1. Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients.
- Author
-
Whitmire P, Rickertsen CR, Hawkins-Daarud A, Carrasco E Jr, Lorence J, De Leon G, Curtin L, Bayless S, Clark-Swanson K, Peeri NC, Corpuz C, Lewis-de Los Angeles CP, Bendok BR, Gonzalez-Cuyar L, Vora S, Mrugala MM, Hu LS, Wang L, Porter A, Kumthekar P, Johnston SK, Egan KM, Gatenby R, Canoll P, Rubin JB, and Swanson KR
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Brain Neoplasms pathology, Brain Neoplasms therapy, Child, Female, Follow-Up Studies, Glioblastoma pathology, Glioblastoma therapy, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Models, Theoretical, Prognosis, Retrospective Studies, Sex Factors, Survival Rate, Young Adult, Brain Neoplasms mortality, Glioblastoma mortality, Magnetic Resonance Imaging methods
- Abstract
Background: Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences., Methods: Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females)., Results: Among males, tumor (T1Gd) radius was a predictor of overall survival (HR = 1.027, p = 0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR = 1.011, p < 0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p = 0.010 t-test), but tumor size was not correlated with female overall survival (p = 0.955 CPH). Both male and female extreme survivors had significantly lower tumor cell net proliferation rates than other patients (M p = 0.004, F p = 0.001, t-test)., Conclusion: Despite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes.
- Published
- 2020
- Full Text
- View/download PDF