233 results on '"A. Agudo"'
Search Results
2. Circulating free insulin-like growth factor-I and prostate cancer: a case-control study nested in the European prospective investigation into cancer and nutrition
- Author
-
Cheng, Tuck Seng, Noor, Urwah, Watts, Eleanor, Pollak, Michael, Wang, Ye, McKay, James, Atkins, Joshua, Masala, Giovanna, Sánchez, Maria-Jose, Agudo, Antonio, Castilla, Jesús, Aune, Dagfinn, Colorado-Yohar, Sandra M., Manfredi, Luca, Gunter, Marc J., Pala, Valeria, Josefsson, Andreas, Key, Timothy J., Smith-Byrne, Karl, and Travis, Ruth C.
- Published
- 2024
- Full Text
- View/download PDF
3. Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy
- Author
-
Blaya-Cánovas, José L., Griñán-Lisón, Carmen, Blancas, Isabel, Marchal, Juan A., Ramírez-Tortosa, César, López-Tejada, Araceli, Benabdellah, Karim, Cortijo-Gutiérrez, Marina, Cano-Cortés, M. Victoria, Graván, Pablo, Navarro-Marchal, Saúl A., Gómez-Morales, Jaime, Delgado-Almenta, Violeta, Calahorra, Jesús, Agudo-Lera, María, Sagarzazu, Amaia, Rodríguez-González, Carlos J., Gallart-Aragón, Tania, Eich, Christina, Sánchez-Martín, Rosario M., and Granados-Principal, Sergio
- Published
- 2024
- Full Text
- View/download PDF
4. First-in-human demonstration of floating EMG sensors and stimulators wirelessly powered and operated by volume conduction
- Author
-
Becerra-Fajardo, Laura, Minguillon, Jesus, Krob, Marc Oliver, Rodrigues, Camila, González-Sánchez, Miguel, Megía-García, Álvaro, Galán, Carolina Redondo, Henares, Francisco Gutiérrez, Comerma, Albert, del-Ama, Antonio J., Gil-Agudo, Angel, Grandas, Francisco, Schneider-Ickert, Andreas, Barroso, Filipe Oliveira, and Ivorra, Antoni
- Published
- 2024
- Full Text
- View/download PDF
5. Correction: Exoskeleton-based training improves walking independence in incomplete spinal cord injury patients: results from a randomized controlled trial
- Author
-
Gil-Agudo, Ángel, Megía-García, Álvaro, Pons, José Luis, Sinovas-Alonso, Isabel, Comino-Suárez, Natalia, Lozano-Berrio, Vicente, and del-Ama, Antonio J.
- Published
- 2023
- Full Text
- View/download PDF
6. A qualitative study to elicit user requirements for lower limb wearable exoskeletons for gait rehabilitation in spinal cord injury
- Author
-
Herrera-Valenzuela, Diana, Díaz-Peña, Laura, Redondo-Galán, Carolina, Arroyo, María José, Cascante-Gutiérrez, Lía, Gil-Agudo, Ángel, Moreno, Juan C., and del-Ama, Antonio J.
- Published
- 2023
- Full Text
- View/download PDF
7. Oral manifestations of COVID-19 in unvaccinated patients: a cross-sectional study
- Author
-
Fernandes, Tatiana Jorge, Ogrzewalska, Maria, Martins, Ezequias Batista, de Siqueira, Marilda Agudo Mendonça Teixeira, Brasil, Patrícia, and Calvet, Guilherme Amaral
- Published
- 2023
- Full Text
- View/download PDF
8. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries: results from the EPIC cohort study
- Author
-
Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, and Agudo, Antonio
- Published
- 2023
- Full Text
- View/download PDF
9. Exoskeleton-based training improves walking independence in incomplete spinal cord injury patients: results from a randomized controlled trial
- Author
-
Gil-Agudo, Ángel, Megía-García, Álvaro, Pons, José Luis, Sinovas-Alonso, Isabel, Comino-Suárez, Natalia, Lozano-Berrio, Vicente, and del-Ama, Antonio J.
- Published
- 2023
- Full Text
- View/download PDF
10. Transmission risk of vector-borne bacterial diseases (Anaplasma spp. and Ehrlichia canis) in Spain and Portugal.
- Author
-
Balmori-de la Puente, Alfonso, Rodríguez-Escolar, Iván, Collado-Cuadrado, Manuel, Infante González-Mohino, Elena, Vieira Lista, María Carmen, Hernández-Lambraño, Ricardo Enrique, Sánchez-Agudo, José Ángel, and Morchón, Rodrigo
- Abstract
Background: Ehrlichiosis and anaplasmosis are vector-borne bacterial diseases produced by intracellular rickettsial species of the genus Ehrlichia and Anaplasma. Ehrlichia canis and Anaplasma spp. (A. platys and A. phagocytophilum) have reported cases of zoonotic transmision and are the main bacterial agents of canine ehrlichiosis and anaplasmosis. They normally present an asymptomatic or mild course in domestic and wild animals with some lethal cases reported. The main vector of these diseases in Europe are the castor bean tick (Ixodes ricinus) and the brown dog tick (Rhipicephalus sanguineus), although only in the latter, the main host is the domestic dogs. The aim of this work is to apply an integrative approach to convert ecological niche models (ENMs) into potential transmission risk models and understand the relative contribution of the two potential vectors (R. sanguineus and I. ricinus) to spread both diseases in the Iberian Peninsula and Balearic Islands. Results: Two ENMs meeting all criteria were successfully generated for R. sanguineus and I. ricinus with human footprint being the most relevant explanatory variable. The novelty of the study lies in the combination of independent ENMs for both species to estimate the disease transmission risk of specific bacteria (E. canis, A. platys and A. phagocytophilum). Only the transmission risk maps that had higher contribution of R. sanguineus than I. ricinus showed relevant and positive significant correlations between risk and seroprevalence in either of the two species of bacteria (R ≥ 0.4; p < 0.05). Regarding Anaplasma spp., the map having 10% contribution of I. ricinus (10I) and 90% of R. sanguineus (90R) inferred 47.4% of infected dogs in very high-risk areas. In the case of E. canis, the model showing a proportion of 25I-75R showed better validation power (53.4% of infected dogs in very high-risk areas). Conclusion: The validation approach used in this study produced a good approximation to understand the relative contribution of the two tick species in bacterial disease transmission in dogs in the Iberian Peninsula and Balearic Islands. Rhipicephalus sanguineus appears as the main transmitter of both diseases in the study area (90% and 75% for anaplasmosis and ehrlichiosis respectively), in accordance with its higher abundance and host preference. This estimate may help veterinary staff, clinicians and owners to optimize the control of these diseases in certain vulnerable areas, and thus reduce the risk of infection in risk areas. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
11. Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
- Author
-
Cairat, Manon, Rinaldi, Sabina, Navionis, Anne-Sophie, Romieu, Isabelle, Biessy, Carine, Viallon, Vivian, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Severi, Gianluca, Kvaskoff, Marina, Fortner, Renée T., Kaaks, Rudolf, Aleksandrova, Krasimira, Schulze, Matthias B., Masala, Giovanna, Tumino, Rosario, Sieri, Sabina, Grasso, Chiara, Mattiello, Amalia, Gram, Inger T., Olsen, Karina Standahl, Agudo, Antonio, Etxezarreta, Pilar Amiano, Sánchez, Maria-Jose, Santiuste, Carmen, Barricarte, Aurelio, Monninkhof, Evelyn, Hiensch, Anouk E., Muller, David, Merritt, Melissa A., Travis, Ruth C., Weiderpass, Elisabete, Gunter, Marc J., and Dossus, Laure
- Published
- 2022
- Full Text
- View/download PDF
12. Immune recognition of syngeneic, allogeneic and xenogeneic stromal cell transplants in healthy retinas
- Author
-
Norte-Muñoz, María, Gallego-Ortega, Alejandro, Lucas-Ruiz, Fernando, González-Riquelme, María J., Changa-Espinoza, Yazmín I., Galindo-Romero, Caridad, Ponsaerts, Peter, Vidal-Sanz, Manuel, García-Bernal, David, and Agudo-Barriuso, Marta
- Published
- 2022
- Full Text
- View/download PDF
13. Transcranial direct current stimulation combined with robotic therapy for upper and lower limb function after stroke: a systematic review and meta-analysis of randomized control trials
- Author
-
Comino-Suárez, Natalia, Moreno, Juan C., Gómez-Soriano, Julio, Megía-García, Álvaro, Serrano-Muñoz, Diego, Taylor, Julian, Alcobendas-Maestro, Mónica, Gil-Agudo, Ángel, del-Ama, Antonio J., and Avendaño-Coy, Juan
- Published
- 2021
- Full Text
- View/download PDF
14. Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort
- Author
-
His, Mathilde, Viallon, Vivian, Dossus, Laure, Schmidt, Julie A., Travis, Ruth C., Gunter, Marc J., Overvad, Kim, Kyrø, Cecilie, Tjønneland, Anne, Lécuyer, Lucie, Rothwell, Joseph A., Severi, Gianluca, Johnson, Theron, Katzke, Verena, Schulze, Matthias B., Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Tumino, Rosario, Macciotta, Alessandra, Boer, Jolanda M. A., Monninkhof, Evelyn M., Olsen, Karina Standahl, Nøst, Therese H., Sandanger, Torkjel M., Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Ardanaz, Eva, Vidman, Linda, Winkvist, Anna, Heath, Alicia K., Weiderpass, Elisabete, Huybrechts, Inge, and Rinaldi, Sabina
- Published
- 2021
- Full Text
- View/download PDF
15. Bisphenol-A exposure and risk of breast and prostate cancer in the Spanish European Prospective Investigation into Cancer and Nutrition study
- Author
-
Salamanca-Fernández, Elena, Rodríguez-Barranco, Miguel, Amiano, Pilar, Delfrade, Josu, Chirlaque, Maria Dolores, Colorado, Sandra, Guevara, Marcela, Jimenez, Ana, Arrebola, Juan Pedro, Vela, Fernando, Olea, Nicolás, Agudo, Antonio, and Sánchez, Maria-José
- Published
- 2021
- Full Text
- View/download PDF
16. Inadequate use of antibiotics in the covid-19 era: effectiveness of antibiotic therapy
- Author
-
Bendala Estrada, Alejandro David, Calderón Parra, Jorge, Fernández Carracedo, Eduardo, Muiño Míguez, Antonio, Ramos Martínez, Antonio, Muñez Rubio, Elena, Rubio-Rivas, Manuel, Agudo, Paloma, Arnalich Fernández, Francisco, Estrada Perez, Vicente, Taboada Martínez, María Luisa, Crestelo Vieitez, Anxela, Pesqueira Fontan, Paula Maria, Bustamante, Marta, Freire, Santiago J., Oriol-Bermúdez, Isabel, Artero, Arturo, Olalla Sierra, Julián, Areses Manrique, María, Carrasco-Sánchez, H. Francisco Javier, Vento, Vanessa Carolina, García García, Gema María, Cubero-Morais, Pablo, Casas-Rojo, José-Manuel, and Núñez-Cortés, Jesús Millán
- Published
- 2021
- Full Text
- View/download PDF
17. Dietary intake of trans fatty acids and breast cancer risk in 9 European countries
- Author
-
Matta, Michèle, Huybrechts, Inge, Biessy, Carine, Casagrande, Corinne, Yammine, Sahar, Fournier, Agnès, Olsen, Karina Standahl, Lukic, Marco, Gram, Inger Torhild, Ardanaz, Eva, Sánchez, Maria-José, Dossus, Laure, Fortner, Renée T., Srour, Bernard, Jannasch, Franziska, Schulze, Matthias B., Amiano, Pilar, Agudo, Antonio, Colorado-Yohar, Sandra, Quirós, J. Ramón, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Tjønneland, Anne, Olsen, Anja, Dahm, Christina C., Rosendahl, Ann H., Borgquist, Signe, Wennberg, Maria, Heath, Alicia K., Aune, Dagfinn, Schmidt, Julie, Weiderpass, Elisabete, Chajes, Veronique, Gunter, Marc J., and Murphy, Neil
- Published
- 2021
- Full Text
- View/download PDF
18. tappAS: a comprehensive computational framework for the analysis of the functional impact of differential splicing
- Author
-
