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The effects of physical exercise on cerebral function have been reported in various research studies, thereby leading to better understanding of the brain's cellular mechanisms related to adaptations concerning physical exercise and the different cell responses which become compromised regarding chronic mechanisms. Relearning patterns of movement may thus be an alternative clinical approach affecting cognition and brain plasticity. Recent evidence has shown that neurogenesis can become increased by exercise; nevertheless, moderation mechanisms and the times involved in this process are not at all clear. This review thus provides an update for understanding physical exercise-induced neurogenesis, covering mediating mechanisms and maturation. This is important as glial cell mechanisms are signals activating the neurons and synaptically influencing them, as well as their development, transmission and plasticity via a series of secreted signals depending on contact in human beings. Neurogenesis thus represents a natural model for understanding how new neurons become regenerated and incorporated into brain circuits, thus representing therapeutic potential regarding delay or repair of brain damage caused by injury or disease., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)