hospitals, HOSPITAL beds, SARS disease
Abstract

Background: The aim of this study is to quantify the hospital burden of COVID-19 during the first wave and how it changed over calendar time; to interpret the results in light of the emergency measures introduced to manage the strain on secondary healthcare. Methods: This is a cohort study of hospitalised confirmed cases of COVID-19 admitted from February–June 2020 and followed up till 17th July 2020, analysed using a mixture multi-state model. All hospital patients with confirmed COVID-19 disease in Regione Lombardia were involved, admitted from February–June 2020, with non-missing hospital of admission and non-missing admission date. Results: The cohort consists of 40,550 patients hospitalised during the first wave. These patients had a median age of 69 (interquartile range 56–80) and were more likely to be men (60%) than women (40%). The hospital-fatality risk, averaged over all pathways through hospital, was 27.5% (95% CI 27.1–28.0%); and steadily decreased from 34.6% (32.5–36.6%) in February to 7.6% (6.3–10.6%) in June. Among surviving patients, median length of stay in hospital was 11.8 (11.6–12.3) days, compared to 8.1 (7.8–8.5) days in non-survivors. Averaged over final outcomes, median length of stay in hospital decreased from 21.4 (20.5–22.8) days in February to 5.2 (4.7–5.8) days in June. Conclusions: The hospital burden, in terms of both risks of poor outcomes and lengths of stay in hospital, has been demonstrated to have decreased over the months of the first wave, perhaps reflecting improved treatment and management of COVID-19 cases, as well as reduced burden as the first wave waned. The quantified burden allows for planning of hospital beds needed for current and future waves of SARS-CoV-2 i. [ABSTRACT FROM AUTHOR]

Published
2021
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3. Decreasing hospital burden of COVID-19 during the first wave in Regione Lombardia: an emergency measures context.

Author

Maria, Grosso Francesca, Margaret, Presanis Anne, Kevin, Kunzmann, Chris, Jackson, Alice, Corbella, Giacomo, Grasselli, Aida, Andreassi, Annalisa, Bodina, Maria, Gramegna, Silvana, Castaldi, Danilo, Cereda, Daniela, De Angelis, Covid-19 Lombardy Working Group, Ambra, Castrofino, Gabriele, Del Castillo, Lucia, Crottogini, Marcello, Tirani, Alberto, Zanella, and Marco, Salmoiraghi

Subjects
COVID-19, MEDICAL care, HOSPITAL admission & discharge, HOSPITALS, SARS-CoV-2
Abstract

Background: The aim of this study is to quantify the hospital burden of COVID-19 during the first wave and how it changed over calendar time; to interpret the results in light of the emergency measures introduced to manage the strain on secondary healthcare.Methods: This is a cohort study of hospitalised confirmed cases of COVID-19 admitted from February-June 2020 and followed up till 17th July 2020, analysed using a mixture multi-state model. All hospital patients with confirmed COVID-19 disease in Regione Lombardia were involved, admitted from February-June 2020, with non-missing hospital of admission and non-missing admission date.Results: The cohort consists of 40,550 patients hospitalised during the first wave. These patients had a median age of 69 (interquartile range 56-80) and were more likely to be men (60%) than women (40%). The hospital-fatality risk, averaged over all pathways through hospital, was 27.5% (95% CI 27.1-28.0%); and steadily decreased from 34.6% (32.5-36.6%) in February to 7.6% (6.3-10.6%) in June. Among surviving patients, median length of stay in hospital was 11.8 (11.6-12.3) days, compared to 8.1 (7.8-8.5) days in non-survivors. Averaged over final outcomes, median length of stay in hospital decreased from 21.4 (20.5-22.8) days in February to 5.2 (4.7-5.8) days in June.Conclusions: The hospital burden, in terms of both risks of poor outcomes and lengths of stay in hospital, has been demonstrated to have decreased over the months of the first wave, perhaps reflecting improved treatment and management of COVID-19 cases, as well as reduced burden as the first wave waned. The quantified burden allows for planning of hospital beds needed for current and future waves of SARS-CoV-2 i. [ABSTRACT FROM AUTHOR]

Published
2021
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