de la Fuente, Lorena, Arzalluz-Luque, Ángeles, Tardáguila, Manuel, del Risco, Héctor, Martí, Cristina, Tarazona, Sonia, Salguero, Pedro, Scott, Raymond, Lerma, Alberto, Alastrue-Agudo, Ana, Bonilla, Pablo, Newman, Jeremy R. B., Kosugi, Shunichi, McIntyre, Lauren M., Moreno-Manzano, Victoria, and Conesa, Ana
- Published
- 2020
- Full Text
- View/download PDF
19. Nutrient-wide association study of 92 foods and nutrients and breast cancer risk
- Author
-
Heath, Alicia K., Muller, David C., van den Brandt, Piet A., Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B., Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F., van Gils, Carla H., Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K., and Tzoulaki, Ioanna
- Published
- 2020
- Full Text
- View/download PDF
20. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
- Author
-
Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam S., Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kühn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C., Menéndez, Virginia, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio Barricarte, Tong, Tammy Y. N., Schmidt, Julie A., Tzoulaki, Ioanna, Tsilidis, Konstantinos K., Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Picavet, H. Susan J., Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Jenab, Mazda, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick J., Gunter, Marc J., and Ferrari, Pietro
- Published
- 2020
- Full Text
- View/download PDF
21. Exoskeleton-based training improves walking independence in incomplete spinal cord injury patients: results from a randomized controlled trial
- Author
-
Instituto de Salud Carlos III, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Gil-Agudo, Á., Megía-García, Á., Pons Rovira, José Luis, Sinovas-Alonso, I., Comino-Suárez, Natalia, Lozano-Berrio, V., Del Ama Espinosa, Antonio José, Instituto de Salud Carlos III, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Gil-Agudo, Á., Megía-García, Á., Pons Rovira, José Luis, Sinovas-Alonso, I., Comino-Suárez, Natalia, Lozano-Berrio, V., and Del Ama Espinosa, Antonio José
- Abstract
Background: In recent years, ambulatory lower limb exoskeletons are being gradually introduced into the clinical practice to complement walking rehabilitation programs. However, the clinical evidence of the outcomes attained with these devices is still limited and nonconclusive. Furthermore, the user-to-robot adaptation mechanisms responsible for functional improvement are still not adequately unveiled. This study aimed to (1) assess the safety and feasibility of using the HANK exoskeleton for walking rehabilitation, and (2) investigate the effects on walking function after a training program with it. Methods: A randomized controlled trial was conducted including a cohort of 23 patients with less than 1 year since injury, neurological level of injury (C2-L4) and severity (American Spinal Cord Injury Association Impairment Scale [AIS] C or D). The intervention was comprised of 15 one-hour gait training sessions with lower limb exoskeleton HANK. Safety was assessed through monitoring of adverse events, and pain and fatigue through a Visual Analogue Scale. LEMS, WISCI-II, and SCIM-III scales were assessed, along with the 10MWT, 6MWT, and the TUG walking tests (see text for acronyms). Results: No major adverse events were reported. Participants in the intervention group (IG) reported 1.8 cm (SD 1.0) for pain and 3.8 (SD 1.7) for fatigue using the VAS. Statistically significant differences were observed for the WISCI-II for both the “group” factor (F = 16.75, p < 0.001) and “group-time” interactions (F = 8.87; p < 0.01). A post-hoc analysis revealed a statistically significant increase of 3.54 points (SD 2.65, p < 0.0001) after intervention for the IG but not in the CG (0.7 points, SD 1.49, p = 0.285). No statistical differences were observed between groups for the remaining variables. Conclusions: The use of HANK exoskeleton in clinical settings is safe and well-tolerated by the patients. Patients receiving treatment with the exoskeleton improved their walking independe
- Published
- 2023
22. A qualitative study to elicit user requirements for lower limb wearable exoskeletons for gait rehabilitation in spinal cord injury
- Author
-
Ministerio de Ciencia e Innovación (España), European Commission, Herrera-Valenzuela, D., Díaz-Peña, L., Redondo-Galán, C., Arroyo, M.J., Cascante-Gutiérrez, L., Gil-Agudo, Á., Moreno, Juan Camilo, Del-Ama, Antonio J., Ministerio de Ciencia e Innovación (España), European Commission, Herrera-Valenzuela, D., Díaz-Peña, L., Redondo-Galán, C., Arroyo, M.J., Cascante-Gutiérrez, L., Gil-Agudo, Á., Moreno, Juan Camilo, and Del-Ama, Antonio J.
- Abstract
Objective: We aim to determine a comprehensive set of requirements, perceptions, and expectations that people with spinal cord injury (SCI) and the clinicians in charge of their rehabilitation have regarding the use of wearable robots (WR) for gait rehabilitation. Background: There are concerns due to the limited user acceptance of WR for gait rehabilitation. Developers need to emphasize understanding the needs and constraints of all stakeholders involved, including the real-life dynamics of rehabilitation centers. Methods: 15 people with SCI, 9 without experience with WR and 6 with experience with these technologies, and 10 clinicians from 3 rehabilitation centers in Spain were interviewed. A directed content analysis approach was used. Results: 78 codes grouped into 9 categories (physical results, usability, psychology-related codes, technical characteristics, activities, acquisition issues, context of use, development of the technologies and clinical rehabilitation context) were expressed by at least 20% of the users interviewed, of whom 16 were not found in the literature. The agreement percentage between each group and subgroup included in the study, calculated as the number of codes that more than 20% of both groups expressed, divided over the total amount of codes any of those two groups agreed on (≥ 20%), showed limited agreement between patients and clinicians (50.00%) and between both types of patients (55.77%). The limited accessibility and availability of lower limb exoskeletons for gait rehabilitation arose in most of the interviews. Conclusions: The limited agreement percentage between patients and clinicians indicates that including both types of users in the design process of these technologies is important, given that their requirements are complementary. Engaging users with prior technology experience is recommended, as they often exhibit strong internal consensus and articulate well-defined requirements. This study adds up the knowledge available
- Published
- 2023
23. Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
- Author
-
Karavasiloglou, Nena, Hüsing, Anika, Masala, Giovanna, van Gils, Carla H., Turzanski Fortner, Renée, Chang-Claude, Jenny, Huybrechts, Inge, Weiderpass, Elisabete, Gunter, Marc, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Tjønneland, Anne, Kyrø, Cecilie, Dahm, Christina C., Vistisen, Helene Tilma, Bakker, Marije F., Sánchez, Maria-Jose, Chirlaque López, María Dolores, Santiuste, Carmen, Ardanaz, Eva, Menéndez, Virginia, Agudo, Antonio, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Butt, Salma Tunå, Borgquist, Signe, Skeie, Guri, Schulze, Matthias, Key, Timothy, Khaw, Kay-Tee, Tsilidis, Kostantinos K., Ellingjord-Dale, Merete, Riboli, Elio, Kaaks, Rudolf, Dossus, Laure, Rohrmann, Sabine, and Kühn, Tilman
- Published
- 2019
- Full Text
- View/download PDF
24. Combined use of smartphone and smartband technology in the improvement of lifestyles in the adult population over 65 years: study protocol for a randomized clinical trial (EVIDENT-Age study)
- Author
-
Recio-Rodríguez, José I., Lugones-Sanchez, Cristina, Agudo-Conde, Cristina, González-Sánchez, Jesús, Tamayo-Morales, Olaya, Gonzalez-Sanchez, Susana, Fernandez-Alonso, Carmen, Maderuelo-Fernandez, Jose A., Mora-Simon, Sara, Gómez-Marcos, Manuel A., Rodriguez-Sanchez, Emiliano, and Garcia-Ortiz, Luis
- Published
- 2019
- Full Text
- View/download PDF
25. Prospective analysis of circulating metabolites and breast cancer in EPIC
- Author
-
His, Mathilde, Viallon, Vivian, Dossus, Laure, Gicquiau, Audrey, Achaintre, David, Scalbert, Augustin, Ferrari, Pietro, Romieu, Isabelle, Onland-Moret, N. Charlotte, Weiderpass, Elisabete, Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Rothwell, Joseph A., Severi, Gianluca, Kühn, Tilman, Fortner, Renée T., Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, van Gils, Carla H., Nøst, Therese H., Sandanger, Torkjel M., Skeie, Guri, Quirós, J. Ramón, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Huerta, José María, Ardanaz, Eva, Schmidt, Julie A., Travis, Ruth C., Riboli, Elio, Tsilidis, Konstantinos K., Christakoudi, Sofia, Gunter, Marc J., and Rinaldi, Sabina
- Published
- 2019
- Full Text
- View/download PDF
26. Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study
- Author
-
Perrier, F., Viallon, V., Ambatipudi, S., Ghantous, A., Cuenin, C., Hernandez-Vargas, H., Chajès, V., Baglietto, L., Matejcic, M., Moreno-Macias, H., Kühn, T., Boeing, H., Karakatsani, A., Kotanidou, A., Trichopoulou, A., Sieri, S., Panico, S., Fasanelli, F., Dolle, M., Onland-Moret, C., Sluijs, I., Weiderpass, E., Quirós, J. R., Agudo, A., Huerta, J. M., Ardanaz, E., Dorronsoro, M., Tong, T. Y. N., Tsilidis, K., Riboli, E., Gunter, M. J., Herceg, Z., Ferrari, P., and Romieu, I.
- Published
- 2019
- Full Text
- View/download PDF
27. Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts
- Author
-
Li, Kuanrong, Anderson, Garnet, Viallon, Vivian, Arveux, Patrick, Kvaskoff, Marina, Fournier, Agnès, Krogh, Vittorio, Tumino, Rosario, Sánchez, Maria-Jose, Ardanaz, Eva, Chirlaque, María-Dolores, Agudo, Antonio, Muller, David C., Smith, Todd, Tzoulaki, Ioanna, Key, Timothy J., Bueno-de-Mesquita, Bas, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, Kaaks, Rudolf, Hüsing, Anika, Fortner, Renée T., Zeleniuch-Jacquotte, Anne, Sund, Malin, Dahm, Christina C., Overvad, Kim, Aune, Dagfinn, Weiderpass, Elisabete, Romieu, Isabelle, Riboli, Elio, Gunter, Marc J., Dossus, Laure, Prentice, Ross, and Ferrari, Pietro
- Published
- 2018
- Full Text
- View/download PDF
28. Receptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: results from the EPIC cohort
- Author
-
Sarink, Danja, Schock, Helena, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Boeing, Heiner, Karakatsani, Anna, Trichopoulou, Antonia, La Vecchia, Carlo, Masala, Giovanna, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, van Gils, Carla H., Peeters, Petra H. M., Weiderpass, Elisabete, Agudo, Antonio, Rodríguez-Barranco, Miguel, Huerta, José María, Ardanaz, Eva, Gil, Leire, Kaw, Kay Tee, Schmidt, Julie A., Dossus, Laure, His, Mathilde, Aune, Dagfinn, Riboli, Elio, Kaaks, Rudolf, and Fortner, Renée T.
