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The article is devoted to the creation of a method for generating anthropomorphic brain models based on magnetic resonance imaging. The selection of the magnetic field amplitude for transcranial magnetic stimulation (TMS) is carried out through modeling using the finite element method (FEM). These FEM models graphically demonstrate information on the distribution of the magnetic field and, therefore, on the occurring neurophysiological and behavioral changes based on the dose of the TMS, the specific resistance of the head tissue and its anatomy. Thus, these models are an integral tool used to design, configure, and program TMS devices, as well as to study parameters such as magnetic field strength and tension. A distinctive aspect of this work is the quality of the resulting head models. When creating the calculated FEM models, an MRI image of the head was used to perform segmentation in the FreeSurfer environment. Next, the image was converted in the Matlab environment. After the assembly of the head model in COMSOL Multiphysics, the TMS was simulated. The results of the transformations is a head model made in the form of a three-dimensional grid, which is suitable for modeling. The obtained data can be used to personalize the TMS method in medicine.

In modern clinical practice, the assessment of the state of blood microcirculation and the diagnosis of microcirculatory disorders are extremely relevant in a variety of diseases: in cardiology, diabetology, oncology, dermatology, dentistry, surgery and resuscitation. Microcirculatory disorders are very diverse both in their pathogenesis and in clinical manifestations. Therefore, in the pattern of various diseases and extreme conditions, as well as in the correction of microcirculatory disorders the methods are needed for both operative assessment of the state of blood flow at tissue level and for its long-term monitoring. The interest in the study of the microvascular bed of the circulatory system is sparked by the significant role of capillaries in the implementation of the basic processes of the body's vital activity, in the trophic support of organs and their direct participation in tissue and cellular respiration. The health and life expectancy of a person depend on the coordinated work of the heart, large blood lines, and microcirculation vessels. The authors have studied modern optical methods for diagnosing microcirculation. The feasibility of using the speckle imaging method for noninvasive rapid assessment of the state of the microvasculature of human surface biological tissues has been substantiated. To implement the speckle-visualization method, methodological and software have been developed. The processing parameters that are most optimal from the point of view of the ratio of spatiotemporal resolution and computation time have been experimentally substantiated. The purpose of this work is the experimental testing of the developed methodological and hardware speckle imaging for the diagnosis of microcirculation of human surface biological tissues. The authors have carried out the studies of the state of microcirculation in the superficial blood vessels of the skin during physiotherapeutic procedures and in the imitation of pathology. The results of the studies have proved the feasibility of using the developed software for a high-quality diagnosis of the state of microcirculation of human surface biological tissues: primary changes in microcirculation are revealed, further changes to occur during physiotherapeutic procedures are visualized.