916 results on '"CHRONIC INSOMNIA"'
Search Results
2. Protocol for a randomized controlled trial exploring the brain mechanism and therapeutic effect of electroacupuncture on cognitive function and sleep quality in chronic insomnia
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Lu, Linhao, Liao, Lizhen, Zheng, Jiaorong, Lin, Weiyi, Wang, TaiShun, and Wen, Xiuyun
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- 2023
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3. Oral nicotinamide mononucleotide (NMN) to treat chronic insomnia: protocol for the multicenter, randomized, double-blinded, placebo-controlled trial
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Gao, Xiangyang, Li, Junhua, Xu, Sanping, Li, Xueying, Wang, Xicheng, Li, Yongli, Huang, Yan, Liu, Shaohui, and Zeng, Qiang
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- 2023
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4. Knowledge, attitude, and practice of chronic insomnia management among general practitioners in China: a cross-sectional survey
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An, Kang, Wu, Zengxiang, Zhang, Lin, Li, Yuqi, An, Zhenmei, and Li, Shuangqing
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- 2024
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5. The 95% effective dose of dexmedetomidine to induce adequate sedation in patients with chronic insomnia disorder: a biased coin design up-and-down sequential allocation trial
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Li, Mengya, Li, Guifeng, Li, Qifang, and Cai, Qing
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- 2024
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6. Tailored individual Yoga practice improves sleep quality, fatigue, anxiety, and depression in chronic insomnia disorder
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Turmel, Denis, Carlier, Sarah, Bruyneel, Anne Violette, and Bruyneel, Marie
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- 2022
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7. The stigma of patients with chronic insomnia: a clinical study
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He, Shuo, Ke, Xue-Jia, Wu, Yan, Kong, Xiao-Yi, Wang, Yun, Sun, Hui-Qin, Xia, Deng-Zhi, and Chen, Gui-Hai
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- 2022
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8. Acupuncture combined with traditional Chinese medicine e-aid cognitive behavioral therapy for insomnia (TCM-eCBT-I) for chronic insomnia: study protocol for a randomized controlled trial
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Liu, Cheng-yong, Zhao, Ya-nan, Wang, Xiao-qiu, Qin, Shan, Wan, Qing-yun, Zheng, Shi-yu, and Wu, Wen-zhong
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- 2022
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9. Efficacy of abdomen-rubbing qigong exercise for chronic insomnia: study protocol for a randomized controlled trial
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Guan, Chong, Cheng, Ziji, Xie, Fangfang, Wang, Ruiping, Zhang, Jing, Yao, Fei, and Fang, Min
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- 2021
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10. The cerebral mechanism of acupuncture for chronic insomnia with gastrointestinal disorder: protocol for a randomized controlled trial
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Peng, Wei, Hong, Xiaojuan, Huangfu, Yaru, Sun, Zhao, Shen, Wei, Feng, Fen, Gong, Liang, Shen, Zhifu, Guo, Baojun, Zhang, Leixiao, Wang, Yanan, Zhao, Ying, Zhu, Tianmin, Hu, Youping, and Yu, Siyi
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- 2021
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11. Central hypersomnia and chronic insomnia: expanding the spectrum of sleep disorders in long COVID syndrome - a prospective cohort study
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Moura, Alissa Elen Formiga, Oliveira, Danilo Nunes, Torres, Danielle Mesquista, Tavares-Júnior, José Wagner Leonel, Nóbrega, Paulo Ribeiro, Braga-Neto, Pedro, and Sobreira-Neto, Manoel Alves
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- 2022
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12. Effects of acupuncture on the hypothalamus-pituitary-adrenal axis in chronic insomnia patients: a study protocol for a randomized controlled trial
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Liu, Chengyong, Zheng, Shiyu, Wu, Wenzhong, Wang, Xiaoqiu, Qin, Shan, Zhao, Yanan, Xi, Hanqing, and Wan, Qingyun
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- 2019
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13. Assessing the feasibility and acceptability of a cluster-randomized study of cognitive behavioral therapy for chronic insomnia in a primary care setting
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Torrens, Isabel, Esteva, Magdalena, Vicens, Caterina, Pizá-Portell, María Rosa, Vidal-Thomàs, María Clara, Vidal-Ribas, Cristina, Lorente-Montalvo, Patricia, and Torres-Solera, Elena
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- 2021
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14. Primary care management of chronic insomnia: a qualitative analysis of the attitudes and experiences of Australian general practitioners
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Haycock, Jenny, Grivell, Nicole, Redman, Anne, Saini, Bandana, Vakulin, Andrew, Lack, Leon, Lovato, Nicole, Sweetman, Alexander, Zwar, Nicholas, Stocks, Nigel, Frank, Oliver, Mukherjee, Sutapa, Adams, Robert, McEvoy, R. Doug, and Hoon, Elizabeth
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- 2021
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15. TIMELAPSE study—efficacy of low-dose amitriptyline versus cognitive behavioral therapy for chronic insomnia in patients with medical comorbidity: study protocol of a randomized controlled multicenter non-inferiority trial
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Rauwerda, Nynke L., Knoop, Hans, Pot, Irene, van Straten, Annemieke, Rikkert, Marian E., Zondervan, Anouk, Timmerhuis, Thom P. J., Braamse, Annemarie M. J., and Boss, H. Myrthe
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- 2021
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16. Prevalence of and factors associated with acute withdrawal symptoms after 24 weeks of eszopiclone treatment in patients with chronic insomnia: a prospective, interventional study
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Inoue, Yuichi, Takaesu, Yoshikazu, and Koebis, Michinori
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- 2021
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17. Chronic insomnia remitting after maxillomandibular advancement for mild obstructive sleep apnea: a case series
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Proothi, Michael, Grazina, Victor J. R., and Gold, Avram R.
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- 2019
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18. Clinico-demographic factors associated with the treatment response to cognitive behavioral therapy for insomnia
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Hotchi, Ayana, Yamadera, Wataru, Iwashita, Masayuki, Utsumi, Tomohiro, Amagai, Misato, Nakamura, Sakumi, Suzuki, Takako, and Shigeta, Masahiro
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- 2024
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19. Digital CBTI hubs as a treatment augmentation strategy in military clinics: study protocol for a pragmatic randomized clinical trial
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Germain, Anne, Wolfson, Megan, Brock, Matthew S., O’Reilly, Brian, Hearn, Hunter, Knowles, Shelley, Mysliwiec, Vincent, and Wallace, Meredith L.
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- 2023
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20. Prevalence of and factors associated with acute withdrawal symptoms after 24 weeks of eszopiclone treatment in patients with chronic insomnia: a prospective, interventional study
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Yoshikazu Takaesu, Yuichi Inoue, and Michinori Koebis
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medicine.medical_specialty ,Benzodiazepine dependence self report questionnaire ,Exacerbation ,medicine.drug_class ,Benzodiazepine dependence ,RC435-571 ,Benzodiazepine receptor agonists ,03 medical and health sciences ,Benzodiazepines ,0302 clinical medicine ,Internal medicine ,Sleep Initiation and Maintenance Disorders ,medicine ,Insomnia ,Prevalence ,Humans ,Hypnotics and Sedatives ,030212 general & internal medicine ,Prospective Studies ,Eszopiclone ,Psychiatry ,Benzodiazepine ,business.industry ,Odds ratio ,medicine.disease ,Confidence interval ,Discontinuation ,Substance Withdrawal Syndrome ,Psychiatry and Mental health ,Withdrawal symptoms ,medicine.symptom ,business ,030217 neurology & neurosurgery ,medicine.drug ,Research Article ,Typical clinical dose - Abstract
Background Although long-term use of benzodiazepines and benzodiazepine receptor agonists (BZDs) has been associated with an increased risk of dependence, the incidence, details of clinical manifestations, and triggering factors of withdrawal symptoms associated with long-term BZD use at common clinical doses remain unclear. Methods In a multicenter, open-label study of 123 Japanese patients with insomnia, patients were given a common clinical dose of eszopiclone (2 mg) for 24 weeks, and then treatment was abruptly discontinued. Withdrawal symptoms were evaluated using the Benzodiazepine Hypnotics Withdrawal Symptom Scale (BHWSS). The Insomnia Severity Index (ISI) was used to rate insomnia severity during treatment and 2 weeks after discontinuation. Dependence and poor compliance during treatment without strict medication controls were evaluated with the Benzodiazepine Dependence Self Report Questionnaire short version (Bendep-SRQ SV) subscale sum scores for problematic use, preoccupation, and lack of compliance. Associations between the presence of clinically relevant withdrawal symptoms (BHWSS≥7) and demographic measures, ISI scores at Week 24, and Bendep-SRQ SV subscale sum scores were evaluated by multivariable stepwise logistic regression analyses. Results Seventy-six patients completed treatment and 2 weeks of withdrawal; eight (10.5%) had clinically relevant withdrawal symptoms. On multiple logistic regression analysis, Bendep-SRQ SV subscale sum scores were correlated with withdrawal symptoms (odds ratio, 1.650; 95% confidence interval, 1.105–2.464; p = 0.014). Exacerbation of post-discontinuation insomnia was not significantly different between patients who showed clinically relevant withdrawal symptoms and those who did not (p = 0.245). Conclusions Dependence and poor compliance may contribute to withdrawal symptoms with long-term BZD use. Providing guidance to ensure proper compliance is thought to be the best way to mitigate withdrawal symptoms. Trial registration UMIN000024462 (18/10/2016).
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- 2021
21. Correlates of self-report chronic insomnia disorders with 1-6 month and 6-month durations in home-dwelling urban older adults - the Shih-Pai Sleep Study in Taiwan: a cross-sectional community study.