- Published
- 2018
- Full Text
- View/download PDF
29. Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
- Author
-
Campa, Daniele, Barrdahl, Myrto, Santoro, Aurelia, Severi, Gianluca, Baglietto, Laura, Omichessan, Hanane, Tumino, Rosario, Bueno-de-Mesquita, H. B(as)., Peeters, Petra H., Weiderpass, Elisabete, Chirlaque, Maria-Dolores, Rodríguez-Barranco, Miguel, Agudo, Antonio, Gunter, Marc, Dossus, Laure, Krogh, Vittorio, Matullo, Giuseppe, Trichopoulou, Antonia, Travis, Ruth C., Canzian, Federico, and Kaaks, Rudolf
- Published
- 2018
- Full Text
- View/download PDF
30. Inadequate use of antibiotics in the covid-19 era: effectiveness of antibiotic therapy
- Author
-
Francisco Arnalich Fernández, H Francisco Javier Carrasco-Sánchez, Jesús Millán Núñez-Cortés, Santiago Jesús Freire, Gema María García García, Julián Olalla Sierra, Paloma Agudo, María Luisa Taboada Martínez, José-Manuel Casas-Rojo, Pablo Cubero-Morais, Elena Rubio, Vanessa Carolina Vento, Manuel Rubio-Rivas, Jorge Calderón Parra, Paula Maria Pesqueira Fontan, Antonio Ramos Martínez, Isabel Oriol-Bermúdez, Marta Bustamante, María Areses Manrique, Anxela Crestelo Vieitez, Antonio Muiño Miguez, Alejandro David Bendala Estrada, Arturo Artero, Eduardo Fernández Carracedo, and Vicente Estrada Perez
- Subjects
medicine.medical_specialty ,Survival ,medicine.drug_class ,Antibiotics ,Antibiòtics ,Infectious and parasitic diseases ,RC109-216 ,Disease ,Azithromycin ,Medical microbiology ,Pandemic ,Clinical endpoint ,medicine ,Humans ,Intensive care medicine ,Supervivència ,Pandemics ,business.industry ,SARS-CoV-2 ,Medical record ,Mortality rate ,Research ,COVID-19 ,Anti-Bacterial Agents ,COVID-19 Drug Treatment ,Infectious Diseases ,Macrolides ,business ,medicine.drug - Abstract
BackgroundSince December 2019, the COVID-19 pandemic has changed the concept of medicine. This work aims to analyze the use of antibiotics in patients admitted to the hospital due to SARS-CoV-2 infection.MethodsThis work analyzes the use and effectiveness of antibiotics in hospitalized patients with COVID-19 based on data from the SEMI-COVID-19 registry, an initiative to generate knowledge about this disease using data from electronic medical records. Our primary endpoint was all-cause in-hospital mortality according to antibiotic use. The secondary endpoint was the effect of macrolides on mortality.ResultsOf 13,932 patients, antibiotics were used in 12,238. The overall death rate was 20.7% and higher among those taking antibiotics (87.8%). Higher mortality was observed with use of all antibiotics (OR 1.40, 95% CI 1.21–1.62;p p ConclusionsBacterial co-infection was uncommon among COVID-19 patients, yet use of antibiotics was high. There is insufficient evidence to support widespread use of empiric antibiotics in these patients. Most may not require empiric treatment and if they do, there is promising evidence regarding azithromycin as a potential COVID-19 treatment.
- Published
- 2021
31. Transcranial direct current stimulation combined with robotic therapy for upper and lower limb function after stroke: a systematic review and meta-analysis of randomized control trials
- Author
-
Comino-Suárez, N., Moreno, J.C, Gómez-Soriano, Julio, Megía-García, Á., Serrano-Muñoz, D., Taylor, J., Alcobendas-Maestro, M., Gil-Agudo, A., del-Ama, A.J., Avendaño-Coy, J., Ministerio de Economía, Industria y Competitividad (España), and European Commission
- Subjects
Stroke ,Neuromodulation ,tDCS ,Transcranial direct current stimulation ,Robotic - Abstract
Background: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation method able to modulate neuronal activity after stroke. The aim of this systematic review was to determine if tDCS combined with robotic therapy (RT) improves limb function after stroke when compared to RT alone. Methods: A search for randomized controlled trials (RCTs) published prior to July 15, 2021 was performed. The main outcome was function assessed with the Fugl-Meyer motor assessment for upper extremities (FM/ue) and 10-m walking test (10MWT) for the lower limbs. As secondary outcomes, strength was assessed with the Motricity Index (MI) or Medical Research Council scale (MRC), spasticity with the modified Ashworth scale (MAS), functional independence with the Barthel Index (BI), and kinematic parameters. Results: Ten studies were included for analysis (n = 368 enrolled participants). The results showed a non-significant effect for tDCS combined with RT to improve upper limb function [standardized mean difference (SMD) = − 0.12; 95% confidence interval (CI): − 0.35–0.11)]. However, a positive effect of the combined therapy was observed in the lower limb function (SMD = 0.48; 95% CI: − 0.15–1.12). Significant results favouring tDCS combined with RT were not found in strength (SMD = − 0.15; 95% CI: − 0.4–0.1), spasticity [mean difference (MD) = − 0.15; 95% CI: − 0.8–0.5)], functional independence (MD = 2.5; 95% CI: − 1.9–6.9) or velocity of movement (SMD = 0.06; 95% CI: − 0.3–0.5) with a “moderate” or “low” recommendation level according to the GRADE guidelines. Conclusions: Current findings suggest that tDCS combined with RT does not improve upper limb function, strength, spasticity, functional independence or velocity of movement after stroke. However, tDCS may enhance the effects of RT alone for lower limb function. tDCS parameters and the stage or type of stroke injury could be crucial factors that determine the effectiveness of this therapy. This was supported by the Ministerio de Economía, Industria y Competitividad. RECODE project [Grant number: DPI2017‑91117‑EXP]; and by Junta de Comunidades de Castilla la Mancha and Fondo Europeo de Desarrollo Regional (Fondos FEDER). EXO‑STIM Project [Grant number: SBPLY/19/180501/000316].
- Published
- 2021
32. Transcranial direct current stimulation combined with robotic therapy for upper and lower limb function after stroke: a systematic review and meta-analysis of randomized control trials
- Author
-
Ministerio de Economía, Industria y Competitividad (España), European Commission, Comino-Suárez, Natalia, Moreno, Juan Camilo, Gómez-Soriano, Julio, Megía-García, Á., Serrano-Muñoz, D., Taylor, Julian S., Alcobendas-Maestro, M., Gil-Agudo, Ángel, Ama, Antonio J. del, Avendaño-Coy, J., Ministerio de Economía, Industria y Competitividad (España), European Commission, Comino-Suárez, Natalia, Moreno, Juan Camilo, Gómez-Soriano, Julio, Megía-García, Á., Serrano-Muñoz, D., Taylor, Julian S., Alcobendas-Maestro, M., Gil-Agudo, Ángel, Ama, Antonio J. del, and Avendaño-Coy, J.
- Abstract
Background: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation method able to modulate neuronal activity after stroke. The aim of this systematic review was to determine if tDCS combined with robotic therapy (RT) improves limb function after stroke when compared to RT alone. Methods: A search for randomized controlled trials (RCTs) published prior to July 15, 2021 was performed. The main outcome was function assessed with the Fugl-Meyer motor assessment for upper extremities (FM/ue) and 10-m walking test (10MWT) for the lower limbs. As secondary outcomes, strength was assessed with the Motricity Index (MI) or Medical Research Council scale (MRC), spasticity with the modified Ashworth scale (MAS), functional independence with the Barthel Index (BI), and kinematic parameters. Results: Ten studies were included for analysis (n = 368 enrolled participants). The results showed a non-significant effect for tDCS combined with RT to improve upper limb function [standardized mean difference (SMD) = − 0.12; 95% confidence interval (CI): − 0.35–0.11)]. However, a positive effect of the combined therapy was observed in the lower limb function (SMD = 0.48; 95% CI: − 0.15–1.12). Significant results favouring tDCS combined with RT were not found in strength (SMD = − 0.15; 95% CI: − 0.4–0.1), spasticity [mean difference (MD) = − 0.15; 95% CI: − 0.8–0.5)], functional independence (MD = 2.5; 95% CI: − 1.9–6.9) or velocity of movement (SMD = 0.06; 95% CI: − 0.3–0.5) with a “moderate” or “low” recommendation level according to the GRADE guidelines. Conclusions: Current findings suggest that tDCS combined with RT does not improve upper limb function, strength, spasticity, functional independence or velocity of movement after stroke. However, tDCS may enhance the effects of RT alone for lower limb function. tDCS parameters and the stage or type of stroke injury could be crucial factors that determine the effectiveness of this therapy.
