15 results on '"Bernabe-Ortiz, Antonio"'
Search Results
2. Aggregation and combination of cardiovascular risk factors and their association with 10-year all-cause mortality: the PERU MIGRANT Study
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Bazalar-Palacios, Janina, Jaime Miranda, J., Carrillo-Larco, Rodrigo M., Gilman, Robert H., Smeeth, Liam, and Bernabe-Ortiz, Antonio
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- 2021
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3. Second-hand smoking, hypertension and cardiovascular risk: findings from Peru
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Bernabe-Ortiz, Antonio and Carrillo-Larco, Rodrigo M.
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- 2021
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4. Indoor air pollution concentrations and cardiometabolic health across four diverse settings in Peru: a cross-sectional study
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Kephart, Josiah L., Fandiño-Del-Rio, Magdalena, Koehler, Kirsten, Bernabe-Ortiz, Antonio, Miranda, J. Jaime, Gilman, Robert H., and Checkley, William
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- 2020
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5. A secondary analysis examining the concordance of self-perception of weight and actual measurement of body fat percentage: The CRONICAS Cohort Study
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Bui, Anthony L., Moscoso, Miguel G., Bernabe-Ortiz, Antonio, Checkley, William, Gilman, Robert H., Smeeth, Liam, and Miranda, J. Jaime
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- 2019
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6. Risk score for first-screening of prevalent undiagnosed chronic kidney disease in Peru: the CRONICAS-CKD risk score.
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Carrillo-Larco, Rodrigo M., Miranda, J. Jaime, Gilman, Robert H., Medina-Lezama, Josefina, Chirinos-Pacheco, Julio A., Muñoz-Retamozo, Paola V., Smeeth, Liam, Checkley, William, Bernabe-Ortiz, Antonio, and CRONICAS Cohort Study Group
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CHRONIC kidney failure ,CROSS-sectional method ,GLUCOSE metabolism ,HYPERTENSION ,LIPIDS ,HYPERTENSION epidemiology ,LONGITUDINAL method ,RESEARCH funding ,DISEASE prevalence ,SEVERITY of illness index ,DIAGNOSIS - Abstract
Background: Chronic Kidney Disease (CKD) represents a great burden for the patient and the health system, particularly if diagnosed at late stages. Consequently, tools to identify patients at high risk of having CKD are needed, particularly in limited-resources settings where laboratory facilities are scarce. This study aimed to develop a risk score for prevalent undiagnosed CKD using data from four settings in Peru: a complete risk score including all associated risk factors and another excluding laboratory-based variables.Methods: Cross-sectional study. We used two population-based studies: one for developing and internal validation (CRONICAS), and another (PREVENCION) for external validation. Risk factors included clinical- and laboratory-based variables, among others: sex, age, hypertension and obesity; and lipid profile, anemia and glucose metabolism. The outcome was undiagnosed CKD: eGFR < 60 ml/min/1.73m2. We tested the performance of the risk scores using the area under the receiver operating characteristic (ROC) curve, sensitivity, specificity, positive/negative predictive values and positive/negative likelihood ratios.Results: Participants in both studies averaged 57.7 years old, and over 50% were females. Age, hypertension and anemia were strongly associated with undiagnosed CKD. In the external validation, at a cut-off point of 2, the complete and laboratory-free risk scores performed similarly well with a ROC area of 76.2% and 76.0%, respectively (P = 0.784). The best assessment parameter of these risk scores was their negative predictive value: 99.1% and 99.0% for the complete and laboratory-free, respectively.Conclusions: The developed risk scores showed a moderate performance as a screening test. People with a score of ≥ 2 points should undergo further testing to rule out CKD. Using the laboratory-free risk score is a practical approach in developing countries where laboratories are not readily available and undiagnosed CKD has significant morbidity and mortality. [ABSTRACT FROM AUTHOR]- Published
- 2017
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7. Disparities in dietary intake and physical activity patterns across the urbanization divide in the Peruvian Andes.