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Chiou JH, Chen HC, Chen KH, and Chou P
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- Aged, Aged, 80 and over, Cross-Sectional Studies, Depression diagnosis, Depression epidemiology, Depression psychology, Female, Humans, Male, Prevalence, Residence Characteristics, Sleep Initiation and Maintenance Disorders psychology, Taiwan epidemiology, Time Factors, Independent Living psychology, Self Report, Sleep Initiation and Maintenance Disorders diagnosis, Sleep Initiation and Maintenance Disorders epidemiology, Urban Population
- Abstract
Background: To examine the correlates of insomnia disorder with different durations in home-dwelling older adults., Methods: A cross-sectional survey in the Shih-Pai area of Taipei City, Taiwan (The Shih-Pai Sleep Study). A total 4047 subjects over the age of 65 years completed the study (2259 men and 1788 women). The Pittsburgh Sleep Quality Index and the duration of insomnia symptoms were used to identify DSM-IV 1-6 month and 6-month insomnia disorders., Results: The prevalence of DSM-IV defined insomnia disorder was 5.8 %; two-thirds of these case lasted for ≥6 months. The shared correlates for both 1-6 and 6-month insomnia disorders were gender (women), depression and moderate pain. Pulmonary diseases were exclusively associated with 1-6 month insomnia disorder (OR: 2.57, 95 % CI: 1.46-4.52). In contrast, heart disease (OR: 1.73, 95 % CI: 1.21-2.49) and severe pain (OR: 2.34, 95 % CI: 1.14-4.40) were associated with 6-month insomnia disorder., Conclusion: The prevalence of persistent insomnia disorder is higher than short-term insomnia disorder. Correlates for less persistent and more persistent insomnia disorder appears to be partially different. Duration quantifiers may be important in the identification of the etiology of insomnia and further studies with follow-ups are needed to examine the order of developing insomnia disorder and associated conditions.
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- 2016
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22. Multimodal neuroimaging exploration of the mechanisms of sleep quality deterioration after SARS-CoV-2 Omicron infection.
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Du, Yanyao, Li, Cong, Zhao, Wei, Li, Jinyue, Zhao, Linlin, Guo, Huili, Jiang, Yingjia, Liu, Weiyin Vivian, Zeng, Song, Zhang, Huiting, Guo, Hu, Ouyang, Xuan, and Liu, Jun
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SLEEP quality ,SARS-CoV-2 Omicron variant ,BRAIN cortical thickness ,MAGNETIC resonance imaging ,SARS-CoV-2 - Abstract
Background: To evaluate the neurological alterations induced by Omicron infection, to compare brain changes in chronic insomnia with those in exacerbated chronic insomnia in Omicron patients, and to examine individuals without insomnia alongside those with new-onset insomnia. Methods: In this study, a total of 135 participants were recruited between January 11 and May 4, 2023, including 26 patients with chronic insomnia without exacerbation, 24 patients with chronic insomnia with exacerbation, 40 patients with no sleep disorder, and 30 patients with new-onset insomnia after infection with Omicron (a total of 120 participants with different sleep statuses after infection), as well as 15 healthy controls who were never infected with Omicron. Neuropsychiatric data, clinical symptoms, and multimodal magnetic resonance imaging data were collected. The gray matter thickness and T1, T2, proton density, and perivascular space values were analyzed. Associations between changes in multimodal magnetic resonance imaging findings and neuropsychiatric data were evaluated with correlation analyses. Results: Compared with healthy controls, gray matter thickness changes were similar in the patients who have and do not have a history of chronic insomnia groups after infection, including an increase in cortical thickness near the parietal lobe and a reduction in cortical thickness in the frontal, occipital, and medial brain regions. Analyses showed a reduced gray matter thickness in patients with chronic insomnia compared with those with an aggravation of chronic insomnia post-Omicron infection, and a reduction was found in the right medial orbitofrontal region (mean [SD], 2.38 [0.17] vs. 2.67 [0.29] mm; P < 0.001). In the subgroups of Omicron patients experiencing sleep deterioration, patients with a history of chronic insomnia whose insomnia symptoms worsened after infection displayed heightened medial orbitofrontal cortical thickness and increased proton density values in various brain regions. Conversely, patients with good sleep quality who experienced a new onset of insomnia after infection exhibited reduced cortical thickness in pericalcarine regions and decreased proton density values. In new-onset insomnia patients post-Omicron infection, the thickness in the right pericalcarine was negatively correlated with the Self-rating Anxiety Scale (r = − 0.538, P = 0.002, P
FDR = 0.004) and Self-rating Depression Scale (r = − 0.406, P = 0.026, PFDR = 0.026) scores. Conclusions: These findings help us understand the pathophysiological mechanisms involved when Omicron invades the nervous system and induces various forms of insomnia after infection. In the future, we will continue to pay attention to the dynamic changes in the brain related to insomnia caused by Omicron infection. [ABSTRACT FROM AUTHOR]- Published
- 2024
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23. How mindfulness changed my sleep: focus groups with chronic insomnia patients.
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Hubbling A, Reilly-Spong M, Kreitzer MJ, and Gross CR
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- Actigraphy, Adaptation, Psychological, Adult, Aged, Female, Focus Groups, Humans, Male, Middle Aged, Self Report, Meditation methods, Mindfulness, Sleep, Sleep Initiation and Maintenance Disorders therapy, Stress, Psychological therapy, Yoga
- Abstract
Background: Chronic insomnia is a major public health problem affecting approximately 10% of adults. Use of meditation and yoga to develop mindful awareness ('mindfulness training') may be an effective approach to treat chronic insomnia, with sleep outcomes comparable to nightly use of prescription sedatives, but more durable and with minimal or no side effects. The purpose of this study was to understand mindfulness training as experienced by patients with chronic insomnia, and suggest procedures that may be useful in optimizing sleep benefits., Methods: Adults (N = 18) who completed an 8-week mindfulness-based stress reduction (MBSR) program as part of a randomized, controlled clinical trial to evaluate MBSR as a treatment for chronic insomnia were invited to participate in post-trial focus groups. Two groups were held. Participants (n = 9) described how their sleep routine, thoughts and emotions were affected by MBSR and about utility (or not) of various mindfulness techniques. Groups were audio-recorded, transcribed and analyzed using content analysis., Results: Four themes were identified: the impact of mindfulness on sleep and motivation to adopt a healthy sleep lifestyle; benefits of mindfulness on aspects of life beyond sleep; challenges and successes in adopting mindfulness-based practices; and the importance of group sharing and support. Participants said they were not sleeping more, but sleeping better, waking more refreshed, feeling less distressed about insomnia, and better able to cope when it occurred. Some participants experienced the course as a call to action, and for them, practicing meditation and following sleep hygiene guidelines became priorities. Motivation to sustain behavioral changes was reinforced by feeling physically better and more emotionally stable, and seeing others in the MBSR class improve. The body scan was identified as an effective tool to enable falling asleep faster. Participants described needing to continue practicing mindfulness to maintain benefits., Conclusions: First-person accounts are consistent with published trial results of positive impacts of MBSR on sleep measured by sleep diary, actigraphy, and self-report sleep scales. Findings indicate that mindfulness training in a group format, combined with sleep hygiene education, is important for effective application of MBSR as a treatment for chronic insomnia.
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- 2014
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24. Effects of eszopiclone on safety, subjective measures of efficacy, and quality of life in elderly and nonelderly Japanese patients with chronic insomnia, both with and without comorbid psychiatric disorders: a 24-week, randomized, double-blind study.
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Naohisa Uchimura, Atsushi Kamijo, and Takao Takase
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- *
ANALYSIS of variance , *FISHER exact test , *HEALTH surveys , *INSOMNIA , *MEDICAL cooperation , *MENTAL illness , *NASOPHARYNX diseases , *QUALITY of life , *RESEARCH , *RESEARCH funding , *STATISTICAL sampling , *SCALES (Weighing instruments) , *SEDATIVES , *T-test (Statistics) , *TASTE disorders , *COMORBIDITY , *RANDOMIZED controlled trials , *BLIND experiment , *DATA analysis software , *DESCRIPTIVE statistics - Abstract
Background: The primary objective of this study was to evaluate long-term (24-week) safety of eszopiclone in elderly and nonelderly Japanese patients with chronic insomnia. The secondary objectives were to evaluate short-term (4-week) efficacy and to assess for rebound insomnia or dependence after long-term treatment. Methods: Patients (n = 164 elderly; n = 161 nonelderly), with or without psychiatric comorbidities, were randomized to receive low-dose (1 mg, elderly; 2 mg, nonelderly) or high-dose (2 mg, elderly; 3 mg, nonelderly) eszopiclone. The safety evaluation included adverse events, vital signs, clinical laboratory parameters, and electrocardiogram. Efficacy was assessed using patient reports of sleep latency (SL), total sleep time (TST), wake time after sleep onset (WASO), number of awakenings (NA), quality of sleep, depth of sleep, daytime sleepiness, daytime ability to function, and the 36-item Short Form (SF-36) Health Survey. Results: The rate of adverse events was 81.5% in the 1-mg elderly group, 79.5% in the 2-mg elderly group, 82.1% in the 2-mg nonelderly group, and 87.0% in the 3-mg nonelderly group. Dysgeusia was the most common adverse event and was dose-related. Of 12 serious adverse events, none were considered by the investigator to be related to study medication. No rebound insomnia was observed. Eszopiclone significantly improved SL, TST, WASO, NA, and daytime sleepiness and function from baseline to Week 4, irrespective of age and psychiatric comorbidity. Improvements were also observed in SF-36 Mental Health Component scores in elderly and nonelderly patients with psychiatric comorbidities. Conclusions: Irrespective of age, eszopiclone appeared safe as administered in this study for 24 weeks. Eszopiclone improved sleep variables in insomnia patients with and without psychiatric disorders and health-related quality of life in those with psychiatric disorders. Trial registration: ClinicalTrials.gov #NCT00770692; ttp://clinicaltrials.gov/ct2/show/NCT00770692. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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25. Effects of eszopiclone on safety, subjective measures of efficacy, and quality of life in elderly and nonelderly Japanese patients with chronic insomnia, both with and without comorbid psychiatric disorders: a 24-week, randomized, double-blind study.