- Published
- 2021
33. Nutrient-wide association study of 92 foods and nutrients and breast cancer risk
- Author
-
Paolo Vineis, Bas Bueno-de-Mesquita, Anja Olsen, Antonio Agudo, Sofia Christakoudi, Nikos Papadimitriou, Aurelio Barricarte, Ulrika Ericson, Salvatore Panico, Elena Critselis, Konstantinos K. Tsilidis, Guy Fagherazzi, Marije F. Bakker, Piet A. van den Brandt, Elio Riboli, Alicia K Heath, Pilar Amiano, Tilman Kühn, María Dolores Chirlaque, Carla H. van Gils, Paolo Contiero, Patrick Arveux, Inge Huybrechts, Paschalis Thriskos, Mathilde His, María José Sánchez, Karina Standahl Olsen, Heinz Freisling, Antonia Trichopoulou, Isabel Drake, Marc J. Gunter, Marie-Christine Boutron-Ruault, David C. Muller, Giovanna Masala, Miguel Rodríguez-Barranco, Pietro Ferrari, Cristina Lasheras, Fulvio Ricceri, Heiner Boeing, Timothy J. Key, Merete Ellingjord-Dale, Elisabete Weiderpass, Anna Winkvist, Guri Skeie, Renée Turzanski-Fortner, Ioanna Tzoulaki, Matthias B. Schulze, Anna Karakatsani, Ingegerd Johansson, Anne Tjønneland, Francesca Mancini, Cancer Research UK, RS: GROW - R1 - Prevention, RS: CAPHRI - R5 - Optimising Patient Care, and Epidemiologie
- Subjects
Dietary Fiber ,PREMENOPAUSAL ,Cancer Research ,dietary fiber intake ,postmenopausal women ,Cohort Studies ,0302 clinical medicine ,Nutrient ,Breast cancer ,Risk Factors ,Surveys and Questionnaires ,80 and over ,Medicine ,030212 general & internal medicine ,Prospective Studies ,Aged, 80 and over ,Hazard ratio ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,Foods ,nutrition ,POSTMENOPAUSAL WOMEN ,Oncology ,030220 oncology & carcinogenesis ,DIETARY FIBER INTAKE ,Female ,Alcohol ,Life Sciences & Biomedicine ,Cohort study ,Research Article ,Adult ,QUESTIONNAIRE ,Breast Neoplasms ,Lower risk ,lcsh:RC254-282 ,Càncer de mama ,POOLED ANALYSIS ,Fibre ,03 medical and health sciences ,Young Adult ,SDG 3 - Good Health and Well-being ,Environmental health ,Journal Article ,Humans ,1112 Oncology and Carcinogenesis ,VDP::Medisinske Fag: 700 ,Oncology & Carcinogenesis ,Nutrició ,METAANALYSIS ,Aged ,SERUM ESTROGEN CONCENTRATIONS ,Nutrition ,Cancer och onkologi ,Science & Technology ,Proportional hazards model ,business.industry ,SCALE PROSPECTIVE COHORT ,Feeding Behavior ,Nutrients ,medicine.disease ,Diet ,VDP::Medical disciplines: 700 ,Nutrition Assessment ,Cancer and Oncology ,business ,Wine intake - Abstract
This work was supported by the World Cancer Research Fund (WCRF UK), as part of the World Cancer Research Fund International grant programme (WCRF 2014/1180 to Konstantinos K Tsilidis). The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF),Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS), Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia, Navarra, and the Catalan Institute of Oncology (Barcelona) (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/ M012190/1 to EPIC-Oxford) (UK)., Heath, A.K., Muller, D.C., Van Den Brandt, P.A., Papadimitriou, N., Critselis, E., Gunter, M., Vineis, P., Weiderpass, E., Fagherazzi, G., Boeing, H., Ferrari, P., Olsen, A., Tjønneland, A., Arveux, P., Boutron-Ruault, M.-C., Mancini, F.R., Kühn, T., Turzanski-Fortner, R., Schulze, M.B., Karakatsani, A., Thriskos, P., Trichopoulou, A., Masala, G., Contiero, P., Ricceri, F., Panico, S., Bueno-De-Mesquita, B., Bakker, M.F., Van Gils, C.H., Olsen, K.S., Skeie, G., Lasheras, C., Agudo, A., Rodríguez-Barranco, M., Sánchez, M.-J., Amiano, P., Chirlaque, M.-D., Barricarte, A., Drake, I., Ericson, U., Johansson, I., Winkvist, A., Key, T., Freisling, H., His, M., Huybrechts, I., Christakoudi, S., Ellingjord-Dale, M., Riboli, E., Tsilidis, K.K., Tzoulaki, I.
- Published
- 2020
- Full Text
- View/download PDF
34. Nutrient-wide association study of 92 foods and nutrients and breast cancer risk
- Author
-
Heath, Alicia K, Muller, David C, van den Brandt, Piet A, Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B, Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F, van Gils, Carla H, Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K, Tzoulaki, Ioanna, Heath, Alicia K, Muller, David C, van den Brandt, Piet A, Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B, Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F, van Gils, Carla H, Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K, and Tzoulaki, Ioanna
- Published
- 2020
35. Nutrient-wide association study of 92 foods and nutrients and breast cancer risk
- Author
-
MS MDL 1, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Heath, Alicia K, Muller, David C, van den Brandt, Piet A, Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B, Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F, van Gils, Carla H, Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K, Tzoulaki, Ioanna, MS MDL 1, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Heath, Alicia K, Muller, David C, van den Brandt, Piet A, Papadimitriou, Nikos, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Fagherazzi, Guy, Boeing, Heiner, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Kühn, Tilman, Turzanski-Fortner, Renée, Schulze, Matthias B, Karakatsani, Anna, Thriskos, Paschalis, Trichopoulou, Antonia, Masala, Giovanna, Contiero, Paolo, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Bakker, Marije F, van Gils, Carla H, Olsen, Karina Standahl, Skeie, Guri, Lasheras, Cristina, Agudo, Antonio, Rodríguez-Barranco, Miguel, Sánchez, Maria-José, Amiano, Pilar, Chirlaque, María-Dolores, Barricarte, Aurelio, Drake, Isabel, Ericson, Ulrika, Johansson, Ingegerd, Winkvist, Anna, Key, Tim, Freisling, Heinz, His, Mathilde, Huybrechts, Inge, Christakoudi, Sofia, Ellingjord-Dale, Merete, Riboli, Elio, Tsilidis, Konstantinos K, and Tzoulaki, Ioanna
- Published
- 2020
36. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
- Author
-
Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam S, Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kühn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C, Menéndez, Virginia, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio Barricarte, Tong, Tammy Y N, Schmidt, Julie A, Tzoulaki, Ioanna, Tsilidis, Konstantinos K, Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Picavet, H Susan J, Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Jenab, Mazda, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick J, Gunter, Marc J, Ferrari, Pietro, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam S, Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kühn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C, Menéndez, Virginia, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio Barricarte, Tong, Tammy Y N, Schmidt, Julie A, Tzoulaki, Ioanna, Tsilidis, Konstantinos K, Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Picavet, H Susan J, Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Jenab, Mazda, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick J, Gunter, Marc J, and Ferrari, Pietro
- Published
- 2020
37. Receptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: results from the EPIC cohort
- Author
-
Helena Schock, Kay Tee Kaw, Elisabete Weiderpass, José María Huerta, Eva Ardanaz, Rudolf Kaaks, Carlotta Sacerdote, Petra H.M. Peeters, Dagfinn Aune, Carla H. van Gils, Claudia Agnoli, Heiner Boeing, Anna Karakatsani, Anja Olsen, Antonia Trichopoulou, Mathilde His, Theron Johnson, Renée T. Fortner, Kim Overvad, Antonio Agudo, Anne Tjønneland, Marina Kvaskoff, Elio Riboli, Laure Dossus, Giovanna Masala, Agnès Fournier, Miguel Rodríguez-Barranco, Leire Gil, Carlo La Vecchia, Salvatore Panico, Danja Sarink, Jenny Chang-Claude, Patrick Arveux, Julie A. Schmidt, Rosario Tumino, Fortner, Renée T [0000-0002-1426-8505], Apollo - University of Cambridge Repository, Sarink, Danja, Schock, Helena, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Fournier, Agnè, Kvaskoff, Marina, Boeing, Heiner, Karakatsani, Anna, Trichopoulou, Antonia, La Vecchia, Carlo, Masala, Giovanna, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, van Gils, Carla H, Peeters, Petra H M, Weiderpass, Elisabete, Agudo, Antonio, Rodríguez-Barranco, Miguel, Huerta, José María, Ardanaz, Eva, Gil, Leire, Kaw, Kay Tee, Schmidt, Julie A, Dossus, Laure, His, Mathilde, Aune, Dagfinn, Riboli, Elio, Kaaks, Rudolf, and Fortner, Renée T
- Subjects
0301 basic medicine ,Oncology ,Cancer Research ,Epidemiology ,PROLACTIN ,Cohort Studies ,0302 clinical medicine ,Breast cancer ,Surgical oncology ,Limit of Detection ,Reproductive ,serum biomarkers of endogenous exposures ,biology ,Hazard ratio ,RANKL ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Prognosis ,BONE METASTASIS ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,FACTOR-KAPPA-B ,reproductive, hormonal, and related factors ,POSTMENOPAUSAL WOMEN ,030220 oncology & carcinogenesis ,Cohort ,GROWTH ,Female ,and related factors ,Life Sciences & Biomedicine ,Serum biomarkers of endogenous exposures ,Research Article ,EXPRESSION ,musculoskeletal diseases ,Adult ,Risk ,medicine.medical_specialty ,Breast Neoplasms ,lcsh:RC254-282 ,Càncer de mama ,03 medical and health sciences ,Osteoprotegerin ,POOR-PROGNOSIS ,Internal medicine ,Genetics ,medicine ,Humans ,Oncology & Carcinogenesis ,Epidemiologia ,Aged ,Science & Technology ,business.industry ,VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 ,RANK Ligand ,medicine.disease ,hormonal ,VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 ,030104 developmental biology ,ESTROGEN-RECEPTOR ,Reproductive, hormonal, and related factor ,Case-Control Studies ,biology.protein ,OPG ,business ,Reproductive, hormonal, and related factors ,1112 Oncology And Carcinogenesis - Abstract
Published version, available at: https://doi.org/10.1186/s12885-018-4887-3 Background Receptor activator of nuclear factor kappa-B (RANK)-signaling is involved in tumor growth and spread in experimental models. Binding of RANK ligand (RANKL) to RANK activates signaling, which is inhibited by osteoprotegerin (OPG). We have previously shown that circulating soluble RANKL (sRANKL) and OPG are associated with breast cancer risk. Here we extend these findings to provide the first data on pre-diagnosis concentrations of sRANKL and OPG and risk of breast cancer-specific and overall mortality after a breast cancer diagnosis. Methods Two thousand six pre- and postmenopausal women with incident invasive breast cancer (1620 (81%) with ER+ disease) participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were followed-up for mortality. Pre-diagnosis concentrations of sRANKL and OPG were quantified in baseline serum samples using an enzyme-linked immunosorbent assay and electrochemiluminescent assay, respectively. Hazard ratios (HRs) and 95% confidence intervals (CIs) for breast cancer-specific and overall mortality were calculated using Cox proportional hazards regression models. Results Especially in women with ER+ disease, higher circulating OPG concentrations were associated with higher risk of breast cancer-specific (quintile 5 vs 1 HR 1.77 [CI 1.03, 3.04]; ptrend 0.10) and overall mortality (q5 vs 1 HR 1.39 [CI 0.94, 2.05]; ptrend 0.02). sRANKL and the sRANKL/OPG ratio were not associated with mortality following a breast cancer diagnosis. Conclusions High pre-diagnosis endogenous concentrations of OPG, the decoy receptor for RANKL, were associated with increased risk of death after a breast cancer diagnosis, especially in those with ER+ disease. These results need to be confirmed in well-characterized patient cohorts.
