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Your search keyword '"JUN SANG BAE"' showing total 2 results
Start Over Author "JUN SANG BAE" Publisher biomed central
2 results on '"JUN SANG BAE"'

1. FAM83H is involved in stabilization of β-catenin and progression of osteosarcomas

Author

Ho Sung Park, Woo Sung Moon, Sang Hoon Ha, Yiping Song, See-Hyoung Park, Kyu Yun Jang, Jun Sang Bae, Byung-Hyun Park, Mi Ae Kang, Usama Khamis Hussein, Young Jae Moon, Kyoung Min Kim, Jung Ryul Kim, and Zhongkai Zhang

Subjects
0301 basic medicine, Male, Cancer Research, Cytoplasm, FAM83H, Vimentin, Mice, 0302 clinical medicine, beta Catenin, Osteosarcoma, biology, Chemistry, Protein Stability, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Prognosis, Up-Regulation, Gene Expression Regulation, Neoplastic, Oncology, 030220 oncology & carcinogenesis, Disease Progression, Female, Sarcoma, Adult, Immunoprecipitation, β-Catenin, Bone Neoplasms, lcsh:RC254-282, 03 medical and health sciences, Cyclin D1, Cell Line, Tumor, medicine, Animals, Humans, Neoplasm Invasiveness, Cell Proliferation, Cell Nucleus, Messenger RNA, Research, Ubiquitination, Proteins, medicine.disease, Survival Analysis, 030104 developmental biology, Apoptosis, Tissue Array Analysis, Catenin, Cancer research, biology.protein, Neoplasm Transplantation
Abstract

Background FAM83H was initially identified as a protein essential for dental enamel formation. Recent reports have shown that FAM83H is also involved in the progression of human cancers in conjunction with tumor-associated molecules, such as MYC and β-catenin. However, the role of FAM83H in sarcoma has not yet been investigated. Methods The expression and roles of FAM83H and β-catenin were evaluated in human osteosarcomas from 34 patients and osteosarcoma cells. Results The expression of nuclear FAM83H, cytoplasmic FAM83H, and β-catenin were significantly associated with each other and significantly associated with shorter survival of osteosarcoma patients by univariate analysis. In multivariate analysis, cytoplasmic expression of FAM83H was an independent indicator of shorter survival of osteosarcoma patients (overall survival; P

Published
2019

2. Expression of nerve growth factor and heme oxygenase-1 predict poor survival of breast carcinoma patients.

Author

Sang Jae Noh, Jun Sang Bae, Jamiyandorj, Urangoo, Ho Sung Park, Keun Sang Kwon, Sung Hoo Jung, Hyun Jo Youn, Ho Lee, Byung-Hyun Park, Myoung Ja Chung, Woo Sung Moon, Myoung Jae Kang, Kyu Yun Jang, Noh, Sang Jae, Bae, Jun Sang, Park, Ho Sung, Kwon, Keun Sang, Jung, Sung Hoo, Youn, Hyun Jo, and Lee, Ho

Subjects
*NERVE growth factor, *HEME oxygenase, *BREAST cancer prognosis, *IMMUNOHISTOCHEMISTRY, *HISTOPATHOLOGY, *METASTASIS, *MULTIVARIATE analysis, *BREAST tumors, *COMPARATIVE studies, *GENE expression, *RESEARCH methodology, *MEDICAL cooperation, *NERVE tissue proteins, *OXIDOREDUCTASES, *PROGNOSIS, *RESEARCH, *TUMOR classification, *EVALUATION research
Abstract

Background: Nerve growth factor (NGF) is a neurotrophin and has been suggested to induce heme oxygenase-1 (HO1) expression. Although the role of HO1 in tumorigenesis remains controversial, recent evidence suggests NGF and HO1 as tumor-progressing factors. However, the correlative role of NGF and HO1 and their prognostic impact in breast carcinoma is unknown.Methods: We investigated the expression and prognostic significance of the expression of NGF and HO1 in 145 cases of breast carcinoma.Results: Immunohistochemical expression of NGF and HO1 was observed in 31% and 49% of breast carcinoma, respectively. The expression of NGF and HO1 significantly associated with each other, and both have a significant association with histologic grade, HER2 expression, and latent distant metastasis. The expression of NGF and HO1 predicted shorter overall survival of breast carcinoma by univariate and multivariate analysis. NGF expression was an independent prognostic indicator for relapse-free survival by multivariate analysis. The combined expression pattern of NGF and HO1 was also an independent prognostic indicator of overall survival and relapse-free survival. The patients with tumors expressing NGF had the shortest survival and the patients with tumor, which did not express NGF or HO1 showed the longest survival time.Conclusions: This study has demonstrated that individual expression of NGF or HO1, and the combined NGF/HO1 expression pattern could be prognostic indicators for breast carcinoma patients. [ABSTRACT FROM AUTHOR]

Published
2013
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