- Author
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Uchimura N, Kamijo A, and Takase T
- Abstract
Background: The primary objective of this study was to evaluate long-term (24-week) safety of eszopiclone in elderly and nonelderly Japanese patients with chronic insomnia. The secondary objectives were to evaluate short-term (4-week) efficacy and to assess for rebound insomnia or dependence after long-term treatment., Methods: Patients (n = 164 elderly; n = 161 nonelderly), with or without psychiatric comorbidities, were randomized to receive low-dose (1 mg, elderly; 2 mg, nonelderly) or high-dose (2 mg, elderly; 3 mg, nonelderly) eszopiclone. The safety evaluation included adverse events, vital signs, clinical laboratory parameters, and electrocardiogram. Efficacy was assessed using patient reports of sleep latency (SL), total sleep time (TST), wake time after sleep onset (WASO), number of awakenings (NA), quality of sleep, depth of sleep, daytime sleepiness, daytime ability to function, and the 36-item Short Form (SF-36) Health Survey., Results: The rate of adverse events was 81.5% in the 1-mg elderly group, 79.5% in the 2-mg elderly group, 82.1% in the 2-mg nonelderly group, and 87.0% in the 3-mg nonelderly group. Dysgeusia was the most common adverse event and was dose-related. Of 12 serious adverse events, none were considered by the investigator to be related to study medication. No rebound insomnia was observed. Eszopiclone significantly improved SL, TST, WASO, NA, and daytime sleepiness and function from baseline to Week 4, irrespective of age and psychiatric comorbidity. Improvements were also observed in SF-36 Mental Health Component scores in elderly and nonelderly patients with psychiatric comorbidities., Conclusions: Irrespective of age, eszopiclone appeared safe as administered in this study for 24 weeks. Eszopiclone improved sleep variables in insomnia patients with and without psychiatric disorders and health-related quality of life in those with psychiatric disorders., Trial Registration: ClinicalTrials.gov #NCT00770692; http://clinicaltrials.gov/ct2/show/NCT00770692.
- Published
- 2012
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26. Correlates of self-report chronic insomnia disorders with 1-6 month and 6-month durations in home-dwelling urban older adults - the Shih-Pai Sleep Study in Taiwan: a cross-sectional community study.
- Author
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Jing-Hui Chiou, Hsi-Chung Chen, Kuang-Hung Chen, Pesus Chou, Chiou, Jing-Hui, Chen, Hsi-Chung, Chen, Kuang-Hung, and Chou, Pesus
- Subjects
INSOMNIACS ,HEALTH of older people ,ETIOLOGY of diseases ,LUNG diseases ,DIAGNOSIS of mental depression ,MENTAL depression ,QUESTIONNAIRES ,INSOMNIA ,SELF-evaluation ,TIME ,CITY dwellers ,RESIDENTIAL patterns ,INDEPENDENT living ,DISEASE prevalence ,CROSS-sectional method ,DIAGNOSIS ,PSYCHOLOGY - Abstract
Background: To examine the correlates of insomnia disorder with different durations in home-dwelling older adults.Methods: A cross-sectional survey in the Shih-Pai area of Taipei City, Taiwan (The Shih-Pai Sleep Study). A total 4047 subjects over the age of 65 years completed the study (2259 men and 1788 women). The Pittsburgh Sleep Quality Index and the duration of insomnia symptoms were used to identify DSM-IV 1-6 month and 6-month insomnia disorders.Results: The prevalence of DSM-IV defined insomnia disorder was 5.8 %; two-thirds of these case lasted for ≥6 months. The shared correlates for both 1-6 and 6-month insomnia disorders were gender (women), depression and moderate pain. Pulmonary diseases were exclusively associated with 1-6 month insomnia disorder (OR: 2.57, 95 % CI: 1.46-4.52). In contrast, heart disease (OR: 1.73, 95 % CI: 1.21-2.49) and severe pain (OR: 2.34, 95 % CI: 1.14-4.40) were associated with 6-month insomnia disorder.Conclusion: The prevalence of persistent insomnia disorder is higher than short-term insomnia disorder. Correlates for less persistent and more persistent insomnia disorder appears to be partially different. Duration quantifiers may be important in the identification of the etiology of insomnia and further studies with follow-ups are needed to examine the order of developing insomnia disorder and associated conditions. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
27. GP's GP, general practitioner's health and willingness to contract family doctors in China: a national cross-sectional study.
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He, Guoshu, Ren, Jingjing, Chen, Xiaoyang, Pan, Qi, and Pan, Tianyuan
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CROSS-sectional method ,HEALTH self-care ,OCCUPATIONAL roles ,MENTAL health ,HEALTH status indicators ,RESEARCH funding ,CONTRACTING out ,INSOMNIA ,QUESTIONNAIRES ,PHYSICIANS' attitudes ,REFLECTION (Philosophy) ,DESCRIPTIVE statistics ,CHI-squared test ,DISEASE prevalence ,CHRONIC diseases ,SLEEP duration ,SURVEYS ,RESEARCH ,PHYSICIAN-patient relations ,TRUST ,INDUSTRIAL hygiene ,COGNITION - Abstract
Objectives: General practitioners are trained to care for patients with a high level of responsibility and professional competency. However, there are few reports on the physical and mental health status of general practitioners (GPs) in China, particularly regarding help seeking and self-treatment. The primary aims of this study were to explore GPs' expectations of their own family doctors and their reflection on role positioning, and to explore the objective factors that hinder the system of family doctors. Study design: Cross-sectional study. Methods: We conducted an online survey of Chinese GPs. Descriptive statistics were used to summarize the findings. Results: More than half of the participants (57.20%) reported that their health was normal over the past year. A total of 420 participants (23.35%) reported having chronic diseases. For sleep duration, 1205 participants (66.98%) reported sleeping 6–8 h per day; 473 participants (26.29%) reported chronic insomnia. Two hundred thirty-one participants (12.84%) had possible depression. A total of 595 (33.07%) participants reported that they had contracted a fixed family doctor. In terms of preventing themselves from contracting for a family doctor, the following factors were identified: lack of sufficient time (54.81%), could solve obstacles themselves (50.97%), and embarrassment (24.24%). The proportion of the contract group (12.44%) taking personal relationship as a consideration was higher than that of the non-contract group (7.64%) (χ2 = 10.934 P = 0.01). Most participants (79.90%) in the non-signed group reported never having seen a family doctor. In terms of obstacles, more than half of the signed group thought that they could solve obstacles themselves, while the non-signed group (39.20%) was less confident in the ability of family doctors than the signed group (29.75%) (χ2 = 15.436, P < 0.01). Conclusions: GPs work under great pressure and lack of self-care awareness, resulting in an increased prevalence of health conditions. Most GPs did not have a regular family doctor. Having a family doctor with a fixed contract is more conducive to the scientific management of their health and provides a reasonable solution to health problems. The main factors hindering GPs from choosing a family doctor were time consumption, abilities to solve obstacles themselves, and trust in the abilities of GPs. Therefore, simplifying the process of family doctor visits, Changing the GPs' medical cognition, and strengthening the policy of GP training would be conducive to promoting a family doctor system that enhances hierarchical diagnosis and treatment. International collaboration could integrate GP health support into global healthcare system. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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28. Sleep-HD trial: short and long-term effectiveness of existing insomnia therapies for patients undergoing hemodialysis.
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Unruh, Mark, Cukor, Daniel, Rue, Tessa, Abad, Kashif, Roumelioti, Maria-Eleni, McCurry, Susan M., Heagerty, Patrick, and Mehrotra, Rajnish
- Subjects
MENTAL health services ,INSOMNIACS ,CHRONIC kidney failure ,HEMODIALYSIS patients ,TREATMENT effectiveness ,HEMODIAFILTRATION ,BRAIN-computer interfaces - Abstract
Background: Patients with end-stage kidney disease (ESKD) treated with hemodialysis (HD) experience many distressing symptoms. One frequently reported symptom is insomnia. There are unique issues about HD treatments and schedules that disrupt regular sleep/wake routines and possibly contribute to the high severity of insomnia. Despite evidence for broad-ranging health effects of insomnia, very few clinical trials have tested the efficacy of treatments for HD patients. Cognitive-behavioral therapy for insomnia (CBT-I) is a recommended first-line therapy but largely inaccessible to HD patients in the United States, partly because they commit considerable amounts of time to thrice-weekly dialysis treatments. Another important reason could be the logistical and reimbursement challenges associated with providing behavioral health care at the dialysis center. CBT-I delivered by telehealth can overcome barriers to access, but its efficacy has never been rigorously tested for these patients. Pharmacotherapy is the most widely used treatment for insomnia; however, some drugs presently used are unsafe as they are associated with a higher risk for death for HD patients (benzodiazepines and zolpidem-like drugs). The efficacy and safety of other medications (trazodone) for the treatment of insomnia has never been tested for patients treated with HD.Methods: This trial tests the short- and long-term comparative effectiveness of 6-week treatment with telehealth CBT-I, trazodone, or medication placebo. This will be accomplished with a randomized controlled trial (RCT) in which 126 participants treated with HD in community-based dialysis facilities with chronic insomnia will be assigned 1:1:1 to telehealth CBT-I, trazodone, or medication placebo, respectively; short-term effectiveness of each treatment arm will be determined at the end of 6-weeks of treatment and long-term effectiveness at 25-weeks. The primary and secondary patient-reported outcomes will be assessed with computer-based telephone interviewing by research scientists blinded to treatment assignment; additional secondary outcomes will be assessed by participant interview and actigraphy.Discussion: This clinical RCT will provide the first evidence for the comparative effectiveness of two distinct approaches for treating chronic insomnia and other patient-reported outcomes for patients receiving maintenance HD.Trial Registration: NCT03534284 May 23, 2018. SLEEP-HD Protocol Version: 1.3.4 (7/22/2020). [ABSTRACT FROM AUTHOR]- Published
- 2020
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29. Treatment strategies for insomnia in Japanese primary care physicians' practice: A Web-based questionnaire survey.
