1. The TB Structural Genomics Consortium: Providing a Structural Foundation for Drug Discovery
- Author
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Geoffrey S. Waldo, Jodie M. Johnston, Edward N. Baker, Radha Chauhan, Min S. Park, Jin KukYang, Bernhard Rupp, David Eisenberg, David Leys, Clare V. Smith, Tom Alber, Kirsty J. McLean, Shekhar C. Mande, Daniel H. Anderson, Marcin I. Apostol, Nandita Bachhawat, Vivek Sharma, William R. Jacobs, Vickery L. Arcus, Thomas C. Terwilliger, Se Won Suh, Andrew W. Munro, Harindarpal S. Gill, Mack Kuo, Avinash Kale, Celia W. Goulding, James C. Sacchettini, J. Shaun Lott, and Joel Berendzen
- Subjects
Microbiology (medical) ,Mycobacterium Tuberculosis Structural Genomics Consortium ,Tuberculosis ,Protein Disulfide-Isomerases ,Computational biology ,Biology ,Structural genomics ,Bacterial Proteins ,Cytochrome P-450 Enzyme System ,Glutamate-Ammonia Ligase ,medicine ,Aldehyde-Lyases ,Pharmacology ,Antigens, Bacterial ,business.industry ,Drug discovery ,Genomics ,Methyltransferases ,Mycobacterium tuberculosis ,medicine.disease ,Anti-Bacterial Agents ,Biotechnology ,Drug Design ,Molecular Medicine ,Myo-Inositol-1-Phosphate Synthase ,Oxidoreductases ,business ,Acyltransferases ,Protein Structure Initiative - Abstract
Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilitating the determination of structures of proteins from Mycobacterium tuberculosis and hopes to determine 400 TB protein structures over 5 years. The Consortium has determined structures of 28 proteins from TB to date. These protein structures are already providing a basis for drug discovery efforts.
- Published
- 2002
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