1. The nutritional requirements of Caenorhabditis elegans
- Author
-
Aleksandra Zečić, Bart P. Braeckman, and Ineke Dhondt
- Subjects
0301 basic medicine ,Somatic cell ,Endocrinology, Diabetes and Metabolism ,ved/biology.organism_classification_rank.species ,Computational biology ,Review ,Biology ,NEMATODE BIOCHEMISTRY ,03 medical and health sciences ,AXENIC CULTURE ,0302 clinical medicine ,Genetics ,LIPID DROPLET SYNTHESIS ,Model organism ,Axenic ,Caenorhabditis elegans ,DE-NOVO BIOSYNTHESIS ,Nutrition ,2. Zero hunger ,chemistry.chemical_classification ,ved/biology ,ALPHA-KETOACID DEHYDROGENASE ,Biology and Life Sciences ,biology.organism_classification ,Diet ,BRANCHED-CHAIN ,Chemically defined medium ,Dietary Requirements ,030104 developmental biology ,CHAIN FATTY-ACIDS ,chemistry ,C-ELEGANS ,TURBATRIX-ACETI ,Essential nutrient ,Axenic culture ,030217 neurology & neurosurgery ,CHEMICALLY-DEFINED MEDIUM - Abstract
Animals require sufficient intake of a variety of nutrients to support their development, somatic maintenance and reproduction. An adequate diet provides cell building blocks, chemical energy to drive cellular processes and essential nutrients that cannot be synthesised by the animal, or at least not in the required amounts. Dietary requirements of nematodes, including Caenorhabditis elegans have been extensively studied with the major aim to develop a chemically defined axenic medium that would support their growth and reproduction. At the same time, these studies helped elucidating important aspects of nutrition-related biochemistry and metabolism as well as the establishment of C. elegans as a powerful model in studying evolutionarily conserved pathways, and the influence of the diet on health.
- Published
- 2019