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Takeshima, Masahiro, Sakurai, Hitoshi, Inada, Ken, Aoki, Yumi, Ie, Kenya, Kise, Morito, Yoshida, Eriko, Matsui, Kentaro, Utsumi, Tomohiro, Shimura, Akiyoshi, Okajima, Isa, Kotorii, Nozomu, Yamashita, Hidehisa, Suzuki, Masahiro, Kuriyama, Kenichi, Shimizu, Eiji, Mishima, Kazuo, Watanabe, Koichiro, and Takaesu, Yoshikazu
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INSOMNIA treatment ,BENZODIAZEPINES ,PSYCHOTHERAPY ,SCALE analysis (Psychology) ,CROSS-sectional method ,CHINESE medicine ,FAMILY medicine ,SEDATIVES ,RESEARCH funding ,DRUG therapy ,QUESTIONNAIRES ,TRANQUILIZING drugs ,DESCRIPTIVE statistics ,PROFESSIONS ,PHYSICIAN practice patterns ,GENERIC drug substitution ,COGNITIVE therapy ,COMPARATIVE studies ,DATA analysis software ,CONFIDENCE intervals ,TRAZODONE ,DRUG utilization ,RELAXATION techniques ,QUETIAPINE ,SLEEP hygiene - Abstract
Background: It is unclear how primary care physicians manage insomnia after the introduction of novel hypnotics such as orexin receptor antagonists and melatonin receptor agonists. This Web-based questionnaire survey aimed to examine treatment strategies for insomnia in Japanese primary care practice. Methods: One-hundred-and-seventeen primary care physicians were surveyed on the familiarity of each management option for insomnia on a binary response scale (0 = "unfamiliar"; 1 = "familiar") and how they managed insomnia using a nine-point Likert scale (1 = "I never prescribe/perform it"; 9 = "I often prescribe/perform it"). Physicians who were unfamiliar with a management option were deemed to have never prescribed or performed it. Results: Regarding medication, most physicians were familiar with novel hypnotics. Suvorexant was the most used hypnotic, followed by lemborexant and ramelteon. These novel hypnotics averaged 4.8–5.4 points and 4.0–4.7 points for sleep onset and sleep maintenance insomnia, respectively. By contrast, most benzodiazepines were seldom used below two points. Regarding psychotherapy, only approximately 40% of the physicians were familiar with cognitive behavioral therapy for insomnia (CBT-I) and they rarely implemented it, at an average of 1.5–1.6 points. More physicians were familiar with single-component psychotherapies (i.e., relaxation, sleep restriction therapy, and stimulus control) compared to CBT-I, and 48–74% of them implemented it slightly more often, with scores ranging from 2.6 to 3.4 points. Conclusion: This study suggests that Japanese primary care physicians seldom use CBT-I to treat insomnia. In addition, they use novel sleep medications more frequently than benzodiazepines in terms of pharmacotherapy. The use and availability of CBT-I in Japanese primary care might be facilitated by: educating primary care physicians, implementing brief or digital CBT-I, and/or developing collaborations between primary care physicians and CBT-I specialists. [ABSTRACT FROM AUTHOR]
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- 2024
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30. A pilot, randomized, placebo-controlled study of mindfulness meditation in treating insomnia in multiple sclerosis.
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Guarnaccia, Joseph B., Njike, Valentine Y., Dutton, Anne, Ayettey, Rockiy G., Treu, Judith A., Comerford, Beth P., and Sinha, Rajita
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MULTIPLE sclerosis ,SLEEP quality ,MINDFULNESS ,QUALITY of life measurement ,MINDFULNESS-based cognitive therapy ,INSOMNIA ,SLEEP hygiene ,GALVANIC skin response - Abstract
Objective: Mindfulness is an established approach to reduce distress and stress reactivity by improving awareness and tolerability of thoughts and emotions. This study compares mindfulness training to sleep hygiene in persons with multiple sclerosis (PWMS) who report chronic insomnia, examining sleep efficiency (SE), self-reported sleep quality and quality of life. Methods: Fifty-three PWMS were randomized (1:1) in a single-blinded, parallel group design to ten, two-hour weekly sessions of Mindfulness Based Stress Intervention for Insomnia (MBSI-I) over a span of ten weeks or a single, one hour sleep hygiene (SH) session over one day. The primary outcome measure was SE, measured by the Fitbit™ Charge 2 wrist device, at 10 and 16 weeks from the start of study interventions. Self-report outcomes included the Pittsburg Sleep Quality Rating Scale (PSQI), Insomnia Severity Index (ISI) and the Multiple Sclerosis Quality of Life Inventory (MSQLI). Nineteen participants in the MBSI-I group and 24 in the SH group completed the primary study. Subsequently, ten participants in the original SH group participated in the 10-week MSBI-I course and their data was added to the MBSI-I cohort (eMSBI-I). Results: While neither SE nor the PSQI showed significant differences between MBSI-I, eMBSI-I and SH groups, ISI improved in both the MSBI-I and eMBSI-I vs SH at 10 weeks (p = 0.0014 and p = 0.0275) but not 16 weeks. However, pre and post assessments within the MBSI-I and eMBSI-I cohorts did show significant improvement in the PSQI and ISI at 10 and 16 weeks, while SH was significant in the ISI only at 16 weeks. Several quality of life measurements, including fatigue, mental health and cognitive function favored the mindfulness cohorts. Conclusion: This pilot study demonstrates beneficial effects of MBSR on insomnia, sleep quality and quality of life in PWMS. Trial registration: NCT03949296. 14 May 2019. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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31. The gap between statistical and clinical significance: time to pay attention to clinical relevance in patient-reported outcome measures of insomnia.
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Qin Z, Zhu Y, Shi DD, Chen R, Li S, and Wu J
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- Humans, Cross-Sectional Studies, Minimal Clinically Important Difference, Surveys and Questionnaires, Treatment Outcome, Clinical Relevance, Randomized Controlled Trials as Topic statistics & numerical data, Sleep Initiation and Maintenance Disorders
- Abstract
Background: Appropriately defining and using the minimal important change (MIC) and the minimal clinically important difference (MCID) are crucial for determining whether the results are clinically significant. The aim of this study is to survey the status of randomized controlled trials (RCTs) for insomnia interventions to assess the inclusion and interpretation of MIC/MCID values., Methods: We conducted a cross-sectional study to survey the status of RCTs for insomnia interventions to assess the inclusion and appropriate interpretation of MIC/MCID values. A literature search was conducted by searching the main sleep medicine journals indexed in PubMed, the Excerpta Medica Database (EMBASE), and the Cochrane Central Register of Controlled Trials (CENTRAL) to identify a broad range of search terms. We included RCTs with no restriction on the intervention. The included studies used the Insomnia Severity Index (ISI) or the Pittsburgh Sleep Quality Index (PSQI) questionnaire as the outcome measures., Results: 81 eligible studies were identified, and more than one-third of the included studies used MIC/MCID (n = 31, 38.3%). Among them, 21 studies with ISI as the outcome used MIC defined as a relative decrease ranging from 3 to 8 points. The most frequently used MIC value was a 6-point decrease (n = 7), followed by 8-point (n = 6) and 7-point decrease (n = 4), a 4 to 5-points decrease (n = 3), and a 30% reduction from baseline; 6 studies used MCID values, ranging from 2.8 to 4 points. The most frequently used MCID value was a 4-point decrease in the ISI (n = 4). 4 studies with PSQI as the outcome used a 3-point change as the MIC (n = 2) and a 2.5 to 2.7-point difference as MCID (n = 2). 4 non-inferiority design studies considered interval estimation when drawing clinically significant conclusions in their MCID usage., Conclusions: The lack of consistent MIC/MCID interpretation and usage in outcome measures for insomnia highlights the urgent need for further efforts to address this issue and improve reporting practices., (© 2024. The Author(s).)
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- 2024
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32. A comparison of cognitive behavioral therapy for insomnia to standard of care in an outpatient substance use disorder clinic embedded within a therapeutic community: a RE-AIM framework evaluation.
