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Your search keyword '"Isasi, Carmen R"' showing total 13 results
Start Over Author "Isasi, Carmen R" Publisher biomed central
13 results on '"Isasi, Carmen R"'

2. The U.S. COVID-19 County Policy Database: a novel resource to support pandemic-related research

Author

Hamad, Rita, Lyman, Kristin A., Lin, Feng, Modrow, Madelaine F., Ozluk, Pelin, Azar, Kristen M. J., Goodin, Amie, Isasi, Carmen R., Kitzman, Heather E., Knight, Sara J., Marcus, Gregory M., McMahill-Walraven, Cheryl N., Meissner, Paul, Nair, Vinit, O’Brien, Emily C., Olgin, Jeffrey E., Peyser, Noah D., Sylwestrzak, Gosia, Williams, Natasha, Pletcher, Mark J., and Carton, Thomas

Published
2022
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4. Demographic and sociocultural risk factors for adulthood weight gain in Hispanic/Latinos: results from the Hispanic Community Health Study / Study of Latinos (HCHS/SOL)

Author

Fernández-Rhodes, Lindsay, Butera, Nicole M., Lodge, Evans K., Franceschini, Nora, Llabre, Maria M., Arredondo, Elva M., Gallo, Linda C., Arguelles, William, Penedo, Frank J., Daviglus, Martha L., Isasi, Carmen R., Smokowski, Paul, Gordon-Larsen, Penny, Aiello, Allison E., Perreira, Krista M., Sotres-Alvarez, Daniela, and North, Kari E.

Published
2021
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7. Author Correction: Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity

Author

Kaplan, Robert C., Wang, Zheng, Usyk, Mykhaylo, Sotres-Alvarez, Daniela, Daviglus, Martha L., Schneiderman, Neil, Talavera, Gregory A., Gellman, Marc D., Thyagarajan, Bharat, Moon, Jee-Young, Vázquez-Baeza, Yoshiki, McDonald, Daniel, Williams-Nguyen, Jessica S., Wu, Michael C., North, Kari E., Shaffer, Justin, Sollecito, Christopher C., Qi, Qibin, Isasi, Carmen R., Wang, Tao, Knight, Rob, and Burk, Robert D.

Published
2020
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8. Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity

Author

Kaplan, Robert C., Wang, Zheng, Usyk, Mykhaylo, Sotres-Alvarez, Daniela, Daviglus, Martha L., Schneiderman, Neil, Talavera, Gregory A., Gellman, Marc D., Thyagarajan, Bharat, Moon, Jee-Young, Vázquez-Baeza, Yoshiki, McDonald, Daniel, Williams-Nguyen, Jessica S., Wu, Michael C., North, Kari E., Shaffer, Justin, Sollecito, Christopher C., Qi, Qibin, Isasi, Carmen R., Wang, Tao, Knight, Rob, and Burk, Robert D.

Published
2019
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9. Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos

Author

Fernández-Rhodes, Lindsay, Howard, Annie Green, Graff, Mariaelisa, Isasi, Carmen R., Highland, Heather M., Young, Kristin L., Parra, Esteban, Below, Jennifer E., Qi, Qibin, Kaplan, Robert C., Justice, Anne E., Papanicolaou, George, Laurie, Cathy C., Grant, Struan F. A., Haiman, Christopher, Loos, Ruth J. F., and North, Kari E.

Published
2018
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12. Embedding weight management into safety-net pediatric primary care: randomized controlled trial.

Author

Wylie-Rosett, Judith, Groisman-Perelstein, Adriana E., Diamantis, Pamela M., Jimenez, Camille C., Shankar, Viswanathan, Conlon, Beth A., Mossavar-Rahmani, Yasmin, Isasi, Carmen R., Martin, Sarah N., Ginsberg, Mindy, Matthan, Nirupa R., and Lichtenstein, Alice H.

