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24 results on '"Gritti A"'

5. Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital with neurosurgical/neuroendovascular facilities: a consensus and clinical recommendations of the Italian Society of Anesthesia and Intensive Care (SIAARTI)–Part 1

Author

Picetti, Edoardo, Barbanera, Andrea, Bernucci, Claudio, Bertuccio, Alessandro, Bilotta, Federico, Boccardi, Edoardo Pietro, Cafiero, Tullio, Caricato, Anselmo, Castioni, Carlo Alberto, Cenzato, Marco, Chieregato, Arturo, Citerio, Giuseppe, Gritti, Paolo, Lanterna, Luigi, Menozzi, Roberto, Munari, Marina, Panni, Pietro, Rossi, Sandra, Stocchetti, Nino, Sturiale, Carmelo, Zoerle, Tommaso, Zona, Gianluigi, Rasulo, Frank, and Robba, Chiara

Published
2022
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7. Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital with neurosurgical/neuroendovascular facilities: a consensus and clinical recommendations of the Italian Society of Anesthesia and Intensive Care (SIAARTI)—part 2

Author

Picetti, Edoardo, Barbanera, Andrea, Bernucci, Claudio, Bertuccio, Alessandro, Bilotta, Federico, Boccardi, Edoardo Pietro, Cafiero, Tullio, Caricato, Anselmo, Castioni, Carlo Alberto, Cenzato, Marco, Chieregato, Arturo, Citerio, Giuseppe, Gritti, Paolo, Lanterna, Luigi, Menozzi, Roberto, Munari, Marina, Panni, Pietro, Rossi, Sandra, Stocchetti, Nino, Sturiale, Carmelo, Zoerle, Tommaso, Zona, Gianluigi, Rasulo, Frank, and Robba, Chiara

Published
2022
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8. Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study

Author

Rasulo, Frank A., Calza, Stefano, Robba, Chiara, Taccone, Fabio Silvio, Biasucci, Daniele G., Badenes, Rafael, Piva, Simone, Savo, Davide, Citerio, Giuseppe, Dibu, Jamil R., Curto, Francesco, Merciadri, Martina, Gritti, Paolo, Fassini, Paola, Park, Soojin, Lamperti, Massimo, Bouzat, Pierre, Malacarne, Paolo, Chieregato, Arturo, Bertuetti, Rita, Aspide, Raffaele, Cantoni, Alfredo, McCredie, Victoria, Guadrini, Lucrezia, and Latronico, Nicola

Published
2022
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12. Early management of patients with aneurysmal subarachnoid hemorrhage in a hospital without neurosurgical/neuroendovascular facilities: a consensus and clinical recommendations of the Italian Society of Anesthesia and Intensive Care (SIAARTI)

Author

Picetti, Edoardo, Berardino, Maurizio, Bertuccio, Alessandro, Bertuetti, Rita, Boccardi, Edoardo Pietro, Caricato, Anselmo, Castioni, Carlo Alberto, Cenzato, Marco, Chieregato, Arturo, Citerio, Giuseppe, Gritti, Paolo, Longhi, Luca, Martino, Costanza, Munari, Marina, Rossi, Sandra, Stocchetti, Nino, Zoerle, Tommaso, Rasulo, Frank, and Robba, Chiara

Published
2021
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14. Impact of a posttraumatic cerebral infarction on outcome in patients with TBI: the Italian multicenter cohort INCEPT study

Author

Latronico, Nicola, Piva, Simone, Fagoni, Nazzareno, Pinelli, Lorenzo, Frigerio, Michele, Tintori, Davide, Berardino, Maurizio, Bottazzi, Andrea, Carnevale, Livio, Casalicchio, Tiziana, Castioni, Carlo Alberto, Cavallo, Simona, Cerasti, Davide, Citerio, Giuseppe, Fontanella, Marco, Galiberti, Serena, Girardini, Alan, Gritti, Paolo, Manara, Ornella, Maremmani, Paolo, Mazzani, Roberta, Natalini, Giuseppe, Patassini, Mirko, Perna, Maria Elena, Pesaresi, Ilaria, Radolovich, Danila Katia, Saini, Maurizio, Stefini, Roberto, Minelli, Cosetta, Gasparotti, Roberto, and Rasulo, Francesco A.

Published
2020
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17. Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K)

Author

Chiara Verpelli, Stefania Beratta, Luisa Ponzoni, Carlo Sala, Mariaelvina Sala, Laura Gritti, Paolo Scalmani, and Massimo Mantegazza

Subjects
Elongation Factor 2 Kinase, Epilepsies, Myoclonic, Biology, Eukaryotic Elongation Factor-2 Kinase, Mice, Developmental Neuroscience, Dravet syndrome, medicine, Animals, EEG, RC346-429, Molecular Biology, Epilepsy, Protein translation, Research, medicine.disease, Cell biology, SCN1A gene, Mice, Inbred C57BL, NAV1.1 Voltage-Gated Sodium Channel, Psychiatry and Mental health, Disease Models, Animal, Neurology. Diseases of the nervous system, Epileptic Syndromes, Inhibitory synapses, Developmental Biology
Abstract

