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Start Over Author "Alan D. Bennett" Publisher biomed central
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1. Preclinical safety testing of an affinity-optimised MAGE-A10 T cell receptor for adoptive T cell therapy

Author

Manoj Saini, Gwendolyn Binder-Scholl, Lini Pandite, Bent K. Jakobsen, Barbara Tavano, Tom Holdich, Rafael G. Amado, Andrew B. Gerry, Joseph P. Sanderson, Miguel Maroto, Ellen Border, Nicholas J. Pumphrey, Alan D. Bennett, and Roslin Y. Docta

Subjects
Pharmacology, Test strategy, Cancer Research, business.industry, T cell, Immunology, Lung squamous cell carcinoma, T-cell receptor, Adoptive immunotherapy, medicine.anatomical_structure, Oncology, Toxicity, Poster Presentation, Molecular Medicine, Immunology and Allergy, Medicine, Cancer/testis antigens, business, Safety testing
Abstract

Meeting abstracts Preclinical safety testing for adoptive immunotherapies utilising T cell receptor-(TCR) engineered T cells relies on stringent target validation and a robust pre-clinical specificity testing strategy. Specific safety concerns include on-target off-tumour toxicity and off-target

Published
2015

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