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Živinarska proizvodnja se širom sveta suoačava sa sve većom učestalošću bolesti izazvanih Adenovirusima živine (engl. Fowl Adenovirus – FAdV). Ova oboljenja imaju značajan ekonomski uticaj, naročito u proizvodnji brojlera. FAdV se smatra glavnim uzročnikom tri sindroma: adenovirusnih erozija i ulceracija mišićnog dela želuca, hepatitisa sa inkluzionim telima i hepatitis-hidroperikardijum sindroma. Virus se širi horizontalno i vertikalno. Moguće ga je izolovati od obolelih, ali i od zdravih odnosno inaparentno obolelih jedinki. Veoma važna osobina ovog virusa je njegov imunosupresivni potencijal, koji se ogleda supresijom humoralnog i ćelijskog imuniteta. U ovom istraživanju je ispitivan imunski odgovor posle primene vakcine protiv Atipične kuge peradi (AKP) u jatima kod kojih je prethodno potvrđena serokonverzija protiv adenovirusa živine. Studija je sprovedena na 5 farmi (farme 1 – 4 i kontrolna farma) kapaciteta od 10 000 do 25 000 pilića. Ispitivanjem je bilo obuhvaćeno ukupno 220 pilića, starosti od četiri do pet nedelja, koji nisu ispoljavali kliničke znakove oboljevanja. Kontrolnu grupu je činilo 20 pilića sa farme kod koje nije utvrđena serokonverzija protiv FAdV. Pilići su između 11. i 13. dana života vakcinisani komercijalno dostupnim živim vakcinama. Primenom ELISA metode, utvrđeno je prisustvo specifičnih antitela protiv FAdV u 130 krvnih seruma (65 procenata). U zavisnosti od farme, prosečna seroprevalencija se kretala od 30-100 procenata. Primenom testa inhibicije hemaglutinalcije, 14-21. dana nakon vakcinacije, utvrđivano je prisustvo specifičnih antitela protiv virusa AKP. Pozitivan heminhibicioni (HI) titar (≥ 16) je utvrđen u 41 (20,5 procenata) serumu, što je značajno manje u poređenju sa kontrolnom farmom, gde je pozitivan HI titar utvrđen u 20 (100 procenata) seruma. Naši rezulati su u skladu sa rezultatima drugih autora i ukazuju na prisustvo infekcije adenovirusima živine na brojlerskim farmama i na ozbiljan imunosupresivni potencijal ovog viru, All over the world the poultry production is facing with an increasing of number of diseases related to Fowl adenovirus (FAdV). These diseases have a significant economic impact, especially in the production of broilers. FAdV is considered to be the main cause of three syndromes: adenoviral gizzard erosions and ulcerations, inclusion body hepatitis and hepatitis-hydropericardium syndrome. The virus spreads horizontally and vertically. It is possible to isolate it from sick, but also from healthy individuals. A very important feature of this virus is its immunosuppressive potential, which is reflected in the suppression of humoral and cellular immunity. In this study, we examined the immune response after administration of the Newcastle disease (ND) vaccine in flocks with previously confirmed seroconversion against Fowl adenovirus. The study was conducted on 5 farms (farm 1, farm 2, farm 3, farm 4 and control farm). A total of 220 chickens, age of four to five weeks, did not show clinical signs of the disease. The control group consisted of 20 chickens from a FAdV-free farm. Chickens were vaccinated with commercially available live vaccines between 11 and 13 days of life. Using the ELISA method, the presence of specific antibodies against FAdV was determined in 130 blood sera (65 %) from farm 1, farm 2, farm 3 and farm 4. Depending on the farm, the average seroprevalence ranged from 30-100%. Using the hemagglutination inhibition assay, in the period from 14-21. days after vaccination, the presence of specific antibodies against ND virus were determined. A positive hemagglutination inhibition (HI) titer (≥ 16) was found in 41 (20.5%) sera, which is significantly less compared to the control farm, where a positive HI titer was found in 20 (100%) sera. Our results are consistent with the results of other authors and indicate the presence of poultry adenovirus infection on broiler farms and a serious immunosuppressive potential of this virus in subclinical infected indiv