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Speed, Traci J., Hanks, Lisa, Turner, Gavin, Gurule, Evelyn, Kearson, Alexandra, Buenaver, Luis, Smith, Michael T., and Antoine, Denis
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THERAPEUTIC communities ,COGNITIVE therapy ,OUTPATIENT medical care ,SUBSTANCE abuse ,INSOMNIA ,SLEEP-wake cycle ,DROWSINESS ,SLEEP interruptions - Abstract
Background: Rates of substance use disorders (SUDs) continue to rise in the USA with parallel rises in admissions to outpatient SUD treatment programs. Insomnia symptoms reduce treatment adherence, trigger relapse, and generally undermine SUD recovery efforts. Cognitive-behavioral therapy for insomnia (CBT-I) is the first-line treatment recommended for chronic insomnia. No study has examined the effectiveness of CBT-I for individuals who recently entered an outpatient SUD treatment program embedded within a therapeutic community (i.e., long-term drug-free residential setting).Methods: A randomized controlled trial conducted at a SUD program embedded in a therapeutic community aimed to compare group-based CBT-I (gCBT-I) (N = 10) with the standard of care (SOC) (N = 11) among individuals who have SUDs and comorbid insomnia. We present a RE-AIM (reach, effectiveness, adoption, implementation, and maintenance) framework evaluation to provide empirical data on gCBT-I feasibility and facilitators and barriers of conducting an insomnia-focused clinical effectiveness study within a therapeutic community.Results: Participants in both study arms reported moderately severe insomnia symptoms at admission and reductions in insomnia symptoms over time. Among participants who completed the Insomnia Severity Index (ISI) beyond admission, ISI decreased to ≤ 8 (the clinical cutoff for mild insomnia) in 80% of individuals in the gCBT-I group compared with 25% of individuals in the SOC group. A RE-AIM framework evaluation showed initial success with Reach and Adoption while Implementation, and Maintenance were limited. Effectiveness was inconclusive because of challenges with recruitment, intervention integrity, and missing data that precluded meeting the planned recruitment and study aims and led to study termination. Coordination and communication with staff and leadership facilitated gCBT-I implementation, yet well-known CBT-I barriers including time- and resource-intensive sleep medicine training for interventionalists and maintenance of treatment integrity during an 8-week intervention limited gCBT-I sustainability.Conclusions: This analysis supports the feasibility of conducting behavioral sleep medicine research in outpatient SUD treatment programs embedded within therapeutic communities. Implementation of an insomnia-focused intervention was widely accepted by patients and providers and has potential to address insomnia symptoms in early SUD recovery. Addressing patient- and organizational-level implementation barriers may enhance the sustainability and scalability of sleep interventions and provide new hope to effectively treat insomnia among people living with SUDs.Trial Registration: Clinicaltrials.gov : NCT03208855. Registered July 6, 2017https://clinicaltrials.gov/ct2/show/NCT03208855?term=NCT03208855&draw=2&rank=1. [ABSTRACT FROM AUTHOR]- Published
- 2022
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33. A hybrid type I trial to increase Veterans' access to insomnia care: study protocol for a randomized controlled trial.
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Bramoweth, Adam D., Germain, Anne, Youk, Ada O., Rodriguez, Keri L., and Chinman, Matthew J.
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INSOMNIA treatment ,MENTAL health services for veterans ,RESEARCH protocols ,RANDOMIZED controlled trials ,PRIMARY care - Abstract
Background: Chronic insomnia is among the most reported complaints of Veterans and military personnel referred for mental health services. It is highly comorbid with medical and psychiatric disorders, and is associated with significantly increased healthcare utilization and costs. Evidence-based psychotherapy, namely Cognitive Behavioral Therapy for Insomnia (CBTI), is an effective treatment and recommended over prescription sleep medications. While CBTI is part of a nationwide rollout in the Veterans Health Administration to train hundreds of providers, access to treatment is still limited for many Veterans due to limited treatment availability, low patient and provider knowledge about treatment options, and Veteran barriers such as distance and travel, work schedules, and childcare. Uptake of a briefer, more primary-care-friendly treatment into routine clinical care in Veterans Affairs (VA) primary care settings, where insomnia is typically first recognized and diagnosed, may effectively and efficiently increase access to effective insomnia interventions and help decrease the risks and burdens related to chronic insomnia.Methods: This hybrid type I trial is composed of two aims. The first preliminarily tests the clinical non-inferiority of Brief Behavioral Treatment for Insomnia (BBTI) versus the current "gold standard" treatment, CBTI. The second is a qualitative needs assessment, guided by the Consolidated Framework for Implementation Research (CFIR), to identify potential factors that may affect successful implementation and integration of behavioral treatments for insomnia in the primary care setting. To identify potential implementation factors, individual interviews are conducted with the Veterans who participate in the clinical trial, as well as VA primary care providers and nursing staff.Discussion: It is increasingly important to better understand barriers to, and facilitators of, implementing insomnia interventions in order to ensure that Veterans have the best access to care. Furthermore, it is important to evaluate the potential for new avenues of treatment delivery, like BBTI in the primary care setting, which can benefit Veterans who may not have adequate access to specialty mental health providers trained in CBTI.Trial Registration: ClinicalTrials.gov, ID: NCT02724800 . Registered on 31 March 2016. [ABSTRACT FROM AUTHOR]- Published
- 2018
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34. Telemedicine-delivered cognitive-behavioral therapy for insomnia in alcohol use disorder (AUD): study protocol for a randomized controlled trial.
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Arnedt, J. Todd, Cardoni, M. Elizabeth, Conroy, Deirdre A., Graham, Mandilyn, Amin, Sajni, Bohnert, Kipling M., Krystal, Andrew D., and Ilgen, Mark A.
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ALCOHOLISM ,COGNITIVE therapy ,RANDOMIZED controlled trials ,TELEMEDICINE ,INSOMNIA ,BEHAVIOR therapy ,RESEARCH protocols - Abstract
Background: Alcohol use disorder (AUD) is a leading preventable cause of morbidity and mortality, but relapse rates are high even with available treatments. Insomnia is a robust predictor of relapse and pilot studies have shown that CBT for insomnia improves insomnia and daytime functioning in adults with AUD and insomnia. The impact of CBT for insomnia on relapse, however, is unclear. This trial will compare telemedicine-delivered CBT for insomnia (CBT-TM) with sleep hygiene education (SHE-TM) on improving insomnia/sleep, daytime symptom, and drinking outcomes in treatment-seeking AUD adults with insomnia. The study will also determine the effects of treatment on sleep mechanisms and their association with clinical outcomes.Methods: This is a single-site randomized controlled trial with planned enrollment of 150 adults meeting criteria for both AUD and chronic insomnia. Eligible participants will be randomized 1:1 to 6 sessions of telemedicine-delivered Cognitive Behavioral Therapy for Insomnia (CBT-TM) or Sleep Hygiene Education (SHE-TM) with clinical assessments conducted at pre-treatment, post- treatment, and at 3, 6, and 12 months post-treatment. Overnight polysomnography will be conducted before and after treatment. Primary clinical outcomes will include post-treatment scores on the Insomnia Severity Index and the General Fatigue subscale of the Multidisciplinary Fatigue Inventory, and the percent of days abstinent (PDA) on the interview-administered Time Line Follow Back. EEG delta activity, derived from overnight polysomnography, will be the primary endpoint to assess the sleep homeostasis mechanism.Discussion: This adequately powered randomized controlled trial will provide clinically relevant information about whether targeting insomnia is effective for improving treatment outcomes among treatment-seeking adults with AUD. Additionally, the study will offer new scientific insights on the impact of an evidence-based non-medication treatment for insomnia on a candidate mechanism of sleep dysfunction in this population - sleep homeostasis.Trial Registration: CClinicalTrials.gov NCT # 04457674 . Registered on 07 July 2020. [ABSTRACT FROM AUTHOR]- Published
- 2022
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35. Sequential psychological and pharmacological therapies for comorbid and primary insomnia: study protocol for a randomized controlled trial.
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Morin, Charles M., Edinger, Jack D., Krystal, Andrew D., Buysse, Daniel J., Beaulieu-Bonneau, Simon, and Ivers, Hans
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INSOMNIA treatment ,DRUG therapy ,COMORBIDITY ,RANDOMIZED controlled trials ,BENZODIAZEPINE receptors ,COGNITIVE therapy ,PSYCHIATRIC diagnosis ,MENTAL illness ,AFFECT (Psychology) ,COMBINED modality therapy ,EXPERIMENTAL design ,RESEARCH protocols ,INSOMNIA ,PYRIDINE ,QUALITY of life ,RESEARCH funding ,SLEEP ,TIME ,POLYSOMNOGRAPHY ,TREATMENT effectiveness ,TRAZODONE ,DIAGNOSIS ,PSYCHOLOGY ,THERAPEUTICS - Abstract
Background: Chronic insomnia is a prevalent disorder associated with significant psychosocial, health, and economic impacts. Cognitive behavioral therapies (CBTs) and benzodiazepine receptor agonist (BzRA) medications are the most widely supported therapeutic approaches for insomnia management. However, few investigations have directly compared their relative and combined benefits, and even fewer have tested the benefits of sequential treatment for those who do not respond to initial insomnia therapy. Moreover, insomnia treatment studies have been limited by small, highly screened study samples, fixed-dose, and fixed-agent pharmacotherapy strategies that do not represent usual clinical practices. This study will address these limitations.Methods/design: This is a two-site randomized controlled trial, which will enroll 224 adults who meet the criteria for a chronic insomnia disorder with or without comorbid psychiatric disorders. Prospective participants will complete clinical assessments and polysomnography and then will be randomly assigned to first-stage therapy involving either behavioral therapy (BT) or zolpidem. Treatment outcomes will be assessed after 6 weeks, and treatment remitters will be followed for the next 12 months on maintenance therapy. Those not achieving remission will be offered randomization to a second, 6-week treatment, again involving either pharmacotherapy (zolpidem or trazodone) or psychological therapy (BT or cognitive therapy (CT)). All participants will be re-evaluated 12 weeks after the protocol initiation and at 3-, 6-, 9-, and 12-month follow-ups. Insomnia remission, defined categorically as a score < 8 on the Insomnia Severity Index, a patient-reported outcome, will serve as the primary endpoint for treatment comparisons. Secondary outcomes will include sleep parameters derived from daily sleep diaries and from polysomnography, subjective measures of fatigue, mood, quality of life, and functional impairments; and measures of adverse events; dropout rates; and treatment acceptability. Centrally trained therapists will administer therapies according to manualized, albeit flexible, treatment algorithms.Discussion: This clinical trial will provide new information about optimal treatment sequencing and will have direct implication for the development of clinical guidelines for managing chronic insomnia with and without comorbid psychiatric conditions.Trial Registration: ClinicalTrials.gov Identifier: NCT01651442 , Protocol version 4, 20 April 2011, registered 26 June 2012. [ABSTRACT FROM AUTHOR]- Published
- 2016
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36. Insomniacs show greater prefrontal activation during verbal fluency task compared to non-insomniacs: a functional near-infrared spectroscopy investigation of depression in patients.
