4 results on '"Dinelli, Marco"'
Number of results to display per page
Search Results
2. Chronic constipation diagnosis and treatment evaluation: the 'CHRO.CO.DI.T.E.' study
- Author
-
Bellini, Massimo, Usai-Satta, Paolo, Bove, Antonio, Bocchini, Renato, Galeazzi, Francesca, Battaglia, Edda, Alduini, Pietro, Buscarini, Elisabetta, Bassotti, Gabrio, Balzano, Antonio, Portincasa, Piero, Bonfrate, Leonilde, D'Alba, Lucia, Badiali, Danilo, Marchi, Santino, Gambaccini, Dario, Neri, Maria Cristina, Muscatiello, Nicola, Di Stefano, Michele, Giannelli, Claudio, Goffredo, Fabio, Turco, Luigi, Camilleri, Salvatore, Ceccarelli, Giovanni, Iovino, Paola, Montalbano, Luigi Maria, Morreale, Gaetano Cristian, Rentini, Silvia, Savarino, Vincenzo, Segato, Sergio, Manfredi, Guido, Cannizzaro, Renato, Passaretti, Sandro, Alessandri, Matteo, Corti, Federico, Cuomo, Rosario, Zito, Francesco Paolo, Mellone, Carmine, Barbera, Roberta, Milazzo, Giuseppe, Pucciani, Filippo, Soncini, Marco, Lai, Maria Antonia, Ruggeri, Maurizio, Savarese, Maria Flavia, De Bona, Manuela, Surrenti, Elisabetta, Arini, Andrea, Dinelli, Marco, Leandro, Gioacchino, Peralta, Sergio, Manta, Raffaele, Quartini, Mariano, Torresan, Francesco, Vilardo, Luigi, Pulvirenti D'Urso, Antonino, Tarantino, Ottaviano, Noris, Roberto Antonio, Monica, Fabio, Carrara, Maurizio, Losco, Alessandra, Lauri, Adriano, Neri, Matteo, Grassini, Mario, Bellini, Massimo, Usai Satta, Paolo, Bove, Antonio, Bocchini, Renato, Battaglia, Edda, Alduini, P, Bassotti, Gabrio, Balzano, Antonio, Portincasa, Piero, Bonfrate, L, D'Alba, L, Badiali, Danilo, Marchi, Santino, Gambaccini, D, Neri, Mc, Muscatiello, N, Di Stefano, M, Giannelli, C, Goffredo, F, Turco, L, Camilleri, S, Ceccarelli, G, Iovino, Paola, Montalbano, Lm, Morreale, G, Rentini, S, Savarino, Vincenzo, Segato, S, Buscarini, E, Manfredi, G, Cannizzaro, Renato, Passaretti, S, Alessandri, M, Corti, F, Cuomo, Rosario, Zito, FRANCESCO PAOLO, Mellone, C, Barbera, Roberta, Milazzo, G, Pucciani, F, Marco, S, Lai, Ma, Ruggeri, M, Savarese, Mf, De Bona, M, Surrenti, E, Arini, A, Dinelli, M, Leandro, G, Peralta, S, Manta, Raffaele, Quartini, M, Torresan, F, Vilardo, L, Pulvirenti D'Urso, A, Tarantino, O, Noris, Ra, Monica, F, Carrara, M, Losco, A, Lauri, A, and Neri, M.
- Subjects
Adult ,Male ,medicine.medical_specialty ,Constipation ,Diet therapy ,Colonoscopy ,Gastroenterology ,Severity of Illness Index ,Irritable Bowel Syndrome ,03 medical and health sciences ,Diagnosis ,Functional constipation ,Irritable bowel syndrome ,Treatment ,Aged ,Chronic Disease ,Defecography ,Digital Rectal Examination ,Female ,Humans ,Italy ,Middle Aged ,Surveys and Questionnaires ,Symptom Assessment ,0302 clinical medicine ,Internal medicine ,medicine ,Gastrointestinal agent ,Chronic constipation ,Prucalopride ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,Diagnosi ,medicine.drug ,Research Article - Abstract
Background According to Rome criteria, chronic constipation (CC) includes functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C). Some patients do not meet these criteria (No Rome Constipation, NRC). The aim of the study was is to evaluate the various clinical presentation and management of FC, IBS-C and NRC in Italy. Methods During a 2-month period, 52 Italian gastroenterologists recorded clinical data of FC, IBS-C and NRC patients, using Bristol scale, PAC-SYM and PAC-QoL questionnaires. In addition, gastroenterologists were also asked to record whether the patients were clinically assessed for CC for the first time or were in follow up. Diagnostic tests and prescribed therapies were also recorded. Results Eight hundred seventy-eight consecutive CC patients (706 F) were enrolled (FC 62.5%, IBS-C 31.3%, NRC 6.2%). PAC-SYM and PAC-QoL scores were higher in IBS-C than in FC and NRC. 49.5% were at their first gastroenterological evaluation for CC. In 48.5% CC duration was longer than 10 years. A specialist consultation was requested in 31.6%, more frequently in IBS-C than in NRC. Digital rectal examination was performed in only 56.4%. Diagnostic tests were prescribed to 80.0%. Faecal calprotectin, thyroid tests, celiac serology, breath tests were more frequently suggested in IBS-C and anorectal manometry in FC. More than 90% had at least one treatment suggested on chronic constipation, most frequently dietary changes, macrogol and fibers. Antispasmodics and psychotherapy were more frequently prescribed in IBS-C, prucalopride and pelvic floor rehabilitation in FC. Conclusions Patients with IBS-C reported more severe symptoms and worse quality of life than FC and NRC. Digital rectal examination was often not performed but at least one diagnostic test was prescribed to most patients. Colonoscopy and blood tests were the “first line” diagnostic tools. Macrogol was the most prescribed laxative, and prucalopride and pelvic floor rehabilitation represented a “second line” approach. Diagnostic tests and prescribed therapies increased by increasing CC severity. Electronic supplementary material The online version of this article (doi:10.1186/s12876-016-0556-7) contains supplementary material, which is available to authorized users.
