1. Effect of long-term aluminum feeding on lipid/phospholipid profiles of rat brain myelin
- Author
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Dave Kunjan R, Pandya Jignesh D, and Katyare Surendra S
- Subjects
lcsh:Nutritional diseases. Deficiency diseases ,Aluminum neurotoxicity ,Research ,Aluminum and myelin lipid ,lipids (amino acids, peptides, and proteins) ,phospholipid profiles ,Alzheimer's disease ,lcsh:RC620-627 ,Aluminum in Alzheimer etiology - Abstract
Effect of long-term (90โ100 days) exposure of rats to soluble salt of aluminum (AlCl3) on myelin lipid profile was examined. The long-term exposure to AlCl3 resulted in a 60 % decrease in the total phospholipid (TPL) content while the cholesterol (CHL) content increased by 55 %. Consequently the TPL / CHL molar ratio decreased significantly by 62 %. The phospholipid composition of the myelin membrane changed drastically; the proportion of practically all the phospholipid classes decreased by 32 to 60 % except for phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Of the latter two, proportion of PC was unchanged while PE increased in proportion by 47 %. Quantitatively, all phospholipid classes decreased by from 42 to 76% with no change in the PE content. However the membrane fluidity was not altered in Al-treated rats. Many of the changes we observe here show striking similarities with the reported phospholipid profiles of Alzheimer brains.
- Published
- 2004