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McCloskey, Morgan L., Tarazona-Meza, Carla E., Jones-Smith, Jessica C., Miele, Catherine H., Gilman, Robert H., Bernabe-Ortiz, Antonio, Miranda, J. Jaime, and Checkley, William
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COMPARATIVE studies ,DIET ,HEALTH behavior ,METROPOLITAN areas ,NUTRITIONAL assessment ,OBESITY ,POPULATION geography ,PROBABILITY theory ,QUESTIONNAIRES ,RURAL conditions ,STATISTICAL sampling ,PEDOMETERS ,LIFESTYLES ,PHYSICAL activity - Abstract
Background: Diet and activity are thought to worsen with urbanization, thereby increasing risk of obesity and chronic diseases. A better understanding of dietary and activity patterns across the urbanization divide may help identify pathways, and therefore intervention targets, leading to the epidemic of overweight seen in low- and middle-income populations. Therefore, we sought to characterize diet and activity in a population-based study of urban and rural residents in Puno, Peru. Methods: We compared diet and activity in 1005 (503 urban, 502 rural) participants via a lifestyle questionnaire. We then recruited an age- and sex-stratified random sample of 50 (25 urban, 25 rural) participants to further characterize diet and activity. Among these participants, diet composition and macronutrient intake was assessed by three non-consecutive 24-h dietary recalls and physical activity was assessed using Omron JH-720itc pedometers. Results: Among 1005 participants, we found that urban residents consumed protein-rich foods, refined grains, sugary items, and fresh produce more frequently than rural residents. Among the 50 subsample participants, urban dwellers consumed more protein (47 vs. 39 g; p = 0.05), more carbohydrates (280 vs. 220 g; p = 0.03), more sugary foods (98 vs. 48 g, p = 0.02) and had greater dietary diversity (6.4 vs 5.8; p = 0.04). Rural subsample participants consumed more added salt (3.1 vs 1.7 g, p = 0.006) and tended to consume more vegetable oil. As estimated by pedometers, urban subsample participants burned fewer calories per day (191 vs 270 kcal, p =0.03). Conclusions: Although urbanization is typically thought to increase consumption of fat, sugar and salt, our 24-h recall results were mixed and showed lower levels of obesity in rural Puno were not necessarily indicative of nutritionally-balanced diets. All subsample participants had relatively traditional lifestyles (low fat intake, limited consumption of processed foods and frequent walking) that may play a role in chronic disease outcomes in this region. [ABSTRACT FROM AUTHOR]
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- 2017
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8. Developing consensus measures for global programs: lessons from the Global Alliance for Chronic Diseases Hypertension research program.
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Riddell, Michaela A., Edwards, Nancy, Thompson, Simon R., Bernabe-Ortiz, Antonio, Praveen, Devarsetty, Johnson, Claire, Kengne, Andre P., Liu, Peter, McCready, Tara, Ng, Eleanor, Nieuwlaat, Robby, Ovbiagele, Bruce, Owolabi, Mayowa, Peiris, David, Thrift, Amanda G., Tobe, Sheldon, Yusoff, Khalid, and GACD Hypertension Research Programme
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WORLD health ,CHRONIC diseases ,RESEARCH funding ,MEDICAL research ,MEDICAL informatics ,CHRONIC disease treatment ,CONSENSUS (Social sciences) ,COOPERATIVENESS ,HYPERTENSION ,RESEARCH personnel - Abstract
Background: The imperative to improve global health has prompted transnational research partnerships to investigate common health issues on a larger scale. The Global Alliance for Chronic Diseases (GACD) is an alliance of national research funding agencies. To enhance research funded by GACD members, this study aimed to standardise data collection methods across the 15 GACD hypertension research teams and evaluate the uptake of these standardised measurements. Furthermore we describe concerns and difficulties associated with the data harmonisation process highlighted and debated during annual meetings of the GACD funded investigators. With these concerns and issues in mind, a working group comprising representatives from the 15 studies iteratively identified and proposed a set of common measures for inclusion in each of the teams' data collection plans. One year later all teams were asked which consensus measures had been implemented.Results: Important issues were identified during the data harmonisation process relating to data ownership, sharing methodologies and ethical concerns. Measures were assessed across eight domains; demographic; dietary; clinical and anthropometric; medical history; hypertension knowledge; physical activity; behavioural (smoking and alcohol); and biochemical domains. Identifying validated measures relevant across a variety of settings presented some difficulties. The resulting GACD hypertension data dictionary comprises 67 consensus measures. Of the 14 responding teams, only two teams were including more than 50 consensus variables, five teams were including between 25 and 50 consensus variables and four teams were including between 6 and 24 consensus variables, one team did not provide details of the variables collected and two teams did not include any of the consensus variables as the project had already commenced or the measures were not relevant to their study.Conclusions: Deriving consensus measures across diverse research projects and contexts was challenging. The major barrier to their implementation was related to the time taken to develop and present these measures. Inclusion of consensus measures into future funding announcements would facilitate researchers integrating these measures within application protocols. We suggest that adoption of consensus measures developed here, across the field of hypertension, would help advance the science in this area, allowing for more comparable data sets and generalizable inferences. [ABSTRACT FROM AUTHOR]- Published
- 2017
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9. Smoking and heavy drinking patterns in rural, urban and rural-to-urban migrants: the PERU MIGRANT Study.
