1. Carbohydrate mimics and lectins: a source of new drugs and therapeutic opportunities.
- Author
-
Reina JJ and Bernardi A
- Subjects
- Animals, Biomimetics methods, Cell Adhesion Molecules antagonists & inhibitors, Cell Adhesion Molecules metabolism, Humans, Lectins antagonists & inhibitors, Lectins, C-Type antagonists & inhibitors, Lectins, C-Type metabolism, Models, Molecular, Receptors, Cell Surface antagonists & inhibitors, Receptors, Cell Surface metabolism, Biomimetic Materials chemistry, Biomimetic Materials pharmacology, Carbohydrates chemistry, Carbohydrates pharmacology, Drug Discovery methods, Lectins metabolism
- Abstract
Mimics of oligosaccharides capable of interfering with lectin activity are currently being pursued by a number of groups in an effort to produce tools for glycobiology and to design antagonists of medically relevant lectins. The field is reviewed in this chapter. After a brief overview of the state of the art, examples from our and others' studies on the dendritic cell receptor DC-SIGN are illustrated.
- Published
- 2012
- Full Text
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