Background Dravet Syndrome is a severe childhood pharmaco-resistant epileptic disorder mainly caused by mutations in the SCN1A gene, which encodes for the α1 subunit of the type I voltage-gated sodium channel (NaV1.1), that causes imbalance between excitation and inhibition in the brain. We recently found that eEF2K knock out mice displayed enhanced GABAergic transmission and tonic inhibition and were less susceptible to epileptic seizures. Thus, we investigated the effect of inhibition of eEF2K on the epileptic and behavioral phenotype of Scn1a ± mice, a murine model of Dravet Syndrome. Methods To elucidate the role of eEF2K pathway in the etiopathology of Dravet syndrome we generated a new mouse model deleting the eEF2K gene in Scn1a ± mice. By crossing Scn1a ± mice with eEF2K−/− mice we obtained the three main genotypes needed for our studies, Scn1a+/+ eEF2K+/+ (WT mice), Scn1a ± eEF2K+/+ mice (Scn1a ± mice) and Scn1a ± eEF2K−/− mice, that were fully characterized for EEG and behavioral phenotype. Furthermore, we tested the ability of a pharmacological inhibitor of eEF2K in rescuing EEG alterations of the Scn1a ± mice. Results We showed that the activity of eEF2K/eEF2 pathway was enhanced in Scn1a ± mice. Then, we demonstrated that both genetic deletion and pharmacological inhibition of eEF2K were sufficient to ameliorate the epileptic phenotype of Scn1a ± mice. Interestingly we also found that motor coordination defect, memory impairments, and stereotyped behavior of the Scn1a ± mice were reverted by eEF2K deletion. The analysis of spontaneous inhibitory postsynaptic currents (sIPSCs) suggested that the rescue of the pathological phenotype was driven by the potentiation of GABAergic synapses. Limitations Even if we found that eEF2K deletion was able to increase inhibitory synapses function, the molecular mechanism underlining the inhibition of eEF2K/eEF2 pathway in rescuing epileptic and behavioral alterations in the Scn1a ± needs further investigations. Conclusions Our data indicate that pharmacological inhibition of eEF2K could represent a novel therapeutic intervention for treating epilepsy and related comorbidities in the Dravet syndrome.

Published
2022

18. Decapneization as supportive therapy for the treatment of status asthmaticus: a case report

Author

Fabrizio Gritti, Irene Esposito, Francesco Imperatore, Giovanni Liguori, Rossella Esposito, Maria De Cristofaro, Chiara Cafora, and Paolo Francesco Marsilia

Subjects
medicine.medical_treatment, Status Asthmaticus, Case Report, 030204 cardiovascular system & hematology, Air trapping, Protective mechanical ventilation, Hypoxemia, Hypercapnia, 03 medical and health sciences, 0302 clinical medicine, medicine, Tidal Volume, Humans, Dynamic hyperinflation, Mechanical ventilation, Respiratory distress, business.industry, General Medicine, Carbon Dioxide, medicine.disease, Respiration, Artificial, Asthma, 030220 oncology & carcinogenesis, Acute severe asthma, Anesthesia, Breathing, Decapneization, Medicine, medicine.symptom, business
Abstract

Background Acute severe asthma is a life-threatening medical emergency. Characteristics of asthma include increased airway resistance and dynamic pulmonary hyperinflation that can manifest in dangerous levels of hypercapnia and acidosis, with significant mortality and morbidity. Severe respiratory distress can lead to endotracheal intubation followed by mechanical ventilation, which can cause increased air trapping with dynamic hyperinflation, predisposing the lungs to barotraumas. Case presentation The present case report describes the use of the minimally invasive ECCO2R ProLUNG® (Estor) with protective low-tidal-volume ventilation, in a Caucasian patient with near-fatal asthma and with no response to conventional therapy. Conclusions Since hypercarbia rather than hypoxemia is the primary abnormality in status asthmaticus, a rescue therapeutic strategy combining the ECCO2R membrane ProLUNG® (Estor) with ultra-protective low-tidal-volume ventilation can be successfully applied to limit the risk of severe barotrauma during invasive mechanical ventilation. ECCO2R ProLUNG® is a partial respiratory support technique that, based on the use of an extracorporeal circuit with a gas-exchange membrane, achieves relevant CO2 clearance directly from the blood using double-lumen venous-venous vascular access, at blood flow in the range of 0.4–1.0 L/minute.

Published
2021

19. Update on the safety of second generation antipsychotics in youths: a call for collaboration among paediatricians and child psychiatrists.