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Xu, HuaSen, Wang, YuXing, Wang, Yi Ming, Cao, YaQi, Li, PeiFan, Hu, YongXue, and Xia, GuangYuan
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NEAR infrared spectroscopy ,HAMILTON Depression Inventory ,MENTAL depression ,SLEEP quality ,VERBAL behavior testing - Abstract
Background: Previous studies have shown that insomnia affects human prefrontal function and that there are specific patterns of brain activation to counteract sleep and improve cognition. However, the effects of insomnia on the prefrontal cortex of MDD (major depressive disorder) patients and the patterns of activation to counteract sleep in MDD patients remain unclear. The aim of this study is to examine this using fNIRS (functional near-infrared spectroscopy). Methods: Eighty depressed patients and 44 healthy controls were recruited for this study. fNIRS was used to assess changes in the concentration of oxygenated hemoglobin ([oxy-Hb]) in the prefrontal cortex of all participants during the VFT (verbal fluency test) and to record the number of words created to assess cognitive ability. The Pittsburgh Sleep Quality Index was used to assess sleep quality, and the Hamilton Rating Scale for Depression (24-item) and Hamilton Rating Scale for Anxiety (14-item) were used to assess the severity of depression and anxiety. Results: When comparing patients, the healthy control group had significantly higher [oxy-Hb] values in the bilateral prefrontal cortex during VFT than the MDD group. In the MDD group, the [oxy-Hb] values in all brain regions except the right DLPFC were significantly higher in the group with insomnia than in the group without insomnia, but their VFT performance was significantly lower than in the group without insomnia and the healthy group. PSQI scores were positively correlated with [oxy-Hb] values in some left-brain regions, whereas HAMD and HAMA scores were not correlated with [oxy-Hb] values. Conclusion: The PFC was significantly less active during VFT in those with MDD than in healthy controls. All brain regions, except the right DLPFC, were significantly more active in MDD patients with insomnia than in those without insomnia, suggesting that sleep quality needs to be an important indicator in fNIRS screening. In addition, there was a positive correlation between the severity of insomnia in the left VLPFC and the level of activation, suggesting a role for the left brain region in the neurophysiology of overcoming sleepiness in MDD patients. these findings may provide new ideas for the treatment of MDD patients in the future. Trial registration: Our experiment was registered in the China Clinical Trial Registry (registration number ChiCTR2200065622) on November 10.(The first patient was recruited in 10/11/2022.) [ABSTRACT FROM AUTHOR]
- Published
- 2023
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37. Music to improve sleep quality in adults with depression-related insomnia (MUSTAFI): study protocol for a randomized controlled trial.
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Lund, Helle Nystrup, Pedersen, Inge Nygaard, Johnsen, Søren Paaske, Heymann-Szlachcinska, Agnieszka M., Tuszewska, Maryla, Bizik, Gustav, Larsen, Jens Ivar, Kulhay, Eszter, Larsen, Anelia, Grønbech, Bettina, Østermark, Helle, Borup, Heidi, Valentin, Jan Brink, and Mainz, Jan
- Subjects
RANDOMIZED controlled trials ,INSOMNIA ,FRAIL elderly ,LISTENING skills ,SLEEP disorders ,ADULTS ,SLEEP - Abstract
Background: Insomnia is a common sleep disorder for adults with depression, with major impact on their quality of life. Previous trials suggest that listening to music may be helpful in the treatment of sleep disturbances in healthy populations, including students and elderly. In addition, small studies with clinical populations of traumatized refugees, adults with chronic insomnia and adults with depression insomnia add to the evidence base. However, the impact of music listening in the treatment of depression related insomnia is not well documented.Objective: To examine the efficacy of music listening on sleep quality, symptoms of depression, and quality of life in adults with depression-related insomnia.Method: A single-center randomized controlled trial (RCT) in a two-arm parallel-group design is conducted and reported according to the CONSORT guidelines. The trial consists of an experimental group and a standard care control group. Both groups receive standard treatment for depression following Danish clinical guidelines in an outpatient psychiatry unit. The experimental group listens to music for a minimum of 30 minutes at bedtime for 4 weeks.Discussion: This trial will provide information on the efficacy of music intervention as a non-pharmacological intervention in the treatment of depression-related insomnia. This study will provide novel knowledge concerning music medicine as an evidence-based treatment for depression.Trial Registration: Clinicaltrials.gov. ID NCT03676491, registered on 19 September 2018. [ABSTRACT FROM AUTHOR]- Published
- 2020
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38. Discontinuation of hypnotics during cognitive behavioural therapy for insomnia.
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Zavesicka, Lucie, Brunovsky, Martin, Matousek, Milos, and Sos, Peter
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HYPNOTICS ,COGNITIVE therapy ,INSOMNIA ,POLYSOMNOGRAPHY ,RAPID eye movement sleep - Abstract
Background: In practical sleep medicine, therapists face the question of whether or not to discontinue the ongoing use of hypnotics in patients, as well as the possible effects of discontinuation. The aim of this study was to evaluate the effects of discontinuing third-generation hypnotics on the results of cognitive-behavioural therapy (CBT) for primary insomnia in patients after long-term abuse. Methods: Twenty-eight outpatients were treated by CBT for 8 weeks. The treatment outcome was estimated by means of differences among subjective clinical scales and polysomnography variables assessed before and after the treatment period. The therapeutic effect in a subgroup of 15 patients who had previously received hypnotics and were successively withdrawn during weeks 2-6 was compared to the effect achieved in patients who had not used hypnotics before CBT. Results: There were no significant differences in baseline subjective and objective sleep characteristics between the hypnotic abusers and non-abusers. According to clinical scales and most polysomnographic measures, CBT was highly effective in both groups of subjects; it produced the greatest changes in total sleep time, REM sleep and sleep efficiency. Unexpectedly, discontinuation of hypnotics, as a factor in the analysis, was followed by an additional improvement of sleep efficiency and wake after sleep onset parameters. Conclusion: Our study confirmed the efficacy of CBT in both hypnotic-abusing and non-abusing patients with chronic insomnia. The results of this study suggest that tapered withdrawal of third-generation hypnotics during CBT therapy for chronic insomnia could be associated with improvement rather than worsening of sleep continuity. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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39. Efficacy and safety of auricular acupressure on reduction of estazolam in patients with insomnia: a study protocol for a three-arm, blinded randomized controlled trial.
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Wu, Qiqi, Wang, Jiawei, Fan, Lijuan, Qian, Lala, Han, Dexiong, Hu, Hantong, and Gao, Hong
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PATIENT safety ,INSOMNIA ,ACUPUNCTURE ,EAR ,TREATMENT effectiveness ,RANDOMIZED controlled trials ,ACUPRESSURE ,ESTAZOLAM (Drug) - Abstract
Background: Drug-dependent insomnia refers to insomnia patients taking sedatives and sleeping pills regularly for a long period. Auricular acupressure (AA) has attracted growing attention as a complementary treatment for insomnia. Nevertheless, there is a lack of rigorous studies evaluating AA specifically for estazolam-dependent insomnia. Our proposed trial aims to assess the therapeutic effect of AA on estazolam-dependent insomnia. Methods: This study is a randomized, single-blinded, three-arm controlled trial. No less than 108 participants will be randomized into one of three groups: AA group, sham auricular acupressure (SAA) group, and conventional dosage reduction group. All treatments will be administered for 4 weeks, with a follow-up period of 1 month. The primary clinical outcomes will be estazolam dosing and reduction rates, serum gamma-aminobutyric acid (GABA) and cortisol (CORT) levels. Secondary outcomes will concern the Pittsburgh sleep quality index (PSQI) and Benzodiazepine Withdrawal Symptom Questionnaire (BWSQ). Both intention-to-treat and per-protocol analyses will be performed, with the significance level determined as 5%. Discussion: The study results will provide evidence on the efficacy and safety of AA in managing estazolam-dependent insomnia by analyzing its immediate effect, time-effect relationship, and reduction of estazolam use. Trial Registration: Clinicaltrials.gov (identification number: NCT06258226; Registered 5 February 2024, https://clinicaltrials.gov/ct2/show/NCT06258226). [ABSTRACT FROM AUTHOR]
- Published
- 2024
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40. A multicountry study on the psychometric properties of the Arabic version of the Sleep Preoccupation Scale (SPS) using both classical testing theory and item response theory.
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Abu-Saleh, Salma Yasser, Irsheid, Wajiha, Husain, Waqar, Ammar, Achraf, Ghazzawi, Hadeel, Trabelsi, Khaled, BaHammam, Ahmed S., Saif, Zahra, Pakpour, Amir, and Jahrami, Haitham
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SLEEP interruptions ,ITEM response theory ,SLEEP duration ,DISCRIMINANT analysis ,PSYCHOMETRICS ,CLASSICAL test theory ,SLEEP hygiene - Abstract
Background: Sleep distrurbances involves daytime preoccupation about sleep, which plays a critical role in perpetuating sleep disturbances. Recent cognitive models highlight the importance of daytime processes, like processing sleep-related information and interpretations during waking hours, in influencing sleep quality and quantity. The Sleep Preoccupation Scale (SPS) quantifies this daytime cognitive activity related to sleep. This study aimed to translate and validate an Arabic version of the SPS for assessing sleep preoccupation among Arabic speakers. Methods: 523 Arabic speakers (mean age 23.6 years, 75% female) from four countries completed the Arabic SPS alongside the Athens Insomnia Scale, Generalized Anxiety Disorder-7 Scale, and the Anxiety and Preoccupation about Sleep Questionnaire (APSQ). The sample repeated the SPS after two weeks for test-retest reliability. Confirmatory factor analysis evaluated the SPS's two-factor structure. Internal consistency, item response theory, and convergent validity with the other scales were examined. Results: Confirmatory factor analysis supported the two-factor model's fit. Measurement invariance results suggest that the SPS exhibits a similar basic factor structure across both insomnia and non-insomnia groups. The Arabic SPS demonstrated good internal consistency (Cronbach's α = 0.92, McDonald's ω = 0.92) and two-way mixed effects, consistency, single rater/measurement intraclass correlation coefficient (ICC) test-retest reliability (ICC = 0.95). Most items exhibited satisfactory item response theory fit statistics and discrimination. The SPS total score showed strong positive correlations with insomnia severity (r = 0.48, p < 0.001), generalized anxiety (r = 0.57, p < 0.001), and sleep-related anxiety/preoccupation (r = 0.79, p < 0.001), demonstrating convergent validity. Conclusion: The Arabic version of the SPS demonstrated good psychometric properties and validity, supporting its use for assessing sleep preoccupation among Arabic speakers. This culturally-adapted version enhances sleep assessment capabilities for improving insomnia understanding and treatment within Arabic-speaking populations. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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41. Assessment of beliefs and attitudes towards benzodiazepines using machine learning based on social media posts: an observational study.
