1. Oxidation of Potassium Channels in Neurodegenerative Diseases: A Mini-Review.
- Author
-
Yang J and Yan X
- Subjects
- Animals, Antioxidants metabolism, Humans, Neurodegenerative Diseases drug therapy, Oxidation-Reduction drug effects, Antioxidants therapeutic use, Oxidative Stress physiology, Potassium Channels metabolism, Reactive Oxygen Species metabolism
- Abstract
Background & Objective: Increased level of reactive oxygen species is a hallmark of common neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease. ROS can oxidize macromolecules including DNA, lipids and proteins and cause oxidative damage to the cell. Emerging evidence indicate that potassium channels in the central nervous system are no exceptions to these oxidative modifications., Conclusion: In this mini-review, we summarized recent reports on the oxidation of potassium channels in the CNS and the consequently resulted changes in cell functions and viability, with focus on its implications in neurodegenerative diseases., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Published
- 2018
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