7 results on '"He, Dandan"'
Search Results
2. Prevalence and molecular characterization of oqxAB in clinical Escherichia coli isolates from companion animals and humans in Henan Province, China
- Author
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Liu, Baoguang, Wu, Hua, Zhai, Yajun, He, Zhipei, Sun, Huarun, Cai, Tian, He, Dandan, Liu, Jianhua, Wang, Shanmei, Pan, Yushan, Yuan, Li, and Hu, Gongzheng
- Published
- 2018
- Full Text
- View/download PDF
3. Prevalence, resistance pattern, and molecular characterization of Staphylococcus aureus isolates from healthy animals and sick populations in Henan Province, China
- Author
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Liu, Baoguang, Sun, Huarun, Pan, Yushan, Zhai, Yajun, Cai, Tian, Yuan, Xiaoling, Gao, Yanling, He, Dandan, Liu, Jianhua, Yuan, Li, and Hu, Gongzheng
- Published
- 2018
- Full Text
- View/download PDF
4. Incidence of breast cancer in Chinese women exposed to the 1959-1961 great Chinese famine.
- Author
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Dandan He, Yuan Fang, Gunter, Marc J., Dongli Xu, Yanping Zhao, Jie Zhou, Hong Fang, Wang Hong Xu, He, Dandan, Fang, Yuan, Xu, Dongli, Zhao, Yanping, Zhou, Jie, Fang, Hong, and Xu, Wang Hong
- Subjects
BREAST cancer patients ,DISEASE incidence ,MALNUTRITION ,CHINESE people ,MEDICAL education ,MEDICAL records ,DISEASES - Abstract
Background: The association of malnutrition in early life with breast cancer risk has been studied in Europe by investigating survivors of the Dutch Hunger Winter Famine, but not in China. We evaluated the effect of exposure to the 1959-1961 Great Leap Forward famine on subsequent breast cancer risk in Chinese women.Methods: A total of 59,060 women born in 1955~1966 were recruited from Minhang district, Shanghai, China, during the period 2008 to 2012. A baseline survey was conducted to collect demographic characteristics and known risk factors for breast cancer. Incident breast cancers were identified by conducting record linkage with the Shanghai Cancer Registry up to June 30, 2015, and confirmed through medical records. Cumulative probabilities of cancer incidence were evaluated after adjusting for age, educational level and other confounders. Cox regression models were applied to estimate the hazard ratios (HR) and 95% confidence intervals (CI) of breast cancer.Results: The overall crude incidence of in situ and invasive breast cancer were 19.2 and 115.0 per 100,000, respectively, in women conceived or born during the famine (1959-1962), slightly higher than those in women born before (1955-1958) (13.2 and 109.8/100,000) and after (1963-1966) (10.4 and 101.5/100,000). Particularly, at age group of 50-52 years when all participants contributed person-year of observations, the age-specific incidence of invasive breast cancer was higher in pre-natal exposed women (123.7/100,000, 95%CI: 94.5-161.9/100,000) than in post-natal exposed (109.6/100,000, 95%CI: 69.1-174.0/100,000) and unexposed women (82.7/100,000, 95%CI: 46.9-145.7/100,000). However, the incidence of cancer in situ was slightly lower in pre-natal exposed women at the age group. Adjusted cumulative probabilities of breast cancer incidence, both in-situ and invasive, were also observed to be higher in women exposed to the famine, however, the difference was not statistically significant.Conclusion: Our results suggest a possible adverse, but limited, impact of exposure to the Great famine on the risk of breast cancer in Chinese women. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
5. Prevalence and molecular characterization of <italic>oqxAB</italic> in clinical <italic>Escherichia coli</italic> isolates from companion animals and humans in Henan Province, China.
- Author
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Liu, Baoguang, Wu, Hua, Zhai, Yajun, He, Zhipei, Sun, Huarun, Cai, Tian, He, Dandan, Liu, Jianhua, Wang, Shanmei, Pan, Yushan, Yuan, Li, and Hu, Gongzheng
- Subjects
ESCHERICHIA coli ,QUINOLONE antibacterial agents ,ANTIBIOTICS - Abstract
Background: The plasmid-encoded multidrug efflux pump
oqxAB confers bacterial resistance primarily to olaquindox, quinolones, and chloramphenicol. The aims of this study were to investigate the prevalence ofoqxAB amongEscherichia coli isolates from dogs, cats, and humans in Henan, China and the susceptibilities ofE. coli isolates to common antibiotics. Methods: From 2012 to 2014, a total of 600 samples which included 400 rectal samples and 200 clinical human specimens were tested for the presence ofE. coli . All isolates were screened foroqxAB genes by PCR and sequencing. The MICs of 11 antimicrobial agents were determined by the broth microdilution method. A total of 30 representativeoqxAB -positive isolates were subjected to ERIC-PCR and MLST. Additionally, conjugation experiments and southern hybridizations were performed. Results: Of 270 isolates, 58.5% (62/106) of the isolates from dogs, 56.25% (36/64) of the isolates from cats, and 42.0% (42/100) of the isolates from humans were positive for theoqxAB . Olaquindox resistance was found for 85.7%-100% ofoqxAB -positive isolates. OfoqxAB -positive isolates from dogs, cats, and humans, ciprofloxacin resistance was inspected for 85.8%, 59.1%, and 93.8%, respectively. SeveraloqxAB -positive isolates were demonstrated by ERIC-PCR and MLST, and have high similarity. Phylogenetic analysis showed thatoqxAB -positive isolates could be divided into 7 major clusters.OqxAB -positive conjugants were obtained, southern hybridization verified that theoqxAB gene complex was primarily located on plasmids. Conclusion: In conclusion,oqxAB -positive isolates were widespread in animals and humans in Henan, China. Carriage ofoqxAB on plasmids ofE. coli isolates may facilitate the emergence of multidrug resistant and its transmission via horizontal transfer, and might pose a potential threat to public health. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
