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Your search keyword '"A İrfan Baran"' showing total 2 results
Start Over Author "A İrfan Baran" Publisher biomed central
2 results on '"A İrfan Baran"'

1. Asymmetric dimethylarginine levels in patients with cutaneous anthrax: a laboratory analysis

Author

Mehmet Tosun, Cenk Aypak, Ali İrfan Baran, Mustafa Kasim Karahocagil, Hayrettin Akdeniz, Zafer Mengeloglu, Mahmut Sunnetcioglu, Abdulkadir Küçükbayrak, Mehmet Reşat Ceylan, BAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Mengeloğlu, Zafer, Tosun, Mehmet, and Küçükbayrak, Abdülkadir

Subjects
Microbiology (medical), Vasculitis, Adult, Male, medicine.medical_specialty, Arginine, Adolescent, Endogeny, Sepsis, Anthrax, chemistry.chemical_compound, Young Adult, Internal medicine, Dimethylarginine, Germany, Medicine, Humans, Endothelial dysfunction, Aged, biology, business.industry, Research, General Medicine, Skin Diseases, Bacterial, Middle Aged, medicine.disease, Nitric oxide synthase, Infectious Diseases, Endocrinology, chemistry, Heart failure, Immunology, biology.protein, Female, business, Asymmetric dimethylarginine, Infection, Biomarkers
Abstract

WOS:000334615100001 PubMed: 24669818 Background: Asymmetric dimethylarginine (ADMA), the main endogenous inhibitor of nitric oxide synthase, is considered to be associated with endothelial dysfunction. High ADMA levels have been shown to be related with disorders causing vascular inflammation such as hypertension, hypercholesterolemia, atherosclerosis, chronic heart failure, stroke and sepsis. Cutaneous anthrax (CA) is a serious infectious disease which may cause vasculitis. The aim of the study was to investigate the serum ADMA levels in patients with CA. Methods: A total of 35 serum samples of the patients with CA and 18 control sera were tested for ADMA levels using ADMA ELISA kit (Immunodiagnostik AG, Bensheim, Germany). Results: ADMA levels were found to be significantly higher in the patients group than the controls (p < 0.001). In addition, ADMA levels were found to be positively associated with sedimentation rates (R = 0.413; p = 0.026), and inversely associated with international normalized ratio (INR) levels (R = -0.46; p = 0.011). A cut-off value of 0.475 of ADMA had a sensitivity of 74.3%, specificity of 77.8%, and accuracy of 75.5% in the diagnosis of CA. Conclusion: Although the exact mechanism still remains unclear, ADMA levels could be related to immune activation in CA. In addition, these data might suggest the higher ADMA levels in patients could be due to the perivascular inflammation and vasculitis in CA.

Published
2014

2. Comparative analysis of pulmonary and extrapulmonary tuberculosis of 411 cases.

Author

Sunnetcioglu, Aysel, Sunnetcioglu, Mahmut, Binici, Irfan, Irfan Baran, Ali, Kasim Karahocagil, Mustafa, and Ridvan Saydan, Muhammed

Subjects
TUBERCULOSIS research, TUBERCULOSIS diagnosis, TUBERCULOSIS treatment, COMPARATIVE studies, PERITONEUM
Abstract

Background: Tuberculosis is a disease that can involve every organ system. While pulmonary tuberculosis is the most common presentation, extrapulmonary tuberculosis (EPT) is also an important clinical problem. The current study aimed to outline and compare the demographic and clinical features of pulmonary and extrapulmonary tuberculosis cases in adults. Methods: Medical records of 411 patients (190 women, 221 men) treated between January 2010 and July 2014 in provincial tuberculosis control dispensary was retrospectively reviewed. Demographic and clinical characteristics were compared for pulmonary and extrapulmonary tuberculosis cases. Results: Of these 411 cases, 208 (50.6 %) had pulmonary tuberculosis (PTB) and 203 were diagnosed with extrapulmonary tuberculosis (EPTB) (49.4 %). The average ages for PTB and EPTB groups were 33.00-27.00 and 31.00-29.75, respectively (p = 0.513). Men were more frequently affected by PTB (59.6 %), while EPTB was more commonly detected in women (52.2 %) (p = 0.016). Main diagnostic modalities for PTB were sputum/smear analyses (72.7 %), clinical-radiological data (21.7 %) and biopsy (6.1 %); while biopsy (71.5 %), sputum/fluid analysis (18.8 %) and clinical-radiological data (4.9 %) were used for confirming EPTB (p < 0.0019). The most common sites of EPTB involvement were lymph nodes (39.4 %), followed by pleura (23.6 %), peritoneum (9.9 %) and bone (7.4 %). Conclusions: Extrapulmonary involvement of tuberculosis is common and females are more likely to be affected. Increased clinical awareness is important since atypical presentations of the disease may constitute diagnostic and therapeutic challenges. [ABSTRACT FROM AUTHOR]

Published
2015
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