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Stress hyperglycemia in the critically ill is a complex process in which insulin signaling is systematically hijacked to provide energy substrate for metabolic priorities such as cell healing or infection containment. Fluctuating levels of plasma glucose are associated with increased mortality in the ICU [1]. We develop a multiscale mathematical model that can characterize the severity of stress hyperglycemia based on a fundamental understanding of the signaling molecules involved.

Kikuchi-Fujimoto Disease is a rare, benign cause of lymphadenopathy that is often associated with fever, night sweats, and weight loss. The clinical and laboratory manifestation of Kikuchi-Fujimoto Disease are similar to those of lymphoma, tuberculosis, sarcoidosis, systemic lupus erythematosus, and it is often mistaken for these disorders. Definitive diagnosis is accomplished by lymph node biopsy. Awareness of Kikuchi-Fujimoto Disease among clinicians and pathologists is essential to avoid misdiagnosis and inappropriate treatment of patients with this self-limited disorder.