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Taype-Rondan, Alvaro, Bernabe-Ortiz, Antonio, Alvarado, Germán F., Gilman, Robert H., Smeeth, Liam, and Miranda, J. Jaime
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SMOKING , *ALCOHOL drinking , *EMIGRATION & immigration , *DISEASE incidence , *ANALYSIS of variance - Abstract
Background: Previous studies have found mixed results about cigarette and alcohol consumption patterns among rural-to-urban migrants. Moreover, there are limited longitudinal data about consumption patterns in this population. As such, this study aimed to compare the smoking and heavy drinking prevalence among rural, urban, and rural-to-urban migrants in Peru, as well as the smoking and heavy drinking incidence in a 5-year follow-up.Methods: We analyzed the PERU MIGRANT Study data from rural, urban, and rural-to-urban migrant populations in Peru. The baseline study was carried out in 2006-2007 and follow-up was performed five years later. For the baseline data analysis, the prevalence of lifetime smoking, current smokers, and heavy drinking was compared by population group using prevalence ratios (PR) and 95% confidence intervals (95% CI). For the longitudinal analysis, the incidence of smoking and heavy drinking was compared by population group with risk ratios (RR) and 95% CI. Poisson regression with robust variance was used to calculate both PRs and RRs.Results: We analyzed data from 988 participants: 200 rural dwellers, 589 migrants, and 199 urban dwellers. Compared with migrants, lifetime smoking prevalence was higher in the urban group (PR = 2.29, 95% CI = 1.64-3.20), but lower in the rural group (PR = 0.55, 95% CI = 0.31-0.99). Compared with migrants, the urban group had a higher current smoking prevalence (PR = 2.29, 95% CI = 1.26-4.16), and a higher smoking incidence (RR = 2.75, 95% CI = 1.03-7.34). Current smoking prevalence and smoking incidence showed no significant difference between rural and migrant groups. The prevalence and incidence of heavy drinking was similar across the three population groups.Conclusions: Our results show a trend in lifetime smoking prevalence (urban > migrant > rural), while smoking incidence was similar between migrant and rural groups, but higher in the urban group. In addition, our results suggest that different definitions of smoking status could lead to different smoking rates and potentially different measures of association. The prevalence and incidence of heavy drinking were similar between the three population groups. [ABSTRACT FROM AUTHOR]- Published
- 2017
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10. Implementation of foot thermometry plus mHealth to prevent diabetic foot ulcers: study protocol for a randomized controlled trial.
