1. Opioid-sparing anesthesia with dexmedetomidine provides stable hemodynamic and short hospital stay in non-intubated video-assisted thoracoscopic surgery: a propensity score matching cohort study.
- Author
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Ke HH, Liou JY, Teng WN, Hsu PK, Tsou MY, Chang WK, and Ting CK
- Subjects
- Humans, Thoracic Surgery, Video-Assisted methods, Analgesics, Opioid therapeutic use, Retrospective Studies, Cohort Studies, Postoperative Nausea and Vomiting drug therapy, Length of Stay, Propensity Score, Dizziness drug therapy, Dizziness etiology, Pain, Postoperative drug therapy, Pain, Postoperative etiology, Hemodynamics, Dyspnea drug therapy, Dyspnea etiology, Dexmedetomidine therapeutic use, Anesthesia, Respiratory Insufficiency etiology
- Abstract
Objectives: Dexmedetomidine is an alpha-2 agonist with anti-anxiety, sedative, and analgesic effects and causes a lesser degree of respiratory depression. We hypothesized that the use of dexmedetomidine in non-intubated video-assisted thoracic surgery (VATS) may reduce opioid-related complications such as postoperative nausea and vomiting (PONV), dyspnea, constipation, dizziness, skin itching, and cause minimal respiratory depression, and stable hemodynamic status., Methods: Patients who underwent non-intubated VATS lung wedge resection with propofol combined with dexmedetomidine (group D) or alfentanil (group O) between December 2016 and May 2022 were enrolled in this retrospective propensity score matching cohort study. Intraoperative vital signs, arterial blood gas data, perioperative results and treatment outcomes were analyzed. Of 100 patients included in the study (group D, 50 and group O, 50 patients), group D had a significantly lower degree of decrement in the heart rate and the blood pressure than group O. Intraoperative one-lung arterial blood gas revealed lower pH and significant ETCO
2 . The common opioid-related side effects, including PONV, dyspnea, constipation, dizziness, and skin itching, all of which occurred more frequently in group O than in group D. Patients in group O had significantly longer postoperative hospital stay and total hospital stay than group D, which might be due to opioid-related side effects postoperatively., Conclusions: The application of dexmedetomidine in non-intubated VATS resulted in a significant reduction in perioperative opioid-related complications and maintenance with acceptable hemodynamic performance. These clinical outcomes found in our retrospective study may enhance patient satisfaction and shorten the hospital stay., (© 2023. The Author(s).)- Published
- 2023
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