1. Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study
- Author
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Kendrick Co Shih, Alex L K Ng, Loraine L. W. Chow, Johnny C. Y. Chan, and Jimmy S. M. Lai
- Subjects
Adult ,Male ,medicine.medical_specialty ,Eye Diseases ,Patient demographics ,Stevens-Johnson syndrome ,Ocular surface disease ,Severity of Illness Index ,Severe cutaneous adverse reactions ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Ophthalmology ,Prevalence ,Medicine ,Humans ,Retrospective Studies ,business.industry ,Incidence ,Significant difference ,Stevens johnson ,Burn center ,Retrospective cohort study ,Toxic epidermal necrolysis ,General Medicine ,medicine.disease ,Dermatology ,Surgery ,Asians ,Ophthalmology ,stomatognathic diseases ,Cross-Sectional Studies ,lcsh:RE1-994 ,030221 ophthalmology & optometry ,Hong Kong ,Female ,business ,Ocular surface ,Research Article ,Follow-Up Studies ,Forecasting - Abstract
Background Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening conditions that initially affect the skin and mucous membranes. The aim of this study was to compare the acute ocular manifestations between SJS and TEN. Methods The initial presenting ophthalmic records of patients with either SJS ( = 30% involvement), who were treated at one tertiary burn center in Hong Kong between 1999 and 2014, were retrospectively analyzed and compared. Results A total of 20 SJS and 12 TEN cases were included. All were drug-induced. The patient demographics and treatment received were comparable. Overall, 40% of SJS and 75% of TEN patients had acute ocular surface inflammation. When comparing the two groups, there was a significant difference in the number of cases with mild involvement (5% in SJS, 42% in TEN, p = 0.01), while no statistically significant differences were found (p > 0.05) comparing between the moderate (15% in SJS, 0% in TEN) and severe groups (20% in SJS, 33% in TEN). Conclusions Ocular surface inflammation was common during the acute phase in both SJS and TEN. TEN had a significantly higher number of cases with mild ocular involvement when compared with SJS, but no significant difference between the number of moderate and severe cases between the two groups.
- Published
- 2017