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Lazo-Porras, Maria, Bernabe-Ortiz, Antonio, Sacksteder, Katherine A., Gilman, Robert H., Malaga, German, Armstrong, David G., and Miranda, J. Jaime
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MEDICAL thermometry , *TREATMENT of diabetic foot , *MOBILE health , *AMPUTATION , *PEOPLE with diabetes , *RANDOMIZED controlled trials , *TYPE 2 diabetes diagnosis , *TYPE 2 diabetes treatment , *DIABETIC foot prevention , *BODY temperature , *COMPARATIVE studies , *EXPERIMENTAL design , *HEALTH attitudes , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH protocols , *MEDICAL thermometers , *TYPE 2 diabetes , *PATIENT education , *RESEARCH , *RESEARCH funding , *HEALTH self-care , *TELEMEDICINE , *TIME , *CELL phones , *TEXT messages , *PRODUCT design , *EVALUATION research , *BURDEN of care , *DIABETIC foot , *TREATMENT effectiveness , *PREDICTIVE tests , *DISEASE incidence , *HEALTH care reminder systems , *DIAGNOSIS - Abstract
Background: Diabetic foot neuropathy (DFN) is one of the most important complications of diabetes mellitus; its early diagnosis and intervention can prevent foot ulcers and the need for amputation. Thermometry, measuring the temperature of the feet, is a promising emerging modality for diabetic foot ulcer prevention. However, patient compliance with at-home monitoring is concerning. Delivering messages to remind patients to perform thermometry and foot care might be helpful to guarantee regular foot monitoring. This trial was designed to compare the incidence of diabetic foot ulcers (DFUs) between participants who receive thermometry alone and those who receive thermometry as well as mHealth (SMS and voice messaging) over a year-long study period.Methods/design: This is an evaluator-blinded, randomized, 12-month trial. Individuals with a diagnosis of type 2 diabetes mellitus, aged between 18-80 years, having a present dorsalis pedis pulse in both feet, are in risk group 2 or 3 using the diabetic foot risk classification system (as specified by the International Working Group on the Diabetic Foot), have an operating cell phone or a caregiver with an operating cell phone, and have the ability to provide informed consent will be eligible to participate in the study. Recruitment will be performed in diabetes outpatient clinics at two Ministry of Health tertiary hospitals in Lima, Peru.Interventions: participants in both groups will receive education about foot care at the beginning of the study and they will be provided with a thermometry device (TempStat™). TempStat™ is a tool that captures a thermal image of the feet, which, depending on the temperature of the feet, shows different colors. In this study, if a participant notes a single yellow image or variance between one foot and the contralateral foot, they will be prompted to notify a nurse to evaluate their activity within the previous 2 weeks and make appropriate recommendations. In addition to thermometry, participants in the intervention arm will receive an mHealth component in the form of SMS and voice messages as reminders to use the thermometry device, and instructions to promote foot care.Outcomes: the primary outcome is foot ulceration, evaluated by a trained nurse, occurring at any point during the study.Discussion: This study has two principal contributions towards the prevention of DFU. First, the introduction of messages to promote self-management of diabetes foot care as well as using reminders as a strategy to improve adherence to daily home-based measurements. Secondly, the implementation of a thermometry-based strategy complemented by SMS and voice messages in an LMIC setting, with wider implications for scalability.Trial Registration: This study is registered in ClinicalTrials.gov: Identifier NCT02373592 . [ABSTRACT FROM AUTHOR]- Published
- 2016
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11. Burden of chronic kidney disease in resource-limited settings from Peru: a population-based study.
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Francis, Elizabeth R., Chin-Chi Kuo, Bernabe-Ortiz, Antonio, Nessel, Lisa, Gilman, Robert H., Checkley, William, Miranda, J. Jaime, and Feldman, Harold I.
