1. Genome-wide association studies on HIV susceptibility, pathogenesis and pharmacogenomics
- Author
-
Daniëlle van Manen, Angélique B. van 't Wout, and Hanneke Schuitemaker
- Subjects
lcsh:Immunologic diseases. Allergy ,Candidate gene ,Genome-wide association study ,Single-nucleotide polymorphism ,HIV Infections ,Review ,Biology ,Genome-wide association studies ,Single-nucleotide polymorphisms ,Pathogenesis ,Virology ,Genetic variation ,HIV susceptibility ,Humans ,Genetic Predisposition to Disease ,Genetic association ,Genetics ,Phenotype ,Host genetics ,Infectious Diseases ,HIV pathogenesis ,Pharmacogenomics ,Host-Pathogen Interactions ,HIV-1 ,lcsh:RC581-607 ,Genome-Wide Association Study - Abstract
Susceptibility to HIV-1 and the clinical course after infection show a substantial heterogeneity between individuals. Part of this variability can be attributed to host genetic variation. Initial candidate gene studies have revealed interesting host factors that influence HIV infection, replication and pathogenesis. Recently, genome-wide association studies (GWAS) were utilized for unbiased searches at a genome-wide level to discover novel genetic factors and pathways involved in HIV-1 infection. This review gives an overview of findings from the GWAS performed on HIV infection, within different cohorts, with variable patient and phenotype selection. Furthermore, novel techniques and strategies in research that might contribute to the complete understanding of virus-host interactions and its role on the pathogenesis of HIV infection are discussed.
- Published
- 2012