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de Anta, Laura, Alvarez-Mon, Miguel Ángel, Pereira-Sanchez, Victor, Donat-Vargas, Carolina C., Lara-Abelenda, Francisco J., Arrieta, María, Montero-Torres, María, García-Montero, Cielo, Fraile-Martínez, Óscar, Mora, Fernando, Ortega, Miguel Ángel, Alvarez-Mon, Melchor, and Quintero, Javier
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SOCIAL media ,SUPERVISED learning ,MEDICAL personnel ,HEALTH facilities ,PUBLIC opinion - Abstract
Background: Benzodiazepines are frequently prescribed drugs; however, their prolonged use can lead to tolerance, dependence, and other adverse effects. Despite these risks, long-term use remains common, presenting a public health concern. This study aims to explore the beliefs and opinions held by the public regarding benzodiazepines, as understanding these perspectives may provide insights into their usage patterns. Methods: We collected public tweets published in English between January 1, 2019, and October 31, 2020, that mentioned benzodiazepines. The content of each tweet and the characteristics of the users were analyzed using a mixed-method approach, including manual analysis and semi-supervised machine learning. Results: Over half of the Twitter users highlighted the efficacy of benzodiazepines, with minimal discussion of their side effects. The most active participants in these conversations were patients and their families, with health professionals and institutions being notably absent. Additionally, the drugs most frequently mentioned corresponded with those most commonly prescribed by healthcare professionals. Conclusions: Social media platforms offer valuable insights into users' experiences and opinions regarding medications. Notably, the sentiment towards benzodiazepines is predominantly positive, with users viewing them as effective while rarely mentioning side effects. This analysis underscores the need to educate physicians, patients, and their families about the potential risks associated with benzodiazepine use and to promote clinical guidelines that support the proper management of these medications. Clinical trial number: Not applicable. Significant outcomes: • Most Twitter users consider benzodiazepines effective, with only 5% mentioning side effects. • A significant percentage of users reported combining benzodiazepines with other psychopharmacological drugs, or even with alcohol and other addictive substances. • Our results indicate an alarming minimization of the risks associated with benzodiazepine use. [ABSTRACT FROM AUTHOR]
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- 2024
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42. Dietary supplementation with pterostilbene activates the PI3K-AKT-mTOR signalling pathway to alleviate progressive oxidative stress and promote placental nutrient transport.
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Cao, Mingming, Bai, Liyun, Wei, Haoyun, Guo, Yantong, Sun, Guodong, Sun, Haoyang, and Shi, Baoming
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BREAST milk ,OXIDANT status ,OXIDATIVE stress ,FETAL development ,DIETARY supplements ,LACTATION - Abstract
Background: Progressive oxidative stress easily occurs as a result of a gradual increase in the intensity of maternal metabolism due to rapid foetal development and increased intensity of lactation. However, studies on the effects of processive oxidative stress on nutrient transport in the placenta have received little attention. The present study was conducted on sows at 85 days of gestation to study the effects of pterostilbene (PTE) on maternal oxidative stress status and placental nutrient transport. Results: PTE increased the antioxidant capacity and immunoglobulin content in mothers' blood and milk, reduced the level of inflammatory factors, and improved the nutrient content of milk. PTE also reduced sow backfat loss and the number of weak sons, and increased piglet weaning weight and total weaning litter weight. We subsequently found that PTE enhanced placental glucose and fatty acid transport and further affected glycolipid metabolism by increasing the expression of LAL, PYGM, and Gbe-1, which activated the PI3K phosphorylation pathway. Moreover, PTE addition altered the relative abundance of the Firmicutes, Proteobacteria, Parabacillus, and Bacteroidetes-like RF16 groups in sow faeces. PTE increased the levels of acetate, propionate, butyrate and isovalerate in the faeces. Conclusions: These findings reveal that the addition of PTE during pregnancy and lactation mitigates the effects of processive oxidative stress on offspring development by altering maternal microbial and placental nutrient transport capacity. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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43. Relationship between longer sleep and serum neurofilament light chain in american adults: evidence from the 2013–2014 US national health and nutrition examination survey.
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Zhang, Chunyan, Yang, Yitian, Liu, Huanxian, and Zhang, Jiaqiang
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SLEEP duration ,SLEEP ,HEALTH & Nutrition Examination Survey ,SLEEP interruptions ,PATHOLOGICAL physiology - Abstract
Background: Sleep disturbance is linked to neurodegenerative diseases and the related brain pathophysiology. Serum neurofilament light chain (NfL) is a reliable biomarker for neurological disorders. This study examined the association between sleep characteristics and serum NfL levels in American adults. Methods: In this cross-sectional study, data from the 2013–2014 US National Health and Nutrition Examination Survey were utilized. Participants were categorized into short (≤ 6 h), normal (7–8 h), and long (≥ 9 h) sleep groups based on their self-reported sleep durations. Sleep duration, trouble sleeping, and diagnosed sleep disorders were queried, forming "sleep pattern (healthy, moderate, and poor)." The association between sleep characteristics and serum NfL levels was assessed using multivariate linear regression models. Stratification and sensitivity analyses were conducted to determine the stability of results. Results: Overall, 1637 participants were included; among them, 48.2% were male and 51.8% were female (mean ± SD, age: 46.9 ± 15.5 years) and 38.8% reported sleeping for ≤ 6 h, 54.4% for 7–8 h, and 6.8% for ≥ 9 h. Participants with longer sleep duration, poor sleep pattern, diagnosed sleep disorders, or trouble sleeping exhibited higher serum NfL levels. A positive correlation was found between extended sleep and elevated serum NfL levels (Adjusted β = 4.82, 95%CI: 2.2, 7.44, P < 0.001), with no significant correlation observed in the short-sleep group or those with poor sleep pattern. Stratified and sensitivity analyses confirmed the robustness of the relationship between longer sleep and elevated serum NfL levels. Conclusions: A long sleep duration is associated with higher serum NfL levels than a normal sleep duration in American adults. [ABSTRACT FROM AUTHOR]
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- 2024
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44. Cardiovascular adaptations and pathological changes induced by spaceflight: from cellular mechanisms to organ-level impacts.
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Han, Han, Jia, Hao, Wang, Yi-Fan, and Song, Jiang-Ping
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GEOMAGNETISM ,ASTROPHYSICAL radiation ,SPACE flight to the moon ,TERRESTRIAL radiation ,CLOCK genes - Abstract
The advancement in extraterrestrial exploration has highlighted the crucial need for studying how the human cardiovascular system adapts to space conditions. Human development occurs under the influence of gravity, shielded from space radiation by Earth's magnetic field, and within an environment characterized by 24-hour day-night cycles resulting from Earth's rotation, thus deviating from these conditions necessitates adaptive responses for survival. With upcoming manned lunar and Martian missions approaching rapidly, it is essential to understand the impact of various stressors induced by outer-space environments on cardiovascular health. This comprehensive review integrates insights from both actual space missions and simulated experiments on Earth, to analyze how microgravity, space radiation, and disrupted circadian affect cardiovascular well-being. Prolonged exposure to microgravity induces myocardial atrophy and endothelial dysfunction, which may be exacerbated by space radiation. Mitochondrial dysfunction and oxidative stress emerge as key underlying mechanisms along with disturbances in ion channel perturbations, cytoskeletal damage, and myofibril changes. Disruptions in circadian rhythms caused by factors such as microgravity, light exposure, and irregular work schedules, could further exacerbate cardiovascular issues. However, current research tends to predominantly focus on disruptions in the core clock gene, overlooking the multifactorial nature of circadian rhythm disturbances in space. Future space missions should prioritize targeted prevention strategies and early detection methods for identifying cardiovascular risks, to preserve astronaut health and ensure mission success. [ABSTRACT FROM AUTHOR]
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- 2024
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45. Construction of an index system of core competence assessment for sleep medicine nurse specialists in China: a Delphi study.