- Published
- 2018
- Full Text
- View/download PDF
38. Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
- Author
-
Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Karavasiloglou, Nena, Hüsing, Anika, Masala, Giovanna, van Gils, Carla H, Turzanski Fortner, Renée, Chang-Claude, Jenny, Huybrechts, Inge, Weiderpass, Elisabete, Gunter, Marc, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Tjønneland, Anne, Kyrø, Cecilie, Dahm, Christina C, Vistisen, Helene Tilma, Bakker, Marije F, Sánchez, Maria-Jose, Chirlaque López, María Dolores, Santiuste, Carmen, Ardanaz, Eva, Menéndez, Virginia, Agudo, Antonio, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Butt, Salma Tunå, Borgquist, Signe, Skeie, Guri, Schulze, Matthias, Key, Timothy, Khaw, Kay-Tee, Tsilidis, Kostantinos K, Ellingjord-Dale, Merete, Riboli, Elio, Kaaks, Rudolf, Dossus, Laure, Rohrmann, Sabine, Kühn, Tilman, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Karavasiloglou, Nena, Hüsing, Anika, Masala, Giovanna, van Gils, Carla H, Turzanski Fortner, Renée, Chang-Claude, Jenny, Huybrechts, Inge, Weiderpass, Elisabete, Gunter, Marc, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Tjønneland, Anne, Kyrø, Cecilie, Dahm, Christina C, Vistisen, Helene Tilma, Bakker, Marije F, Sánchez, Maria-Jose, Chirlaque López, María Dolores, Santiuste, Carmen, Ardanaz, Eva, Menéndez, Virginia, Agudo, Antonio, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Butt, Salma Tunå, Borgquist, Signe, Skeie, Guri, Schulze, Matthias, Key, Timothy, Khaw, Kay-Tee, Tsilidis, Kostantinos K, Ellingjord-Dale, Merete, Riboli, Elio, Kaaks, Rudolf, Dossus, Laure, Rohrmann, Sabine, and Kühn, Tilman
- Published
- 2019
39. Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study
- Author
-
Augustin Scalbert, Dagfinn Aune, Andrew T. Gewirtz, Mazda Jenab, Veronika Fedirko, Christina Bamia, Nicholas J. Wareham, Elio Riboli, J. Ramón Quirós, Rudolf Kaaks, Aurelio Barricarte, Rosario Tumino, Salvatore Panico, María José Sánchez, Gianluca Severi, Kim Overvad, Antonia Trichopoulou, Sara Grioni, Domenico Palli, H. B. Bueno-De-Mesquita, Antonio Agudo, Isabelle Romieu, Mårten Werner, Tilman Kühn, Elisabete Weiderpass, Oskar Hemmingsson, Kathryn E. Bradbury, Pagona Lagiou, Hao Quang Tran, Marie-Christine Boutron-Ruault, Anne Tjønneland, Alessio Naccarati, José María Huerta Castaño, Franck Carbonnel, Magdalena Stepien, Kay-Tee Khaw, Krasimira Aleksandrova, Bodil Ohlsson, Petra H.M. Peeters, Heiner Boeing, Anja Olsen, Konstantinos K. Tsilidis, Miren Dorronsoro, Klas Sjöberg, Khaw, Kay-Tee [0000-0002-8802-2903], Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository, Fedirko, Veronika, Tran, Hao Quang, Gewirtz, Andrew T, Stepien, Magdalena, Trichopoulou, Antonia, Aleksandrova, Krasimira, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Carbonnel, Franck, Boutron Ruault, Marie Christine, Severi, Gianluca, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Bamia, Christina, Lagiou, Pagona, Grioni, Sara, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Naccarati, Alessio, Peeters, Petra H, Bueno de Mesquita, H. B, Weiderpass, Elisabete, Castaño, José María Huerta, Barricarte, Aurelio, Sánchez, María José, Dorronsoro, Miren, Quirós, J. Ramón, Agudo, Antonio, Sjöberg, Kla, Ohlsson, Bodil, Hemmingsson, Oskar, Werner, Mårten, Bradbury, Kathryn E, Khaw, Kay Tee, Wareham, Nick, Tsilidis, Konstantinos K, Aune, Dagfinn, Scalbert, Augustin, Romieu, Isabelle, Riboli, Elio, and Jenab, Mazda
- Subjects
Lipopolysaccharides ,Male ,0301 basic medicine ,Immunoglobulin A ,Hepatocellular carcinoma ,lcsh:Medicine ,Cohort Studies ,0302 clinical medicine ,Endotoxin ,Risk Factors ,Prospective cohort study ,RISK ,Medicine(all) ,biology ,NONALCOHOLIC STEATOHEPATITIS ,GUT MICROBIOTA ,Liver Neoplasms ,Confounding ,11 Medical And Health Sciences ,General Medicine ,VDP::Medical disciplines: 700::Health sciences: 800 ,Middle Aged ,Hepatitis B ,CANCER ,CROHNS-DISEASE ,Multicenter Study ,VDP::Medisinske Fag: 700::Helsefag: 800 ,030220 oncology & carcinogenesis ,NUTRITION ,Female ,Liver cancer ,Life Sciences & Biomedicine ,Research Article ,Adult ,DIET-INDUCED OBESITY ,Carcinoma, Hepatocellular ,Lipopolysaccharide ,Càncer de fetge ,03 medical and health sciences ,Medicine, General & Internal ,SDG 3 - Good Health and Well-being ,General & Internal Medicine ,Journal Article ,medicine ,Humans ,FATTY LIVER-DISEASE ,Aged ,Science & Technology ,business.industry ,lcsh:R ,Klinisk medicin ,medicine.disease ,Endotoxins ,030104 developmental biology ,PROSPECTIVE COHORT ,Case-Control Studies ,Immunoglobulin G ,Nested case-control study ,Immunology ,biology.protein ,Clinical Medicine ,business ,Prospective studies ,Flagellin - Abstract
All Author: Veronika Fedirko, Hao Quang Tran, Andrew T. Gewirtz, Magdalena Stepien, Antonia Trichopoulou, Krasimira Aleksandrova, Anja Olsen, Anne Tjønneland, Kim Overvad, Franck Carbonnel, Marie-Christine Boutron-Ruault, Gianluca Severi, Tilman Kühn, Rudolf Kaaks, Heiner Boeing, Christina Bamia, Pagona Lagiou, Sara Grioni, Salvatore Panico, Domenico Palli, Rosario Tumino, Alessio Naccarati, Petra H. Peeters, H. B. Bueno-de-Mesquita, Elisabete Weiderpass, José María Huerta Castaño, Aurelio Barricarte, María-José Sánchez, Miren Dorronsoro, J. Ramón Quirós, Antonio Agudo, Klas Sjöberg, Bodil Ohlsson, Oskar Hemmingsson, Mårten Werner, Kathryn E. Bradbury, Kay-Tee Khaw, Nick Wareham, Konstantinos K. Tsilidis, Dagfinn Aune, Augustin Scalbert, Isabelle Romieu, Elio Riboli and Mazda Jenab., Background: Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking. Methods: We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma. A total of 139 men and women diagnosed with hepatocellular carcinoma between 1992 and 2010 were matched to 139 control subjects. Multivariable rate ratios (RRs), including adjustment for potential confounders, hepatitis B/C positivity, and degree of liver dysfunction, were calculated with conditional logistic regression. Results: Antibody response to LPS and flagellin was associated with a statistically significant increase in the risk of hepatocellular carcinoma (highest vs. lowest quartile: RR = 11.76, 95% confidence interval = 1.70–81.40; Ptrend = 0.021). This finding did not vary substantially by time from enrollment to diagnosis, and did not change after adjustment for chronic infection with hepatitis B and C viruses. Conclusions: These novel findings, based on exposures up to several years prior to diagnosis, support a role for gut-derived bacterial products in hepatocellular carcinoma development. Further study into the role of gut barrier failure and exposure to bacterial products in liver diseases is warranted., This work was supported by the French National Cancer Institute (L’Institut National du Cancer; INCA) (grant number 2009-139; Principal Investigator: M. Jenab). The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by the Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, and Institut National de la Santé et de la Recherche Médicale (INSERM) (France); Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); the Sicilian Government, AIRE ONLUS Ragusa, AVIS Ragusa, Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), and Statistics Netherlands (the Netherlands); Nordic Centre of Excellence programme on Food, Nutrition and Health. (Norway); Health Research Fund (FIS), PI13/00061 to Granada), Regional Governments of Andalucía, Asturias, Basque Country, Murcia (no. 6236) and Navarra, Regional Government of Asturias (Asturias, Spain), and ISCIII RETIC (RD06/0020) (Spain); Swedish Cancer Society, Swedish Scientific Council, and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 to EPIC-Oxford) and Medical Research Council (1000143 to EPIC-Norfolk) (United Kingdom); and a Girdlers’ New Zealand Health Research Council Fellowship (to Dr. K.E. Bradbury). The funding sources had no influence on the design of the study; the collection, analysis, and interpretation of data; the writing of the report; or the decision to submit the paper for publication.
- Published
- 2017
- Full Text
- View/download PDF
40. Osteoprotegerin and breast cancer risk by hormone receptor subtype: A nested case-control study in the EPIC cohort
- Author
-
Miren Dorronsoro, Marc J. Gunter, Mathilde His, Helena Schock, Sabina Sieri, Maria Dolores Chirlaque, Aurélie Affret, Rudolf Kaaks, Elisabete Weiderpass, H. Bas Bueno-de-Mesquita, Philippos Orfanos, Melissa A. Merritt, Anne Tjønneland, Domenico Palli, J. Ramón Quirós, María José Sánchez, Theron Johnson, Danja Sarink, Eva Ardanaz, Antonio Agudo, Renée T. Fortner, Laure Dossus, Timothy J. Key, Kim Overvad, Rosario Tumino, Androniki Naska, Petra H.M. Peeters, Heiner Boeing, Amalia Mattiello, Anja Olsen, Sabina Rinaldi, Eiliv Lund, Antonia Trichopoulou, Carla H. van Gils, Marie-Christine Boutron-Ruault, Kay-Tee Khaw, Elio Riboli, Fulvio Ricceri, Khaw, Kay-Tee [0000-0002-8802-2903], Apollo - University of Cambridge Repository, University Medical Center Utrecht, Imperial College Trust, [Fortner,RT, Sarink,D, Schock,H, Johnson,T, Kaaks,R] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [Tjønneland,A, Olsen,A] Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark. [Overvad,K] Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark. [Affret,A, His,M, Boutron-Ruault,MC] Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France. [Affret,A, Boutron-Ruault,MC] Villejuif, France. [Boeing,H] Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. [Trichopoulou,A, Naska,A, Orfanos,P] Hellenic Health Foundation, Athens, Greece. [Trichopoulou,A, Orfanos,P] WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece. [Palli,D] Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy. [Sieri,S] Epidemiology and Prevention Unit, Department of Preventive & Predictive Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. [Mattiello,A] Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy. [Tumino,R] Cancer Registry and Histopathology Unit, 'Civic - M.p.Arezzo' Hospital, ASP Ragusa, Italy. [Ricceri,F] Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco (TO), Italy. [Ricceri,F] Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy. [Bueno-de-Mesquita,HB] Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. [Bueno-de-Mesquita,HB, Merritt,MA, Riboli,E] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. [Bueno-de-Mesquita,HB] Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. [Peeters,PH, Van Gils,CH] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands. [Peeters,PH] MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK. [Weiderpass,E, Lund,E] Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. [Weiderpass,E] Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway. [Weiderpass,E] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. [Weiderpass,E] Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland. [Quirós,JR] Public Health Directorate, Asturias, Spain. [Agudo,A] Unit of Nutrition and Cancer. Cancer Epidemiology Research Program. Catalan Institute of Oncology-IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain. [Sánchez,MJ] Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. [Sánchez,MJ, Chirlaque,MD, Ardanaz,E] CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Chirlaque,MD] Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain. [Chirlaque,MD] Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain. [Ardanaz,E] Navarra Public Health Institute, Pamplona, Spain. [Ardanaz,E] IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. [Dorronsoro,M] Public Health Direction and Biodonostia Research Institute CIBERESP, Basque Regional Health Department, San Sebastian, Spain. [Key,T] Nuffield Department of Population Health, University of Oxford, Oxford, UK. [Khaw,KT] Cancer Epidemiology Unit, University of Cambridge, Cambridge, UK. [Rinaldi,S, Dossus,L, Gunter,M] International Agency for Research on Cancer, Lyon, France., This project was funded by research grant 111454 from the Deutsche Kresbshilfe. RT Fortner was supported by a Marie Curie International Incoming Fellowship of the European Commission’s Seventh Framework Programme (MC-IIF-623984). The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by the Danish Cancer Society (Denmark), Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, and Institut National de la Santé et de la Recherche Médicale (INSERM) (France), German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, and Federal Ministry of Education and Research (Germany), the Hellenic Health Foundation (Greece), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and the National Research Council (Italy), the Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), and Statistics Netherlands (The Netherlands), ERC-2009-AdG 232997 and Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway), Health Research Fund (FIS), PI13/00061 to Granada, PI13/01162 to EPIC-Murcia, Regional Governments of Andalucía, Asturias, Basque Country, Murcia, and Navarra, and ISCIII RETIC (RD06/0020) (Spain), the Swedish Cancer Society, Swedish Research Council, and County Councils of Skåne and Västerbotten (Sweden), and Cancer Research UK (14136 to EPIC-Norfolk, and C570/A16491 and C8221/A19170 to EPIC-Oxford), and the Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (UK).