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CHRONIC kidney failure ,DISEASE prevalence ,PREVENTION of disease progression ,HYPERTENSION ,DIABETES - Abstract
Background: The silent progression of chronic kidney diseases (CKD) and its association with other chronic diseases, and high treatment costs make it a great public health concern worldwide. The population burden of CKD in Peru has yet to be fully described. Methods: We completed a cross sectional study of CKD prevalence among 404 participants (total study population median age 54.8 years, 50.2 % male) from two sites, highly-urbanized Lima and less urbanized Tumbes, who were enrolled in the population-based CRONICAS Cohort Study of cardiopulmonary health in Peru. Factors potentially associated with the presence of CKD were explored using Poisson regression, a statistical methodology used to determine prevalence ratios. Results: In total, 68 participants (16.8 %, 95 % CI 13.5-20.9 %) met criteria for CKD: 60 (14.9%) with proteinuria, four (1%) with eGFR <60mL/min/1.73m2, and four (1%) with both. CKD prevalence was higher in Lima (20.7 %, 95 % CI 15.8-27.1) than Tumbes (12.9 %, 95 % CI 9.0-18.5). Among participants with CKD, the prevalence of diabetes and hypertension was 19.1 % and 42.7 %, respectively. After multivariable adjustment, CKD was associated with older age, female sex, greater wealth tertile (although all wealth strata were below the poverty line), residence in Lima, and presence of diabetes and hypertension. Conclusions: The high prevalence rates of CKD identified in Lima and Tumbes are similar to estimates from high-income settings. These findings highlight the need to identify occult CKD and implement strategies to prevent disease progression and secondary morbidity. [ABSTRACT FROM AUTHOR]
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- 2015
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12. Prevalence of chronic obstructive pulmonary disease and variation in risk factors across four geographically diverse resource-limited settings in Peru.
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Jaganath, Devan, Miranda, J. Jaime, Gilman, Robert H., Wise, Robert A., Diette, Gregory B., Miele, Catherine H., Bernabe-Ortiz, Antonio, and Checkley, William
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OBSTRUCTIVE lung diseases ,LUNG diseases ,RESPIRATORY obstructions ,ASTHMA - Abstract
Background: It is unclear how geographic and social diversity affects the prevalence of chronic obstructive pulmonary disease (COPD). We sought to characterize the prevalence of COPD and identify risk factors across four settings in Peru with varying degrees of urbanization, altitude, and biomass fuel use. Methods: We collected sociodemographics, clinical history, and post-bronchodilator spirometry in a randomly selected, age-, sex- and site-stratified, population-based sample of 2,957 adults aged ≥35 years (median age was 54.8 years and 49.3% were men) from four resource-poor settings: Lima, Tumbes, urban and rural Puno. We defined COPD as a post-bronchodilator FEV1/FVC < 70%. Results: Overall prevalence of COPD was 6.0% (95% CI 5.1%-6.8%) but with marked variation across sites: 3.6% in semi-urban Tumbes, 6.1% in urban Puno, 6.2% in Lima, and 9.9% in rural Puno (p < 0.001). Population attributable risks (PARs) of COPD due to smoking ≥10 pack-years were less than 10% for all sites, consistent with a low prevalence of daily smoking (3.3%). Rather, we found that PARs of COPD varied by setting. In Lima, for example, the highest PARs were attributed to post-treatment tuberculosis (16% and 22% for men and women, respectively). In rural Puno, daily biomass fuel for cooking among women was associated with COPD (prevalence ratio 2.22, 95% CI 1.02-4.81) and the PAR of COPD due to daily exposure to biomass fuel smoke was 55%. Conclusions: The burden of COPD in Peru was not uniform and, unlike other settings, was not predominantly explained by tobacco smoking. This study emphasizes the role of biomass fuel use, and highlights pulmonary tuberculosis as an often neglected risk factor in endemic areas. [ABSTRACT FROM AUTHOR]
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- 2015
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13. Launching a salt substitute to reduce blood pressure at the population level: a cluster randomized stepped wedge trial in Peru.
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Bernabe-Ortiz, Antonio, Diez-Canseco, Francisco, Gilman, Robert H., Cárdenas, María K., Sacksteder, Katherine A., and Miranda, J. Jaime
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Background: Controlling hypertension rates and maintaining normal blood pressure, particularly in resource-constrained settings, represent ongoing challenges of effective and affordable implementation in health care. One of the strategies being largely advocated to improve high blood pressure calls for salt reduction strategies. This study aims to estimate the impact of a population-level intervention based on sodium reduction and potassium increase – in practice, introducing a low-sodium, high-potassium salt substitute – on adult blood pressure levels. Methods/Design: The proposed implementation research study includes two components: Phase 1, an exploratory component, and Phase 2, an intervention component. The exploratory component involves a triangle taste test and a formative research study designed to gain an understanding of the best implementation methods. Phase 2 involves a pragmatic stepped wedge trial design where the intervention will be progressively implemented in several clusters starting the intervention randomly at different times. In addition, we will evaluate the implementation strategy using a cost-effectiveness analysis. Discussion: This is the first project in a Latin-American setting to implement a salt substitution intervention at the population level to tackle high blood pressure. Data generated and lessons learnt from this study will provide a strong platform to address potential interventions applicable to other similar low- and middle-income settings. [ABSTRACT FROM AUTHOR]
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- 2014
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14. Handheld computers for self-administered sensitive data collection: A comparative study in Peru.