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Jiang, Nan, Liu, Wei Bin, Zong, YanHong, Yu, Li, and Cheng, ShuHua
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RESEARCH funding ,RESEARCH methodology evaluation ,QUESTIONNAIRES ,DESCRIPTIVE statistics ,NURSING ,NURSE practitioners ,EXPERIMENTAL design ,NURSING services administration ,RESEARCH methodology ,COMMUNICATION ,PROFESSIONAL employee training ,DATA analysis software ,DELPHI method ,SLEEP disorders ,PROFESSIONAL competence ,CRITICAL thinking ,EVALUATION - Abstract
Aim: To construct an evaluation index system for the core competence of nurses in sleep medicine specialties. Background: Specialized nurses in sleep medicine must handle treatment, nursing, and management well, which requires nurses to have excellent competence in knowledge, skills, and ability. However, a competency evaluation system for sleep medicine nurses has not been established in China. Methods: We used a literature review and an expert meeting to establish a draft indicator system. Subsequently, two rounds of correspondence were conducted with 27 experts from 5 provinces using the Delphi method to solicit their opinions on the core competency evaluation indicators for sleep medicine nurse specialists and to qualitatively evaluate the experts' scores. The consensus was defined in advance as a mean score of 4.0 or above, with at least 75% agreement among participants. In this way, the final indicator framework was determined. Results: The final evaluation indexes of the core competencies for sleep medicine Nurse Specialists included 6 first-level indexes (Practical ability, Theoretical Knowledge, Critical thinking, Communication and coordination, Nursing Management, and Professional Development), 16 s-level indexes, and 64 third-level indexes. The effective response rates of the two expert consultation rounds were 100%. The expert authority coefficients were 0.878 and 0.865 in the first and second rounds of consultation, respectively. In the second round of consultation, the first, second, and third indexes of Kendall's coefficient of concordance were 0.373, 0.351, and 0.286, respectively (P < 0.05). Conclusion: The core competence evaluation index system for sleep medicine nurses established in this study is scientific and reliable and can provide a theoretical reference for the training, assessment, and evaluation of sleep medicine nurses in the future. Implications for nursing management: The evaluation index system of sleep medicine nurses' core competence will provide an effective practical framework for nursing management to evaluate, train, and examine the core competence of sleep medicine nurses. [ABSTRACT FROM AUTHOR]
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- 2024
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46. Impulsivity mediates the relationship between sleep quality and interpersonal functioning: a cross-sectional study in a sample of university students.
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Farrell III, Brian J., Emmerton, Robert W., Camilleri, Christina, and Sammut, Stephen
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- 2024
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47. Age-related changes in sleep spindle characteristics in individuals over 75 years of age: a retrospective and comparative study.
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Poirson, Bastien, Vandel, Pierre, Bourdin, Hubert, and Galli, Silvio
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SLEEP duration ,SLEEP spindles ,SLEEP stages ,OLDER people ,AGE groups - Abstract
Background: Sleep and its architecture are affected and changing through the whole lifespan. We know main modifications of the macro-architecture with a shorter sleep, occurring earlier and being more fragmented. We have been studying sleep micro-architecture through its pathological modification in sleep, psychiatric or neurocognitive disorders whereas we are still unable to say if the sleep micro-architecture of an old and very old person is rather normal, under physiological changes, or a concern for a future disorder to appear. We wanted to evaluate age-related changes in sleep spindle characteristics in individuals over 75 years of age compared with younger individuals. Methods: This was an exploratory study based on retrospective and comparative laboratory-based polysomnography data registered in the normal care routine for people over 75 years of age compared to people aged 65–74 years. We were studying their sleep spindle characteristics (localization, density, frequency, amplitude, and duration) in the N2 and N3 sleep stages. ANOVA and ANCOVA using age, sex and OSA were applied. Results: We included 36 participants aged > 75 years and 57 participants aged between 65 and 74 years. An OSA diagnosis was most common in both groups. Older adults receive more medication to modify their sleep. Spindle localization becomes more central after 75 years of age. Changes in the other sleep spindle characteristics between the N2 and N3 sleep stages and between the slow and fast spindles were conformed to literature data, but age was a relevant modifier only for density and duration. Conclusion: We observed the same sleep spindle characteristics in both age groups except for localization. We built our study on a short sample, and participants were not free of all sleep disorders. We could establish normative values through further studies with larger samples of people without any sleep disorders to understand the modifications in normal aging and pathological conditions and to reveal the predictive biomarker function of sleep spindles. [ABSTRACT FROM AUTHOR]
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- 2024
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48. The effect of early initiation of self-management program based on multidisciplinary education in heart failure patients.
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Jia, Na, Zhao, Yajie, Sun, Xuelin, Wang, Mingfang, and Guo, Di
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SLEEP quality ,HEART failure patients ,SELF-management (Psychology) ,PATIENT education ,CARDIAC rehabilitation - Abstract
Aims: To explore the effect of early initiation of self-management based on multidisciplinary education in heart failure (HF) patients. Methods: HF patients in the Cardiology Department of Beijing Hospital were consecutively enrolled from June 2022 to February 2023. In-hospital HF patients from June 2022 to October 2022 were divided into the control group, and HF patients from November 2022 to February 2023 were divided into the cardiac rehabilitation (CR) group. A series of self-management education sessions with cardiologists, pharmacologists, nutritionists, and nurses was initiated early in the CR group. Continuous strengthening education was provided during the 3 months of discharge. Patients in the control group only received education twice during hospitalization. Minnesota Living with Heart Failure Questionnaire (MLHFQ), Pittsburgh sleep quality index (PSQI), anxiety Self-rating anxiety scale (SAS), and Self-rating depression scale (SDS) were compared between the two groups. Major cardiovascular adverse events (MACEs) were recorded during follow-up. Results: A total of 91 HF patients were enrolled. There were 44 patients in the CR group and 47 in the control group. Compared with before the program, the MLHFQ and SAS scores significantly decreased at 3 months after discharge in both groups. PSQI also showed mild improvement without significant differences in both groups. Furthermore, SDS showed a significant increase in the CR group but within the normal range. MACE occurrences did not show a significant difference. Conclusion: Early initiation of self-management program based on multidisciplinary education may help improve quality of life, sleep quality, and reduce anxiety for hospitalized HF patients. [ABSTRACT FROM AUTHOR]
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- 2024
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49. Sex-specific chrono-nutritional patterns and association with body weight in a general population in Spain (GCAT study).
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Pons-Muzzo, Luciana, de Cid, Rafael, Obón-Santacana, Mireia, Straif, Kurt, Papantoniou, Kyriaki, Santonja, Isabel, Kogevinas, Manolis, Palomar-Cros, Anna, and Lassale, Camille
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CROSS-sectional method ,PATIENT compliance ,LIFESTYLES ,BODY mass index ,RESEARCH funding ,MEDITERRANEAN diet ,CLUSTER analysis (Statistics) ,NUTRITIONAL assessment ,SEX distribution ,QUESTIONNAIRES ,MULTIVARIATE analysis ,DESCRIPTIVE statistics ,LONGITUDINAL method ,SLEEP duration ,FOOD habits ,CIRCADIAN rhythms ,SLEEP quality ,MEALS ,SOCIODEMOGRAPHIC factors ,COMPARATIVE studies ,CONFIDENCE intervals ,REGRESSION analysis - Abstract
Background: Altered meal timing patterns can disrupt the circadian system and affect metabolism. Our aim was to describe sex-specific chrono-nutritional patterns, assess their association with body mass index (BMI) and investigate the role of sleep in this relationship. Methods: We used the 2018 questionnaire data from the population-based Genomes for Life (GCAT) (n = 7074) cohort of adults aged 40–65 in Catalonia, Spain, for cross-sectional analysis and its follow-up questionnaire data in 2023 (n = 3128) for longitudinal analysis. We conducted multivariate linear regressions to explore the association between mutually adjusted meal-timing variables (time of first meal, number of eating occasions, nighttime fasting duration) and BMI, accounting for sleep duration and quality, and additional relevant confounders including adherence to a Mediterranean diet. Finally, cluster analysis was performed to identify chrono-nutritional patterns, separately for men and women, and sociodemographic and lifestyle characteristics were compared across clusters and analyzed for associations with BMI. Results: In the cross-sectional analysis, a later time of first meal (β 1 h increase = 0.32, 95% CI 0.18, 0.47) and more eating occasions (only in women, β 1 more eating occasion = 0.25, 95% CI 0.00, 0.51) were associated with a higher BMI, while longer nighttime fasting duration with a lower BMI (β 1 h increase=-0.27, 95% CI -0.41, -0.13). These associations were particularly evident in premenopausal women. Longitudinal analyses corroborated the associations with time of first meal and nighttime fasting duration, particularly in men. Finally, we obtained 3 sex-specific clusters, that mostly differed in number of eating occasions and time of first meal. Clusters defined by a late first meal displayed lower education and higher unemployment in men, as well as higher BMI for both sexes. A clear "breakfast skipping" pattern was identified only in the smallest cluster in men. Conclusions: In a population-based cohort of adults in Catalonia, we found that a later time of first meal was associated with higher BMI, while longer nighttime fasting duration associated with a lower BMI, both in cross-sectional and longitudinal analyses. [ABSTRACT FROM AUTHOR]
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- 2024
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50. Comparative insomnia prevalence between geriatrics lived in urban and rural areas: a multicenter nationwide study analysis.
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Budiman, Susanty, Sri, Hasan, Faizul, and Apriliyasari, Renny Wulan
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OLDER people ,AGE groups ,ALCOHOL drinking ,CITIES & towns ,INSOMNIA - Abstract
Aims: Insomnia is a common complaint among older adults. However, the comparative prevalence between older adults living in urban versus rural areas remains under-researched. This study aims to validate the overall prevalence of insomnia among older adults in Indonesia and investigate the comparative prevalence between older adults living in urban and rural areas. Methods: The data were derived from the 2018 Indonesian Basic Health Research Study. We included a total of 93,830 older participants aged > 60 years old who completed the insomnia questions. The prevalence and regression models were analyzed using the SPSS software. Results: The insomnia group has a higher age compared to the non-insomnia group (P < 0.05). Insomnia is more prevalent in females compared to males (P < 0.05). When classified by age groups (60–64, 65–69, 70–74, and > 75 years old), the prevalence of insomnia was 20%, 21%, 23%, and 24%, respectively. The prevalence of insomnia among older individuals living in rural areas was higher compared to those living in urban areas. In addition, increasing age, being female, unemployed, having comorbidities, being less active, and drinking alcohol are associated with insomnia symptoms. Conclusion: The findings of this study indicated that the prevalence of insomnia is high among older adults in Indonesia, with older adults living in rural areas exhibiting a higher prevalence compared to those living in urban areas. Our findings strengthen the importance of sleep management in clinical or community settings. [ABSTRACT FROM AUTHOR]
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- 2024
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