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1. The potential for targeting oncogenic WNT/beta-catenin signaling in therapy.

Author

Ewan KB and Dale TC

Subjects
Animals, Apoptosis drug effects, Cell Differentiation drug effects, Drug Delivery Systems, Humans, Neoplasms physiopathology, Signal Transduction drug effects, Neoplasms drug therapy, Wnt Proteins metabolism, beta Catenin metabolism
Abstract

There has been a surge of interest in the therapeutic targeting of the Wnt pathway following the demonstration that it is activated in a wide variety of tumors and that blocking aberrant signaling promoted tumor cell apoptosis or differentiation. This review describes recent therapeutic approaches and discusses potential opportunities for intervention at multiple levels within the Wnt pathway.

Published
2008
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