1. Successful Use of Aliskiren in a Case of IgA- Mesangial Glomerulonephritis Unresponsive to Conventional Therapies
- Author
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Elena Pelagi, Nicolino Comi, Emanuela Libri, Ramona Nicotera, Giorgio Fuiano, Mariadelina Simeoni, Simeoni, M., Nicotera, R., Pelagi, E., Libri, E., Comi, N., and Fuiano, G.
- Subjects
Amide ,Male ,Time Factors ,030232 urology & nephrology ,Chronic kidney disease (CKD) ,030204 cardiovascular system & hematology ,Immunosuppressive Agent ,chemistry.chemical_compound ,0302 clinical medicine ,Fumarates ,Ramipril ,Proteinuria ,Fumarate ,Biopsy, Needle ,Glomerulonephritis ,General Medicine ,Middle Aged ,Immunohistochemistry ,Drug Resistance, Multiple ,Direct Renin ,Treatment Outcome ,Retreatment ,Drug Therapy, Combination ,Glomerulonephritis iga ,medicine.symptom ,IgA GMN ,Immunosuppressive Agents ,Human ,medicine.medical_specialty ,Time Factor ,Urology ,Drug Administration Schedule ,Follow-Up Studie ,03 medical and health sciences ,Case report ,medicine ,Humans ,Adverse effect ,Pharmacology ,business.industry ,Glomerulonephritis, IGA ,Irbesartan ,Aliskiren ,medicine.disease ,Amides ,chemistry ,Prednisone ,business ,Conventional therapie ,Follow-Up Studies - Abstract
Introduction: The early suspension of Altitude trial in recent years has induced most nephrologists and cardiologists to abandon Aliskiren use. Consequently, the potential usefulness of the direct renin inhibition in IgA glomerulonephritis remained an under-investigated therapeutic option. Case Report: We report the case of a 53 years old IgA GMN patient unresponsive to all conventional anti-angiotensin-2 agents, steroids and immunosuppressants, in which the administration of Aliskiren permitted to achieve and maintain a complete proteinuria remission in the absence of any adverse event. Conclusion: Aliskiren might represent a valid and safe therapeutic option in IgA GMN, although further investigations would be needed to confirm this conclusion.
- Published
- 2019