1. Trandifferentiation-inducing HCCR-1 oncogene.
- Author
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Seon-Ah Ha, Hyun K. Kim, JinAh Yoo, SangHee Kim, Shin, Seung M., Lee, Youn S., Hur, Soo Y., Kim, Yong W., Kim, Tae E., Chung, Yeun J., Jeun, Shin S., Kim, Dong W., Park, Yong G., Jin Kim, Shin, Soon Y., Lee, Young H., and Kim, Jin W.
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PHENOTYPES ,ONCOGENIC viruses ,CANCER ,STEM cells ,SARCOMA ,MORPHOGENESIS - Abstract
Background: Cell transdifferentiation is characterized by loss of some phenotypes along with acquisition of new phenotypes in differentiated cells. The differentiated state of a given cell is not irreversible. It depends on the up- and downregulation exerted by specific molecules. Results: We report here that HCCR-1, previously shown to play an oncogenic role in human cancers, induces epithelialto- mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) in human and mouse, respectively. The stem cell factor receptor CD117/c-Kit was induced in this transdifferentiated (EMT) sarcoma tissues. This MET occurring in HCCR-1 transfected cells is reminiscent of the transdifferentiation process during nephrogenesis. Indeed, expression of HCCR-1 was observed during the embryonic development of the kidney. This suggests that HCCR-1 might be involved in the transdifferentiation process of cancer stem cell. Conclusions: Therefore, we propose that HCCR-1 may be a regulatory factor that stimulates morphogenesis of epithelia or mesenchyme during neoplastic transformation. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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