- Subjects
0301 basic medicine ,Oncology ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Transcription Factors::Receptors, Cytoplasmic and Nuclear::Receptors, Steroid::Receptors, Progesterone [Medical Subject Headings] ,Estrogen receptor ,Progesterone receptor ,Cohort Studies ,0302 clinical medicine ,Breast cancer ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Cytokine::Receptors, Tumor Necrosis Factor::Receptor Activator of Nuclear Factor-kappa B [Medical Subject Headings] ,Risk Factors ,Prospective Studies ,Prospective cohort study ,Medicine(all) ,Osteoprotegerina ,biology ,VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801 ,11 Medical And Health Sciences ,General Medicine ,Middle Aged ,Necrosi ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,RANK axis ,RANKL ,030220 oncology & carcinogenesis ,Neoplasias de la mama ,Female ,Research Article ,musculoskeletal diseases ,medicine.medical_specialty ,Receptores estrogénicos ,Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Causality::Risk Factors [Medical Subject Headings] ,Breast Neoplasms ,Receptores de progesterona ,Receptores de hormonas ,Hormone receptor ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Receptors, Cytoplasmic and Nuclear::Receptors, Steroid::Receptors, Estrogen [Medical Subject Headings] ,Càncer de mama ,Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings] ,Necrosis ,03 medical and health sciences ,Osteoprotegerin ,General & Internal Medicine ,Internal medicine ,Journal Article ,medicine ,Humans ,Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings] ,business.industry ,Case-control study ,medicine.disease ,Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Prospective Studies [Medical Subject Headings] ,030104 developmental biology ,Endocrinology ,Case-Control Studies ,Nested case-control study ,Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Climacteric::Menopause::Postmenopause [Medical Subject Headings] ,biology.protein ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Cytokine::Receptors, Tumor Necrosis Factor::Tumor Necrosis Factor Decoy Receptors::Osteoprotegerin [Medical Subject Headings] ,VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801 ,business - Abstract
All Author: Renée T. Fortner, Danja Sarink, Helena Schock, Theron Johnson, Anne Tjønneland, Anja Olsen, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Domenico Palli, Sabina Sieri, Amalia Mattiello, Rosario Tumino, Fulvio Ricceri, H. Bas Bueno-de-Mesquita, Petra H. M. Peeters, Carla H. Van Gils, Elisabete Weiderpass, Eiliv Lund, J. Ramón Quirós, Antonio Agudo, Maria-José Sánchez, María-Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Tim Key, Kay-Tee Khaw, Sabina Rinaldi, Laure Dossus, Marc Gunter, Melissa A. Merritt, Elio Riboli and Rudolf Kaaks, Background: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study. Methods: A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n = 1622; ER–, n = 386), matched 1:1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Results: The associations between OPG and ER+ and ER– breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER– breast cancer (top vs. bottom tertile RR = 1.93 [95% CI 1.24–3.02]; ptrend = 0.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER– disease did not differ by menopausal status at blood collection (phet = 0.97), and we observed no heterogeneity by HT use at blood collection (phet ≥ 0.43) or age at breast cancer diagnosis (phet ≥ 0.30). Conclusions: This study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER– breast cancer., This project was funded by research grant 111454 from the Deutsche Kresbshilfe. RT Fortner was supported by a Marie Curie International Incoming Fellowship of the European Commission’s Seventh Framework Programme (MC-IIF-623984). The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by the Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, and Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and the National Research Council (Italy); the Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), and Statistics Netherlands (The Netherlands); ERC-2009-AdG 232997 and Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway); Health Research Fund (FIS), PI13/00061 to Granada, PI13/01162 to EPIC-Murcia, Regional Governments of Andalucía, Asturias, Basque Country, Murcia, and Navarra, and ISCIII RETIC (RD06/0020) (Spain); the Swedish Cancer Society, Swedish Research Council, and County Councils of Skåne and Västerbotten (Sweden); and Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford), and the Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (UK).
- Published
- 2017
- Full Text
- View/download PDF
41. Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts
- Author
-
Garnet L. Anderson, Marina Kvaskoff, Pietro Ferrari, Kim Overvad, Timothy J. Key, Agnès Fournier, Christina C. Dahm, Anika Hüsing, Anne Zeleniuch-Jacquotte, Ioanna Tzoulaki, Philippos Orfanos, Patrick Arveux, Elisabete Weiderpass, Christina Bamia, Antonio Agudo, Kuanrong Li, Vivian Viallon, Laure Dossus, Renée T. Fortner, Rosario Tumino, Elio Riboli, Isabelle Romieu, Ross L. Prentice, María José Sánchez, Dagfinn Aune, Eva Ardanaz, Bas Bueno-de-Mesquita, Marc J. Gunter, Antonia Trichopoulou, David C. Muller, Malin Sund, Vittorio Krogh, Todd Smith, Maria-Dolores Chirlaque, and Rudolf Kaaks
- Subjects
Oncology ,HORMONE-REPLACEMENT THERAPY ,medicine.medical_treatment ,WHI ,0302 clinical medicine ,Breast cancer ,Risk Factors ,Estrogen receptor ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,2. Zero hunger ,Incidence ,Hormone replacement therapy (menopause) ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Prognosis ,Risk prediction ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,Menopause ,POSTMENOPAUSAL WOMEN ,Receptors, Estrogen ,PLUS PROGESTIN ,030220 oncology & carcinogenesis ,Cohort ,Female ,Risk assessment ,Research Article ,medicine.medical_specialty ,MODELS ,Antineoplastic Agents ,Breast Neoplasms ,Estrògens ,lcsh:RC254-282 ,Models, Biological ,Risk Assessment ,VALIDATION ,Càncer de mama ,MAMMOGRAPHY ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Oncology & Carcinogenesis ,Cancer och onkologi ,VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 ,business.industry ,MORTALITY ,Kirurgi ,Prospective cohort ,medicine.disease ,Estrogen ,VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 ,Cancer and Oncology ,Surgery ,business ,EPIC ,1112 Oncology And Carcinogenesis ,Body mass index ,Follow-Up Studies - Abstract
Source at https://doi.org/10.1186/s13058-018-1073-0. Licensed CC BY-NC-ND 4.0. Background: Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, we examined whether modeling this heterogeneity could improve prediction. Methods: We built two models, for ER+ (ModelER+) and ER- tumors (ModelER-) , respectively, in 281,330 women (51% postmenopausal at recruitment) from the European Prospective Investigation into Cancer and Nutrition cohort. Discrimination (C-statistic) and calibration (the agreement between predicted and observed tumor risks) were assessed both internally and externally in 82,319 postmenopausal women from the Women’s Health Initiative study. We performed decision curve analysis to compare ModelER+ and the Gail model (ModelGail) regarding their applicability in risk assessment for chemoprevention. Results: Parity, number of full-term pregnancies, age at first full-term pregnancy and body height were only associated with ER+ tumors. Menopausal status, age at menarche and at menopause, hormone replacement therapy, postmenopausal body mass index, and alcohol intake were homogeneously associated with ER+ and ER- tumors. Internal validation yielded a C-statistic of 0.64 for ModelER+ and 0.59 for ModelER-. External validation reduced the C-statistic of ModelER+ (0.59) and ModelGail (0.57). In external evaluation of calibration, ModelER+ outperformed the ModelGail: the former led to a 9% overestimation of the risk of ER+ tumors, while the latter yielded a 22% underestimation of the overall BC risk. Compared with the treat-all strategy, ModelER+ produced equal or higher net benefits irrespective of the benefit-to-harm ratio of chemoprevention, while ModelGail did not produce higher net benefits unless the benefit-to-harm ratio was below 50. The clinical applicability, i.e. the area defined by the net benefit curve and the treat-all and treat-none strategies, was 12.7 × 10− 6 for ModelER+ and 3.0 × 10− 6 for ModelGail. Conclusions: Modeling heterogeneous epidemiological risk factors might yield little improvement in BC risk prediction. Nevertheless, a model specifically predictive of ER+ tumor risk could be more applicable than an omnibus model in risk assessment for chemoprevention.
- Published
- 2018
- Full Text
- View/download PDF
42. Receptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: Results from the EPIC cohort
- Author
-
Epi Methoden Team 4, Cancer, JC onderzoeksprogramma Kanker, Sarink, Danja, Schock, Helena, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Boeing, Heiner, Karakatsani, Anna, Trichopoulou, Antonia, La Vecchia, Carlo, Masala, Giovanna, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Van Gils, Carla H., Peeters, Petra H.M., Weiderpass, Elisabete, Agudo, Antonio, Rodríguez-Barranco, Miguel, Huerta, José María, Ardanaz, Eva, Gil, Leire, Kaw, Kay Tee, Schmidt, Julie A., Dossus, Laure, His, Mathilde, Aune, Dagfinn, Riboli, Elio, Kaaks, Rudolf, Fortner, Renée T., Epi Methoden Team 4, Cancer, JC onderzoeksprogramma Kanker, Sarink, Danja, Schock, Helena, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Boeing, Heiner, Karakatsani, Anna, Trichopoulou, Antonia, La Vecchia, Carlo, Masala, Giovanna, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Van Gils, Carla H., Peeters, Petra H.M., Weiderpass, Elisabete, Agudo, Antonio, Rodríguez-Barranco, Miguel, Huerta, José María, Ardanaz, Eva, Gil, Leire, Kaw, Kay Tee, Schmidt, Julie A., Dossus, Laure, His, Mathilde, Aune, Dagfinn, Riboli, Elio, Kaaks, Rudolf, and Fortner, Renée T.
