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Start Over Author "Yuya Asanomi" Publisher bentham science publishers ltd.
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1. Drastic Effects on Fibril Formation of Amyloid-β Peptides by the Addition of Amino Acid Residue Units to the Termini

Author

Kohei Uosaki, Yoshiro Chuman, Kazuyasu Sakaguchi, Xinjiang Chen, Yumiko Kobayashi, Takuya Masuda, Yuya Asanomi, and Hiroki Sakai

Subjects
chemistry.chemical_classification, Amyloid, Chemistry, Stereochemistry, education, Peptide, macromolecular substances, General Medicine, Fibril, Amyloid fibril, Biochemistry, Amyloid β peptide, Amino acid, Fibril formation, Structural Biology, Amino acid residue
Abstract

We report that the addition of amino acids to the amyloid peptide dramatically affected the structure and the rate of formation of amyloid fibrils. The attachment of three lysines to Aβ(10-35) gave the formation of remarkably long fibrils, while three glutamates resulted in a faster formation rate of the fibrils.

Published
2010
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