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Sodium trifluoromethanesulfinate, CF 3 SO 2 Na, and trifluoromethanesulfonyl chloride, CF 3 SO 2 Cl, are two popular reagents that are widely used for the direct trifluoromethylation of a large range of substrates. Further, these two reagents are employed for the direct trifluoromethylsulfenylation and trifluoromethylsulfinylation, the introduction of the SCF 3 and the S(O)CF 3 group, respectively. In addition to the aforementioned reactions, the versatility of these two reagents is presented in other reactions such as sulfonylation and chlorination. This first part is dedicated to sodium trifluoromethanesulfinate.

The recent progresses of the application of trifluoromethanesulfonyl chloride, CF 3 SO 2 Cl, in the formation of C-CF 3 , C-SCF 3 , C-SOCF 3 , and C-Cl bonds are summarised in this second part of a two-part review published back-to-back on both sodium trifluoromethanesulfinate, CF 3 SO 2 Na, (Part 1) and trifluoromethanesulfonyl chloride, CF 3 SO 2 Cl (Part 2). There are many reactions in common between these two reagents but it should be noted that CF 3 SO 2 Cl reacts under reductive conditions while CF 3 SO 2 Na requires oxidative conditions. Electrophilic chlorination is obviously the exclusive preserve of CF 3 SO 2 Cl that has been exploited with emphasis in enantioselective chlorination.