- Published
- 2018
43. Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
- Author
-
Epi Methoden Team 2, Cancer, JC onderzoeksprogramma Kanker, Campa, Daniele, Barrdahl, Myrto, Santoro, Aurelia, Severi, Gianluca, Baglietto, Laura, Omichessan, Hanane, Tumino, Rosario, Bueno-de-Mesquita, H. B(as), Peeters, Petra H., Weiderpass, Elisabete, Chirlaque, Maria Dolores, Rodríguez-Barranco, Miguel, Agudo, Antonio, Gunter, Marc, Dossus, Laure, Krogh, Vittorio, Matullo, Giuseppe, Trichopoulou, Antonia, Travis, Ruth C., Canzian, Federico, Kaaks, Rudolf, Epi Methoden Team 2, Cancer, JC onderzoeksprogramma Kanker, Campa, Daniele, Barrdahl, Myrto, Santoro, Aurelia, Severi, Gianluca, Baglietto, Laura, Omichessan, Hanane, Tumino, Rosario, Bueno-de-Mesquita, H. B(as), Peeters, Petra H., Weiderpass, Elisabete, Chirlaque, Maria Dolores, Rodríguez-Barranco, Miguel, Agudo, Antonio, Gunter, Marc, Dossus, Laure, Krogh, Vittorio, Matullo, Giuseppe, Trichopoulou, Antonia, Travis, Ruth C., Canzian, Federico, and Kaaks, Rudolf
- Published
- 2018
44. Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition
- Author
-
Schmidt, JA, Fensom, GK, Rinaldi, S, Scalbert, A, Appleby, PN, Achaintre, D, Gicquiau, A, Gunter, MJ, Ferrari, P, Kaaks, R, Kühn, T, Floegel, A, Boeing, H, Trichopoulou, A, Lagiou, P, Anifantis, E, Agnoli, C, Palli, D, Trevisan, M, Tumino, R, Bueno-de-Mesquita, HB, Agudo, A, Larrañaga, N, Redondo-Sánchez, D, Barricarte, A, Huerta, JM, Quirós, JM, Wareham, N, Khaw, K-T, Perez-Cornago, A, Johansson, M, Cross, AJ, Tsilidis, KK, Riboli, E, Key, TJ, Travis, RC, Imperial College Trust, Wareham, Nicholas [0000-0003-1422-2993], Khaw, Kay-Tee [0000-0002-8802-2903], and Apollo - University of Cambridge Repository
- Subjects
Male ,Biogenic amines ,lcsh:Medicine ,Mass Spectrometry ,Cohort Studies ,PHOSPHATIDYLCHOLINE ,REPRODUCIBILITY ,Odds Ratio ,Prospective Studies ,Càncer ,Cancer ,SPHINGOMYELIN ,PLASMA ,Medicine (all) ,PROLIFERATION ,11 Medical And Health Sciences ,Middle Aged ,VARIABILITY ,Amino acids ,Life Sciences & Biomedicine ,Research Article ,Acylcarnitines ,Nutritional Status ,European Prospective Investigation into Cancer and Nutrition (EPIC) ,Glycerophospholipids ,Medicine, General & Internal ,SDG 3 - Good Health and Well-being ,Hexose ,General & Internal Medicine ,Metabolomics ,Humans ,Prospective study ,Nutrició ,Nutrition ,Aged ,Sphingolipids ,Science & Technology ,Mass spectrometry ,Prostate cancer risk ,lcsh:R ,Prostatic Neoplasms ,PREVENTION ,Espectrometria de masses ,Logistic Models ,PROSPECTIVE COHORT ,Case-Control Studies ,COLLECTION ,Biomarkers ,Follow-Up Studies - Abstract
Background Little is known about how pre-diagnostic metabolites in blood relate to risk of prostate cancer. We aimed to investigate the prospective association between plasma metabolite concentrations and risk of prostate cancer overall, and by time to diagnosis and tumour characteristics, and risk of death from prostate cancer. Methods In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition, pre-diagnostic plasma concentrations of 122 metabolites (including acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexose and sphingolipids) were measured using targeted mass spectrometry (AbsoluteIDQ p180 Kit) and compared between 1077 prostate cancer cases and 1077 matched controls. Risk of prostate cancer associated with metabolite concentrations was estimated by multi-variable conditional logistic regression, and multiple testing was accounted for by using a false discovery rate controlling procedure. Results Seven metabolite concentrations, i.e. acylcarnitine C18:1, amino acids citrulline and trans-4-hydroxyproline, glycerophospholipids PC aa C28:1, PC ae C30:0 and PC ae C30:2, and sphingolipid SM (OH) C14:1, were associated with prostate cancer (p
- Published
- 2017
- Full Text
- View/download PDF
45. Mechanistic added value of a trans-Sulfonamide-Platinum-Complex in human melanoma cell lines and synergism with cis-Platin
- Author
-
Elena Prieto-García, Carmen Navarro-Ranninger, Alba Agudo-López, C. Vanesa Díaz-García, Silvia Cabrera, José Alemán, Lucía Parrilla-Rubio, Jose A. Lopez-Martin, Hernán Cortés-Funes, M. Teresa Agulló-Ortuño, and Carlos A. Perez
- Subjects
0301 basic medicine ,Cyclin-Dependent Kinase Inhibitor p21 ,Cancer Research ,Organoplatinum Compounds ,Antineoplastic Agents ,Pharmacology ,Biology ,Mono-Sulfonamide ,Microtubule polymerization ,03 medical and health sciences ,0302 clinical medicine ,Mechanisms of action ,Cell Line, Tumor ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Cytotoxic T cell ,Humans ,Cytotoxicity ,Melanoma ,Cell Proliferation ,Cisplatin ,Sulfonamides ,Cell Cycle control ,Research ,Cell Cycle ,Drug Synergism ,Cell cycle ,In vitro ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,Oncology ,Mechanism of action ,Cell culture ,030220 oncology & carcinogenesis ,Mutation ,Molecular Medicine ,medicine.symptom ,Tumor Suppressor Protein p53 ,Transplatin ,Cyclin-Dependent Kinase Inhibitor p27 ,medicine.drug - Abstract
Background Cisplatin is a potent antitumor agent. However, toxicity and primary and secondary resistance are major limitations of cisplatin-based chemotherapy, leading to therapeutic failure. We have previously reported that mono-sulfonamide platinum complexes have good antitumor activity against different tumoral cell lines and with a different and better cytotoxic profile than cisplatin. Besides, N-sulfonamides have been used extensively in medicinal chemistry as bactericides, anticonvulsant, inhibitors of the carbonic anhydrase, inhibitors of histone deacetylases, and inhibitors of microtubule polymerization, among others. Methods We aimed to compare the cytotoxic effects of cisplatin and a trans-sulfonamide-platinum-complex (TSPC), in two human melanoma cell lines that differ in their TP53 status: SK-MEL-5, TP53 wild type, and SK-MEL-28, TP53 mutated. We performed cytotoxicity assays with both drugs, alone and in combination, cell cycle analyses, western blotting and immunoprecipitation, and fluorescence immunocytochemistry. Results TSPC had similar antiproliferative activity than cisplatin against SK-MEL-5 (3.24 ± 1.08 vs 2.89 ± 1.12 μM) and higher against SK-MEL-28 cells (5.83 ± 1.06 vs 10.17 ± 1.29 μM). Combination of both drugs inhibited proliferation in both cell lines, being especially important in SK-MEL-28, and showing a synergistic effect. In contrast to cisplatin, TSPC caused G1 instead G2/M arrest in both cell lines. Our present findings indicate that the G1 arrest is associated with the induction of CDKN1A and CDKN1B proteins, and that this response is also present in melanoma cells containing TP53 mutated. Also, strong accumulation of CDKN1A and CDKN1B in cells nuclei was seen upon TSPC treatment in both cell lines. Conclusions Overall, these findings provide a new promising TSPC compound with in vitro antitumor activity against melanoma cell lines, and with a different mechanism of action from that of cisplatin. Besides, TSPC synergism with cisplatin facilitates its potential use for co-treatment to reduce toxicity and resistance against cisplatin. TSPC remains a promising lead compound for the generation of novel antineoplastic agent and to explore its synergism with other DNA damaging agents.
- Published
- 2017
46. Circulating prolactin and in situ breast cancer risk in the European EPIC cohort: a case-control study
- Author
-
Sabina Rinaldi, Aurelio Barricarte, Dimitrios Trichopoulos, Evelyn M. Monninkhof, Françoise Clavel-Chapelon, Anne Tjønneland, Amalia Mattiello, Laure Dossus, Renée T. Fortner, Virginia Menéndez, Vittorio Krogh, Kim Overvad, Fulvio Ricceri, Antonia Trichopoulou, Rosario Tumino, Laura Baglietto, Kaja Tikk, Elisabete Weiderpass, Disorn Sookthai, Ruth C. Travis, Timothy J. Key, María José Sánchez, Antonio Agudo, Giovanna Masala, Isabelle Romieu, Elio Riboli, Heiner Boeing, María Dolores Chirlaque, Malin Sund, Theron Johnson, Anja Olsen, N. Charlotte Onland-Moret, Anne Andresson, Rudolf Kaaks, Hbas Bueno-de-Mesquita, Pagona Lagiou, Pilar Amiano, Kay-Tee Khaw, Melissa A. Merritt, [Tikk,K, Sookthai,D, Fortner,RT, Johnson,T, Kaaks,R] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [Rinaldi,S, Romieu,I] Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France. [Tjønneland,D, Olsen,A] Danish Cancer Society Research Center, Copenhagen, Denmark. [Overvad,K] Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark. [Clavel-Chapelon,F, Dossus,l] INSERM, Centre for Research in Epidemiology and Population Health [CESP], Nutrition, Hormones and Women’s Health team, Villejuif, France. [Clavel-Chapelon,F, Dossus,l] Univ Paris Sud, Villejuif, France. [Clavel-Chapelon,F, Dossus,l] IGR, Villejuif, France. [Baglietto,L] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia. [Boeing,H] Department of Epidemiology, German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke, Nuthetal, Germany. [Trichopoulou,A, Trichopoulos,D] Hellenic Health Foundation, Athens, Greece.[Trichopoulou,A, Lagiou.P] Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Goudi, Athens, Greece. [Trichopoulou,A, Lagiou,P, Trichopoulos,D] Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. [Lagiou,P, Trichopoulos,D] Department of Epidemiology, Harvard School of Public Health, Boston, USA. [Masala,G] Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, Florence, Italy. [Krogh,V] Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy. [Tumino,R] Cancer Registry and Histopathology Unit, 'Civic - M.P.Arezzo' Hospital ASP, Ricceri, Ragusa, Italy. [Ricceri,F] Unit of Cancer Epidemiology, AO Citta’ della Salute e della Scienza, University of Turin, Torino, Italy. Unit of Cancer Epidemiology, AO Citta’ della Salute e della Scienza, University of Turin, Torino, Italy. [Mattiello,A] Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. [Agudo,A] Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology-ICO, IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain. [Menéndez,V] Public Health Directorate, Asturias, Spain. [Sánchez,M] Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitario de Granada (Granada.ibs), Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. [Amiano,P] Public Health Division of Gipuzkoa, BioDonostia Reserach Institute, San Sebastian, Spain. [Chirlaque,M] Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain. [Barricarte,A] Navarre Public Health Institute, Pamplona, Spain. [Sánchez, M, Amiano, P, Chirlaque,M, Barricarte,A] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER de Epidemiología y Salud Pública (CIBERESP)), Madrid, Spain. [Bueno-de-Mesquita,H] Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands. Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. [Bueno-de-Mesquita,H, Merritt,MA, Riboli,E] Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College, London, UK. [Monninkhof,EM, Onland-Moret,NC] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. [Andresson,A] Department of Radiation Sciences, University of Umeå, Umeå, Sweden. [Sund,M] Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden. [Weiderpass,E] Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway. Department of Research, Cancer Registry of Norway, Oslo, Norway. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Samfundet Folkhälsan, Helsinki, Finland, [Khaw,K] School of Clinical Medicine, University of Cambridge, Cambridge, UK. [Key,TJ, and Travis,RC] Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. [Tikk,K] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany.
