1. Epidemiology of Urinary Tract Infections in HIV Positive Patients at a Tertiary Care University Hospital in Central Europe (2011 - 2016).
- Author
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Klasinc R, Rieger A, Presterl E, Wrba T, and Diab-Elschahawi M
- Subjects
- Adolescent, Adult, Anti-Infective Agents therapeutic use, CD4 Lymphocyte Count, Case-Control Studies, Drug Resistance, Multiple, Bacterial drug effects, Escherichia coli drug effects, Escherichia coli Infections diet therapy, Escherichia coli Infections epidemiology, Escherichia coli Infections microbiology, Europe epidemiology, Female, HIV Infections drug therapy, HIV Infections immunology, Hospitals, University, Humans, Male, Middle Aged, Prevalence, Retrospective Studies, Risk Factors, Tertiary Healthcare, Urinary Tract Infections drug therapy, Urinary Tract Infections microbiology, Escherichia coli immunology, Escherichia coli Infections immunology, HIV Infections epidemiology, Urinary Tract Infections epidemiology
- Abstract
Objectives: There is limited published data concerning the recent epidemiology of urinary tract infections (UTI) in HIV-patients, thus we analysed independent risk factors for UTI in HIV positive individuals and antimicrobial resistance rates of E. coli to antimicrobial agents commonly used in UTI. To determine the prevalence of symptomatic urinary tract infections (UTI) in HIV-patients, we performed a retrospective case-control study., Methods: We included 313 HIV-patients, 101 with UTI and 212 age and gendermatched controls, attending the HIV outpatient clinic at the Vienna University Hospital (VUH) over a period from January 2011 to September 2016. The patients' specific data was gathered from the electronic database of the VUH. The statistical analysis was performed using SPSS Software Version 20.0., Results: HIV infected individuals with CD4 count >200 cells/mm3 were less likely than HIV infected individuals with CD4 count <200 cells/mm3 to experience UTI (OR 0.811, 95% CI 0.712-0.923 vs. OR 2.555, 95% CI 1.553 - 4.205, respectively). The in vitro resistance rate of E. coli to antimicrobial agents was as follows: ciprofloxacin (41%), mecillinam (20.5%), trimethoprim (61%), ampicillin (67%), ampicillin/ clavulanic acid (23%), cefuroxime (17%), nitrofurantoin (2%), amikacin (0%) and gentamicin (9.5%)., Conclusion: Immunological status (CD4 count) is an important parameter for risk assessment of UTIs in HIV-patients. The increased resistance rate of E. coli to commonly used antimicrobial agents needs to be considered when it comes to the management of UTI, additionally, surveillance strategies should be implemented in HIV-patients., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Published
- 2018
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