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Aim: Compare within site effects of three interventions designed to enhance outcomes of hospitalized cognitively impaired elders., Methods: Prospective, nonrandomized, confirmatory phased study. In Phase I, 183 patients received one of three interventions: augmented standard care (ASC), resource nurse care (RNC) or Transitional Care Model (TCM). In Phase II, 205 patients received the TCM., Results: Time to first rehospitalization or death was longer for the TCM versus ASC group (p = 0.017). Rates for total all-cause rehospitalizations and days were significantly reduced in the TCM versus ASC group (p < 0.001, both). No differences were observed between RNC versus TCM., Conclusion: Findings suggest the TCM is more effective than ASC. However, potential effects of the RNC relative to the TCM warrant further study., Competing Interests: Financial & competing interests disclosure This work was funded by the National Institute on Aging [Grant Number: R01 AG023116]; and the Marian S Ware Alzheimer's Program at the University of Pennsylvania. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.