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Background: Goalball is a popular sport among visually impaired individuals, offering many physical and social benefits. Evaluating performance in Goalball, particularly understanding factors influencing ball velocity during throwing techniques, is essential for optimizing training programs and enhancing player performance. However, there is limited research on muscle activation patterns during Goalball throwing movements, needing further investigation to address this gap. Therefore, this study aims to examine muscle activity in sub-elite visually impaired Goalball players during different throwing techniques and visual conditions, focusing on its relationship with ball velocity. Methods: 15 sub-elite Goalball players (2 female, 13 males; mean age of 20.46 ± 2.23 years) participated in the study. Muscle activity was evaluated with the Myo armband, while ball velocity was measured using two cameras and analyzed with MATLAB software. Different visual conditions were simulated using an eye band, and the effects of these conditions on muscle activation and ball velocity were examined. Results: The flexor muscles were found to be more active during the spin throw techniques with the eyes open (p = 0.011). The extensor muscles were found to be more active in the eyes-closed spin throw techniques compared to the eyes-open position (p = 0.031). Ball velocity was found related to the flexor muscles. Interestingly, no significant differences in ball velocity were observed between different throwing techniques or visual conditions (p > 0.05). Conclusions: Ball velocity, one of the performance indicators of the athlete, is primarily related to upper extremity flexor muscle strength rather than visual acuity. It has less visual acuity, but an athlete with more upper-extremity flexor muscle strength will have an advantage in Goalball game. The spin throw technique, which is reported to provide a biomechanical advantage for professional players in the literature, did not provide an advantage in terms of ball velocity for the sub elite players evaluated in our study. This knowledge can inform the development of targeted training programs aimed at improving technique and enhancing ball velocity in Goalball players. [ABSTRACT FROM AUTHOR]