6. Incidence of breast cancer in Chinese women exposed to the 1959-1961 great Chinese famine.
- Author
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He D, Fang Y, Gunter MJ, Xu D, Zhao Y, Zhou J, Fang H, and Xu WH
- Subjects
- China epidemiology, Female, Humans, Incidence, Middle Aged, Proportional Hazards Models, Risk Factors, Breast Neoplasms epidemiology, Carcinoma, Ductal, Breast epidemiology, Carcinoma, Intraductal, Noninfiltrating epidemiology, Starvation
- Abstract
Background: The association of malnutrition in early life with breast cancer risk has been studied in Europe by investigating survivors of the Dutch Hunger Winter Famine, but not in China. We evaluated the effect of exposure to the 1959-1961 Great Leap Forward famine on subsequent breast cancer risk in Chinese women., Methods: A total of 59,060 women born in 1955~1966 were recruited from Minhang district, Shanghai, China, during the period 2008 to 2012. A baseline survey was conducted to collect demographic characteristics and known risk factors for breast cancer. Incident breast cancers were identified by conducting record linkage with the Shanghai Cancer Registry up to June 30, 2015, and confirmed through medical records. Cumulative probabilities of cancer incidence were evaluated after adjusting for age, educational level and other confounders. Cox regression models were applied to estimate the hazard ratios (HR) and 95% confidence intervals (CI) of breast cancer., Results: The overall crude incidence of in situ and invasive breast cancer were 19.2 and 115.0 per 100,000, respectively, in women conceived or born during the famine (1959-1962), slightly higher than those in women born before (1955-1958) (13.2 and 109.8/100,000) and after (1963-1966) (10.4 and 101.5/100,000). Particularly, at age group of 50-52 years when all participants contributed person-year of observations, the age-specific incidence of invasive breast cancer was higher in pre-natal exposed women (123.7/100,000, 95%CI: 94.5-161.9/100,000) than in post-natal exposed (109.6/100,000, 95%CI: 69.1-174.0/100,000) and unexposed women (82.7/100,000, 95%CI: 46.9-145.7/100,000). However, the incidence of cancer in situ was slightly lower in pre-natal exposed women at the age group. Adjusted cumulative probabilities of breast cancer incidence, both in-situ and invasive, were also observed to be higher in women exposed to the famine, however, the difference was not statistically significant., Conclusion: Our results suggest a possible adverse, but limited, impact of exposure to the Great famine on the risk of breast cancer in Chinese women.
- Published
- 2017
- Full Text
- View/download PDF
7. MicroRNA-encoding long non-coding RNAs.
- Author
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He S, Su H, Liu C, Skogerbø G, He H, He D, Zhu X, Liu T, Zhao Y, and Chen R
- Subjects
- Animals, Base Sequence, Chromosome Mapping, Conserved Sequence, Databases, Nucleic Acid, Female, Male, Mice, Mice, Inbred C57BL, MicroRNAs chemistry, Molecular Sequence Data, Nucleic Acid Conformation, Oligonucleotide Array Sequence Analysis, Pregnancy, RNA Splicing, RNA, Untranslated chemistry, Reverse Transcriptase Polymerase Chain Reaction, Software, MicroRNAs genetics, RNA, Untranslated genetics
- Abstract
Background: Recent analysis of the mouse transcriptional data has revealed the existence of approximately 34,000 messenger-like non-coding RNAs (ml-ncRNAs). Whereas the functional properties of these ml-ncRNAs are beginning to be unravelled, no functional information is available for the large majority of these transcripts., Results: A few ml-ncRNA have been shown to have genomic loci that overlap with microRNA loci, leading us to suspect that a fraction of ml-ncRNA may encode microRNAs. We therefore developed an algorithm (PriMir) for specifically detecting potential microRNA-encoding transcripts in the entire set of 34,030 mouse full-length ml-ncRNAs. In combination with mouse-rat sequence conservation, this algorithm detected 97 (80 of them were novel) strong miRNA-encoding candidates, and for 52 of these we obtained experimental evidence for the existence of their corresponding mature microRNA by microarray and stem-loop RT-PCR. Sequence analysis of the microRNA-encoding RNAs revealed an internal motif, whose presence correlates strongly (R2 = 0.9, P-value = 2.2 x 10(-16)) with the occurrence of stem-loops with characteristics of known pre-miRNAs, indicating the presence of a larger number microRNA-encoding RNAs (from 300 up to 800) in the ml-ncRNAs population., Conclusion: Our work highlights a unique group of ml-ncRNAs and offers clues to their functions.
- Published
- 2008
- Full Text
- View/download PDF
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