Subjects
AGE distribution, ASPARTATE aminotransferase, BEHAVIOR modification, REGULATION of body weight, CHOLESTEROL, COUNSELING, HISPANIC Americans, LOW density lipoproteins, CHILDHOOD obesity, PEDIATRICIANS, PEDIATRICS, PRIMARY health care, SEX distribution, ALANINE aminotransferase, BODY mass index, LIFESTYLES, RANDOMIZED controlled trials, HUMAN services programs, SAFETY-net health care providers
Abstract

Background: Implementing evidence-based recommendations for treating pediatric overweight and obesity is challenging in low-resource settings. We conducted a randomized controlled trial to evaluate the effects of implementing the American Academy of Pediatrics overweight/obesity recommendations using a Standard Care approach alone or with the addition of an enhanced program in a safety-net pediatric primary care setting (located in Bronx, New York, United States). Methods: In a 12-month trial, families of children (age 7--12 years; body mass index ≥85th American percentile for age and sex; 74% self-identified as Hispanic/Latino; n = 360) were randomly assigned to receive Standard Care Alone or Standard Care + Enhanced Program. An English/Spanish bilingual staff provided the Standard Care Alone consisting of quarterly semi-structured pediatrician visits targeting family-based behavioral changes. The Standard Care + Enhanced Program was enriched with eight Skill-Building Core and monthly Post-Core Support sessions. Results: The mean body mass index Z-score declined in both arms (P < 0.01) with no significant difference between the Standard Care Alone (0.12 kg [SE: 0.03]) and Standard Care + Enhanced Program (0.15 kg [SE: 0.03]) arm (P =0.15). Compared to the Standard Care Alone, the Standard Care + Enhanced Program resulted in significantly greater improvements in total cholesterol (P = 0.05), low-density lipoprotein cholesterol (P = 0.04), aspartate aminotransferase (P =0.02), and alanine transaminase (P = 0.03) concentrations. Conclusions: Safety-net primary care settings can provide efficacious pediatric weight management services. Targeted family-based behavioral counseling helps overweight/obese children achieve a modest body mass index Z-score improvement. A more intensive lifestyle intervention program may improve some metabolic parameters. Trial registration: ClinicalTrials.gov Identifier: NCT00851201. Registered 23 February 2009. [ABSTRACT FROM AUTHOR]

Published
2018
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13. Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos

Author

North, Kari E, Haiman, Christopher, Qi, Qibin, Justice, Anne E, Laurie, Cathy C, Howard, Annie G, Grant, Struan F A, Graff, Mariaelisa, Below, Jennifer E, Loos, Ruth J F, Parra, Esteban, Isasi, Carmen R, Kaplan, Robert C, Fernández-Rhodes, Lindsay, Young, Kristin L, Highland, Heather M, and Papanicolaou, George

Subjects
2. Zero hunger, 3. Good health
Abstract

Background Genome-wide association studies have implicated the transcription factor 7-like 2 (TCF7L2) gene in type 2 diabetes risk, and more recently, in decreased body mass index. Given the contrary direction of genetic effects on these two traits, it has been suggested that the observed association with body mass index may reflect either selection bias or a complex underlying biology at TCF7L2. Methods Using 9031 Hispanic/Latino adults (21–76 years) with complete weight history and genetic data from the community-based Hispanic Community Health Study/Study of Latinos (HCHS/SOL, Baseline 2008–2011), we estimated the multivariable association between the additive number of type 2 diabetes increasing-alleles at TCF7L2 (rs7903146-T) and body mass index. We then used structural equation models to simultaneously model the genetic association on changes in body mass index across the life course and estimate the odds of type 2 diabetes per TCF7L2 risk allele. Results We observed both significant increases in type 2 diabetes prevalence at examination (independent of body mass index) and decreases in mean body mass index and waist circumference across genotypes at rs7903146. We observed a significant multivariable association between the additive number of type 2 diabetes-risk alleles and lower body mass index at examination. In our structured modeling, we observed non-significant inverse direct associations between rs7903146-T and body mass index at ages 21 and 45 years, and a significant positive association between rs7903146-T and type 2 diabetes onset in both middle and late adulthood. Conclusions Herein, we replicated the protective effect of rs7930146-T on body mass index at multiple time points in the life course, and observed that these effects were not explained by past type 2 diabetes status in our structured modeling. The robust replication of the negative effects of TCF7L2 on body mass index in multiple samples, including in our diverse Hispanic/Latino community-based sample, supports a growing body of literature on the complex biologic mechanism underlying the functional consequences of TCF7L2 on obesity and type 2 diabetes across the life course.

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