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Your search keyword '"Liesz, Arthur"' showing total 6 results
Start Over Author "Liesz, Arthur" Publisher biomed central
6 results on '"Liesz, Arthur"'

1. Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease

Author

Zatcepin, Artem, Gnörich, Johannes, Rauchmann, Boris-Stephan, Bartos, Laura M., Wagner, Stephan, Franzmeier, Nicolai, Malpetti, Maura, Xiang, Xianyuan, Shi, Yuan, Parhizkar, Samira, Grosch, Maximilian, Wind-Mark, Karin, Kunte, Sebastian T., Beyer, Leonie, Meyer, Carolin, Brösamle, Desirée, Wendeln, Ann-Christin, Osei-Sarpong, Collins, Heindl, Steffanie, Liesz, Arthur, Stoecklein, Sophia, Biechele, Gloria, Finze, Anika, Eckenweber, Florian, Lindner, Simon, Rominger, Axel, Bartenstein, Peter, Willem, Michael, Tahirovic, Sabina, Herms, Jochen, Buerger, Katharina, Simons, Mikael, Haass, Christian, Rupprecht, Rainer, Riemenschneider, Markus J., Albert, Nathalie L., Beyer, Marc, Neher, Jonas J., Paeger, Lars, Levin, Johannes, Höglinger, Günter U., Perneczky, Robert, Ziegler, Sibylle I., and Brendel, Matthias

Published
2024
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3. Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo

Author

Riemenschneider, Henrick, Simonetti, Francesca, Sheth, Udit, Katona, Eszter, Roth, Stefan, Hutten, Saskia, Farny, Daniel, Michaelsen, Meike, Nuscher, Brigitte, Schmidt, Michael K., Flatley, Andrew, Schepers, Aloys, Gruijs da Silva, Lara A., Zhou, Qihui, Klopstock, Thomas, Liesz, Arthur, Arzberger, Thomas, Herms, Jochen, Feederle, Regina, Gendron, Tania F., Dormann, Dorothee, and Edbauer, Dieter

Published
2023
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6. Comparison of humoral neuroinflammation and adhesion molecule expression in two models of experimental intracerebral hemorrhage.

Author

Liesz A, Middelhoff M, Zhou W, Karcher S, Illanes S, and Veltkamp R

Abstract

Background: Inflammatory cascades contribute to secondary injury after intracerebral hemorrhage (ICH) via humoral factors and cell-mediated cytotoxicity. Several experimental models were previously developed to analyze post-hemorrhagic neuroinflammation. However, neuroinflammatory markers have not been compared face-to-face between these models so far, and therefore, pathophysiological conclusions drawn from only one individual model may not be valid., Methods: We compared neuroinflammatory pathways in the two most common murine models: striatal injection of autologous blood or collagenase. Expression of pro- and anti-inflammatory cytokines (IL-1, TNF-α, IFN-γ, IL-6, TGF-β and IL-10) as well adhesion molecule expression (VCAM-1, ICAM-1) was analyzed by RT-PCR at several time points after ICH induction. Outcome and physiological parameters were compared between the models., Results: Both models induced a profound and dynamic increase in the expression of pro-inflammatory cytokines and adhesion molecules. However, blood injection resulted in significantly more pronounced alteration of these markers than collagenase injection. This difference was associated with worse outcome after blood injection compared to the collagenase model despite equal ICH volumes., Conclusions: This is the first study performing a face-to-face comparison of neuroinflammatory pathways in the two most widely used murine ICH models, revealing substantial differences between the models. This discrepancies need to be taken into account in designing future studies employing experimental ICH models, especially when analyzing neuroinflammatory pathways and therapies.

Published
2011
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