Author

Pisano, Simone, Catone, Gennaro, Veltri, Stefania, Lanzara, Valentina, Pozzi, Marco, Clementi, Emilio, Iuliano, Raffaella, Riccio, Maria Pia, Radice, Sonia, Molteni, Massimo, Capuano, Annalisa, Gritti, Antonella, Coppola, Giangennaro, Milone, Annarita, Bravaccio, Carmela, and Masi, Gabriele

Subjects
PREVENTION of drug side effects, ANTIPSYCHOTIC agents, INTERPROFESSIONAL relations, TYPE 2 diabetes, PATIENT monitoring, PATIENT safety, PEDIATRICIANS, PSYCHIATRISTS
Abstract

During the past decade, a substantial increase in the use of second generation antipsychotics (SGAs) has occurred for a number of juvenile psychiatric disorders, often as off-label prescriptions. Although they were thought to be safer than older, first generation antipsychotics, mainly due to a lower risk of neurological adverse reactions, recent studies have raised significant concerns regarding their safety regarding metabolic, endocrinological and cardiovascular side effects. Aim of this paper is to update with a narrative review, the latest findings on safety of SGAs in youths. Results suggest that different SGAs may present different safety profiles. Metabolic adverse events are the most frequent and troublesome, with increasing evidences of heightened risk for type II diabetes mellitus. Results are discussed with specific emphasis on possible strategies of an active monitoring, which could enable both paediatricians and child psychiatrists to a possible prevention, early detection, and a timely management of such effects. [ABSTRACT FROM AUTHOR]

Published
2016
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22. Epidemiological study on behavioural and emotional problems in developmental age: prevalence in a sample of Italian children, based on parent and teacher reports.

Author

Gritti, Antonella, Bravaccio, Carmela, Signoriello, Simona, Salerno, Filomena, Pisano, Simone, Catone, Gennaro, Gallo, Ciro, and Pascotto, Antonio

Subjects
*BEHAVIOR disorders in children, *CHILD Behavior Checklist, *RESEARCH funding, *STATISTICS, *DATA analysis, *WELL-being, *PARENT attitudes, *COLLEGE teacher attitudes, *DATA analysis software, *DESCRIPTIVE statistics
Abstract

Background: The aim of this study is to examine the prevalence of behavioural and emotional problems in a sample of school children living in Campania, a region of South Italy. Methods: The Child Behavior Checklist (CBCL) Parent Report Form (PRF) and the CBCL Teacher Rating Form (TRF) were administered to parents and teachers of a sample of school children aged 8-9 yr. Results: The subjects (SS) eligible for the study were 3072. In 2137 (69.5%) cases parents returned the envelopes back. 1228 (57.4%) subjects were excluded because of lack of signed consensus, unfilled or incomplete forms. Parents reported children's behavioural or emotional Total Problems in 14.7% of the SS. (5.2% borderline, 9.5% clinical), Internalizing Problems in 18.5% (8.0% borderline, 10.5% clinical), and Externalizing Problems in 8.5% (3.8% borderline, 4.7% clinical) respectively. At the Competence Scale of CBCL more than 2/3 of the sample show high rate for Total Competence Problem (24.3% borderline, 47.3% clinical.) Teachers reported 8.7% of SS having Total Problems, (4.3% borderline, 4.4% clinical), Internalizing problems were detected in 13.3% of the sample (4.9% borderline and 8.4% clinical), while Externalizing problems were reported for 9.6% of SS (4.1% borderline and 5.5% clinical). In the sub-scale of Academic Performances teachers report a high number of subjects with problems, 18.7%, whose 4.3% had a "borderline" score, and 14.4% had a "clinical" score. Conclusion: Concerning Total Problems (clinical and borderline SS, 14.7% as reported by parents, 8.7% as reported by teachers) we obtained a prevalence similar to that reported in the rest of the country, with differences in gender (males 13.2%, females 16.0% as reported by parents; males 7.4%, females 9.7% as reported by teachers). The difficulties in social and relationship competencies area were higher (4 / 10 children). This datum should be cautiously evaluated because the possible inadequacy of CBCL competences scale. [ABSTRACT FROM AUTHOR]

Published
2014
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23. Health-related quality of life in pediatric liver transplanted patients compared with a chronic liver disease group.

Author

Gritti, Antonella, Pisano, Simone, Salvati, Tiziana, Di Cosmo, Nicolina, Iorio, Raffaele, and Vajro, Pietro

Subjects
*ACADEMIC medical centers, *CHRONIC diseases, *FISHER exact test, *HEALTH status indicators, *LIVER transplantation, *PEDIATRICS, *QUALITY of life, *QUESTIONNAIRES, *STATISTICS, *U-statistics, *DATA analysis, *EFFECT sizes (Statistics), *DESCRIPTIVE statistics
Abstract

Background: Achieving a good health-related quality of life (HRQoL) is currently one of the main aims in long term survival of liver transplanted children (PLT). Purpose of our study is to compare HRQoL of PLT patients (N = 33, mean age 12.8 y) vs. sex and age matched patients with compensated and clinically stable chronic liver disease (CLD) (N = 25, mean age 11.9 y). Methods: HRQoL was measured from both patient and parental perspectives using the CHQ-CF87 and CHQ-PF50 questionnaires, respectively. Results: General Health Perception scores of PLT subjects resulted significantly lower than those of CLD both at self- and parental report (p < 0.05 and p < 0.01, respectively). No other significant differences in other HRQoL domains were found between groups. Conclusion: Our results suggest that the two populations are quite similar regarding HRQoL, but both parents and children of PLT group perceive a worse general health. Further studies are needed to confirm these results. [ABSTRACT FROM AUTHOR]

Published
2013
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