- Subjects
Oncology ,Cancer Research ,Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Gonadotropins::Gonadotropins, Pituitary::Prolactin [Medical Subject Headings] ,PERIOD ,Prolactina ,Cohort Studies ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,0302 clinical medicine ,Breast cancer ,Risk Factors ,REPRODUCIBILITY ,HISTORY ,Odds Ratio ,0303 health sciences ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings] ,Neoplasias de la Mama ,Estudios de Casos y Controles ,Middle Aged ,Adult ,Aged ,Breast Neoplasms ,Carcinoma in Situ ,Case-Control Studies ,Europe ,Female ,Follow-Up Studies ,Humans ,Logistic Models ,Menopause ,Prolactin ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,POSTMENOPAUSAL WOMEN ,PREMENOPAUSAL WOMEN ,030220 oncology & carcinogenesis ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk [Medical Subject Headings] ,Cohort ,Life Sciences & Biomedicine ,Cohort study ,Research Article ,medicine.medical_specialty ,CARCINOMA ,STEROID-HORMONES ,Riesgo ,Càncer de mama ,03 medical and health sciences ,Internal medicine ,parasitic diseases ,medicine ,Journal Article ,Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings] ,030304 developmental biology ,Cancer och onkologi ,Science & Technology ,business.industry ,Carcinoma in situ ,Case-control study ,Odds ratio ,medicine.disease ,Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Carcinoma in Situ [Medical Subject Headings] ,Cancer and Oncology ,PLASMA PROLACTIN ,business - Abstract
Introduction The relationship between circulating prolactin and invasive breast cancer has been investigated previously, but the association between prolactin levels and in situ breast cancer risk has received less attention. Methods We analysed the relationship between pre-diagnostic prolactin levels and the risk of in situ breast cancer overall, and by menopausal status and use of postmenopausal hormone therapy (HT) at blood donation. Conditional logistic regression was used to assess this association in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, including 307 in situ breast cancer cases and their matched control subjects. Results We found a significant positive association between higher circulating prolactin levels and risk of in situ breast cancer among all women [pre-and postmenopausal combined, ORlog2 = 1.35 (95% CI 1.04-1.76), P-trend = 0.03]. No statistically significant heterogeneity was found between prolactin levels and in situ cancer risk by menopausal status (P-het = 0.98) or baseline HT use (P-het = 0.20), although the observed association was more pronounced among postmenopausal women using HT compared to non-users (P-trend = 0.06 vs P-trend = 0.35). In subgroup analyses, the observed positive association was strongest in women diagnosed with in situ breast tumors = 4 years after blood donation (P-trend = 0.01 vs P-trend = 0.63; P-het = 0.04) and among nulliparous women compared to parous women (P-trend = 0.03 vs P-trend = 0.15; P-het = 0.07). Conclusions Our data extends prior research linking prolactin and invasive breast cancer to the outcome of in situ breast tumours and shows that higher circulating prolactin is associated with increased risk of in situ breast cancer.The relationship between circulating prolactin and invasive breast cancer has been investigated previously, but the association between prolactin levels and in situ breast cancer risk has received less attention.
- Published
- 2015
- Full Text
- View/download PDF
47. Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries : A cross-sectional analysis in the EPIC-InterAct study
- Author
-
Zheng, Ju-Sheng, Sharp, Stephen J., Imamura, Fumiaki, Koulman, Albert, Schulze, Matthias B., Ye, Zheng, Griffin, Jules, Guevara, Marcela, Huerta, José María, Kröger, Janine, Sluijs, Ivonne, Agudo, Antonio, Barricarte, Aurelio, Boeing, Heiner, Colorado-Yohar, Sandra M, Dow, Courtney, Dorronsoro, Miren, Dinesen, Pia T, Fagherazzi, Guy, Franks, Paul W., Feskens, Edith J. M., Kühn, Tilman, Katzke, Verena Andrea, Key, Timothy J., Khaw, Kay Tee, de Magistris, Maria Santucci, Mancini, Francesca Romana, Molina-Portillo, Elena, Nilsson, Peter M., Olsen, Anja, Overvad, Kim, Palli, Domenico, Quirós, Jose Ramón, Rolandsson, Olov, Ricceri, Fulvio, Spijkerman, Annemieke M. W., Slimani, Nadia, Tagliabue, Giovanna, Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Langenberg, Claudia, Riboli, Elio, Forouhi, Nita G., Wareham, Nicholas J., Zheng, Ju-Sheng, Sharp, Stephen J., Imamura, Fumiaki, Koulman, Albert, Schulze, Matthias B., Ye, Zheng, Griffin, Jules, Guevara, Marcela, Huerta, José María, Kröger, Janine, Sluijs, Ivonne, Agudo, Antonio, Barricarte, Aurelio, Boeing, Heiner, Colorado-Yohar, Sandra M, Dow, Courtney, Dorronsoro, Miren, Dinesen, Pia T, Fagherazzi, Guy, Franks, Paul W., Feskens, Edith J. M., Kühn, Tilman, Katzke, Verena Andrea, Key, Timothy J., Khaw, Kay Tee, de Magistris, Maria Santucci, Mancini, Francesca Romana, Molina-Portillo, Elena, Nilsson, Peter M., Olsen, Anja, Overvad, Kim, Palli, Domenico, Quirós, Jose Ramón, Rolandsson, Olov, Ricceri, Fulvio, Spijkerman, Annemieke M. W., Slimani, Nadia, Tagliabue, Giovanna, Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Langenberg, Claudia, Riboli, Elio, Forouhi, Nita G., and Wareham, Nicholas J.
- Published
- 2017
48. Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma : A nested case-control study
- Author
-
Fedirko, Veronika, Tran, Hao Quang, Gewirtz, Andrew T., Stepien, Magdalena, Trichopoulou, Antonia, Aleksandrova, Krasimira, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Carbonnel, Franck, Boutron-Ruault, Marie Christine, Severi, Gianluca, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Bamia, Christina, Lagiou, Pagona, Grioni, Sara, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Naccarati, Alessio, Peeters, Petra H., Bueno-de-Mesquita, H. B., Weiderpass, Elisabete, Castaño, José María Huerta, Barricarte, Aurelio, Sánchez, María José, Dorronsoro, Miren, Quirós, J. Ramón, Agudo, Antonio, Sjöberg, Klas, Ohlsson, Bodil, Hemmingsson, Oskar, Werner, Mårten, Bradbury, Kathryn E., Khaw, Kay Tee, Wareham, Nick, Tsilidis, Konstantinos K., Aune, Dagfinn, Scalbert, Augustin, Romieu, Isabelle, Riboli, Elio, Jenab, Mazda, Fedirko, Veronika, Tran, Hao Quang, Gewirtz, Andrew T., Stepien, Magdalena, Trichopoulou, Antonia, Aleksandrova, Krasimira, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Carbonnel, Franck, Boutron-Ruault, Marie Christine, Severi, Gianluca, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Bamia, Christina, Lagiou, Pagona, Grioni, Sara, Panico, Salvatore, Palli, Domenico, Tumino, Rosario, Naccarati, Alessio, Peeters, Petra H., Bueno-de-Mesquita, H. B., Weiderpass, Elisabete, Castaño, José María Huerta, Barricarte, Aurelio, Sánchez, María José, Dorronsoro, Miren, Quirós, J. Ramón, Agudo, Antonio, Sjöberg, Klas, Ohlsson, Bodil, Hemmingsson, Oskar, Werner, Mårten, Bradbury, Kathryn E., Khaw, Kay Tee, Wareham, Nick, Tsilidis, Konstantinos K., Aune, Dagfinn, Scalbert, Augustin, Romieu, Isabelle, Riboli, Elio, and Jenab, Mazda
- Published
- 2017
49. Osteoprotegerin and breast cancer risk by hormone receptor subtype : a nested case-control study in the EPIC cohort
- Author
-
Fortner, Renée T, Sarink, Danja, Schock, Helena, Johnson, Theron, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Affret, Aurélie, His, Mathilde, Boutron-Ruault, Marie-Christine, Boeing, Heiner, Trichopoulou, Antonia, Naska, Androniki, Orfanos, Philippos, Palli, Domenico, Sieri, Sabina, Mattiello, Amalia, Tumino, Rosario, Ricceri, Fulvio, Bueno-de-Mesquita, H Bas, Peeters, Petra H M, Van Gils, Carla H, Weiderpass, Elisabete, Lund, Eiliv, Quirós, J Ramón, Agudo, Antonio, Sánchez, Maria-José, Chirlaque, María-Dolores, Ardanaz, Eva, Dorronsoro, Miren, Key, Tim, Khaw, Kay-Tee, Rinaldi, Sabina, Dossus, Laure, Gunter, Marc, Merritt, Melissa A, Riboli, Elio, Kaaks, Rudolf, Fortner, Renée T, Sarink, Danja, Schock, Helena, Johnson, Theron, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Affret, Aurélie, His, Mathilde, Boutron-Ruault, Marie-Christine, Boeing, Heiner, Trichopoulou, Antonia, Naska, Androniki, Orfanos, Philippos, Palli, Domenico, Sieri, Sabina, Mattiello, Amalia, Tumino, Rosario, Ricceri, Fulvio, Bueno-de-Mesquita, H Bas, Peeters, Petra H M, Van Gils, Carla H, Weiderpass, Elisabete, Lund, Eiliv, Quirós, J Ramón, Agudo, Antonio, Sánchez, Maria-José, Chirlaque, María-Dolores, Ardanaz, Eva, Dorronsoro, Miren, Key, Tim, Khaw, Kay-Tee, Rinaldi, Sabina, Dossus, Laure, Gunter, Marc, Merritt, Melissa A, Riboli, Elio, and Kaaks, Rudolf
- Published
- 2017
50. Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: A cross-sectional analysis in the EPIC-InterAct study
- Author
-
UMC Utrecht, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epidemiologie, Zheng, Ju-Sheng, Sharp, Stephen J., Imamura, Fumiaki, Koulman, Albert, Schulze, Matthias B., Ye, Zheng, Griffin, Jules, Guevara, Marcela, Huerta, José María, Kröger, Janine, Sluijs, Ivonne, Agudo, Antonio, Barricarte, Aurelio, Boeing, Heiner, Colorado-Yohar, Sandra M, Dow, Courtney, Dorronsoro, Miren, Dinesen, Pia T, Fagherazzi, Guy, Franks, Paul W., Feskens, Edith J. M., Kühn, Tilman, Katzke, Verena Andrea, Key, Timothy J., Khaw, Kay Tee, de Magistris, Maria Santucci, Mancini, Francesca Romana, Molina-Portillo, Elena, Nilsson, Peter M., Olsen, Anja, Overvad, Kim, Palli, Domenico, Quirós, Jose Ramón, Rolandsson, Olov, Ricceri, Fulvio, Spijkerman, Annemieke M. W., Slimani, Nadia, Tagliabue, Giovanna, Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Langenberg, Claudia, Riboli, Elio, Forouhi, Nita G., Wareham, Nicholas J., UMC Utrecht, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epidemiologie, Zheng, Ju-Sheng, Sharp, Stephen J., Imamura, Fumiaki, Koulman, Albert, Schulze, Matthias B., Ye, Zheng, Griffin, Jules, Guevara, Marcela, Huerta, José María, Kröger, Janine, Sluijs, Ivonne, Agudo, Antonio, Barricarte, Aurelio, Boeing, Heiner, Colorado-Yohar, Sandra M, Dow, Courtney, Dorronsoro, Miren, Dinesen, Pia T, Fagherazzi, Guy, Franks, Paul W., Feskens, Edith J. M., Kühn, Tilman, Katzke, Verena Andrea, Key, Timothy J., Khaw, Kay Tee, de Magistris, Maria Santucci, Mancini, Francesca Romana, Molina-Portillo, Elena, Nilsson, Peter M., Olsen, Anja, Overvad, Kim, Palli, Domenico, Quirós, Jose Ramón, Rolandsson, Olov, Ricceri, Fulvio, Spijkerman, Annemieke M. W., Slimani, Nadia, Tagliabue, Giovanna, Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Langenberg, Claudia, Riboli, Elio, Forouhi, Nita G., and Wareham, Nicholas J.
- Published
- 2017
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.