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Bernabe-Ortiz, Antonio, Curioso, Walter H., Gonzales, Marco A., Evangelista, Wilfredo, Castagnetto, Jesus M., Carcamo, Cesar P., Hughes, James P., Garcia, Patricia J., Garnett, Geoffrey P., and Holmes, King K.
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POCKET computers , *AUTOMATIC data collection systems , *QUESTIONNAIRES , *SEX customs , *CROSS-sectional method - Abstract
Background: Low-cost handheld computers (PDA) potentially represent an efficient tool for collecting sensitive data in surveys. The goal of this study is to evaluate the quality of sexual behavior data collected with handheld computers in comparison with paper-based questionnaires. Methods: A PDA-based program for data collection was developed using Open-Source tools. In two cross-sectional studies, we compared data concerning sexual behavior collected with paper forms to data collected with PDA-based forms in Ancon (Lima). Results: The first study enrolled 200 participants (18-29 years). General agreement between data collected with paper format and handheld computers was 86%. Categorical variables agreement was between 70.5% and 98.5% (Kappa: 0.43-0.86) while numeric variables agreement was between 57.1% and 79.8% (Spearman: 0.76-0.95). Agreement and correlation were higher in those who had completed at least high school than those with less education. The second study enrolled 198 participants. Rates of responses to sensitive questions were similar between both kinds of questionnaires. However, the number of inconsistencies (p = 0.0001) and missing values (p = 0.001) were significantly higher in paper questionnaires. Conclusion: This study showed the value of the use of handheld computers for collecting sensitive data, since a high level of agreement between paper and PDA responses was reached. In addition, a lower number of inconsistencies and missing values were found with the PDA-based system. This study has demonstrated that it is feasible to develop a low-cost application for handheld computers, and that PDAs are feasible alternatives for collecting field data in a developing country. [ABSTRACT FROM AUTHOR]
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- 2008
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15. A cross-sectional study of differences in 6-min walk distance in healthy adults residing at high altitude versus sea level.
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Caffrey D, Miranda JJ, Gilman RH, Davila-Roman VG, Cabrera L, Dowling R, Stewart T, Bernabe-Ortiz A, Wise R, Leon-Velarde F, and Checkley W
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Background: We sought to determine if adult residents living at high altitude have developed sufficient adaptation to a hypoxic environment to match the functional capacity of a similar population at sea level. To test this hypothesis, we compared the 6-min walk test distance (6MWD) in 334 residents living at sea level vs. at high altitude., Methods: We enrolled 168 healthy adults aged ≥35 years residing at sea level in Lima and 166 individuals residing at 3,825 m above sea level in Puno, Peru. Participants completed a 6-min walk test, answered a sociodemographics and clinical questionnaire, underwent spirometry, and a blood test., Results: Average age was 54.0 vs. 53.8 years, 48% vs. 43% were male, average height was 155 vs. 158 cm, average blood oxygen saturation was 98% vs. 90%, and average resting heart rate was 67 vs. 72 beats/min in Lima vs. Puno. In multivariable regression, participants in Puno walked 47.6 m less (95% CI -81.7 to -13.6 m; p < 0.01) than those in Lima. Other variables besides age and height that were associated with 6MWD include change in heart rate (4.0 m per beats/min increase above resting heart rate; p < 0.001) and percent body fat (-1.4 m per % increase; p = 0.02)., Conclusions: The 6-min walk test predicted a lowered functional capacity among Andean high altitude vs. sea level natives at their altitude of residence, which could be explained by an incomplete adaptation or a protective mechanism favoring neuro- and cardioprotection over psychomotor activity.
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- 2014
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