1. Height predict incident non-alcoholic fatty liver disease among general adult population in Tianjin, China, independent of body mass index, waist circumference, waist-to-height ratio, and metabolic syndrome.
- Author
-
Kumari S, Wang X, Liu Y, Gu Y, Huang Y, Zhang Q, Liu L, Meng G, Wu H, Sun S, Wang X, Zhou M, Jia Q, Wang G, Song K, and Niu K
- Subjects
- Adult, Body Mass Index, China epidemiology, Female, Humans, Male, Metabolic Syndrome epidemiology, Middle Aged, Predictive Value of Tests, Prospective Studies, Risk Assessment, Waist Circumference, Waist-Height Ratio, Body Height, Non-alcoholic Fatty Liver Disease epidemiology
- Abstract
Background: Early-life hormonal and nutritional factors can greatly influence the risk of non-alcoholic fatty liver disease (NAFLD). Adult height is a simple marker for these factors. This study aimed to investigate the association between adult height and NAFLD., Methods: We performed a prospective cohort study of 35,994 participants aged 25 years or over with measured height at baseline. NAFLD was diagnosed by abdominal ultrasound and self-reported history of alcohol intake. Multivariable Cox proportional hazards regression models were conducted to assess the gender-specific association between height and the risk of NAFLD., Results: During a follow-up period of 5.5 years, 6245 of 35,994 subjects developed NAFLD. The adjusted hazard ratios (95% confidence interval) of NAFLD for increasing quintiles of height were 1.00 (reference), 0.82 (0.73, 0.92), 0.84 (0.73, 0.97), 0.72 (0.61, 0.85) and 0.63 (0.50, 0.79) (P for trend < 0.0001) in males, and 1.00 (reference), 1.00 (reference), 0.80 (0.69, 0.91), 0.72 (0.61, 0.85), 0.60 (0.49, 0.74) and 0.45 (0.35, 0.59) (P for trend < 0.0001) in females, respectively., Conclusions: A higher adult height was associated with lower risk of NAFLD among males and females in Tianjin, China.
- Published
- 2020
- Full Text
- View/download PDF