- Published
- 2017
3. miRNA-regulated gene expression differs in celiac disease patients according to the age of presentation.
- Author
-
Comani, Gaia Buoli, Panceri, Roberto, Dinelli, Marco, Biondi, Andrea, Mancuso, Clara, Meneveri, Raffaella, and Barisani, Donatella
- Abstract
Celiac disease is an intestinal disease which shows different symptoms and clinical manifestations among pediatric and adult patients. These variations could be imputable to age-related changes in gut architecture and intestinal immune system, which could be characterized by gene expression differences possibly regulated by miRNAs. We analyzed a panel of miRNAs and their target genes in duodenal biopsies of Marsh 3AB and 3C pediatric celiac patients, compared to controls. Moreover, to assess variation of expression in plasma samples, we evaluated circulating miRNA levels in controls and patients at diagnosis or on gluten-free diet. We detected a decreased miR192-5p expression in celiac patients, but no variations in NOD2 and CXCL2, targets previously identified in adults. Conversely, we detected a significant increase in mRNA and protein levels of another target, MAD2L1, protein related to cell cycle control. miR-31-5p and miR-338-3p were down-regulated and their respective targets, FOXP3 and RUNX1, involved in Treg function, resulted up-regulated in celiac patients. Finally, we detected, in celiac patients, an increased expression of miR-21-5p, possibly caused by a regulatory loop with its putative target STAT3, which showed an increased activation in Marsh 3C patients. The analysis of plasma revealed a trend similar to that observed in biopsies, but in presence of gluten-free diet we could not detect circulating miRNAs values comparable to controls. miRNAs and their gene targets showed an altered expression in duodenal mucosa and plasma of celiac disease pediatric patients, and these alterations could be different from adult ones. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
4. miRNA-regulated gene expression differs in celiac disease patients according to the age of presentation.
- Author
-
Buoli Comani G, Panceri R, Dinelli M, Biondi A, Mancuso C, Meneveri R, and Barisani D
- Abstract
Celiac disease is an intestinal disease which shows different symptoms and clinical manifestations among pediatric and adult patients. These variations could be imputable to age-related changes in gut architecture and intestinal immune system, which could be characterized by gene expression differences possibly regulated by miRNAs. We analyzed a panel of miRNAs and their target genes in duodenal biopsies of Marsh 3AB and 3C pediatric celiac patients, compared to controls. Moreover, to assess variation of expression in plasma samples, we evaluated circulating miRNA levels in controls and patients at diagnosis or on gluten-free diet. We detected a decreased miR-192-5p expression in celiac patients, but no variations in NOD2 and CXCL2, targets previously identified in adults. Conversely, we detected a significant increase in mRNA and protein levels of another target, MAD2L1, protein related to cell cycle control. miR-31-5p and miR-338-3p were down-regulated and their respective targets, FOXP3 and RUNX1, involved in Treg function, resulted up-regulated in celiac patients. Finally, we detected, in celiac patients, an increased expression of miR-21-5p, possibly caused by a regulatory loop with its putative target STAT3, which showed an increased activation in Marsh 3C patients. The analysis of plasma revealed a trend similar to that observed in biopsies, but in presence of gluten-free diet we could not detect circulating miRNAs values comparable to controls. miRNAs and their gene targets showed an altered expression in duodenal mucosa and plasma of celiac disease pediatric patients, and these alterations could be different from adult ones.
- Published
- 2015
- Full Text
- View/download PDF
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.